1 |
SYK | parental protein | 106 | 0.087 | 7287.000 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
2 |
APP | protein found in more fusions | 21 | 0.195 | 122.941 | APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein |
3 |
BLNK | suppressor | 15 | 0.448 | 30.481 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
4 |
BTK | suppressor | 17 | 0.342 | 49.463 | BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
5 |
CALM1 | interactor | 5 | 0.600 | 2.583 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
6 |
CBL | suppressor | 40 | 0.313 | 233.588 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
7 |
CBLB | oncoprotein | 23 | 0.342 | 87.744 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
8 |
CD19 | interactor | 6 | 0.400 | 6.956 | V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
9 |
CD22 | interactor | 7 | 0.524 | 5.044 | C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
10 |
CD3E | interactor | 6 | 0.667 | 1.555 | ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain |
11 |
CD4 | suppressor | 6 | 0.500 | 3.667 | ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region |
12 |
CD72 | interactor | 4 | 1.000 | 0 | DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain |
13 |
CD79A | oncoprotein | 5 | 0.500 | 4.167 | ig (PF00047, IPR013151, SM00409): Immunoglobulin domain |
14 |
CD79B | oncoprotein | 3 | 1.000 | 0 | ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif V-set (PF07686, IPR013106): Immunoglobulin V-set domain Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal |
15 |
CRKL | oncoprotein | 14 | 0.560 | 18.647 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
16 |
CSF3R | oncoprotein | 3 | 0.667 | 0.125 | EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain |
17 |
CTTN | oncoprotein | 8 | 0.714 | 2.383 | FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
18 |
EGFR | oncoprotein | 42 | 0.267 | 326.783 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
19 |
EPOR | oncoprotein | 11 | 0.691 | 4.127 | EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain |
20 |
ERBB2 | oncoprotein | 25 | 0.428 | 62.769 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
21 |
ERBB3 | oncoprotein | 16 | 0.543 | 15.321 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
22 |
ERBB4 | suppressor | 10 | 0.667 | 3.927 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
23 |
FAM46A | interactor | 2 | 1.000 | 0 | NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase |
24 |
FCER1A | interactor | 1 | 0 | 0 | Adeno_E3_CR1 (PF02440, IPR003471): Adenovirus E3 region protein CR1 TadE (PF07811, IPR012495): TadE-like protein Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
25 |
FCER1G | interactor | 1 | 0 | 0 | TCR_zetazeta (PF11628, IPR021663): T-cell surface glycoprotein CD3 zeta chain |
26 |
FCGR1A | interactor | 4 | 0.500 | 2.333 | ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain PIRT (PF15099, IPR028068): Phosphoinositide-interacting protein family |
27 |
FCGR2A | interactor | 6 | 0.667 | 1.852 | DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827) Ig_2 (PF13895, IPR007110): Immunoglobulin domain ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator |
28 |
FCGR3A | interactor | 3 | 0.667 | 1.000 | Ig_2 (PF13895, IPR007110): Immunoglobulin domain |
29 |
FCRL3 | interactor | 2 | 1.000 | 0 | ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
30 |
FGR | oncoprotein | 7 | 0.762 | 2.833 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
31 |
FYN | oncoprotein | 23 | 0.346 | 68.864 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
32 |
GRAP2 | interactor | 8 | 0.679 | 2.075 | NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal SH2 (PF00017, IPR000980, SM00252): SH2 domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
33 |
GRB2 | oncoprotein | 38 | 0.290 | 251.613 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
34 |
HCLS1 | interactor | 6 | 0.333 | 7.125 | HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) TMEM210 (PF15195, IPR028123): TMEM210 family SPESP1 (PF15754, IPR026743): Sperm equatorial segment protein 1 |
35 |
HDAC1 | suppressor | 7 | 0.533 | 5.667 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
36 |
HDAC2 | suppressor | 5 | 1.000 | 0 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 |
37 |
HDAC3 | suppressor | 9 | 0.464 | 11.400 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
38 |
HDAC4 | oncoprotein | 6 | 0.600 | 3.500 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
39 |
HDAC6 | oncoprotein | 12 | 0.418 | 17.708 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein |
40 |
HDAC9 | interactor | 5 | 0.667 | 1.167 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 CEP19 (PF14933, IPR029412): CEP19-like protein |
41 |
HGS | interactor | 9 | 0.417 | 13.402 | FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo |
42 |
IL17RA | interactor | 4 | 1.000 | 0 | SEFIR (PF08357, IPR013568): SEFIR domain IL17R_fnIII_D1 (PF16556, IPR032356): Interleukin-17 receptor, fibronectin-III-like domain 1 IL17R_fnIII_D2 (PF16578): Interleukin 17 receptor D |
43 |
INPP5D | interactor | 10 | 0.644 | 6.319 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SH2 (PF00017, IPR000980, SM00252): SH2 domain |
44 |
ITGA4 | interactor | 10 | 0.583 | 8.519 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
45 |
ITGB2 | interactor | 3 | 1.000 | 0 | EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain |
46 |
ITGB3 | suppressor | 4 | 0.833 | 0.182 | EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain |
47 |
KLRA1P | interactor | 2 | 1.000 | 0 | DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain |
48 |
LAT | interactor | 17 | 0.419 | 44.211 | LAT (PF15234, IPR008359): Linker for activation of T-cells |
49 |
LCK | oncoprotein | 14 | 0.385 | 28.398 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
50 |
LCP2 | interactor | 14 | 0.582 | 13.781 | SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SDA1 (PF05285, IPR007949): SDA1 SH2 (PF00017, IPR000980, SM00252): SH2 domain |
51 |
LYN | oncoprotein | 24 | 0.257 | 117.806 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
52 |
MAP3K7 | oncoprotein | 11 | 0.467 | 14.550 | Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
53 |
MAPT | protein found in more fusions | 13 | 0.409 | 21.294 | Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat |
54 |
MEGF10 | interactor | 1 | 0 | 0 | DSL (PF01414, IPR001774, SM00051): Delta serrate ligand EGF_2 (PF07974, IPR013111): EGF-like domain Syndecan (PF01034, IPR027789): Syndecan domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like |
55 |
MS4A2 | interactor | 4 | 0.667 | 0.667 | CD20 (PF04103, IPR007237): CD20-like family |
56 |
MYD88 | oncoprotein | 11 | 0.511 | 13.671 | Death (PF00531, IPR000488, SM00005): Death domain TIR (PF01582, IPR000157, SM00255): TIR domain |
57 |
NCK1 | oncoprotein | 16 | 0.433 | 30.760 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
58 |
NEDD4 | suppressor | 11 | 0.444 | 11.650 | Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
59 |
PAG1 | protein found in more fusions | 9 | 0.607 | 2.612 | PAG (PF15347, IPR032748): Phosphoprotein associated with glycosphingolipid-enriched |
60 |
PEAR1 | oncoprotein | 1 | 0 | 0 | C_tripleX (PF02363, IPR003341): Cysteine rich repeat DSL (PF01414, IPR001774, SM00051): Delta serrate ligand EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like |
61 |
PIK3CG | oncoprotein | 2 | 1.000 | 0 | Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244) DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135) |
62 |
PIK3R1 | oncoprotein | 30 | 0.372 | 123.407 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
63 |
PIK3R2 | oncoprotein | 18 | 0.451 | 43.963 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
64 |
PLCG1 | oncoprotein | 17 | 0.507 | 29.013 | C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain |
65 |
PLCG2 | interactor | 12 | 0.576 | 10.049 | C2 (PF00168, IPR000008, SM00239): C2 domain EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain |
66 |
PRKD1 | oncoprotein | 5 | 0.833 | 0.286 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
67 |
PTK2 | protein found in more fusions | 22 | 0.419 | 58.030 | FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein |
68 |
PTK2B | interactor | 17 | 0.483 | 29.245 | FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
69 |
PTPN6 | suppressor | 17 | 0.478 | 37.823 | SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus |
70 |
PTPRO | interactor | 2 | 1.000 | 0 | CDC24 (PF06395, IPR010481): CDC24 Calponin fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase |
71 |
PXN | oncoprotein | 19 | 0.333 | 75.822 | LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family |
72 |
RHOU | interactor | 2 | 1.000 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain |
73 |
RPS10 | interactor | 7 | 0.524 | 6.233 | S10_plectin (PF03501, IPR005326): Plectin/S10 domain |
74 |
RPS6KB1 | interactor | 8 | 0.571 | 3.541 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
75 |
RPS6KB2 | interactor | 5 | 0.600 | 1.389 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
76 |
SEC23B | protein found in more fusions | 3 | 1.000 | 0 | Gelsolin (PF00626, IPR007123): Gelsolin repeat Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger |
77 |
SH2D2A | interactor | 8 | 0.786 | 6.000 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
78 |
SH3BP2 | oncoprotein | 10 | 0.778 | 2.174 | PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain |
79 |
SIRPB1 | interactor | 2 | 1.000 | 0 | CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family V-set (PF07686, IPR013106): Immunoglobulin V-set domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
80 |
SIT1 | interactor | 3 | 0.667 | 0.200 | DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381) SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT |
81 |
SLA | interactor | 6 | 0.933 | 0.200 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
82 |
SLC4A1 | oncoprotein | 2 | 0 | 0 | Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family |
83 |
SP1 | protein found in more fusions | 8 | 0.524 | 8.000 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
84 |
SRC | oncoprotein | 30 | 0.313 | 172.168 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
85 |
STAT3 | suppressor | 21 | 0.374 | 80.508 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
86 |
TBK1 | interactor | 14 | 0.372 | 29.560 | DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain |
87 |
TERF1 | interactor | 3 | 1.000 | 0 | TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
88 |
TICAM1 | protein found in more fusions | 8 | 0.714 | 1.789 | Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator RHIM (PF12721, IPR025735): RIP homotypic interaction motif TIR_2 (PF13676, IPR000157): TIR domain |
89 |
TLR3 | interactor | 8 | 0.571 | 5.006 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain TIR (PF01582, IPR000157, SM00255): TIR domain LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat |
90 |
TLR4 | interactor | 9 | 0.500 | 8.130 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat TIR (PF01582, IPR000157, SM00255): TIR domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat LRR_9 (PF14580): Leucine-rich repeat |
91 |
TLR9 | interactor | 7 | 0.619 | 2.597 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat TIR (PF01582, IPR000157, SM00255): TIR domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat |
92 |
TNFRSF1A | oncoprotein | 11 | 0.600 | 7.136 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
93 |
TRAF3 | oncoprotein | 14 | 0.423 | 20.969 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain MPS2 (PF17060, IPR031433): Monopolar spindle protein 2 Spc29 (PF17082, IPR031392): Spindle Pole Component 29 |
94 |
TRAF3IP2 | interactor | 7 | 0.667 | 2.556 | SEFIR (PF08357, IPR013568): SEFIR domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) |
95 |
TRAF6 | protein found in more fusions | 19 | 0.288 | 66.513 | SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
96 |
TRAIP | interactor | 6 | 0.700 | 1.056 | Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein ORF6C (PF10552, IPR018878): ORF6C domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
97 |
TRIM15 | suppressor | 6 | 0.900 | 0.333 | Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta |
98 |
TUBA1A | oncoprotein | 10 | 0.511 | 11.044 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
99 |
TUBB | interactor | 16 | 0.400 | 42.525 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
100 |
TUBG1 | protein found in more fusions | 8 | 0.571 | 4.533 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
101 |
TYROBP | interactor | 3 | 0.667 | 1.000 | DAP10 (PF07213, IPR009861): DAP10 membrane protein DUF4741 (PF15897, IPR031773): Domain of unknown function (DUF4741) |
102 |
UBASH3B | interactor | 11 | 0.556 | 12.138 | His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain |
103 |
USP25 | protein found in more fusions | 3 | 1.000 | 0 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase UBA_4 (PF14555): UBA-like domain |
104 |
VAV1 | oncoprotein | 25 | 0.397 | 87.859 | PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain |
105 |
VAV2 | oncoprotein | 9 | 0.611 | 5.745 | PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain CotJB (PF12652, IPR024207): CotJB protein |
106 |
VCAM1 | interactor | 6 | 0.800 | 1.233 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |