Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins STAT5B (from a repository: Sun Mar 11 20:03:34 2018)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins17 (31.48 %)
The number (and %) of the tumor suppressors6 (11.11 %)
Total number of binary PPIs (saturation %)197 (13.77 %)
The number (and %) of affected PPIs54 (27.41 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI6.556
Assortativity coefficient-0.1564
The network average Clustering coefficient0.637
The number (and %) of a zero Clustering coefficients4 (7.41 %)
The number (and %) of a zero Betweenness Centrality16 (29.63 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: STAT5B All fusions
Proteins found in more fusions JAK2 (see 3 fusions); STAT3 (see 2 fusions); JAK1 (see 1 fusions); SHC1 (see 1 fusions); PTPN11 (see 1 fusions); APP (see 4 fusions); POU2F1 (see 1 fusions); FGFR2 (see 3 fusions); PRLR (see 1 fusions); NTRK1/TFG (see 1 fusions); EGFR (see 2 fusions); NR3C1 (see 8 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 STAT5Bparental protein540.0902054.005SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
2 AARSinteractor70.4769.000DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3 AFTPHinteractor21.0000Clathrin_bdg (PF15045, IPR029205): Clathrin-binding box of Aftiphilin, vesicle trafficking
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
4 ALADoncoprotein41.0000ALAD (PF00490, IPR001731, SM01004): Delta-aminolevulinic acid dehydratase
5 ANKMY2interactor40.6671.500zf-MYND (PF01753, IPR002893): MYND finger
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
zf-C6H2 (PF15801, IPR031615): zf-MYND-like zinc finger, mRNA-binding
6 APPprotein found in more fusions90.28618.500APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ASF1Binteractor100ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
8 C18orf8interactor100Mic1 (PF07035, IPR009755): Colon cancer-associated protein Mic1-like
9 CCR5interactor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
10 CD247interactor21.0000ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif
TCR_zetazeta (PF11628, IPR021663): T-cell surface glycoprotein CD3 zeta chain
11 CTLA4interactor31.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
12 DLATinteractor60.9330.4002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
Stm1_N (PF09598, IPR019084): Stm1
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
13 DLDinteractor60.9330.400Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
14 DMRTA1interactor100DM (PF00751, IPR001275, SM00301): DM DNA binding domain
DMA (PF03474, IPR005173): DMRTA motif
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
YyzF (PF14116, IPR025626): YyzF-like protein
15 DPP9interactor70.6674.500DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
16 EGFRoncoprotein140.37235.402Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
17 ELP2interactor50.8000.450WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Lar_restr_allev (PF14354): Restriction alleviation protein Lar
18 FGFR2oncoprotein50.6671.333Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
19 GHRoncoprotein80.6672.152EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
GHBP (PF12772, IPR025871): Growth hormone receptor binding
20 HAX1interactor31.0000Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
21 HIVEP1suppressor30.6671.000PHD (PF00628, IPR019787, SM00249): PHD-finger
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
22 IL15interactor21.0000IL15 (PF02372, IPR003443): Interleukin 15
23 IL2RBoncoprotein50.7000.867IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
24 INSRinteractor80.6073.902fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
25 JAK1oncoprotein120.47313.702FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
26 JAK2oncoprotein170.32556.655FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
27 JAK3oncoprotein70.4768.533Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
28 KANSL3interactor100NA
29 KIToncoprotein50.7001.233ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
30 MCMBPinteractor30.6670.667MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
31 MVPoncoprotein40.6671.000Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
32 NIF3L1interactor70.6673.500NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
33 NMIinteractor41.0000IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
34 NR3C1protein found in more fusions50.6671.333GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
35 NTRK1oncoprotein200.240119.336I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
36 PDHA1interactor60.9330.400E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
37 PDHBinteractor60.9330.400Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
38 PDHXinteractor51.00002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
39 PGRsuppressor50.6671.333Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
40 POU2F1protein found in more fusions50.5002.000Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
41 PRLRoncoprotein41.0000EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
42 PTPN1suppressor80.5717.786Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
43 PTPN11suppressor120.47319.652SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
44 PTPN6suppressor60.6671.950SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
45 PUS7Linteractor21.0000R3H (PF01424, IPR001374, SM00393): R3H domain
TruD (PF01142, IPR001656): tRNA pseudouridine synthase D (TruD)
46 RPRD1Ainteractor60.4676.500CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
GlutR_N (PF05201, IPR015895): Glutamyl-tRNAGlu reductase, N-terminal domain
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
47 RPRD1Binteractor70.6674.500CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
48 SERTAD1interactor30.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
49 SHC1oncoprotein100.44412.919PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
50 STAT3suppressor190.28191.021SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
51 SURF2interactor80.50010.667SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
52 TFGoncoprotein31.0000ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
MucBP (PF06458, IPR009459): MucBP domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
53 TOM1L1interactor80.5717.833GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
54 VCAM1interactor30.6670.667C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain

B a c k    t o    T o p ⇑