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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TCL1A (from a repository: Mon Nov 14 00:49:58 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins9 (34.62 %)
The number (and %) of the tumor suppressors4 (15.38 %)
Total number of binary PPIs (saturation %)50 (15.38 %)
The number (and %) of affected PPIs26 (52.00 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI2.923
Assortativity coefficient-0.4228
The network average Clustering coefficient0.335
The number (and %) of a zero Clustering coefficients14 (53.85 %)
The number (and %) of a zero Betweenness Centrality19 (73.08 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TCL1A All fusions
: AA417758;
Proteins found in more fusions TCL1A (see 1 fusions); FOS (see 4 fusions); EP300 (see 1 fusions); TXLNA (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TCL1Aparental protein260.043550.000TCL1_MTCP1 (PF01840, IPR004832): TCL1/MTCP1 family
2 AKT1oncoprotein31.0000PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 AKT2oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 AKT3oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 ALS2CR12interactor100PNPase (PF03726, IPR015848): Polyribonucleotide nucleotidyltransferase, RNA binding domain
FAM76 (PF16046, IPR032017): FAM76 protein
6 ATMsuppressor200FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
7 CADPSinteractor100DUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
PH (PF00169, IPR001849, SM00233): PH domain
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
8 CALCOCO2interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
9 CARD9interactor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
10 CEP55interactor200DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
11 DNMT3Asuppressor100DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
12 EP300oncoprotein90.32118.333Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
13 FOSoncoprotein50.8330.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
14 GOLGA2interactor30.6670.667ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
15 HIST3H2Ainteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
16 JUNoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
17 JUNBoncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
18 LSM3interactor100LSM (PF01423, IPR001163): LSM domain
19 PRTFDC1interactor100Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
20 TCF4suppressor30.6671.000CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
21 TP53BP2suppressor30.6670.667ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
22 TRAF1oncoprotein200HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
23 TTC33interactor100TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
24 TXLNAprotein found in more fusions50.5002.667Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
25 TXLNBinteractor31.0000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
26 WDR47interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3752 (PF12572, IPR022226): Protein of unknown function (DUF3752)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4798 (PF16055, IPR032056): Domain of unknown function (DUF4798)

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