Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PHLDB1, TAGLN (from a repository: Sun Mar 12 04:27:18 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins12 (20.69 %)
The number (and %) of the tumor suppressors4 (6.90 %)
Total number of binary PPIs (saturation %)277 (16.76 %)
The number (and %) of affected PPIs57 (20.58 %)
The number of possible different fusions8
PPI diameter3
PPI radius2
The average degree of PPI8.897
Assortativity coefficient-0.1851
The network average Clustering coefficient0.456
The number (and %) of a zero Clustering coefficients9 (15.52 %)
The number (and %) of a zero Betweenness Centrality9 (15.52 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: TAGLN,PHLDB1 All fusions
: AW352228;
Proteins found in more fusions SF1 (see 1 fusions); BAG3 (see 4 fusions); SH3KBP1 (see 1 fusions); GAN (see 1 fusions); JAK1 (see 1 fusions); SRPK2 (see 1 fusions); HINT1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TAGLNparental protein500.1371690.339Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
2 PHLDB1parental protein70.19053.362DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501)
FHA (PF00498, IPR000253, SM00240): FHA domain
PH (PF00169, IPR001849, SM00233): PH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
3 ACAA2interactor90.6119.251Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ACDinteractor70.57119.712TPP1 (PF10341, IPR019437): Shelterin complex subunit, TPP1/ACD
5 ACTA1interactor40.6671.339Actin (PF00022, IPR004000, SM00268): Actin
6 ALDOAinteractor140.48746.160Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
7 ALDOCinteractor100.48914.357Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
8 BAG3oncoprotein130.212105.753BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
9 CCDC8interactor70.13319.514Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
10 CFL1interactor110.41822.691Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
11 DUSP6suppressor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
12 EEF2interactor80.357105.649EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
13 ENO1oncoprotein220.411191.505Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
14 ENO2interactor210.47671.287Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
15 ENO3interactor150.7337.222Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
16 FABP3suppressor40.5002.615Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
17 FABP5interactor130.57716.921Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
18 FABP7interactor21.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
19 FKBP1Ainteractor170.54237.363FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
20 FKBP1Binteractor100.7117.554FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
21 FKBP2interactor150.60021.301FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
22 GANprotein found in more fusions300.952BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
23 GIPC1interactor201.005PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
24 GPX4interactor140.61515.779GSHPx (PF00255, IPR000889): Glutathione peroxidase
25 GSTO1interactor50.3005.921GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
26 HINT1suppressor190.51646.741HIT (PF01230, IPR001310): HIT domain
27 HSD17B10interactor170.54434.771adh_short (PF00106, IPR002198): short chain dehydrogenase
28 HSPE1interactor130.51318.235Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
29 ISG15suppressor90.38918.116ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
30 JAK1oncoprotein301.005FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
31 MRPL53interactor50.6003.500MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
32 NCF1interactor200p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
33 NDUFA7interactor40.6671.733CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
34 NME1-NME2interactor130.56427.482NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
35 NME2interactor120.7644.134NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
36 NTRK1oncoprotein230.130264.137I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
37 NUTF2interactor51.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
38 PGDoncoprotein60.4674.9496PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
39 PIK3CDoncoprotein100PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
40 PLS3interactor70.4769.417CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
41 POT1interactor80.6194.819POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
42 PPIBinteractor140.51637.053Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
43 RBM27interactor30.6670.500DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
PWI (PF01480, IPR002483, SM00311): PWI domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)
DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
44 RNF14interactor200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
RWD (PF05773, IPR006575, SM00591): RWD domain
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
45 S100A9oncoprotein301.005S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
46 SARNPoncoprotein21.0000SAP (PF02037, IPR003034, SM00513): SAP domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
Prok-E2_A (PF14457, IPR032865): Prokaryotic E2 family A
47 SF1protein found in more fusions60.50011.279UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
48 SH3KBP1protein found in more fusions302.193Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
49 SNX12interactor21.0000PX (PF00787, IPR001683, SM00312): PX domain
50 SNX3interactor70.42910.856PX (PF00787, IPR001683, SM00312): PX domain
51 SRPK2oncoprotein50.5002.974DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
52 SRPRBinteractor70.33328.150MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
53 STIP1interactor160.41759.381TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
54 SUGP1interactor70.42925.318G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
55 TINF2interactor60.9000.333TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
56 UCHL3interactor120.54514.450Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
57 XPO1interactor60.20019.912CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
58 YKT6interactor31.0000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

B a c k    t o    T o p ⇑


List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 HINT1suppressorHIT (PF01230, IPR001310): HIT domainAW352228
2 MRPL53interactorMRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53AW352228
3 PHLDB1parental proteinDUF501 (PF04417, IPR007511): Protein of unknown function (DUF501)
FHA (PF00498, IPR000253, SM00240): FHA domain
PH (PF00169, IPR001849, SM00233): PH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
AW352228
4 TAGLNparental proteinCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
AW352228

B a c k    t o    T o p ⇑