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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins14 (28.57 %)
The number (and %) of the tumor suppressors4 (8.16 %)
Total number of binary PPIs (saturation %)273 (23.21 %)
The number (and %) of affected PPIs49 (17.95 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI10.286
Assortativity coefficient-0.2558
The network average Clustering coefficient0.619
The number (and %) of a zero Clustering coefficients2 (4.08 %)
The number (and %) of a zero Betweenness Centrality6 (12.24 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TAF4 All fusions
: BF331400; BE074753; BE074659; BQ318943;
Proteins found in more fusions TAF8 (see 2 fusions); EWSR1 (see 2 fusions); AHR (see 1 fusions); EGFR (see 2 fusions); HTT (see 1 fusions); NAP1L4 (see 3 fusions); TCF12 (see 2 fusions); TAF4 (see 4 fusions); CREB1 (see 2 fusions); NCL (see 3 fusions); SP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TAF4parental protein490.1811228.430TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
2 AHRsuppressor70.6672.633HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
PAS_4 (PF08448, IPR013656): PAS fold
3 ANAPC1suppressor70.8571.067PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1
4 ANAPC13interactor51.0000Apc13p (PF05839, IPR008401): Apc13p protein
5 ANAPC7interactor90.7862.633TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_21 (PF09976, IPR018704): Tetratricopeptide repeat-like domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
6 ATF7interactor40.6671.333bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
7 CBX5suppressor70.6004.900Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
8 CDC16interactor90.6676.400Dynein_light (PF01221, IPR001372): Dynein light chain type 1
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
9 CDC23interactor100.6397.067ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
10 CDC27oncoprotein90.6794.967TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
11 CREB1oncoprotein80.33310.567bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
12 CREMsuppressor30.6670.400bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
13 EGFRoncoprotein50.5003.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 ELAVL1oncoprotein110.35620.652RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 EWSR1oncoprotein90.28612.200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
16 FBXO6interactor30.6671.000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
17 GTF2A1oncoprotein90.5569.652TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
18 GTF2A2interactor51.0000TFIIA_gamma_C (PF02751, IPR015871): Transcription initiation factor IIA, gamma subunit
TFIIA_gamma_N (PF02268, IPR015872): Transcription initiation factor IIA, gamma subunit, helical domain
19 GTF2F2interactor70.5714.386TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
20 HIST1H3Einteractor30.6671.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
21 HIST3H3interactor190.52652.549Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
22 HTTprotein found in more fusions50.5002.667HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
23 JUNoncoprotein90.42911.152bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
24 KAT2Ainteractor110.7334.210Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
25 KIFAP3interactor41.0000KAP (PF05804): Kinesin-associated protein (KAP)
26 MED26interactor130.7568.156Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
27 NAP1L4protein found in more fusions100.6117.233NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
28 NCLprotein found in more fusions100.47213.833DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
29 NUP50interactor100NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
30 SF3B3interactor70.5719.000CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
31 SOX6interactor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3947 (PF13135, IPR025039): Protein of unknown function (DUF3947)
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
32 SP1protein found in more fusions80.4768.900zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
33 SUPT3Hinteractor90.7782.863TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
DUF4093 (PF13331, IPR025156): Domain of unknown function (DUF4093)
34 TAF1oncoprotein170.63222.930Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
LcrG (PF07216, IPR009863): LcrG protein
Opi1 (PF08618, IPR013927): Transcription factor Opi1
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
TBP-binding (PF09247, IPR009067): TATA box-binding protein binding
U3_snoRNA_assoc (PF08297, IPR013268): U3 snoRNA associated
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3591 (PF12157, IPR022591): Protein of unknown function (DUF3591)
zf-CCHC_6 (PF15288): Zinc knuckle
35 TAF10interactor200.58434.725TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
36 TAF12interactor120.65214.065TFIID_20kDa (PF03847, IPR003228): Transcription initiation factor TFIID subunit A
37 TAF13interactor120.9240.897TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
38 TAF1Linteractor70.9050.667Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
LcrG (PF07216, IPR009863): LcrG protein
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
TBP-binding (PF09247, IPR009067): TATA box-binding protein binding
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3591 (PF12157, IPR022591): Protein of unknown function (DUF3591)
zf-CCHC_6 (PF15288): Zinc knuckle
RXLR (PF16810, IPR031825): RXLR phytopathogen effector protein, Avirulence activity
39 TAF3interactor150.58125.547Bromo_TP (PF07524, IPR006565): Bromodomain associated
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
FHIPEP (PF00771, IPR001712): FHIPEP family
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
40 TAF5interactor230.46677.262Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Late_protein_L2 (PF00513, IPR000784): Late Protein L2
TFIID_NTD2 (PF04494, IPR007582): WD40 associated region in TFIID subunit, NTD2 domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
41 TAF6interactor200.58930.608CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
42 TAF7interactor140.7807.322DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ELM2 (PF01448, IPR000949): ELM2 domain
TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
XhlA (PF10779, IPR019715): Haemolysin XhlA
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
43 TAF8protein found in more fusions140.8971.682Bromo_TP (PF07524, IPR006565): Bromodomain associated
TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
DUF3090 (PF11290, IPR021441): Protein of unknown function (DUF3090)
44 TAF9interactor190.59629.043TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
45 TAF9Binteractor160.68614.259TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
46 TBPinteractor270.372137.916TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
47 TBPL1interactor90.6675.986TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
48 TCF12oncoprotein41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
49 TRRAPinteractor100.8222.241BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal

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