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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TLK1 (from a repository: Sat Aug 7 19:26:58 2021)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins5 (31.25 %)
The number (and %) of the tumor suppressors2 (12.50 %)
Total number of binary PPIs (saturation %)33 (27.50 %)
The number (and %) of affected PPIs16 (48.48 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.250
Assortativity coefficient-0.6408
The network average Clustering coefficient0.530
The number (and %) of a zero Clustering coefficients5 (31.25 %)
The number (and %) of a zero Betweenness Centrality11 (68.75 %)


List of the fusions

PPI for parental proteins: TLK1 All fusions
: AA313889;
Proteins found in more fusions TPM3 (see 3 fusions); UBE3C (see 1 fusions); AURKA (see 1 fusions); TLK1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TLK1parental protein160.105169.667Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
2 ASF1Ainteractor31.0000ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
3 ASF1Binteractor40.8330.667ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
4 AURKAoncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
5 CHEK1suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
6 DYNLL1interactor50.6672.000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
7 ELAVL1oncoprotein50.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 INPP1interactor21.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
9 LUZP4interactor200Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
10 MBPinteractor100Myelin_MBP (PF01669, IPR000548): Myelin basic protein
11 NBNsuppressor100FHA (PF00498, IPR000253, SM00240): FHA domain
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
12 TLK2interactor70.38112.667IncA (PF04156, IPR007285): IncA protein
Phage_1_1 (PF08200, IPR013232): Bacteriophage 1.1 Protein
Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
13 TPM3oncoprotein31.0000Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
14 UBE3Cprotein found in more fusions31.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
15 XPO7interactor21.0000IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
16 YWHAEoncoprotein10014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 TLK1parental proteinPkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term

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