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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)87
The number (and %) of the onco-proteins27 (31.03 %)
The number (and %) of the tumor suppressors3 (3.45 %)
Total number of binary PPIs (saturation %)453 (12.11 %)
The number (and %) of affected PPIs87 (19.21 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI9.724
Assortativity coefficient-0.3209
The network average Clustering coefficient0.596
The number (and %) of a zero Clustering coefficients10 (11.49 %)
The number (and %) of a zero Betweenness Centrality23 (26.44 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: SYVN1 All fusions
: BI820138;
Proteins found in more fusions UBE2D2 (see 1 fusions); APP (see 5 fusions); PSMB7 (see 2 fusions); MYH9/OS9 (see 1 fusions); SYVN1 (see 1 fusions); VCP (see 4 fusions); PSMA7 (see 5 fusions); HTT (see 1 fusions); SARAF/FAF2 (see 1 fusions); ATN1 (see 1 fusions); PSMB3 (see 1 fusions); OS9 (see 2 fusions); SGK1 (see 5 fusions); CLU (see 5 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SYVN1parental protein870.0924992.445Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
2 AMFRoncoprotein400.232446.575CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
3 APOBinteractor90.6433.938DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
4 APPprotein found in more fusions160.20073.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ASGR1interactor30.6670.667Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
6 ASGR2interactor40.6670.650UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
7 ATF6interactor50.5002.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
8 ATN1protein found in more fusions40.6670.400Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
9 ATP6AP1interactor100ATP-synt_S1 (PF05827, IPR024722): Vacuolar ATP synthase subunit S1 (ATP6S1)
10 ATXN3interactor60.6001.622Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
11 AUP1interactor90.7223.687CUE (PF02845, IPR003892, SM00546): CUE domain
12 BAG1oncoprotein50.7001.500BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
13 BAG6interactor110.48915.919DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 BSGinteractor40.8330.182Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
15 CLUsuppressor50.6671.667Clusterin (PF01093, IPR000753): Clusterin
16 DERL1interactor230.294113.914DER1 (PF04511, IPR007599): Der1-like family
17 DERL2interactor180.41255.692DER1 (PF04511, IPR007599): Der1-like family
18 ERLEC1interactor90.50012.471PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
19 ERLIN1interactor51.0000Ribosomal_L33 (PF00471, IPR001705): Ribosomal protein L33
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
20 ERLIN2interactor100.51111.711Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
21 ERN1interactor60.6001.905Pkinase (PF00069, IPR000719): Protein kinase domain
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
Ribonuc_2-5A (PF06479, IPR010513): Ribonuclease 2-5A
CytochromB561_N (PF09786, IPR019176): Cytochrome B561, N terminal
PQQ_2 (PF13360, IPR002372): PQQ-like domain
22 FAF2protein found in more fusions220.39071.313DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
23 FAM8A1interactor60.5336.333RDD (PF06271, IPR010432): RDD family
24 FDFT1interactor100SQS_PSY (PF00494, IPR002060): Squalene/phytoene synthase
25 GABRA1interactor31.0000Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
26 GLRA2interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
27 GPR37interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
28 HERPUD1oncoprotein90.5288.311Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
29 HEY1oncoprotein41.0000Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
HTH_Crp_2 (PF13545, IPR012318): Crp-like helix-turn-helix domain
30 HEY2interactor50.7002.167Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
31 HFEoncoprotein100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
32 HLA-Aoncoprotein90.47210.589DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
33 HMGCRoncoprotein60.8670.833HMG-CoA_red (PF00368, IPR002202): Hydroxymethylglutaryl-coenzyme A reductase
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
34 HMOX1interactor40.6670.333Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
35 HSPA5oncoprotein180.32465.579HSP70 (PF00012, IPR013126): Hsp70 protein
36 HTTprotein found in more fusions70.5334.417HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
37 IGF1Roncoprotein30.6671.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
38 IGHMinteractor30.6670.667C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
39 MBTPS2interactor30.6670.500FixS (PF03597, IPR004714): Cytochrome oxidase maturation protein cbb3-type
Peptidase_M50 (PF02163, IPR008915): Peptidase family M50
DUF4667 (PF15700, IPR031426): Domain of unknown function (DUF4667)
40 MYH9suppressor80.5366.558IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
41 NAAAinteractor30.6671.000CBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family
NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
42 OS9protein found in more fusions180.39755.228DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
43 PDIA2interactor21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
44 PMP22interactor30.6671.000PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
45 PORinteractor31.0000FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
46 PPARGC1Binteractor100Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Mak16 (PF04874, IPR006958): Mak16 protein C-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632)
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
47 PSMA1interactor190.8308.080Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
48 PSMA2interactor200.77812.019Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
49 PSMA3interactor220.65238.752Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
50 PSMA5oncoprotein190.74325.604Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
51 PSMA6interactor170.9043.192Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
52 PSMA7protein found in more fusions190.8308.080Proteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
53 PSMB1interactor160.9750.422Proteasome (PF00227, IPR001353): Proteasome subunit
54 PSMB2interactor160.9750.422Proteasome (PF00227, IPR001353): Proteasome subunit
55 PSMB3protein found in more fusions180.86810.322Proteasome (PF00227, IPR001353): Proteasome subunit
56 PSMB4interactor180.8248.938Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
57 PSMB6interactor170.8973.882DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Proteasome (PF00227, IPR001353): Proteasome subunit
58 PSMB7protein found in more fusions180.8759.755Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
59 PSMD1interactor170.81610.967PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
60 PSMD2oncoprotein210.54368.219PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
61 PSMD7interactor151.0000JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
62 RER1interactor21.0000Rer1 (PF03248, IPR004932): Rer1 family
63 SARAFprotein found in more fusions70.7624.333SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
64 SEL1Loncoprotein210.286106.529fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
65 SELENOSinteractor110.61810.488Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
66 SGK1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
67 SHHoncoprotein51.0000HH_signal (PF01085, IPR000320): Hedgehog amino-terminal signalling domain
Hint (PF01079, IPR001767): Hint module
68 STXBP5Linteractor100Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
Serglycin (PF04360, IPR007455): Serglycin
Synaptobrevin (PF00957, IPR001388): Synaptobrevin
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
69 SVIPinteractor51.0000SVIP (PF15811, IPR031632): Small VCP/p97-interacting protein
70 TMEM129interactor90.6076.082Tmpp129 (PF10272, IPR018801): Putative transmembrane protein precursor
71 TMUB1interactor50.5003.889DUF347 (PF03988, IPR007136): Repeat of Unknown Function (DUF347)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF4227 (PF14004, IPR025321): Protein of unknown function (DUF4227)
72 TP53suppressor110.31122.569DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
73 TRAoncoprotein70.5244.448NA
74 TYRinteractor100DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
75 UBAC2interactor51.0000Rhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
76 UBE2D2oncoprotein31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
77 UBE2D3interactor50.5001.508UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
78 UBE2J1interactor110.6368.903UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
79 UBE2Uinteractor100UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal
TMEM154 (PF15102, IPR028064): TMEM154 protein family
80 UBE2Zinteractor100UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
81 UBXN8interactor31.0000Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
UBX (PF00789, IPR001012, SM00166): UBX domain
82 USP19interactor60.6004.000CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
83 USP7oncoprotein120.38223.167MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
84 VCPprotein found in more fusions320.241250.970AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
85 WBP1interactor30.6671.000WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
86 WFS1interactor30.6670.667FixQ (PF05545, IPR008621): Cbb3-type cytochrome oxidase component FixQ
Cytochrome-c551 (PF10643, IPR019604): Photosystem P840 reaction-centre cytochrome c-551
HTH_16 (PF12645, IPR024760): Helix-turn-helix domain
Adipogenin (PF15202, IPR027938): Adipogenin
87 YOD1interactor70.7621.689OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain

B a c k    t o    T o p ⇑


List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AMFRoncoproteinCUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BI820138
2 APOBinteractorDUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
BI820138
3 ASGR1interactorLectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
BI820138
4 ASGR2interactorUL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
BI820138
5 ATF6interactorbZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
BI820138
6 ATN1interactorAtrophin-1 (PF03154, IPR002951): Atrophin-1 familyBI820138
7 ATP6AP1interactorATP-synt_S1 (PF05827, IPR024722): Vacuolar ATP synthase subunit S1 (ATP6S1)BI820138
8 ATXN3interactorJosephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
BI820138
9 AUP1interactorCUE (PF02845, IPR003892, SM00546): CUE domainBI820138
10 BAG1oncoproteinBAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
BI820138
11 BAG6interactorDUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
BI820138
12 BSGinteractorIg_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
BI820138
13 CLUsuppressorClusterin (PF01093, IPR000753): ClusterinBI820138
14 DERL1interactorDER1 (PF04511, IPR007599): Der1-like familyBI820138
15 DERL2interactorDER1 (PF04511, IPR007599): Der1-like familyBI820138
16 ERLEC1interactorPRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
BI820138
17 ERLIN1interactorRibosomal_L33 (PF00471, IPR001705): Ribosomal protein L33
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
BI820138
18 ERLIN2interactorBand_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
BI820138
19 ERN1interactorPkinase (PF00069, IPR000719): Protein kinase domain
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
Ribonuc_2-5A (PF06479, IPR010513): Ribonuclease 2-5A
CytochromB561_N (PF09786, IPR019176): Cytochrome B561, N terminal
PQQ_2 (PF13360, IPR002372): PQQ-like domain
BI820138
20 FAM8A1interactorRDD (PF06271, IPR010432): RDD familyBI820138
21 FDFT1interactorSQS_PSY (PF00494, IPR002060): Squalene/phytoene synthaseBI820138
22 GABRA1interactorNeur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
BI820138
23 GLRA2interactorNeur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
BI820138
24 GPR37interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)BI820138
25 HERPUD1oncoproteinNeisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
BI820138
26 HEY1oncoproteinHairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
HTH_Crp_2 (PF13545, IPR012318): Crp-like helix-turn-helix domain
BI820138
27 HEY2interactorHairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
BI820138
28 HLA-AoncoproteinDUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
BI820138
29 HMGCRoncoproteinHMG-CoA_red (PF00368, IPR002202): Hydroxymethylglutaryl-coenzyme A reductase
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
BI820138
30 HMOX1interactorHeme_oxygenase (PF01126, IPR016053): Heme oxygenaseBI820138
31 HSPA5oncoproteinHSP70 (PF00012, IPR013126): Hsp70 proteinBI820138
32 HTTinteractorHEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
BI820138
33 IGF1Roncoproteinfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
BI820138
34 IGHMinteractorC2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
BI820138
35 MBTPS2interactorFixS (PF03597, IPR004714): Cytochrome oxidase maturation protein cbb3-type
Peptidase_M50 (PF02163, IPR008915): Peptidase family M50
DUF4667 (PF15700, IPR031426): Domain of unknown function (DUF4667)
BI820138
36 MYH9suppressorIQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BI820138
37 NAAAinteractorCBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family
NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
BI820138
38 OS9interactorDNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
BI820138
39 PDIA2interactorThioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
BI820138
40 PMP22interactorPBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminalBI820138
41 PORinteractorFAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
BI820138
42 PPARGC1BinteractorCwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Mak16 (PF04874, IPR006958): Mak16 protein C-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632)
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
BI820138
43 PSMA1interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
BI820138
44 PSMA2interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
BI820138
45 PSMA3interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
BI820138
46 PSMA5oncoproteinProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
BI820138
47 PSMA6interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
BI820138
48 PSMA7interactorProteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
BI820138
49 PSMB1interactorProteasome (PF00227, IPR001353): Proteasome subunitBI820138
50 PSMB2interactorProteasome (PF00227, IPR001353): Proteasome subunitBI820138
51 PSMB3interactorProteasome (PF00227, IPR001353): Proteasome subunitBI820138
52 PSMB4interactorIntegrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
BI820138
53 PSMB6interactorDUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Proteasome (PF00227, IPR001353): Proteasome subunit
BI820138
54 PSMB7interactorProteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
BI820138
55 PSMD1interactorPA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
BI820138
56 PSMD2oncoproteinPC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
BI820138
57 PSMD7interactorJAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
BI820138
58 RER1interactorRer1 (PF03248, IPR004932): Rer1 familyBI820138
59 SARAFinteractorSARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasisBI820138
60 SEL1Loncoproteinfn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
BI820138
61 SELENOSinteractorSelenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
BI820138
62 SGK1oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
BI820138
63 SHHoncoproteinHH_signal (PF01085, IPR000320): Hedgehog amino-terminal signalling domain
Hint (PF01079, IPR001767): Hint module
BI820138
64 STXBP5LinteractorLgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
Serglycin (PF04360, IPR007455): Serglycin
Synaptobrevin (PF00957, IPR001388): Synaptobrevin
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
BI820138
65 SVIPinteractorSVIP (PF15811, IPR031632): Small VCP/p97-interacting proteinBI820138
66 SYVN1parental proteinAlpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BI820138
67 TMEM129interactorTmpp129 (PF10272, IPR018801): Putative transmembrane protein precursorBI820138
68 TMUB1interactorDUF347 (PF03988, IPR007136): Repeat of Unknown Function (DUF347)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF4227 (PF14004, IPR025321): Protein of unknown function (DUF4227)
BI820138
69 TRAoncoproteinNABI820138
70 TYRinteractorDUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
BI820138
71 UBAC2interactorRhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
BI820138
72 UBE2J1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
BI820138
73 UBXN8interactorBap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
UBX (PF00789, IPR001012, SM00166): UBX domain
BI820138
74 USP19interactorCS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
BI820138
75 USP7oncoproteinMATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
BI820138
76 VCPinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
BI820138
77 WBP1interactorWBP-1 (PF11669, IPR021684): WW domain-binding protein 1BI820138
78 WFS1interactorFixQ (PF05545, IPR008621): Cbb3-type cytochrome oxidase component FixQ
Cytochrome-c551 (PF10643, IPR019604): Photosystem P840 reaction-centre cytochrome c-551
HTH_16 (PF12645, IPR024760): Helix-turn-helix domain
Adipogenin (PF15202, IPR027938): Adipogenin
BI820138
79 YOD1interactorOTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
BI820138

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