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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins20 (31.25 %)
The number (and %) of the tumor suppressors3 (4.69 %)
Total number of binary PPIs (saturation %)251 (12.45 %)
The number (and %) of affected PPIs64 (25.50 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI7.438
Assortativity coefficient-0.3241
The network average Clustering coefficient0.527
The number (and %) of a zero Clustering coefficients7 (10.94 %)
The number (and %) of a zero Betweenness Centrality18 (28.12 %)


List of the fusions

PPI for parental proteins: STOM All fusions
: CN415527;
Proteins found in more fusions FMNL1 (see 1 fusions); STOM (see 1 fusions); UBC (see 1 fusions); SF1 (see 1 fusions); PUF60 (see 2 fusions); DVL3 (see 1 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 STOMparental protein640.0902854.808Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
2 ADRB2interactor70.4674.2177tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
3 ASIC1interactor100ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
4 ASIC2interactor21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
5 ASIC3interactor21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
6 ATIConcoprotein21.0000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
7 ATP6V1Ainteractor70.42910.500ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
8 ATP6V1B1interactor30.6670.667ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
9 CCT3interactor80.7501.593Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CCT8interactor80.6077.010Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CLTConcoprotein140.41831.203Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
12 CUL2suppressor90.38914.507Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
13 DBN1oncoprotein100.57811.153Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
14 DVL3protein found in more fusions31.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
15 EGFRoncoprotein160.26757.825Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16 EPRSinteractor80.6072.553GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
17 ERGIC3interactor100COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
18 ESR1oncoprotein140.32127.533Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
19 FAF2interactor70.5334.583DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
20 FAPinteractor100DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
21 FBXO6interactor170.21369.800FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
22 FGFR1OP2oncoprotein21.0000Cauli_AT (PF03233, IPR004917): Aphid transmission protein
DUF837 (PF05769, IPR008555): Protein of unknown function (DUF837)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
23 FMNL1protein found in more fusions40.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
SlyX (PF04102, IPR007236): SlyX
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
24 FN1oncoprotein190.28169.456fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
25 FOXA3interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
HNF_C (PF09354, IPR018533): HNF3 C-terminal domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
26 FOXL1oncoprotein21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
27 GIMAP2interactor100AIG1 (PF04548, IPR006703): AIG1 family
28 GOLT1Binteractor31.0000Got1 (PF04178, IPR007305): Got1/Sft2-like family
29 HNRNPMinteractor120.42420.841RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M
Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
30 ILF3oncoprotein140.23153.469dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
31 ITGA4interactor190.35349.482FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
32 LIMA1suppressor100.44420.950LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
33 MYH9oncoprotein100.6227.687IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
34 MYO19interactor61.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
35 PNKDinteractor100Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
36 PON2interactor60.4673.158Arylesterase (PF01731, IPR002640): Arylesterase
37 PTPN1suppressor40.5002.067Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
38 PUF60protein found in more fusions60.5004.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
39 RAB2Aoncoprotein70.33312.333Ras (PF00071, IPR001806, SM00173): Ras family
40 RAB7Aoncoprotein50.5004.000Ras (PF00071, IPR001806, SM00173): Ras family
41 RAPGEF2interactor30.6670.222PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
42 RNF26interactor21.0000GtrA (PF04138, IPR007267): GtrA-like protein
Herpes_UL37_1 (PF03970, IPR005655): Herpesvirus UL37 tegument protein
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
43 RPL13Ainteractor50.6000.787Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
44 RUVBL1oncoprotein70.6671.428TIP49 (PF06068, IPR010339): TIP49 C-terminus
45 RUVBL2oncoprotein100.5006.769TIP49 (PF06068, IPR010339): TIP49 C-terminus
46 SBDSoncoprotein30.6671.000SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
47 SCO2interactor30.6671.000SCO1-SenC (PF02630, IPR003782): SCO1/SenC
48 SERINC2interactor100Serinc (PF03348, IPR005016): Serine incorporator (Serinc)
49 SF1protein found in more fusions80.5716.433UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
50 SF3B3interactor60.6003.167CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
51 SF3B4interactor60.4674.200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
52 SFXN3interactor21.0000Mtc (PF03820, IPR004686): Tricarboxylate carrier
53 SLC2A1interactor31.0000Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
54 SNRPA1interactor90.47212.002LRR_9 (PF14580): Leucine-rich repeat
55 SNRPCinteractor40.6670.900zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
56 SUGP1interactor30.6671.000G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
57 SVILinteractor80.7146.233Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
58 TMEM17interactor40.6671.667Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
59 TMPOinteractor40.6672.000LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
60 TRIP6interactor40.5001.667DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
61 UBCprotein found in more fusions160.33344.607ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
62 VAPAinteractor100.33319.210DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
63 VCAM1interactor170.31643.534C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
64 XPO1interactor150.34351.280CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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