Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SQSTM1 (from a repository: Sun May 26 19:02:28 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 221 The number (and %) of the onco-proteins 65 (29.41 %) The number (and %) of the tumor suppressors 37 (16.74 %) Total number of binary PPIs (saturation %) 1503 (6.18 %) The number (and %) of affected PPIs 221 (14.70 %) The number of possible different fusions 49 PPI diameter 2 PPI radius 1 The average degree of PPI 12.697 Assortativity coefficient -0.2459 The network average Clustering coefficient 0.456 The number (and %) of a zero Clustering coefficients 18 (8.14 %) The number (and %) of a zero Betweenness Centrality 40 (18.10 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SQSTM1	All fusions : CK003998; AA071142; BG910921; BU727331; BU171956;
Proteins found in more fusions	PSMC2 (see 1 fusions); MAPK1 (see 1 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); PRKCD (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); OPTN (see 1 fusions); LGALS3 (see 2 fusions); ULK1 (see 2 fusions); RARA (see 4 fusions); YWHAZ (see 1 fusions); PIK3R1 (see 1 fusions); SKI (see 1 fusions); HTT (see 1 fusions); UBC (see 1 fusions); MTOR (see 1 fusions); TP53 (see 3 fusions); TRAF6 (see 1 fusions); RARA/PML (see 20 fusions); CHMP2B (see 1 fusions); TKT (see 5 fusions); ENC1 (see 1 fusions); GABARAP (see 2 fusions); SQSTM1 (see 5 fusions); LCK (see 1 fusions); LDHA/SKI (see 3 fusions); MAPK14 (see 1 fusions); EEF1D (see 3 fusions); MAPT (see 1 fusions); NDUFS3 (see 1 fusions); MALT1 (see 1 fusions); RARA/NPM1 (see 1 fusions); BAG3 (see 4 fusions); RIPK1 (see 1 fusions); STUB1 (see 1 fusions); HSPB1 (see 3 fusions); CSNK2A1 (see 1 fusions); EPAS1 (see 1 fusions); DAZAP2 (see 2 fusions); CDC37 (see 2 fusions); TGM2 (see 4 fusions); PML (see 4 fusions); RPTOR (see 3 fusions); MEIS2 (see 1 fusions); SMAD3 (see 3 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SQSTM1	parental protein	221	0.049	34555.355	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
2	ABHD10	interactor	1	0	0	Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
3	AGAP1	interactor	2	1.000	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf Pap_E4 (PF02711, IPR003861): E4 protein PH (PF00169, IPR001849, SM00233): PH domain Ras (PF00071, IPR001806, SM00173): Ras family Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
4	AJUBA	oncoprotein	8	0.357	9.859	LIM (PF00412, IPR001781, SM00132): LIM domain
5	AKT1S1	interactor	6	0.900	0.250	Pap_E4 (PF02711, IPR003861): E4 protein PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
6	ARHGEF28	interactor	3	1.000	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
7	ASPH	interactor	3	1.000	0	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region Asp_Arg_Hydrox (PF05118, IPR007803): Aspartyl/Asparaginyl beta-hydroxylase LUC7 (PF03194, IPR004882): LUC7 N_terminus SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat
8	ATG4B	interactor	11	0.455	14.717	Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
9	ATG7	interactor	10	0.422	11.921	ThiF (PF00899, IPR000594): ThiF family ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
10	ATXN3	interactor	14	0.372	28.719	Josephin (PF02099, IPR006155): Josephin UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
11	BAG3	oncoprotein	30	0.180	208.952	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
12	BCL10	suppressor	10	0.417	13.187	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
13	BCL2	oncoprotein	15	0.374	32.639	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
14	BID	oncoprotein	10	0.417	14.591	BID (PF06393, IPR010479): BH3 interacting domain (BID)
15	BLOC1S5	interactor	2	1.000	0	Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
16	BNIP1	interactor	2	1.000	0	DUF1537 (PF07005, IPR010737): Putative sugar-binding N-terminal domain Sec20 (PF03908, IPR005606): Sec20
17	BPTF	interactor	7	0.381	8.619	Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT DDT (PF02791, IPR004022, SM00571): DDT domain DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) GRP (PF07172, IPR010800): Glycine rich protein family OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PHD (PF00628, IPR019787, SM00249): PHD-finger SDA1 (PF05285, IPR007949): SDA1 Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Bromodomain (PF00439, IPR001487, SM00297): Bromodomain WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1 WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
18	C10orf2	interactor	1	0	0	T2SSE (PF00437, IPR001482): Type II/IV secretion system protein SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain AAA_25 (PF13481): AAA domain
19	CALCOCO2	interactor	15	0.341	31.331	bZIP_1 (PF00170, IPR004827): bZIP transcription factor CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding zf-C2H2_4 (PF13894): C2H2-type zinc finger
20	CALM1	interactor	20	0.284	76.210	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
21	CAMK2A	interactor	6	0.600	1.733	CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain Pkinase (PF00069, IPR000719): Protein kinase domain
22	CASP8	suppressor	17	0.300	56.934	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
23	CASP9	oncoprotein	3	1.000	0	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
24	CAV1	suppressor	15	0.286	49.668	Caveolin (PF01146, IPR001612): Caveolin
25	CCNB1	oncoprotein	8	0.357	11.517	Adeno_E1A (PF02703, IPR003853): Early E1A protein Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
26	CD44	suppressor	4	0.500	1.833	VP4_2 (PF08935, IPR015031): Viral protein VP4 subunit Xlink (PF00193, IPR000538, SM00445): Extracellular link domain S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial
27	CD48	interactor	3	0.667	1.000	I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain
28	CDC37	protein found in more fusions	20	0.275	60.070	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
29	CDK1	oncoprotein	16	0.333	38.477	Pkinase (PF00069, IPR000719): Protein kinase domain
30	CDK9	protein found in more fusions	11	0.444	14.121	Pkinase (PF00069, IPR000719): Protein kinase domain
31	CEP135	interactor	11	0.327	20.413	DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family LPP (PF04728, IPR006817): Lipoprotein leucine-zipper RasGAP_C (PF03836, IPR000593): RasGAP C-terminus Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TPD52 (PF04201, IPR007327): Tumour protein D52 family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
32	CEP78	interactor	6	0.467	1.424	Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil DUF3122 (PF11320, IPR021469): Protein of unknown function (DUF3122) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
33	CFTR	suppressor	10	0.472	12.832	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
34	CHAF1A	interactor	4	0.667	0.400	CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
35	CHDH	interactor	2	1.000	0	GMC_oxred_C (PF05199, IPR007867): GMC oxidoreductase GMC_oxred_N (PF00732, IPR000172): GMC oxidoreductase
36	CHMP2B	protein found in more fusions	3	1.000	0	Involucrin (PF00904, IPR000354): Involucrin repeat Snf7 (PF03357, IPR005024): Snf7
37	CNTRL	oncoprotein	4	0.667	1.333	APG6 (PF04111, IPR007243): Autophagy protein Apg6 BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fez1 (PF06818): Fez1 Laminin_II (PF06009, IPR010307): Laminin Domain II Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMPIT (PF07851, IPR012926): TMPIT-like protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) LRR_9 (PF14580): Leucine-rich repeat
38	CRHBP	interactor	1	0	0	CRF-BP (PF05428, IPR008435): Corticotropin-releasing factor binding protein (CRF-BP)
39	CSNK2A1	oncoprotein	26	0.317	99.813	Pkinase (PF00069, IPR000719): Protein kinase domain
40	CSNK2A2	interactor	12	0.394	24.231	Pkinase (PF00069, IPR000719): Protein kinase domain
41	CTNND1	suppressor	11	0.309	18.756	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2 Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
42	CUL1	suppressor	27	0.366	84.768	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
43	CUL2	suppressor	19	0.480	32.225	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
44	CUL3	protein found in more fusions	48	0.201	554.911	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
45	CUL7	protein found in more fusions	27	0.225	132.036	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
46	CYLD	suppressor	15	0.371	39.955	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-HIT (PF04438, IPR007529): HIT zinc finger CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
47	DAZAP2	protein found in more fusions	8	0.429	7.482	DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
48	DCP2	interactor	4	0.500	1.186	DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain NUDIX (PF00293, IPR000086): NUDIX domain
49	DIP2B	interactor	2	1.000	0	AMP-binding (PF00501, IPR000873): AMP-binding enzyme DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
50	DNAI1	interactor	1	0	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
51	DNAI2	interactor	1	0	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
52	DVL2	interactor	15	0.308	31.044	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
53	EDEM1	interactor	1	0	0	Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
54	EEF1D	protein found in more fusions	13	0.409	22.027	EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
55	EGLN3	suppressor	9	0.357	10.371	2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
56	EMILIN3	interactor	1	0	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) ZapB (PF06005, IPR009252): Cell division protein ZapB EMI (PF07546, IPR011489): EMI domain Erythro-docking (PF09277, IPR015357): Erythronolide synthase, docking FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SlyX (PF04102, IPR007236): SlyX Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
57	ENC1	oncoprotein	6	0.700	1.150	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain HTH_12 (PF08461, IPR013668): Ribonuclease R winged-helix domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
58	ENPP1	interactor	2	1.000	0	Endonuclease_NS (PF01223, IPR001604, SM00892): DNA/RNA non-specific endonuclease Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
59	EPAS1	suppressor	14	0.321	32.109	Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 PAS_11 (PF14598): PAS domain
60	EPDR1	interactor	1	0	0	Ependymin (PF00811, IPR001299, SM00026): Ependymin
61	EPM2A	interactor	3	1.000	0	CBM_20 (PF00686, IPR002044): Starch binding domain DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
62	FAS	suppressor	9	0.393	11.067	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
63	FHOD3	interactor	1	0	0	Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region AAA_11 (PF13086): AAA domain DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
64	FKBP4	interactor	11	0.418	13.669	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
65	FLNB	oncoprotein	12	0.333	29.394	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain
66	FUS	suppressor	20	0.405	60.524	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
67	GABARAP	suppressor	23	0.333	76.126	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
68	GABARAPL1	interactor	25	0.323	77.150	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
69	GABARAPL2	interactor	24	0.333	80.376	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
70	GAS6	oncoprotein	1	0	0	EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Laminin_G_1 (PF00054, IPR001791): Laminin G domain Laminin_G_2 (PF02210, IPR001791): Laminin G domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
71	GBAS	interactor	18	0.438	39.140	NIPSNAP (PF07978, IPR012577): NIPSNAP
72	GBP2	interactor	2	1.000	0	GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
73	GEMIN4	interactor	6	0.500	3.733	NA
74	GFM2	interactor	1	0	0	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
75	GLG1	interactor	3	0.667	0.200	BAT2_N (PF07001, IPR009738): BAT2 N-terminus Cys_rich_FGFR (PF00839, IPR001893): Cysteine rich repeat
76	GPC4	interactor	3	0.667	0.667	Glypican (PF01153, IPR001863): Glypican
77	GRIA1	interactor	1	0	0	ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region Lig_chan (PF00060, IPR001320): Ligand-gated ion channel Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
78	GTF3C3	interactor	6	0.667	1.212	BUD22 (PF09073, IPR015158): BUD22 PGA2 (PF07543, IPR011431): Protein trafficking PGA2 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1 DUF3369 (PF11849, IPR021800): Domain of unknown function (DUF3369) ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat TPR_20 (PF14561): Tetratricopeptide repeat
79	HADHA	interactor	16	0.383	31.417	3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
80	HADHB	interactor	16	0.375	27.660	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
81	HDAC6	oncoprotein	27	0.302	119.882	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
82	HIF1A	suppressor	16	0.383	34.329	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
83	HNRNPA2B1	oncoprotein	18	0.497	25.377	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
84	HSPA4	interactor	37	0.300	198.146	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
85	HSPA5	oncoprotein	30	0.377	115.556	HSP70 (PF00012, IPR013126): Hsp70 protein
86	HSPB1	oncoprotein	33	0.296	167.787	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
87	HTT	protein found in more fusions	17	0.217	54.460	HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
88	IFI16	suppressor	11	0.291	26.120	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
89	IKBKG	interactor	32	0.202	241.294	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
90	INA	interactor	5	0.400	1.030	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
91	INSR	interactor	8	0.429	12.408	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain
92	IRAK1	interactor	23	0.325	76.659	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
93	IRF8	suppressor	4	0.667	0.500	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
94	ISG15	suppressor	10	0.467	10.514	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
95	KEAP1	oncoprotein	27	0.200	182.717	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
96	KIAA0753	interactor	7	0.476	6.852	MNR (PF15718, IPR031447): Protein moonraker
97	KIF5B	interactor	8	0.393	8.704	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
98	KLHL3	interactor	4	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
99	LCK	oncoprotein	13	0.227	37.827	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
100	LDHA	protein found in more fusions	11	0.444	14.112	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
101	LGALS3	oncoprotein	7	0.400	8.667	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
102	LIMD1	suppressor	6	0.400	2.621	LIM (PF00412, IPR001781, SM00132): LIM domain
103	LINC00341	interactor	2	1.000	0	NA
104	LLGL1	suppressor	9	0.472	7.676	Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
105	LLGL2	interactor	8	0.381	8.522	Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
106	MALT1	oncoprotein	7	0.667	1.243	Peptidase_C14 (PF00656, IPR011600): Caspase domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
107	MAP1LC3A	interactor	31	0.189	221.809	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
108	MAP1LC3B	interactor	22	0.338	60.489	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
109	MAP1LC3C	interactor	11	0.509	7.202	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
110	MAP2K5	oncoprotein	7	0.600	2.041	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
111	MAP3K3	oncoprotein	13	0.318	24.736	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
112	MAPK1	oncoprotein	25	0.232	144.882	Pkinase (PF00069, IPR000719): Protein kinase domain
113	MAPK13	oncoprotein	3	0.667	1.000	Pkinase (PF00069, IPR000719): Protein kinase domain
114	MAPK14	oncoprotein	9	0.500	7.602	Pkinase (PF00069, IPR000719): Protein kinase domain
115	MAPT	protein found in more fusions	19	0.353	57.662	Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
116	MBP	interactor	11	0.218	30.857	Myelin_MBP (PF01669, IPR000548): Myelin basic protein
117	MED4	interactor	16	0.242	62.882	Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
118	MEIS2	protein found in more fusions	2	0	0	Homeobox_KN (PF05920, IPR008422): Homeobox KN domain Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1
119	MLH1	suppressor	6	0.467	3.349	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
120	MLST8	interactor	9	0.528	6.174	Hira (PF07569, IPR011494): TUP1-like enhancer of split WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
121	MOV10	interactor	31	0.232	165.963	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
122	MRPL38	interactor	5	0.900	0.095	PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein DUF3095 (PF11294, IPR021445): Protein of unknown function (DUF3095)
123	MTOR	oncoprotein	24	0.281	106.814	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
124	MYC	oncoprotein	36	0.185	284.346	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
125	MYD88	oncoprotein	8	0.571	3.355	Death (PF00531, IPR000488, SM00005): Death domain TIR (PF01582, IPR000157, SM00255): TIR domain
126	NBR1	oncoprotein	17	0.250	61.557	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681) N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
127	NCOR1	oncoprotein	14	0.352	32.042	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
128	NDUFA5	interactor	5	0.600	2.476	ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
129	NDUFS2	interactor	9	0.639	2.413	Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
130	NDUFS3	protein found in more fusions	15	0.462	22.099	Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
131	NEFM	interactor	2	1.000	0	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
132	NFE2L2	oncoprotein	10	0.444	15.173	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
133	NGFR	suppressor	6	0.700	1.733	LHC (PF00556, IPR000066): Antenna complex alpha/beta subunit
134	NIPSNAP1	interactor	16	0.458	20.777	NIPSNAP (PF07978, IPR012577): NIPSNAP
135	NOD2	interactor	7	0.933	0.250	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
136	NPM1	suppressor	38	0.285	250.137	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
137	NSUN4	interactor	1	0	0	DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) RSRP (PF17069): Arginine/Serine-Rich protein 1
138	NTRK1	oncoprotein	69	0.129	1387.930	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
139	NTRK2	oncoprotein	4	0.500	1.833	I-set (PF07679, IPR013098): Immunoglobulin I-set domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
140	NTRK3	suppressor	3	1.000	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
141	NXF1	interactor	45	0.184	434.154	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
142	OPTN	protein found in more fusions	18	0.287	46.439	ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
143	OSBPL8	interactor	4	0.500	1.175	CDC45 (PF02724, IPR003874): CDC45-like protein DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980) Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein PH (PF00169, IPR001849, SM00233): PH domain
144	PAN2	interactor	16	0.250	53.519	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
145	PARK2	suppressor	37	0.200	285.707	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
146	PARP10	interactor	4	0.833	0.111	PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
147	PAWR	suppressor	4	0.667	1.167	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
148	PCK1	interactor	7	0.619	3.468	PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
149	PDE4A	oncoprotein	1	0	0	NadA (PF02445, IPR003473): Quinolinate synthetase A protein PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
150	PEX5	interactor	4	0.667	0.236	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat SHNi-TPR (PF10516, IPR019544): SHNi-TPR TPR_12 (PF13424): Tetratricopeptide repeat TPR_15 (PF13429): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
151	PIK3CA	oncoprotein	6	0.667	2.952	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
152	PIK3R1	oncoprotein	12	0.327	26.975	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
153	PIK3R2	oncoprotein	8	0.607	4.643	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
154	PML	suppressor	23	0.294	89.569	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
155	PPHLN1	interactor	5	0.700	1.236	Lge1 (PF11488): Transcriptional regulatory protein LGE1 HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
156	PRKCD	suppressor	13	0.439	17.805	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
157	PRKCI	interactor	20	0.289	80.402	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
158	PRKCZ	interactor	16	0.276	53.495	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
159	PSMC2	protein found in more fusions	22	0.400	52.640	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
160	PSMD10	interactor	11	0.582	8.266	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
161	PSMD12	interactor	18	0.471	28.737	Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain PCI (PF01399, IPR000717, SM00088): PCI domain
162	PSMD3	interactor	15	0.448	18.137	Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat PCI (PF01399, IPR000717, SM00088): PCI domain Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
163	PSMD4	interactor	21	0.395	62.497	UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
164	PYCARD	suppressor	5	0.667	1.667	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
165	RAD23A	oncoprotein	14	0.500	17.610	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
166	RAD54L2	interactor	1	0	0	SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
167	RARA	oncoprotein	10	0.389	14.071	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
168	RBM45	interactor	7	0.600	3.900	RNA_bind (PF08675, IPR014789): RNA binding domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
169	RCN2	interactor	10	0.378	12.026	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
170	RELN	interactor	2	0	0	BNR (PF02012, IPR002860): BNR/Asp-box repeat EB (PF01683, IPR006149): EB module EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain Reeler (PF02014, IPR002861): Reeler domain
171	RIPK1	protein found in more fusions	14	0.359	34.535	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
172	RPL37	interactor	3	1.000	0	Ribosomal_L37e (PF01907, IPR001569): Ribosomal protein L37e
173	RPS6KB1	interactor	9	0.429	6.790	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
174	RPTOR	protein found in more fusions	21	0.332	67.251	HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
175	RRAGB	interactor	5	0.800	1.333	Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
176	RRAGC	interactor	6	0.733	2.833	Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
177	SASS6	interactor	5	0.700	0.889	CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SAS-6_N (PF16531, IPR032396): Centriolar protein SAS N-terminal
178	SCCPDH	interactor	2	1.000	0	Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
179	SDHA	suppressor	10	0.733	2.819	FAD_binding_2 (PF00890, IPR003953): FAD binding domain Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
180	SESN1	interactor	3	0.667	0.167	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
181	SESN2	interactor	3	0.667	0.250	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
182	SKI	oncoprotein	12	0.382	17.540	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
183	SMAD3	oncoprotein	20	0.287	82.765	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
184	SNCA	interactor	19	0.327	51.311	Synuclein (PF01387, IPR001058): Synuclein
185	SPRED2	interactor	2	1.000	0	Sprouty (PF05210, IPR007875): Sprouty protein (Spry) WH1 (PF00568, IPR000697, SM00461): WH1 domain
186	SRRM2	interactor	11	0.618	5.621	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
187	STAT5A	suppressor	5	0.667	1.400	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
188	STUB1	suppressor	29	0.291	147.187	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
189	STXBP1	interactor	3	0.667	0.182	Sec1 (PF00995, IPR001619): Sec1 family
190	SYNPO2	suppressor	5	0.600	0.919	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
191	TARDBP	interactor	21	0.442	53.097	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
192	TBK1	interactor	16	0.286	44.552	DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain
193	TGM2	protein found in more fusions	8	0.429	4.756	Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
194	TKT	protein found in more fusions	11	0.511	11.483	Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
195	TMEM17	interactor	12	0.227	34.886	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
196	TNFRSF10A	suppressor	4	0.667	1.167	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region TMIE (PF16038, IPR032006): TMIE protein
197	TNK2	interactor	9	0.286	14.764	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GTPase_binding (PF09027, IPR015116): GTPase binding Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6 UBA_4 (PF14555): UBA-like domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
198	TOLLIP	interactor	12	0.364	21.287	C2 (PF00168, IPR000008, SM00239): C2 domain CUE (PF02845, IPR003892, SM00546): CUE domain
199	TP53	suppressor	44	0.196	437.834	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
200	TP53INP1	suppressor	5	0.500	1.269	DOR (PF14839, IPR029431): DOR family
201	TRAF1	oncoprotein	10	0.500	11.686	HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
202	TRAF6	protein found in more fusions	38	0.164	385.855	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
203	TRIB3	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
204	TRIM13	suppressor	5	0.500	1.952	ATP-synt_E_2 (PF08112, IPR012508): ATP synthase epsilon subunit Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
205	TRIM21	interactor	18	0.309	57.757	DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
206	TRIM5	interactor	7	0.600	1.747	Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0) Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
207	TRIM50	interactor	3	0.667	0.500	Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif SPRY (PF00622, IPR003877, SM00449): SPRY domain Trm112p (PF03966, IPR005651): Trm112p-like protein zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
208	TRIM55	interactor	6	0.600	3.333	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein NABP (PF07990, IPR012940): Nucleic acid binding protein NABP zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
209	TRIM63	interactor	6	0.600	2.500	DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) KIP1 (PF07765, IPR011684): KIP1-like protein RED_C (PF07807, IPR012492): RED-like protein C-terminal region zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
210	TRMT61B	interactor	1	0	0	GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit
211	TTN	interactor	10	0.378	18.946	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
212	TUBA1A	oncoprotein	17	0.301	44.977	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
213	TXNL1	interactor	10	0.733	3.482	PITH (PF06201, IPR010400): PITH domain Thioredoxin (PF00085, IPR013766): Thioredoxin
214	UBC	protein found in more fusions	60	0.186	856.300	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
215	UBXN1	interactor	10	0.722	2.711	Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UBX (PF00789, IPR001012, SM00166): UBX domain
216	ULK1	protein found in more fusions	18	0.324	58.824	Pkinase (PF00069, IPR000719): Protein kinase domain DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
217	ULK2	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
218	WDFY3	interactor	10	0.400	8.422	Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4 PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704) DUF4800 (PF16057): Domain of unknown function (DUF4800)
219	XPO1	interactor	44	0.140	583.737	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
220	YWHAZ	protein found in more fusions	33	0.244	224.593	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
221	ZFAND5	interactor	4	1.000	0	zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger FAM53 (PF15242, IPR029356): Family of FAM53

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