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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins16 (32.65 %)
The number (and %) of the tumor suppressors6 (12.24 %)
Total number of binary PPIs (saturation %)218 (18.54 %)
The number (and %) of affected PPIs49 (22.48 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI7.878
Assortativity coefficient-0.3060
The network average Clustering coefficient0.572
The number (and %) of a zero Clustering coefficients4 (8.16 %)
The number (and %) of a zero Betweenness Centrality10 (20.41 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TBL1X All fusions
: BQ774627; AI129599;
Proteins found in more fusions HDAC7 (see 1 fusions); TAB2 (see 1 fusions); CTBP1 (see 2 fusions); HUWE1 (see 2 fusions); HDAC5 (see 1 fusions); KHDRBS1 (see 1 fusions); SIAH1 (see 1 fusions); TBL1X (see 2 fusions); SMARCB1 (see 12 fusions); THRA (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TBL1Xparental protein490.1291404.728K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
2 CACYBPinteractor60.7001.786CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
3 CDC34oncoprotein40.6670.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
4 CTBP1protein found in more fusions80.5714.2862-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
5 CTNNB1oncoprotein120.37926.867Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
6 DLX3interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DLL_N (PF12413, IPR022135): Homeobox protein distal-less-like N terminal
DUF4292 (PF14125, IPR025634): Domain of unknown function (DUF4292)
7 DNAJB4suppressor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
8 ELAVL1oncoprotein100.38918.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 EMDinteractor90.6793.722LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
10 FKBP6interactor30.6671.000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
11 FOXK2interactor70.7621.327FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
12 GID8interactor40.6670.500LisH (PF08513, IPR013720, SM00667): LisH
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
13 GPS2oncoprotein130.53821.173G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
14 HDAC3suppressor190.39948.987Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
15 HDAC5protein found in more fusions150.54917.696Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
16 HDAC7protein found in more fusions90.7502.486Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
17 HIST1H4Ainteractor60.6673.167CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
18 HIST2H2AA3interactor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
19 HIST2H2BEinteractor40.5001.800Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
20 HIST2H3Cinteractor30.6670.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
21 HIST2H4Ainteractor21.0000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
22 HPinteractor21.0000Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
23 HRinteractor40.8330.222JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
24 HUWE1oncoprotein70.4676.067BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
25 KHDRBS1protein found in more fusions200KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
26 NANOGinteractor70.5336.333Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
27 NCOR1oncoprotein180.46439.201BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
28 NCOR2oncoprotein160.43337.429CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
29 NRDCinteractor60.7002.667Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
30 RELAoncoprotein70.4676.019DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
31 SIAH1suppressor80.4299.119Sina (PF03145, IPR018121): Seven in absentia protein family
32 SIN3Aoncoprotein90.6117.005Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
33 SKP1oncoprotein60.5335.000Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
34 SMARCB1suppressor100.5289.408SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
35 SMARCD1interactor70.7143.167ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
DivIC (PF04977, IPR007060): Septum formation initiator
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
36 SMARCD2interactor41.0000SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
37 SMARCD3interactor41.0000SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
38 SNRNP40interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
39 TAB2oncoprotein90.7861.741CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
40 TBL1XR1oncoprotein250.253178.123LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
41 TERF1interactor50.5002.500TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
42 THRAsuppressor100.6674.917C1_2 (PF03107, IPR004146): C1 domain
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
43 THRBsuppressor80.8570.617zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
44 TINF2interactor40.6671.000TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
45 TSC22D4interactor21.0000AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
46 UBE2D1interactor80.4766.633UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
47 UBE2E3interactor40.6670.400UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
48 UBE2Iinteractor150.42930.402UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
49 XPO1interactor150.33349.174CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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