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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TAF8 (from a repository: Wed Nov 30 21:58:47 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins5 (18.52 %)
The number (and %) of the tumor suppressors2 (7.41 %)
Total number of binary PPIs (saturation %)133 (37.89 %)
The number (and %) of affected PPIs27 (20.30 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI9.407
Assortativity coefficient-0.3883
The network average Clustering coefficient0.679
The number (and %) of a zero Clustering coefficients4 (14.81 %)
The number (and %) of a zero Betweenness Centrality8 (29.63 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TAF8 All fusions
: AI969977; AI659647;
Proteins found in more fusions TAF8 (see 2 fusions); KPNB1 (see 2 fusions); TAF4 (see 4 fusions); ZDHHC17 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TAF8parental protein270.311299.159Bromo_TP (PF07524, IPR006565): Bromodomain associated
TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
DUF3090 (PF11290, IPR021441): Protein of unknown function (DUF3090)
2 GNB2interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
3 HIST3H3interactor160.65817.722Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
4 KIAA1107interactor21.0000Acyl-thio_N (PF12590, IPR021113): Acyl-ATP thioesterase
SOBP (PF15279, IPR026092): Sine oculis-binding protein
DUF4596 (PF15363, IPR027907): Domain of unknown function (DUF4596)
5 KIF7suppressor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
MMR_HSR1_C (PF08438, IPR013646): GTPase of unknown function C-terminal
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
XhlA (PF10779, IPR019715): Haemolysin XhlA
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
YlqD (PF11068, IPR021297): YlqD protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
6 KPNA2interactor31.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
7 KPNB1protein found in more fusions60.5002.971Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
8 MED26interactor130.7566.175Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
9 MEF2Aoncoprotein40.8330.667TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
10 PLK2suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
11 SUPT7Linteractor31.0000Bromo_TP (PF07524, IPR006565): Bromodomain associated
12 TAF1oncoprotein140.8354.499Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
LcrG (PF07216, IPR009863): LcrG protein
Opi1 (PF08618, IPR013927): Transcription factor Opi1
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
TBP-binding (PF09247, IPR009067): TATA box-binding protein binding
U3_snoRNA_assoc (PF08297, IPR013268): U3 snoRNA associated
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3591 (PF12157, IPR022591): Protein of unknown function (DUF3591)
zf-CCHC_6 (PF15288): Zinc knuckle
13 TAF10interactor170.61835.855TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
14 TAF11interactor70.7142.987CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
TAFII28 (PF04719, IPR006809): hTAFII28-like protein conserved region
15 TAF12interactor90.8611.619TFIID_20kDa (PF03847, IPR003228): Transcription initiation factor TFIID subunit A
16 TAF13interactor130.8593.128TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
17 TAF2interactor100.9780.154DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
HEAT (PF02985, IPR000357): HEAT repeat
Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
HEAT_2 (PF13646): HEAT repeats
AP3D1 (PF06375): AP-3 complex subunit delta-1
18 TAF4protein found in more fusions140.8971.758TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
19 TAF4Binteractor70.6193.459TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
20 TAF5interactor150.8005.940Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Late_protein_L2 (PF00513, IPR000784): Late Protein L2
TFIID_NTD2 (PF04494, IPR007582): WD40 associated region in TFIID subunit, NTD2 domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
21 TAF6interactor140.8682.688CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
22 TAF7interactor110.9640.354DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ELM2 (PF01448, IPR000949): ELM2 domain
TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
XhlA (PF10779, IPR019715): Haemolysin XhlA
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
23 TAF9interactor160.68324.688TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
24 TAF9Binteractor120.9820.182TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
25 TBPinteractor190.60833.993TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
26 TTC29interactor100DUF1266 (PF06889, IPR009677): Protein of unknown function (DUF1266)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2225 (PF09986, IPR018708): Uncharacterized protein conserved in bacteria (DUF2225)
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_20 (PF14561): Tetratricopeptide repeat
27 ZDHHC17protein found in more fusions200zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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