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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TLE2 (from a repository: Mon Dec 5 00:24:38 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins7 (43.75 %)
The number (and %) of the tumor suppressors1 (6.25 %)
Total number of binary PPIs (saturation %)35 (29.17 %)
The number (and %) of affected PPIs16 (45.71 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI3.500
Assortativity coefficient-0.7815
The network average Clustering coefficient0.789
The number (and %) of a zero Clustering coefficients1 (6.25 %)
The number (and %) of a zero Betweenness Centrality12 (75.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TLE2 All fusions
: BI046568; BF806201;
Proteins found in more fusions MSX1 (see 1 fusions); CUL4A (see 4 fusions); TLE2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TLE2parental protein160.124127.000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
2 BARHL1interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
3 CUL4Aprotein found in more fusions31.0000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
4 CUL4Boncoprotein30.6671.000Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
5 EMX2interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
6 FOXA3interactor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
HNF_C (PF09354, IPR018533): HNF3 C-terminal domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
7 HES1oncoprotein21.0000Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
8 LEF1oncoprotein21.0000CTNNB1_binding (PF08347, IPR013558): N-terminal CTNNB1 binding
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
9 MSX1protein found in more fusions31.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
10 MSX2interactor40.6671.000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
11 PAX9oncoprotein21.0000PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
12 PRDM1suppressor31.0000SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
13 TLE1interactor130.16755.000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
14 TLX3oncoprotein21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
15 UTYinteractor21.0000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
Nnf1 (PF03980, IPR007128): Nnf1
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
16 VENTXinteractor31.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain

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