1 |
STRAP | parental protein | 65 | 0.092 | 2913.415 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
2 |
ABCE1 | interactor | 5 | 0.667 | 0.622 | ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain |
3 |
ACADM | oncoprotein | 3 | 0.667 | 1.000 | Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain |
4 |
ACO1 | interactor | 5 | 0.600 | 1.905 | Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase) Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain |
5 |
AXIN1 | suppressor | 5 | 0.667 | 1.333 | Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain |
6 |
BARD1 | suppressor | 5 | 0.833 | 0.500 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
7 |
BMI1 | oncoprotein | 9 | 0.464 | 11.767 | zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like |
8 |
CAPZA1 | interactor | 10 | 0.289 | 25.175 | F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit |
9 |
CAPZA2 | interactor | 2 | 1.000 | 0 | F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit |
10 |
CHEK2 | suppressor | 3 | 1.000 | 0 | FHA (PF00498, IPR000253, SM00240): FHA domain Pkinase (PF00069, IPR000719): Protein kinase domain |
11 |
CSDE1 | oncoprotein | 4 | 1.000 | 0 | CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain SUZ-C (PF12901, IPR024642): SUZ-C motif S1-like (PF14444, IPR025223): S1-like |
12 |
CTPS1 | interactor | 8 | 0.476 | 7.389 | CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus GATase (PF00117, IPR017926): Glutamine amidotransferase class-I |
13 |
DDX20 | interactor | 16 | 0.429 | 41.905 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
14 |
ECT2 | suppressor | 3 | 0.667 | 0.500 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal |
15 |
EGFR | oncoprotein | 10 | 0.444 | 13.106 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
16 |
EP300 | oncoprotein | 11 | 0.511 | 17.300 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type |
17 |
FBXO6 | interactor | 11 | 0.218 | 30.533 | FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like |
18 |
FYTTD1 | interactor | 5 | 0.500 | 1.952 | FYTT (PF07078, IPR009782): Forty-two-three protein |
19 |
GEMIN2 | interactor | 12 | 0.652 | 11.821 | SIP1 (PF04938): Survival motor neuron (SMN) interacting protein 1 (SIP1) Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain |
20 |
GEMIN5 | interactor | 15 | 0.448 | 40.965 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
21 |
GEMIN6 | interactor | 10 | 0.800 | 4.638 | Gemin6 (PF06372, IPR009422): Gemin6 protein |
22 |
GEMIN7 | interactor | 9 | 0.944 | 0.571 | Gemin7 (PF11095, IPR020338): Gem-associated protein 7 (Gemin7) SUZ-C (PF12901, IPR024642): SUZ-C motif |
23 |
GH1 | interactor | 1 | 0 | 0 | Hormone_1 (PF00103, IPR001400): Somatotropin hormone family |
24 |
GSK3B | suppressor | 7 | 0.400 | 6.583 | Pkinase (PF00069, IPR000719): Protein kinase domain |
25 |
HDAC1 | suppressor | 10 | 0.528 | 15.067 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
26 |
HDAC5 | protein found in more fusions | 10 | 0.333 | 19.917 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
27 |
HNRNPA1 | interactor | 12 | 0.327 | 25.460 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1 |
28 |
HSF1 | protein found in more fusions | 3 | 1.000 | 0 | DUF247 (PF03140, IPR004158): Plant protein of unknown function Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding |
29 |
HUWE1 | oncoprotein | 11 | 0.400 | 20.856 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
30 |
LARP4B | interactor | 3 | 1.000 | 0 | La (PF05383, IPR006630, SM00715): La domain |
31 |
MOV10 | interactor | 9 | 0.333 | 17.167 | AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain |
32 |
NME1 | suppressor | 5 | 0.500 | 2.167 | NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase |
33 |
NOS2 | interactor | 5 | 0.667 | 1.067 | FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain |
34 |
NOTCH3 | suppressor | 3 | 0.667 | 0.500 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
35 |
NPEPPS | interactor | 6 | 0.400 | 6.122 | Peptidase_M1 (PF01433, IPR014782): Peptidase family M1 ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain |
36 |
NTRK1 | oncoprotein | 21 | 0.205 | 124.350 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
37 |
NXF1 | interactor | 14 | 0.218 | 47.100 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
38 |
OFD1 | protein found in more fusions | 4 | 1.000 | 0 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit GrpE (PF01025, IPR000740): GrpE NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein XhlA (PF10779, IPR019715): Haemolysin XhlA DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372) LisH_2 (PF16045, IPR006594): LisH |
39 |
PAXIP1 | interactor | 7 | 0.476 | 8.067 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain |
40 |
PBLD | oncoprotein | 2 | 0 | 0 | PhzC-PhzF (PF02567, IPR003719): Phenazine biosynthesis-like protein |
41 |
PDPK1 | interactor | 3 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain PH_3 (PF14593): PH domain |
42 |
PLBD2 | interactor | 2 | 1.000 | 0 | Phospholip_B (PF04916, IPR007000): Phospholipase B DUF3693 (PF12472, IPR021096): Phage related protein |
43 |
PLCG1 | oncoprotein | 5 | 0.600 | 2.119 | C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain |
44 |
RAPH1 | oncoprotein | 2 | 1.000 | 0 | PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain BORG_CEP (PF14957, IPR029273): Cdc42 effector FAM76 (PF16046, IPR032017): FAM76 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins |
45 |
RN7SL1 | interactor | 7 | 1.000 | 0 | NA |
46 |
RNPS1 | interactor | 6 | 0.667 | 2.117 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) Macoilin (PF09726, IPR019130): Transmembrane protein |
47 |
RNU1-1 | interactor | 8 | 1.000 | 0 | NA |
48 |
RNU2-1 | interactor | 8 | 1.000 | 0 | NA |
49 |
RPL22 | oncoprotein | 6 | 0.600 | 4.500 | Ribosomal_L22e (PF01776, IPR002671): Ribosomal L22e protein family |
50 |
RPL24 | interactor | 5 | 0.800 | 0.800 | MAS20 (PF02064, IPR002056): MAS20 protein import receptor Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e |
51 |
RPS27A | interactor | 7 | 0.524 | 8.000 | DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049) |
52 |
SMAD2 | suppressor | 11 | 0.556 | 14.967 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
53 |
SMAD3 | oncoprotein | 10 | 0.611 | 9.800 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
54 |
SMAD6 | interactor | 4 | 1.000 | 0 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
55 |
SMAD7 | interactor | 10 | 0.511 | 16.733 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
56 |
SMN1 | interactor | 14 | 0.551 | 24.355 | SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) |
57 |
SP1 | protein found in more fusions | 7 | 0.733 | 3.500 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
58 |
SPRTN | interactor | 2 | 1.000 | 0 | GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term SprT-like (PF10263, IPR006640, SM00731): SprT-like family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein |
59 |
SZRD1 | interactor | 3 | 0.667 | 0.286 | SUZ (PF12752, IPR024771): SUZ domain SUZ-C (PF12901, IPR024642): SUZ-C motif T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB |
60 |
TGFBR1 | oncoprotein | 7 | 0.714 | 3.667 | Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain Pkinase (PF00069, IPR000719): Protein kinase domain TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif |
61 |
TGFBR2 | suppressor | 3 | 1.000 | 0 | ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
62 |
TP53BP1 | suppressor | 7 | 0.429 | 9.619 | 53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
63 |
UBA6 | interactor | 5 | 0.600 | 3.167 | ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site |
64 |
VCAM1 | interactor | 7 | 0.571 | 5.033 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
65 |
XPO1 | interactor | 20 | 0.189 | 130.519 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |