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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)79
The number (and %) of the onco-proteins32 (40.51 %)
The number (and %) of the tumor suppressors2 (2.53 %)
Total number of binary PPIs (saturation %)321 (10.42 %)
The number (and %) of affected PPIs79 (24.61 %)
The number of possible different fusions21
PPI diameter2
PPI radius1
The average degree of PPI7.392
Assortativity coefficient-0.3991
The network average Clustering coefficient0.552
The number (and %) of a zero Clustering coefficients12 (15.19 %)
The number (and %) of a zero Betweenness Centrality27 (34.18 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TGM2 All fusions
: BF748178; BP287181; AA345479;
Proteins found in more fusions TAB2 (see 1 fusions); CDH1 (see 3 fusions); APP (see 4 fusions); YWHAG (see 1 fusions); YWHAZ (see 1 fusions); CBL (see 1 fusions); MCM2 (see 1 fusions); G6PD (see 3 fusions); FN1/YWHAG (see 1 fusions); ECHS1 (see 1 fusions); A2M (see 2 fusions); PAK2 (see 2 fusions); SQSTM1 (see 5 fusions); PLOD3 (see 2 fusions); SLC9A3R1 (see 2 fusions); TGM2 (see 4 fusions); PINK1 (see 3 fusions); VHL (see 1 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TGM2parental protein790.0714649.783Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
2 A2Mprotein found in more fusions40.6670.333A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
3 ABCA1oncoprotein21.0000ABC_tran (PF00005, IPR003439): ABC transporter
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
4 ADARinteractor21.0000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
z-alpha (PF02295, IPR000607, SM00550): Adenosine deaminase z-alpha domain
A_deamin (PF02137, IPR002466, SM00552): Adenosine-deaminase (editase) domain
5 ANKRD28interactor30.6671.000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
6 APPprotein found in more fusions180.22187.572APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ATF4oncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
8 BNIP3oncoprotein200BNIP3 (PF06553, IPR010548): BNIP3
9 C3interactor21.0000A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
10 CALM1interactor50.6002.233EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
11 CBLoncoprotein80.4766.156Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
12 CDC42BPAinteractor100CNH (PF00780, IPR001180, SM00036): CNH domain
DivIC (PF04977, IPR007060): Septum formation initiator
DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
XkdW (PF09636, IPR019094): XkdW protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
13 CDH1oncoprotein40.6670.286Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
14 CDK11Boncoprotein80.4769.139DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
15 CKBinteractor100.7783.124ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
16 CNDP2suppressor100.6677.069Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
17 COL4A3BPinteractor200Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
PH (PF00169, IPR001849, SM00233): PH domain
START (PF01852, IPR002913, SM00234): START domain
18 COL5A1interactor21.0000COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
19 COL5A2interactor100COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
20 COLGALT1interactor40.8330.333Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
21 CSE1Loncoprotein150.36244.575CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
22 CSNK2A2interactor60.3339.667Pkinase (PF00069, IPR000719): Protein kinase domain
23 ECHS1protein found in more fusions80.7142.650ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
24 ENOPH1interactor100Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
25 FBXO6interactor170.20687.808FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
26 FN1oncoprotein170.34660.091fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
27 FNTAinteractor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PPTA (PF01239, IPR002088): Protein prenyltransferase alpha subunit repeat
TPR_14 (PF13428): Tetratricopeptide repeat
DUF4219 (PF13961, IPR025314): Domain of unknown function (DUF4219)
28 G6PDprotein found in more fusions160.55221.626G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
29 GCGRinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
30 GRNoncoprotein30.6670.333Granulin (PF00396, IPR000118, SM00277): Granulin
Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
31 GSTP1suppressor41.0000GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
32 HIST3H3interactor31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
33 HNRNPFinteractor90.50011.877RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
34 HNRNPUL1interactor60.6003.333Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
35 HPinteractor30.6670.500Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
36 HSPA1Ainteractor90.5289.527HSP70 (PF00012, IPR013126): Hsp70 protein
37 HSPA1Binteractor70.4765.994HSP70 (PF00012, IPR013126): Hsp70 protein
38 HSPA8oncoprotein140.31941.179HSP70 (PF00012, IPR013126): Hsp70 protein
39 KPNA4interactor40.5001.452Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
40 LACRTinteractor40.6671.250NA
41 LDHBinteractor170.55023.279Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
42 MCM2oncoprotein190.34070.941AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
43 MVPoncoprotein60.4004.333Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
44 NPEPPSinteractor100.6447.852Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
45 PAK1oncoprotein61.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
46 PAK2protein found in more fusions120.60012.705PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
47 PGDoncoprotein60.9330.3336PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
48 PIAS4interactor70.5248.500CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
49 PINK1protein found in more fusions40.6670.400Pkinase (PF00069, IPR000719): Protein kinase domain
50 PLCD1oncoprotein21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
EF-hand_10 (PF14788): EF hand
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
51 PLOD3protein found in more fusions50.8330.3332OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily
Anp1 (PF03452, IPR005109): Anp1
52 PPP4R3Binteractor50.9000.250Diphtheria_T (PF02764, IPR022405): Diphtheria toxin, T domain
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
IGF2_C (PF08365, IPR013576): Insulin-like growth factor II E-peptide
WH1 (PF00568, IPR000697, SM00461): WH1 domain
53 PSMD4interactor50.5002.071UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
54 RB1oncoprotein21.0000RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
55 RBM25interactor21.0000Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
PWI (PF01480, IPR002483, SM00311): PWI domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
DUF3441 (PF11923, IPR021846): Domain of unknown function (DUF3441)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4778 (PF16008, IPR031958): Domain of unknown function (DUF4778)
56 RPS6KA3interactor50.7001.619Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
57 SERTAD1interactor30.6670.500CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
58 SF3B4interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
59 SIPA1L2interactor100IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
SPAR_C (PF11881, IPR021818): C-terminal domain of SPAR protein
60 SLC7A9interactor100AA_permease_2 (PF13520, IPR002293): Amino acid permease
UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
61 SLC9A3R1oncoprotein140.57716.857EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
62 SMAD2oncoprotein51.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
63 SMAD3oncoprotein110.31126.186MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
64 SQSTM1oncoprotein80.4299.033PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
65 SRGAP3interactor100CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
TMPIT (PF07851, IPR012926): TMPIT-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
66 TAB2oncoprotein60.9000.250CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
67 TMEM126Ainteractor21.0000TMEM126 (PF07114, IPR009801): Transmembrane protein 126
68 TMEM176Ainteractor100CD20 (PF04103, IPR007237): CD20-like family
69 TP53oncoprotein160.23862.722DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
70 TWISTNBinteractor100Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
71 TXNDC5interactor80.6434.450Thioredoxin (PF00085, IPR013766): Thioredoxin
72 UBE2V1interactor80.7862.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
73 UBFD1interactor110.7454.326ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
74 VHLoncoprotein120.34529.221Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
75 YWHAGprotein found in more fusions190.44444.16014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
76 YWHAQinteractor210.38180.03514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
77 YWHAZprotein found in more fusions220.32994.25114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
78 ZFYVE19interactor41.0000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
79 ZNF512Binteractor40.6672.000YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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