Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SYK (from a repository: Sun Dec 4 18:02:52 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 106 The number (and %) of the onco-proteins 45 (42.45 %) The number (and %) of the tumor suppressors 13 (12.26 %) Total number of binary PPIs (saturation %) 627 (11.27 %) The number (and %) of affected PPIs 106 (16.91 %) The number of possible different fusions 27 PPI diameter 2 PPI radius 1 The average degree of PPI 10.906 Assortativity coefficient -0.2206 The network average Clustering coefficient 0.570 The number (and %) of a zero Clustering coefficients 5 (4.72 %) The number (and %) of a zero Betweenness Centrality 20 (18.87 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SYK	All fusions : CB242349;
Proteins found in more fusions	TUBG1 (see 1 fusions); TRAF6 (see 1 fusions); APP (see 4 fusions); SYK (see 1 fusions); USP25 (see 1 fusions); LYN (see 2 fusions); CBL (see 1 fusions); TICAM1 (see 1 fusions); HDAC4 (see 1 fusions); GRB2 (see 1 fusions); LCK (see 1 fusions); FYN (see 1 fusions); SP1 (see 1 fusions); TNFRSF1A (see 2 fusions); MAPT (see 1 fusions); ERBB3 (see 2 fusions); STAT3 (see 2 fusions); PAG1 (see 1 fusions); SEC23B (see 2 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); CTTN (see 1 fusions); MAP3K7 (see 7 fusions); PTK2 (see 2 fusions); CBLB (see 4 fusions); NEDD4 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SYK	parental protein	106	0.087	7287.000	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
2	APP	protein found in more fusions	21	0.195	122.941	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3	BLNK	suppressor	15	0.448	30.481	SH2 (PF00017, IPR000980, SM00252): SH2 domain
4	BTK	suppressor	17	0.342	49.463	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5	CALM1	interactor	5	0.600	2.583	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
6	CBL	suppressor	40	0.313	233.588	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
7	CBLB	oncoprotein	23	0.342	87.744	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 PRIMA1 (PF16101): Proline-rich membrane anchor 1
8	CD19	interactor	6	0.400	6.956	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
9	CD22	interactor	7	0.524	5.044	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
10	CD3E	interactor	6	0.667	1.555	ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
11	CD4	suppressor	6	0.500	3.667	ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
12	CD72	interactor	4	1.000	0	DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
13	CD79A	oncoprotein	5	0.500	4.167	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
14	CD79B	oncoprotein	3	1.000	0	ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif V-set (PF07686, IPR013106): Immunoglobulin V-set domain Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
15	CRKL	oncoprotein	14	0.560	18.647	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16	CSF3R	oncoprotein	3	0.667	0.125	EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
17	CTTN	oncoprotein	8	0.714	2.383	FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
18	EGFR	oncoprotein	42	0.267	326.783	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
19	EPOR	oncoprotein	11	0.691	4.127	EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
20	ERBB2	oncoprotein	25	0.428	62.769	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
21	ERBB3	oncoprotein	16	0.543	15.321	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
22	ERBB4	suppressor	10	0.667	3.927	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
23	FAM46A	interactor	2	1.000	0	NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
24	FCER1A	interactor	1	0	0	Adeno_E3_CR1 (PF02440, IPR003471): Adenovirus E3 region protein CR1 TadE (PF07811, IPR012495): TadE-like protein Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
25	FCER1G	interactor	1	0	0	TCR_zetazeta (PF11628, IPR021663): T-cell surface glycoprotein CD3 zeta chain
26	FCGR1A	interactor	4	0.500	2.333	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain PIRT (PF15099, IPR028068): Phosphoinositide-interacting protein family
27	FCGR2A	interactor	6	0.667	1.852	DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827) Ig_2 (PF13895, IPR007110): Immunoglobulin domain ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
28	FCGR3A	interactor	3	0.667	1.000	Ig_2 (PF13895, IPR007110): Immunoglobulin domain
29	FCRL3	interactor	2	1.000	0	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
30	FGR	oncoprotein	7	0.762	2.833	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31	FYN	oncoprotein	23	0.346	68.864	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
32	GRAP2	interactor	8	0.679	2.075	NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal SH2 (PF00017, IPR000980, SM00252): SH2 domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
33	GRB2	oncoprotein	38	0.290	251.613	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
34	HCLS1	interactor	6	0.333	7.125	HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) TMEM210 (PF15195, IPR028123): TMEM210 family SPESP1 (PF15754, IPR026743): Sperm equatorial segment protein 1
35	HDAC1	suppressor	7	0.533	5.667	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
36	HDAC2	suppressor	5	1.000	0	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
37	HDAC3	suppressor	9	0.464	11.400	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
38	HDAC4	oncoprotein	6	0.600	3.500	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
39	HDAC6	oncoprotein	12	0.418	17.708	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
40	HDAC9	interactor	5	0.667	1.167	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 CEP19 (PF14933, IPR029412): CEP19-like protein
41	HGS	interactor	9	0.417	13.402	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo
42	IL17RA	interactor	4	1.000	0	SEFIR (PF08357, IPR013568): SEFIR domain IL17R_fnIII_D1 (PF16556, IPR032356): Interleukin-17 receptor, fibronectin-III-like domain 1 IL17R_fnIII_D2 (PF16578): Interleukin 17 receptor D
43	INPP5D	interactor	10	0.644	6.319	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SH2 (PF00017, IPR000980, SM00252): SH2 domain
44	ITGA4	interactor	10	0.583	8.519	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
45	ITGB2	interactor	3	1.000	0	EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain
46	ITGB3	suppressor	4	0.833	0.182	EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain
47	KLRA1P	interactor	2	1.000	0	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
48	LAT	interactor	17	0.419	44.211	LAT (PF15234, IPR008359): Linker for activation of T-cells
49	LCK	oncoprotein	14	0.385	28.398	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
50	LCP2	interactor	14	0.582	13.781	SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SDA1 (PF05285, IPR007949): SDA1 SH2 (PF00017, IPR000980, SM00252): SH2 domain
51	LYN	oncoprotein	24	0.257	117.806	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
52	MAP3K7	oncoprotein	11	0.467	14.550	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
53	MAPT	protein found in more fusions	13	0.409	21.294	Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
54	MEGF10	interactor	1	0	0	DSL (PF01414, IPR001774, SM00051): Delta serrate ligand EGF_2 (PF07974, IPR013111): EGF-like domain Syndecan (PF01034, IPR027789): Syndecan domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
55	MS4A2	interactor	4	0.667	0.667	CD20 (PF04103, IPR007237): CD20-like family
56	MYD88	oncoprotein	11	0.511	13.671	Death (PF00531, IPR000488, SM00005): Death domain TIR (PF01582, IPR000157, SM00255): TIR domain
57	NCK1	oncoprotein	16	0.433	30.760	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
58	NEDD4	suppressor	11	0.444	11.650	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
59	PAG1	protein found in more fusions	9	0.607	2.612	PAG (PF15347, IPR032748): Phosphoprotein associated with glycosphingolipid-enriched
60	PEAR1	oncoprotein	1	0	0	C_tripleX (PF02363, IPR003341): Cysteine rich repeat DSL (PF01414, IPR001774, SM00051): Delta serrate ligand EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
61	PIK3CG	oncoprotein	2	1.000	0	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244) DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135)
62	PIK3R1	oncoprotein	30	0.372	123.407	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
63	PIK3R2	oncoprotein	18	0.451	43.963	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
64	PLCG1	oncoprotein	17	0.507	29.013	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
65	PLCG2	interactor	12	0.576	10.049	C2 (PF00168, IPR000008, SM00239): C2 domain EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
66	PRKD1	oncoprotein	5	0.833	0.286	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
67	PTK2	protein found in more fusions	22	0.419	58.030	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
68	PTK2B	interactor	17	0.483	29.245	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
69	PTPN6	suppressor	17	0.478	37.823	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
70	PTPRO	interactor	2	1.000	0	CDC24 (PF06395, IPR010481): CDC24 Calponin fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
71	PXN	oncoprotein	19	0.333	75.822	LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family
72	RHOU	interactor	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
73	RPS10	interactor	7	0.524	6.233	S10_plectin (PF03501, IPR005326): Plectin/S10 domain
74	RPS6KB1	interactor	8	0.571	3.541	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
75	RPS6KB2	interactor	5	0.600	1.389	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
76	SEC23B	protein found in more fusions	3	1.000	0	Gelsolin (PF00626, IPR007123): Gelsolin repeat Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
77	SH2D2A	interactor	8	0.786	6.000	SH2 (PF00017, IPR000980, SM00252): SH2 domain
78	SH3BP2	oncoprotein	10	0.778	2.174	PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
79	SIRPB1	interactor	2	1.000	0	CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family V-set (PF07686, IPR013106): Immunoglobulin V-set domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
80	SIT1	interactor	3	0.667	0.200	DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381) SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
81	SLA	interactor	6	0.933	0.200	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
82	SLC4A1	oncoprotein	2	0	0	Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family
83	SP1	protein found in more fusions	8	0.524	8.000	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
84	SRC	oncoprotein	30	0.313	172.168	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
85	STAT3	suppressor	21	0.374	80.508	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
86	TBK1	interactor	14	0.372	29.560	DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain
87	TERF1	interactor	3	1.000	0	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
88	TICAM1	protein found in more fusions	8	0.714	1.789	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator RHIM (PF12721, IPR025735): RIP homotypic interaction motif TIR_2 (PF13676, IPR000157): TIR domain
89	TLR3	interactor	8	0.571	5.006	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain TIR (PF01582, IPR000157, SM00255): TIR domain LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
90	TLR4	interactor	9	0.500	8.130	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat TIR (PF01582, IPR000157, SM00255): TIR domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat LRR_9 (PF14580): Leucine-rich repeat
91	TLR9	interactor	7	0.619	2.597	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat TIR (PF01582, IPR000157, SM00255): TIR domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
92	TNFRSF1A	oncoprotein	11	0.600	7.136	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
93	TRAF3	oncoprotein	14	0.423	20.969	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain MPS2 (PF17060, IPR031433): Monopolar spindle protein 2 Spc29 (PF17082, IPR031392): Spindle Pole Component 29
94	TRAF3IP2	interactor	7	0.667	2.556	SEFIR (PF08357, IPR013568): SEFIR domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
95	TRAF6	protein found in more fusions	19	0.288	66.513	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
96	TRAIP	interactor	6	0.700	1.056	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein ORF6C (PF10552, IPR018878): ORF6C domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
97	TRIM15	suppressor	6	0.900	0.333	Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
98	TUBA1A	oncoprotein	10	0.511	11.044	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
99	TUBB	interactor	16	0.400	42.525	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
100	TUBG1	protein found in more fusions	8	0.571	4.533	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
101	TYROBP	interactor	3	0.667	1.000	DAP10 (PF07213, IPR009861): DAP10 membrane protein DUF4741 (PF15897, IPR031773): Domain of unknown function (DUF4741)
102	UBASH3B	interactor	11	0.556	12.138	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
103	USP25	protein found in more fusions	3	1.000	0	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase UBA_4 (PF14555): UBA-like domain
104	VAV1	oncoprotein	25	0.397	87.859	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
105	VAV2	oncoprotein	9	0.611	5.745	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain CotJB (PF12652, IPR024207): CotJB protein
106	VCAM1	interactor	6	0.800	1.233	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain

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