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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SUFU (from a repository: Sun Nov 13 08:53:23 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins5 (18.52 %)
The number (and %) of the tumor suppressors1 (3.70 %)
Total number of binary PPIs (saturation %)38 (10.83 %)
The number (and %) of affected PPIs27 (71.05 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.519
Assortativity coefficient-0.5932
The network average Clustering coefficient0.260
The number (and %) of a zero Clustering coefficients17 (62.96 %)
The number (and %) of a zero Betweenness Centrality21 (77.78 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SUFU All fusions
: AA362631;
Proteins found in more fusions SUFU (see 1 fusions); STK36 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SUFUparental protein270.025626.333SUFU (PF05076, IPR020941): Suppressor of fused protein (SUFU)
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
2 ALDH1B1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 EDEM1interactor100Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
4 FAM90A1interactor100zf-CCHC_6 (PF15288): Zinc knuckle
5 FBXL17interactor30.6671.000TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
6 GLI1suppressor40.5002.667zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
7 GLI2oncoprotein21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
8 GLI3oncoprotein30.6670.667zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
9 GLIS3interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
10 HDXinteractor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
11 LDLRAD4interactor100Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
12 LIPT1interactor100BPL_LplA_LipB (PF03099, IPR004143): Biotin/lipoate A/B protein ligase family
13 MID1IP1interactor100Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
14 NFATC3oncoprotein100DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
15 NR2E1interactor100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
16 NXPH3interactor100Neurexophilin (PF06312, IPR026845): Neurexophilin
17 PEX26interactor100Pex26 (PF07163, IPR010797): Pex26 protein
18 QPRTinteractor200QRPTase_C (PF01729, IPR002638): Quinolinate phosphoribosyl transferase, C-terminal domain
QRPTase_N (PF02749, IPR022412): Quinolinate phosphoribosyl transferase, N-terminal domain
19 RCN3interactor100EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
20 SAP18interactor30.6670.667SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
21 STK36protein found in more fusions50.5002.667Pkinase (PF00069, IPR000719): Protein kinase domain
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
22 TTLL3oncoprotein100TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
23 ZBTB46interactor21.0000ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
C1_2 (PF03107, IPR004146): C1 domain
Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
DUF4428 (PF14471, IPR027872): Domain of unknown function (DUF4428)
24 ZNF263interactor21.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
25 ZNF446interactor31.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
26 ZNF747interactor100Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
27 ZNF764interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2256 (PF10013, IPR017136): Uncharacterized protein conserved in bacteria (DUF2256)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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