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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)149
The number (and %) of the onco-proteins29 (19.46 %)
The number (and %) of the tumor suppressors15 (10.07 %)
Total number of binary PPIs (saturation %)465 (4.22 %)
The number (and %) of affected PPIs149 (32.04 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI5.772
Assortativity coefficient-0.4360
The network average Clustering coefficient0.603
The number (and %) of a zero Clustering coefficients28 (18.79 %)
The number (and %) of a zero Betweenness Centrality80 (53.69 %)


List of the fusions

PPI for parental proteins: TERF2IP All fusions
: AA113346;
Proteins found in more fusions TERF2IP (see 1 fusions); CTBP1 (see 2 fusions); CHMP2B (see 1 fusions); AIMP2 (see 1 fusions); MCM2 (see 1 fusions); PPP2R5E (see 1 fusions); PPP1R10 (see 1 fusions); EPAS1 (see 1 fusions); PARP1 (see 1 fusions); PML (see 4 fusions); PRDX6 (see 1 fusions); PRPF40A (see 2 fusions); PACSIN2 (see 1 fusions); SP100 (see 1 fusions); NOL3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TERF2IPparental protein1490.02617945.436BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
2 ACDinteractor130.41028.791TPP1 (PF10341, IPR019437): Shelterin complex subunit, TPP1/ACD
3 ADAinteractor30.6670.333A_deaminase (PF00962, IPR001365): Adenosine/AMP deaminase
4 AIMP2suppressor31.0000GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
5 AK1interactor40.8330.222AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ADK (PF00406, IPR000850): Adenylate kinase
6 AKR1A1interactor31.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
7 AKR1B10interactor100Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
8 AKR7A3interactor200Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
9 AKT1oncoprotein70.3338.167PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
10 ANXA5oncoprotein50.8000.650Annexin (PF00191, IPR018502, SM00335): Annexin
11 ANXA8L1interactor41.0000DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
12 AP2B1interactor40.8330.667Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
13 APEX1interactor90.44413.033Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
14 ARPP21interactor21.0000R3H (PF01424, IPR001374, SM00393): R3H domain
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
15 BABAM1interactor21.0000VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
16 BANPsuppressor70.4676.900DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
17 BCL7Bsuppressor21.0000BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
18 C1orf174interactor21.0000UPF0688 (PF15772, IPR031530): UPF0688 family
19 C9orf78interactor100DHOR (PF06537, IPR010538): Di-haem oxidoreductase, putative peroxidase
Hep_59 (PF07052, IPR010756): Hepatocellular carcinoma-associated antigen 59
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
20 CALML3interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
21 CCDC106interactor21.0000CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
22 CHMP2Bprotein found in more fusions31.0000Involucrin (PF00904, IPR000354): Involucrin repeat
Snf7 (PF03357, IPR005024): Snf7
23 COTL1oncoprotein21.0000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
24 CPNE2interactor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
25 CPNE3interactor50.8000.833C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
26 CRKoncoprotein60.4007.186SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
27 CRYBB1interactor21.0000Crystall (PF00030, IPR001064, SM00247): Beta/Gamma crystallin
28 CRYGSinteractor31.0000Crystall (PF00030, IPR001064, SM00247): Beta/Gamma crystallin
29 CTBP1protein found in more fusions50.6671.3332-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
30 DBNLinteractor41.0000RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
31 DCLRE1Binteractor80.7143.589DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
32 DDX23interactor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3698 (PF12479, IPR022167): Protein of unknown function (DUF3698)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
33 DDX24interactor70.5246.833DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tti2 (PF10521, IPR018870): Tti2 family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
34 DDX39Ainteractor60.5003.900DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
35 DHX38interactor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
36 DNMT3Asuppressor21.0000DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
37 DPP3interactor41.0000Peptidase_M49 (PF03571): Peptidase family M49
38 ENAHoncoprotein31.0000MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
39 EPAS1suppressor50.5001.667Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
40 EPS8L1interactor100PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
TetR_C_11 (PF16859, IPR011075): Bacterial transcriptional repressor C-terminal
41 FABP2interactor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
42 FAM122Ainteractor21.0000NA
43 FBLinteractor70.4766.039Fibrillarin (PF01269, IPR000692): Fibrillarin
44 GAGE5interactor100NA
45 GAMTinteractor31.0000Methyltransf_25 (PF13649): Methyltransferase domain
46 GGCXinteractor100Cupin_2 (PF07883, IPR013096): Cupin domain
VKG_Carbox (PF05090, IPR007782): Vitamin K-dependent gamma-carboxylase
47 GNMTsuppressor70.7334.000TehB (PF03848, IPR015985): Tellurite resistance protein TehB
Methyltransf_25 (PF13649): Methyltransferase domain
48 GPKOWinteractor30.6671.000KOW (PF00467, IPR005824, SM00739): KOW motif
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
49 HAAOinteractor21.00003-HAO (PF06052, IPR010329): 3-hydroxyanthranilic acid dioxygenase
Cupin_2 (PF07883, IPR013096): Cupin domain
50 HAGHinteractor100Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
51 HDGFRP3interactor100PPP4R2 (PF09184, IPR015267): PPP4R2
PWWP (PF00855, IPR000313, SM00293): PWWP domain
52 HIST1H1Ainteractor80.4649.667Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
53 HIST1H2ALinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
54 HIST1H4Binteractor100CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
55 HMGB1oncoprotein40.6671.000HMG_box_2 (PF09011, IPR009071): HMG-box domain
NOA36 (PF06524, IPR010531): NOA36 protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
56 HMGB3interactor21.0000HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
57 HMGN3interactor31.0000HMG14_17 (PF01101, IPR000079, SM00527): HMG14 and HMG17
58 HMGN4interactor31.0000HMG14_17 (PF01101, IPR000079, SM00527): HMG14 and HMG17
59 HNRNPKoncoprotein100.33317.000ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
60 HSPA4interactor110.34531.133Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
61 IDO1oncoprotein100IDO (PF01231, IPR000898): Indoleamine 2,3-dioxygenase
62 IL1RNinteractor21.0000IL1 (PF00340, IPR000975, SM00125): Interleukin-1 / 18
63 KIAA1191interactor30.6670.286P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
64 LANCL2interactor30.6670.222Glyco_hydro_127 (PF07944, IPR012878): Beta-L-arabinofuranosidase, GH127
LANC_like (PF05147, IPR007822): Lanthionine synthetase C-like protein
65 LGALSLinteractor31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
66 MAGOHBinteractor30.6670.222Mago_nashi (PF02792, IPR004023): Mago nashi protein
67 MCM2oncoprotein190.203102.011AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
68 MDH1interactor50.7002.500Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
69 MPGinteractor30.6671.000Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)
70 MRE11Aoncoprotein120.43618.756APG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
71 MRTO4interactor50.6003.167Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
72 MT1Xinteractor31.0000Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
73 MT3interactor100Metallothio (PF00131, IPR003019): Metallothionein
74 NAIF1interactor21.0000Myb_DNA-bind_5 (PF13873, IPR028002): Myb/SANT-like DNA-binding domain
75 NASPinteractor21.0000Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
SlyX (PF04102, IPR007236): SlyX
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
XhlA (PF10779, IPR019715): Haemolysin XhlA
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
76 NBNsuppressor80.6794.422FHA (PF00498, IPR000253, SM00240): FHA domain
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
77 NOL3oncoprotein60.7002.167CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
78 NUDT14interactor31.0000NUDIX (PF00293, IPR000086): NUDIX domain
79 NUDT18interactor21.0000NUDIX (PF00293, IPR000086): NUDIX domain
80 NUMA1oncoprotein50.5002.833Colicin (PF01024, IPR000293): Colicin pore forming domain
Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
81 NXNL1interactor41.0000TraF (PF13728): F plasmid transfer operon protein
Thioredoxin_8 (PF13905, IPR012336): Thioredoxin-like
82 OCM2interactor31.0000EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
83 OGFRinteractor21.0000OGFr_III (PF04680, IPR006770): Opioid growth factor receptor repeat
OGFr_N (PF04664, IPR006757): Opioid growth factor receptor (OGFr) conserved region
SspP (PF08179, IPR012614): Small acid-soluble spore protein P family
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
84 PACSIN2oncoprotein50.6671.167DegS (PF05384, IPR008595): Sensor protein DegS
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
85 PACSIN3interactor50.5001.833FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
GrpE (PF01025, IPR000740): GrpE
SH3_9 (PF14604, IPR001452): Variant SH3 domain
86 PAFAH1B3interactor50.6670.889Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
87 PANK4interactor100DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
Fumble (PF03630, IPR004567): Fumble
88 PARP1suppressor70.4675.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
89 PCNPinteractor100PCNP (PF15473, IPR029169): PEST, proteolytic signal-containing nuclear protein family
90 PCP4interactor31.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
91 PEA15suppressor100DED (PF01335, IPR001875, SM00031): Death effector domain
92 PGLSinteractor40.8330.400Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
93 PGM1interactor70.6194.900PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
94 PMLsuppressor70.3338.667zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
95 PNMTinteractor21.0000NNMT_PNMT_TEMT (PF01234, IPR000940): NNMT/PNMT/TEMT family
96 POLD1interactor30.6670.250DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
97 POT1interactor350.132399.122POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
98 PPM1Ginteractor50.7003.000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
99 PPP1R10protein found in more fusions50.6672.000Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
100 PPP1R2interactor21.0000IPP-2 (PF04979, IPR007062): Protein phosphatase inhibitor 2 (IPP-2)
101 PPP2R5Eprotein found in more fusions200B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
102 PPP6R3interactor50.5004.067SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
103 PRDX6protein found in more fusions60.8001.333AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
104 PRPF40Aprotein found in more fusions50.8330.333FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
105 PRXinteractor200Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
CCDC74_C (PF14917, IPR029422): Coiled coil protein 74, C terminal
106 PTMAoncoprotein50.9000.333Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
107 RABIFinteractor100Mss4 (PF04421, IPR007515): Mss4 protein
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
108 RAD50interactor70.7142.556DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
YscO (PF07321, IPR009929): Type III secretion protein YscO
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2703 (PF10865, IPR021219): Domain of unknown function (DUF2703)
DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015)
AAA_13 (PF13166, IPR026866): AAA domain
AAA_23 (PF13476): AAA domain
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
109 RAD51interactor31.0000Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
110 RBBP9interactor100Ser_hydrolase (PF06821, IPR010662): Serine hydrolase
111 RECQL4oncoprotein50.7001.500DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Drc1-Sld2 (PF11719, IPR021110): DNA replication and checkpoint protein
112 RGMAinteractor100RGM_C (PF06534, IPR009496): Repulsive guidance molecule (RGM) C-terminus
RGM_N (PF06535, IPR010536): Repulsive guidance molecule (RGM) N-terminus
113 RIF1interactor30.6670.667Rif1_N (PF12231, IPR022031): Rap1-interacting factor 1 N terminal
DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
114 RPAP1interactor40.5001.186ATP-synt_B (PF00430, IPR002146): ATP synthase B/B' CF(0)
RPAP1_C (PF08620, IPR013929): RPAP1-like, C-terminal
RPAP1_N (PF08621, IPR013930): RPAP1-like, N-terminal
115 RPP25interactor100Alba (PF01918, IPR002775): Alba
116 S100Poncoprotein31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
117 SBDSoncoprotein41.0000SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
118 SCLYinteractor100Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
119 SCRN2interactor21.0000AAT (PF03417, IPR005079): Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
Peptidase_C69 (PF03577, IPR005322): Peptidase family C69
120 SEToncoprotein100.5836.528NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
121 SLC16A3oncoprotein21.0000MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
122 SLX4suppressor50.9000.333BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Slx4 (PF09494, IPR018574): Slx4 endonuclease
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
123 SMARCC2interactor60.3336.389GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
124 SNCGoncoprotein31.0000Synuclein (PF01387, IPR001058): Synuclein
125 SP100suppressor60.5004.500Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
SAND (PF01342, IPR000770, SM00258): SAND domain
HSR (PF03172, IPR004865): HSR domain; Sp100 domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
126 TADA2Binteractor21.0000SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
127 TALDO1interactor60.6003.400TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
128 TBC1D10Ainteractor31.0000LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
TonB_N (PF16031): TonB N-terminal region
129 TBCAinteractor100TBCA (PF02970, IPR004226): Tubulin binding cofactor A
130 TERF1interactor590.0871305.158TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
131 TERF2interactor450.113705.778Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
132 TFAP4oncoprotein100.33324.067DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
133 TINF2interactor240.221158.411TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
134 TMSB10oncoprotein41.0000CheR (PF01739, IPR022642): CheR methyltransferase, SAM binding domain
135 TMSB4Yinteractor31.0000Thymosin (PF01290, IPR001152, SM00152): Thymosin beta-4 family
136 TOR1AIP1interactor30.6670.667LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Pap_E4 (PF02711, IPR003861): E4 protein
137 TSSC4suppressor100TSSC4 (PF15264, IPR029338): Tumour suppressing sub-chromosomal transferable candidate 4
138 TWF2interactor40.5001.186Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
139 UCHL1suppressor30.6671.000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
140 VGLL4interactor100Vg_Tdu (PF07545, IPR011520): Vestigial/Tondu family
VGLL4 (PF15245, IPR028184): Transcription cofactor vestigial-like protein 4
141 WDFY3interactor100Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)
142 WDR5interactor50.4003.150WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
143 WDR92interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
144 WIPI2interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
145 XAGE2interactor21.0000GAGE (PF05831, IPR008625): GAGE protein
146 XPO1interactor250.117243.267CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
147 XRCC5suppressor110.51112.711Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
148 XRCC6oncoprotein150.35239.289Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
149 ZNF414interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon

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