Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SRSF2 (from a repository: Sun Dec 4 23:53:02 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PNG file PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 109 The number (and %) of the onco-proteins 29 (26.61 %) The number (and %) of the tumor suppressors 13 (11.93 %) Total number of binary PPIs (saturation %) 880 (14.95 %) The number (and %) of affected PPIs 109 (12.39 %) The number of possible different fusions 18 PPI diameter 2 PPI radius 1 The average degree of PPI 15.339 Assortativity coefficient -0.1731 The network average Clustering coefficient 0.501 The number (and %) of a zero Clustering coefficients 4 (3.67 %) The number (and %) of a zero Betweenness Centrality 11 (10.09 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SRSF2	All fusions : CB250684;
Proteins found in more fusions	SREK1 (see 4 fusions); SRSF2 (see 1 fusions); U2AF2 (see 2 fusions); HUWE1 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); SRPK2 (see 1 fusions); OFD1 (see 1 fusions); CDK6 (see 1 fusions); PSME3 (see 2 fusions); EWSR1 (see 2 fusions); SRSF1 (see 1 fusions); KAT5 (see 3 fusions); POLR2A (see 2 fusions); CSNK2A1 (see 1 fusions); COPS5 (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SRSF2	parental protein	109	0.126	6212.218	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP2 (PF01254, IPR000678): Nuclear transition protein 2 Transformer (PF06495, IPR010519): Fruit fly transformer protein Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
2	ACBD3	interactor	3	1.000	0	ACBP (PF00887, IPR000582): Acyl CoA binding protein CDC45 (PF02724, IPR003874): CDC45-like protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking NINJA_B (PF16136, IPR032310): Putative nuclear localisation signal
3	AIRE	interactor	7	0.533	1.668	PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
4	ALYREF	interactor	23	0.554	20.141	FYTT (PF07078, IPR009782): Forty-two-three protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
5	ATP6V1F	interactor	4	0.500	2.667	ATP-synt_F (PF01990, IPR008218): ATP synthase (F/14-kDa) subunit
6	BAG6	interactor	8	0.381	10.000	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
7	BARD1	suppressor	18	0.471	27.465	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
8	BTF3	interactor	5	0.400	4.833	NAC (PF01849, IPR002715): NAC domain
9	CAND1	interactor	35	0.496	69.424	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
10	CCT5	interactor	11	0.600	8.421	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11	CDC5L	interactor	29	0.476	59.217	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
12	CDK6	suppressor	7	0.667	2.376	Pkinase (PF00069, IPR000719): Protein kinase domain
13	CEP128	interactor	14	0.341	42.986	DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
14	CEP164	interactor	6	0.467	6.167	DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) WW (PF00397, IPR001202, SM00456): WW domain KxDL (PF10241, IPR019371): Uncharacterized conserved protein XhlA (PF10779, IPR019715): Haemolysin XhlA KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
15	CEP72	interactor	7	0.524	7.352	LRR_9 (PF14580): Leucine-rich repeat FAM76 (PF16046, IPR032017): FAM76 protein
16	CIR1	interactor	4	1.000	0	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A) Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 IncA (PF04156, IPR007285): IncA protein Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR YebO (PF13974, IPR025594): YebO-like protein CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
17	CNTRL	oncoprotein	5	0.700	2.333	APG6 (PF04111, IPR007243): Autophagy protein Apg6 BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fez1 (PF06818): Fez1 Laminin_II (PF06009, IPR010307): Laminin Domain II Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMPIT (PF07851, IPR012926): TMPIT-like protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) LRR_9 (PF14580): Leucine-rich repeat
18	COPE	interactor	8	0.429	5.764	Coatomer_E (PF04733, IPR006822): Coatomer epsilon subunit TPR_19 (PF14559): Tetratricopeptide repeat
19	COPS5	protein found in more fusions	28	0.547	39.446	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
20	CSNK2A1	oncoprotein	19	0.412	30.503	Pkinase (PF00069, IPR000719): Protein kinase domain
21	CUL1	suppressor	33	0.490	68.732	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22	CUL2	suppressor	22	0.554	25.150	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
23	CUL3	protein found in more fusions	46	0.360	294.101	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
24	CUL5	suppressor	19	0.626	24.317	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25	DCTN1	interactor	9	0.536	10.554	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain FlgN (PF05130, IPR007809): FlgN protein HOOK (PF05622, IPR008636): HOOK protein SlyX (PF04102, IPR007236): SlyX TSC22 (PF01166, IPR000580): TSC-22/dip/bun family DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443) ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Dynactin (PF12455, IPR022157): Dynein associated protein Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
26	DEK	oncoprotein	11	0.418	7.667	DEK_C (PF08766, IPR014876): DEK C terminal domain Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family SAP (PF02037, IPR003034, SM00513): SAP domain Bud13 (PF09736, IPR018609): Pre-mRNA-splicing factor of RES complex DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
27	DSTN	interactor	5	0.400	5.667	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
28	EED	suppressor	20	0.468	31.419	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
29	EIF4A3	interactor	27	0.618	21.848	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
30	EIF5	interactor	5	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5 W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
31	ESR1	suppressor	27	0.348	110.356	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
32	EWSR1	oncoprotein	34	0.403	142.420	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
33	FBF1	interactor	13	0.269	35.667	DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family YlqD (PF11068, IPR021297): YlqD protein KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
34	FGFR1OP	oncoprotein	9	0.429	11.900	FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
35	GOLGA2	interactor	12	0.348	15.850	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
36	HDGF	interactor	18	0.438	30.716	PWWP (PF00855, IPR000313, SM00293): PWWP domain
37	HNRNPA2B1	oncoprotein	29	0.426	87.213	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38	HNRNPDL	interactor	21	0.586	23.653	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
39	HSPA1A	interactor	19	0.386	53.951	HSP70 (PF00012, IPR013126): Hsp70 protein
40	HUWE1	oncoprotein	22	0.424	50.544	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
41	KAT5	suppressor	11	0.378	14.956	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
42	KATNA1	interactor	4	0.833	0.154	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) ABC_tran (PF00005, IPR003439): ABC transporter Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat AAA_22 (PF13401, IPR003593): AAA domain
43	KRT31	interactor	4	0.667	0.536	Filament (PF00038, IPR001664): Intermediate filament protein
44	KRT40	interactor	7	0.381	4.812	Filament (PF00038, IPR001664): Intermediate filament protein UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
45	LIG4	interactor	2	1.000	0	APG17 (PF04108, IPR007240): Autophagy protein Apg17 BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
46	LZTS2	suppressor	8	0.321	9.121	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127) Fez1 (PF06818): Fez1 ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
47	MAGOH	interactor	18	0.523	15.435	Mago_nashi (PF02792, IPR004023): Mago nashi protein
48	MYO1C	interactor	5	0.400	3.126	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
49	NCF1	interactor	2	0	0	p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain PX (PF00787, IPR001683, SM00312): PX domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
50	NEDD8	interactor	18	0.471	38.641	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
51	NPHP1	interactor	6	0.600	2.833	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FAM176 (PF14851): FAM176 family Speriolin_N (PF15058, IPR029385): Speriolin N terminus DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
52	NTRK1	oncoprotein	54	0.242	617.047	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
53	NUBP2	interactor	4	0.500	2.333	ParA (PF10609, IPR019591): NUBPL iron-transfer P-loop NTPase
54	NUDCD2	interactor	1	0	0	CS (PF04969, IPR007052): CS domain DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
55	NXF1	interactor	34	0.322	188.254	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
56	OBSL1	interactor	28	0.447	45.582	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
57	OFD1	protein found in more fusions	15	0.297	49.652	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit GrpE (PF01025, IPR000740): GrpE NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein XhlA (PF10779, IPR019715): Haemolysin XhlA DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372) LisH_2 (PF16045, IPR006594): LisH
58	PARK2	suppressor	19	0.359	47.280	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
59	PAXIP1	interactor	12	0.455	9.974	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
60	POC1B	interactor	3	0.667	1.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
61	POC5	interactor	6	0.533	5.400	vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated IMUP (PF15761, IPR026621): Immortalisation up-regulated protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
62	POLR2A	protein found in more fusions	22	0.329	66.919	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
63	PPARGC1A	interactor	5	0.500	1.882	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
64	PSMA1	interactor	22	0.248	110.577	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
65	PSMA5	oncoprotein	16	0.517	23.784	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
66	PSMB1	interactor	9	0.556	9.058	Proteasome (PF00227, IPR001353): Proteasome subunit
67	PSME3	protein found in more fusions	12	0.418	14.376	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
68	PTMA	oncoprotein	8	0.250	16.233	Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
69	RAD23A	oncoprotein	9	0.536	8.152	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
70	RNPS1	interactor	26	0.505	52.671	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) Macoilin (PF09726, IPR019130): Transmembrane protein
71	RPGRIP1L	interactor	9	0.389	15.467	bZIP_1 (PF00170, IPR004827): bZIP transcription factor C2 (PF00168, IPR000008, SM00239): C2 domain DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FtsL (PF04999, IPR011922): Cell division protein FtsL T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1 BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4497 (PF14924): Protein of unknown function (DUF4497)
72	RUVBL1	oncoprotein	21	0.453	33.906	TIP49 (PF06068, IPR010339): TIP49 C-terminus
73	SASS6	interactor	3	1.000	0	CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SAS-6_N (PF16531, IPR032396): Centriolar protein SAS N-terminal
74	SBNO1	oncoprotein	3	0.667	0.222	Helicase_C_4 (PF13871, IPR026937): C-terminal domain on Strawberry notch homologue AAA_34 (PF13872): P-loop containing NTP hydrolase pore-1
75	SCLT1	oncoprotein	4	0.833	0.500	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) SlyX (PF04102, IPR007236): SlyX XhlA (PF10779, IPR019715): Haemolysin XhlA TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding Imm7 (PF15585, IPR028965): Immunity protein 7 CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
76	SF3A2	interactor	15	0.724	4.161	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
77	SF3B3	interactor	24	0.511	41.816	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
78	SFN	suppressor	10	0.444	7.712	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
79	SIRT7	interactor	16	0.433	21.205	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
80	SNW1	protein found in more fusions	28	0.450	81.703	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
81	SORT1	interactor	2	1.000	0	Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
82	SREK1	protein found in more fusions	17	0.592	8.442	Ureide_permease (PF07168, IPR009834): Ureide permease RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
83	SRPK1	interactor	22	0.597	19.566	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
84	SRPK2	oncoprotein	23	0.610	21.082	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
85	SRRM1	interactor	25	0.493	39.323	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
86	SRSF1	protein found in more fusions	44	0.398	195.684	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
87	SRSF11	interactor	17	0.640	12.491	Rtf2 (PF04641, IPR027799): Rtf2 RING-finger RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP2 (PF01254, IPR000678): Nuclear transition protein 2 Transformer (PF06495, IPR010519): Fruit fly transformer protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
88	SRSF3	oncoprotein	34	0.403	127.422	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
89	SRSF4	interactor	20	0.495	34.251	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
90	SRSF9	interactor	22	0.571	22.478	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
91	STIP1	interactor	7	0.714	2.500	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
92	SUB1	interactor	10	0.444	8.490	Dehydrin (PF00257, IPR000167): Dehydrin PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4)
93	TBC1D9	interactor	1	0	0	GRAM (PF02893, IPR004182, SM00568): GRAM domain RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
94	TCF4	suppressor	4	0.833	0.143	CDC45 (PF02724, IPR003874): CDC45-like protein HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
95	TCTN1	interactor	1	0	0	DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
96	TCTN3	interactor	5	0.500	4.167	DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
97	TMEM126A	interactor	3	1.000	0	TMEM126 (PF07114, IPR009801): Transmembrane protein 126
98	TPM4	oncoprotein	4	0.833	0.143	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
99	TRA2B	interactor	29	0.495	70.779	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
100	TRIM27	oncoprotein	8	0.333	7.990	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
101	TTN	interactor	8	0.821	1.279	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
102	U2AF1	oncoprotein	20	0.616	19.344	DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509) KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
103	U2AF2	protein found in more fusions	42	0.448	124.349	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
104	UBA2	interactor	8	0.500	10.533	ThiF (PF00899, IPR000594): ThiF family UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
105	UBE2B	interactor	6	0.400	5.667	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
106	UBQLN4	interactor	8	0.333	13.167	CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Arm_2 (PF04826, IPR006911): Armadillo-like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
107	XPO1	interactor	25	0.280	128.272	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
108	YAP1	suppressor	8	0.464	9.806	Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181
109	YWHAE	oncoprotein	19	0.474	41.448	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k    t o    T o p ⇑