Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins STRAP (from a repository: Sat Dec 3 09:52:03 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 65 The number (and %) of the onco-proteins 17 (26.15 %) The number (and %) of the tumor suppressors 11 (16.92 %) Total number of binary PPIs (saturation %) 278 (13.37 %) The number (and %) of affected PPIs 65 (23.38 %) The number of possible different fusions 12 PPI diameter 2 PPI radius 1 The average degree of PPI 7.692 Assortativity coefficient -0.2676 The network average Clustering coefficient 0.618 The number (and %) of a zero Clustering coefficients 2 (3.08 %) The number (and %) of a zero Betweenness Centrality 17 (26.15 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: STRAP	All fusions : BU509169;
Proteins found in more fusions	EGFR (see 2 fusions); GSK3B (see 1 fusions); HSF1 (see 3 fusions); HUWE1 (see 2 fusions); HDAC5 (see 1 fusions); EP300 (see 1 fusions); OFD1 (see 1 fusions); PBLD (see 1 fusions); STRAP (see 2 fusions); SP1 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	STRAP	parental protein	65	0.092	2913.415	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
2	ABCE1	interactor	5	0.667	0.622	ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain
3	ACADM	oncoprotein	3	0.667	1.000	Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4	ACO1	interactor	5	0.600	1.905	Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase) Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
5	AXIN1	suppressor	5	0.667	1.333	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
6	BARD1	suppressor	5	0.833	0.500	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
7	BMI1	oncoprotein	9	0.464	11.767	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
8	CAPZA1	interactor	10	0.289	25.175	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
9	CAPZA2	interactor	2	1.000	0	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
10	CHEK2	suppressor	3	1.000	0	FHA (PF00498, IPR000253, SM00240): FHA domain Pkinase (PF00069, IPR000719): Protein kinase domain
11	CSDE1	oncoprotein	4	1.000	0	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain SUZ-C (PF12901, IPR024642): SUZ-C motif S1-like (PF14444, IPR025223): S1-like
12	CTPS1	interactor	8	0.476	7.389	CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
13	DDX20	interactor	16	0.429	41.905	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
14	ECT2	suppressor	3	0.667	0.500	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
15	EGFR	oncoprotein	10	0.444	13.106	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16	EP300	oncoprotein	11	0.511	17.300	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
17	FBXO6	interactor	11	0.218	30.533	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
18	FYTTD1	interactor	5	0.500	1.952	FYTT (PF07078, IPR009782): Forty-two-three protein
19	GEMIN2	interactor	12	0.652	11.821	SIP1 (PF04938): Survival motor neuron (SMN) interacting protein 1 (SIP1) Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain
20	GEMIN5	interactor	15	0.448	40.965	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
21	GEMIN6	interactor	10	0.800	4.638	Gemin6 (PF06372, IPR009422): Gemin6 protein
22	GEMIN7	interactor	9	0.944	0.571	Gemin7 (PF11095, IPR020338): Gem-associated protein 7 (Gemin7) SUZ-C (PF12901, IPR024642): SUZ-C motif
23	GH1	interactor	1	0	0	Hormone_1 (PF00103, IPR001400): Somatotropin hormone family
24	GSK3B	suppressor	7	0.400	6.583	Pkinase (PF00069, IPR000719): Protein kinase domain
25	HDAC1	suppressor	10	0.528	15.067	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
26	HDAC5	protein found in more fusions	10	0.333	19.917	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
27	HNRNPA1	interactor	12	0.327	25.460	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
28	HSF1	protein found in more fusions	3	1.000	0	DUF247 (PF03140, IPR004158): Plant protein of unknown function Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
29	HUWE1	oncoprotein	11	0.400	20.856	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
30	LARP4B	interactor	3	1.000	0	La (PF05383, IPR006630, SM00715): La domain
31	MOV10	interactor	9	0.333	17.167	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
32	NME1	suppressor	5	0.500	2.167	NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
33	NOS2	interactor	5	0.667	1.067	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
34	NOTCH3	suppressor	3	0.667	0.500	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
35	NPEPPS	interactor	6	0.400	6.122	Peptidase_M1 (PF01433, IPR014782): Peptidase family M1 ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
36	NTRK1	oncoprotein	21	0.205	124.350	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
37	NXF1	interactor	14	0.218	47.100	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
38	OFD1	protein found in more fusions	4	1.000	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit GrpE (PF01025, IPR000740): GrpE NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein XhlA (PF10779, IPR019715): Haemolysin XhlA DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372) LisH_2 (PF16045, IPR006594): LisH
39	PAXIP1	interactor	7	0.476	8.067	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
40	PBLD	oncoprotein	2	0	0	PhzC-PhzF (PF02567, IPR003719): Phenazine biosynthesis-like protein
41	PDPK1	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain PH_3 (PF14593): PH domain
42	PLBD2	interactor	2	1.000	0	Phospholip_B (PF04916, IPR007000): Phospholipase B DUF3693 (PF12472, IPR021096): Phage related protein
43	PLCG1	oncoprotein	5	0.600	2.119	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
44	RAPH1	oncoprotein	2	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain BORG_CEP (PF14957, IPR029273): Cdc42 effector FAM76 (PF16046, IPR032017): FAM76 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
45	RN7SL1	interactor	7	1.000	0	NA
46	RNPS1	interactor	6	0.667	2.117	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) Macoilin (PF09726, IPR019130): Transmembrane protein
47	RNU1-1	interactor	8	1.000	0	NA
48	RNU2-1	interactor	8	1.000	0	NA
49	RPL22	oncoprotein	6	0.600	4.500	Ribosomal_L22e (PF01776, IPR002671): Ribosomal L22e protein family
50	RPL24	interactor	5	0.800	0.800	MAS20 (PF02064, IPR002056): MAS20 protein import receptor Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
51	RPS27A	interactor	7	0.524	8.000	DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
52	SMAD2	suppressor	11	0.556	14.967	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
53	SMAD3	oncoprotein	10	0.611	9.800	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
54	SMAD6	interactor	4	1.000	0	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
55	SMAD7	interactor	10	0.511	16.733	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
56	SMN1	interactor	14	0.551	24.355	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
57	SP1	protein found in more fusions	7	0.733	3.500	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
58	SPRTN	interactor	2	1.000	0	GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term SprT-like (PF10263, IPR006640, SM00731): SprT-like family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
59	SZRD1	interactor	3	0.667	0.286	SUZ (PF12752, IPR024771): SUZ domain SUZ-C (PF12901, IPR024642): SUZ-C motif T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
60	TGFBR1	oncoprotein	7	0.714	3.667	Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain Pkinase (PF00069, IPR000719): Protein kinase domain TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
61	TGFBR2	suppressor	3	1.000	0	ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
62	TP53BP1	suppressor	7	0.429	9.619	53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
63	UBA6	interactor	5	0.600	3.167	ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
64	VCAM1	interactor	7	0.571	5.033	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
65	XPO1	interactor	20	0.189	130.519	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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