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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)59
The number (and %) of the onco-proteins19 (32.20 %)
The number (and %) of the tumor suppressors10 (16.95 %)
Total number of binary PPIs (saturation %)199 (11.63 %)
The number (and %) of affected PPIs59 (29.65 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI5.797
Assortativity coefficient-0.4679
The network average Clustering coefficient0.515
The number (and %) of a zero Clustering coefficients14 (23.73 %)
The number (and %) of a zero Betweenness Centrality25 (42.37 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SREBF2 All fusions
: BF081770;
Proteins found in more fusions CREBBP (see 6 fusions); KPNB1 (see 2 fusions); COPS5 (see 1 fusions); EP300 (see 1 fusions); ATXN1 (see 3 fusions); OS9 (see 2 fusions); PIAS1 (see 2 fusions); LZTR1 (see 2 fusions); CREB1 (see 2 fusions); MAPK1 (see 1 fusions); ZDHHC17 (see 2 fusions); SP1 (see 1 fusions); SMAD3 (see 3 fusions); PIAS2 (see 2 fusions); SREBF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SREBF2parental protein590.0682673.867HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
2 ABLIM1interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
3 ABLIM2interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
4 ARHGEF1interactor200RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Syntaxin_2 (PF14523): Syntaxin-like protein
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
5 ARRB1interactor50.5004.667Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ATF6interactor60.8001.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
7 ATF7IPoncoprotein50.6001.733TCP (PF03634, IPR005333): TCP family transcription factor
DUF2951 (PF11166, IPR021337): Protein of unknown function (DUF2951)
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
ATF7IP_BD (PF16788, IPR031870): ATF-interacting protein binding domain
fn3_4 (PF16794, IPR003961): Fibronectin-III type domain
8 ATXN1protein found in more fusions70.4677.333AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
9 CASP3interactor31.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
10 CASP8AP2interactor41.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
IncA (PF04156, IPR007285): IncA protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF3304 (PF11745, IPR021733): Protein of unknown function (DUF3304)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
11 CGRRF1interactor100zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
12 COPS5protein found in more fusions60.6002.667JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
13 CREB1oncoprotein110.40019.233bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
14 CREBBPsuppressor160.43837.300Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
15 EGR1suppressor41.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3432 (PF11914, IPR021839): Domain of unknown function (DUF3432)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
16 EP300oncoprotein150.40734.017Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
17 ERLIN2interactor60.6674.167Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
18 FHL3interactor60.5003.417LIM (PF00412, IPR001781, SM00132): LIM domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
19 GOLGB1interactor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spectrin (PF00435, IPR002017): Spectrin repeat
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
Tup_N (PF08581, IPR013890): Tup N-terminal
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial
SOGA (PF11365, IPR027881): Protein SOGA
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
CT_C_D (PF02682): Carboxyltransferase domain, subdomain C and D
20 HDAC3suppressor60.9000.250Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
21 HINFPinteractor21.0000SLIDE (PF09111, IPR015195): SLIDE
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
22 HLA-DPA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
23 HNF4Asuppressor110.57811.483zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
24 HSPA5oncoprotein90.32117.000HSP70 (PF00012, IPR013126): Hsp70 protein
25 INSIG1interactor60.9000.500INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
26 ITGB4oncoprotein30.6671.000Calx-beta (PF03160, IPR003644, SM00237): Calx-beta domain
EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
SEA (PF01390, IPR000082, SM00200): SEA domain
STOP (PF05217, IPR024963): STOP protein
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
27 KLF13interactor41.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
28 KPNB1protein found in more fusions60.5002.583Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
29 LZTR1oncoprotein200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
30 MAPK1oncoprotein100.7225.717Pkinase (PF00069, IPR000719): Protein kinase domain
31 MAPK3oncoprotein90.6795.733Pkinase (PF00069, IPR000719): Protein kinase domain
32 MRPS6interactor100Ribosomal_S6 (PF01250, IPR000529): Ribosomal protein S6
33 NAE1interactor100ThiF (PF00899, IPR000594): ThiF family
34 NFYAinteractor60.7332.000CBFB_NFYA (PF02045, IPR001289): CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
MSP1_C (PF07462, IPR010901): Merozoite surface protein 1 (MSP1) C-terminus
FixG_C (PF11614, IPR032879): IG-like fold at C-terminal of FixG, putative oxidoreductase
DUF4237 (PF14021, IPR025331): Protein of unknown function (DUF4237)
35 NFYCinteractor60.6005.167CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Fucose_iso_C (PF02952, IPR015888): L-fucose isomerase, C-terminal domain
36 NPATinteractor40.5002.667Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
NPAT_C (PF15712, IPR031442): NPAT C terminus
37 NRG1interactor21.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
38 OS9protein found in more fusions31.0000DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
39 PARK7suppressor41.0000DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
40 PIAS1suppressor70.6004.000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
41 PIAS2protein found in more fusions60.6002.917SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
42 PIAS3oncoprotein50.9000.250SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
43 PSMD4interactor100UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
44 PTH1Rinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
45 RNF139oncoprotein41.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
46 SCAPinteractor50.9000.500WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
47 SLC39A4suppressor100Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
48 SLC4A4interactor100Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family
Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain
FAM176 (PF14851): FAM176 family
49 SMAD3oncoprotein140.30843.417MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
50 SP1protein found in more fusions160.40047.317zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
51 SPINT2suppressor100Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
52 SPTBN1suppressor40.6671.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
53 SREBF1interactor150.38548.950HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
54 TRRAPinteractor30.6670.667BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
55 TTC1interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
56 UBE2Iinteractor180.25083.817UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
57 ZDHHC17protein found in more fusions40.6671.000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
58 ZMYM2oncoprotein31.0000YHS (PF04945, IPR007029): YHS domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
59 ZYXsuppressor40.5002.667DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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