1 |
SQSTM1 | parental protein | 221 | 0.049 | 34555.355 | PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain |
2 |
ABHD10 | interactor | 1 | 0 | 0 | Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family |
3 |
AGAP1 | interactor | 2 | 1.000 | 0 | ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf Pap_E4 (PF02711, IPR003861): E4 protein PH (PF00169, IPR001849, SM00233): PH domain Ras (PF00071, IPR001806, SM00173): Ras family Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
4 |
AJUBA | oncoprotein | 8 | 0.357 | 9.859 | LIM (PF00412, IPR001781, SM00132): LIM domain |
5 |
AKT1S1 | interactor | 6 | 0.900 | 0.250 | Pap_E4 (PF02711, IPR003861): E4 protein PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1 |
6 |
ARHGEF28 | interactor | 3 | 1.000 | 0 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
7 |
ASPH | interactor | 3 | 1.000 | 0 | Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region Asp_Arg_Hydrox (PF05118, IPR007803): Aspartyl/Asparaginyl beta-hydroxylase LUC7 (PF03194, IPR004882): LUC7 N_terminus SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat |
8 |
ATG4B | interactor | 11 | 0.455 | 14.717 | Peptidase_C54 (PF03416, IPR005078): Peptidase family C54 |
9 |
ATG7 | interactor | 10 | 0.422 | 11.921 | ThiF (PF00899, IPR000594): ThiF family ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus |
10 |
ATXN3 | interactor | 14 | 0.372 | 28.719 | Josephin (PF02099, IPR006155): Josephin UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
11 |
BAG3 | oncoprotein | 30 | 0.180 | 208.952 | BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain |
12 |
BCL10 | suppressor | 10 | 0.417 | 13.187 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain |
13 |
BCL2 | oncoprotein | 15 | 0.374 | 32.639 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4 |
14 |
BID | oncoprotein | 10 | 0.417 | 14.591 | BID (PF06393, IPR010479): BH3 interacting domain (BID) |
15 |
BLOC1S5 | interactor | 2 | 1.000 | 0 | Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein |
16 |
BNIP1 | interactor | 2 | 1.000 | 0 | DUF1537 (PF07005, IPR010737): Putative sugar-binding N-terminal domain Sec20 (PF03908, IPR005606): Sec20 |
17 |
BPTF | interactor | 7 | 0.381 | 8.619 | Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT DDT (PF02791, IPR004022, SM00571): DDT domain DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) GRP (PF07172, IPR010800): Glycine rich protein family OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PHD (PF00628, IPR019787, SM00249): PHD-finger SDA1 (PF05285, IPR007949): SDA1 Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Bromodomain (PF00439, IPR001487, SM00297): Bromodomain WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1 WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR |
18 |
C10orf2 | interactor | 1 | 0 | 0 | T2SSE (PF00437, IPR001482): Type II/IV secretion system protein SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain AAA_25 (PF13481): AAA domain |
19 |
CALCOCO2 | interactor | 15 | 0.341 | 31.331 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding zf-C2H2_4 (PF13894): C2H2-type zinc finger |
20 |
CALM1 | interactor | 20 | 0.284 | 76.210 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
21 |
CAMK2A | interactor | 6 | 0.600 | 1.733 | CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain Pkinase (PF00069, IPR000719): Protein kinase domain |
22 |
CASP8 | suppressor | 17 | 0.300 | 56.934 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
23 |
CASP9 | oncoprotein | 3 | 1.000 | 0 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
24 |
CAV1 | suppressor | 15 | 0.286 | 49.668 | Caveolin (PF01146, IPR001612): Caveolin |
25 |
CCNB1 | oncoprotein | 8 | 0.357 | 11.517 | Adeno_E1A (PF02703, IPR003853): Early E1A protein Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain |
26 |
CD44 | suppressor | 4 | 0.500 | 1.833 | VP4_2 (PF08935, IPR015031): Viral protein VP4 subunit Xlink (PF00193, IPR000538, SM00445): Extracellular link domain S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial |
27 |
CD48 | interactor | 3 | 0.667 | 1.000 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain |
28 |
CDC37 | protein found in more fusions | 20 | 0.275 | 60.070 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
29 |
CDK1 | oncoprotein | 16 | 0.333 | 38.477 | Pkinase (PF00069, IPR000719): Protein kinase domain |
30 |
CDK9 | protein found in more fusions | 11 | 0.444 | 14.121 | Pkinase (PF00069, IPR000719): Protein kinase domain |
31 |
CEP135 | interactor | 11 | 0.327 | 20.413 | DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family LPP (PF04728, IPR006817): Lipoprotein leucine-zipper RasGAP_C (PF03836, IPR000593): RasGAP C-terminus Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TPD52 (PF04201, IPR007327): Tumour protein D52 family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
32 |
CEP78 | interactor | 6 | 0.467 | 1.424 | Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil DUF3122 (PF11320, IPR021469): Protein of unknown function (DUF3122) LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
33 |
CFTR | suppressor | 10 | 0.472 | 12.832 | ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain |
34 |
CHAF1A | interactor | 4 | 0.667 | 0.400 | CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA |
35 |
CHDH | interactor | 2 | 1.000 | 0 | GMC_oxred_C (PF05199, IPR007867): GMC oxidoreductase GMC_oxred_N (PF00732, IPR000172): GMC oxidoreductase |
36 |
CHMP2B | protein found in more fusions | 3 | 1.000 | 0 | Involucrin (PF00904, IPR000354): Involucrin repeat Snf7 (PF03357, IPR005024): Snf7 |
37 |
CNTRL | oncoprotein | 4 | 0.667 | 1.333 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fez1 (PF06818): Fez1 Laminin_II (PF06009, IPR010307): Laminin Domain II Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMPIT (PF07851, IPR012926): TMPIT-like protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) LRR_9 (PF14580): Leucine-rich repeat |
38 |
CRHBP | interactor | 1 | 0 | 0 | CRF-BP (PF05428, IPR008435): Corticotropin-releasing factor binding protein (CRF-BP) |
39 |
CSNK2A1 | oncoprotein | 26 | 0.317 | 99.813 | Pkinase (PF00069, IPR000719): Protein kinase domain |
40 |
CSNK2A2 | interactor | 12 | 0.394 | 24.231 | Pkinase (PF00069, IPR000719): Protein kinase domain |
41 |
CTNND1 | suppressor | 11 | 0.309 | 18.756 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2 Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain |
42 |
CUL1 | suppressor | 27 | 0.366 | 84.768 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
43 |
CUL2 | suppressor | 19 | 0.480 | 32.225 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
44 |
CUL3 | protein found in more fusions | 48 | 0.201 | 554.911 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
45 |
CUL7 | protein found in more fusions | 27 | 0.225 | 132.036 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
46 |
CYLD | suppressor | 15 | 0.371 | 39.955 | CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-HIT (PF04438, IPR007529): HIT zinc finger CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured |
47 |
DAZAP2 | protein found in more fusions | 8 | 0.429 | 7.482 | DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2) |
48 |
DCP2 | interactor | 4 | 0.500 | 1.186 | DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain NUDIX (PF00293, IPR000086): NUDIX domain |
49 |
DIP2B | interactor | 2 | 1.000 | 0 | AMP-binding (PF00501, IPR000873): AMP-binding enzyme DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain |
50 |
DNAI1 | interactor | 1 | 0 | 0 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
51 |
DNAI2 | interactor | 1 | 0 | 0 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795) |
52 |
DVL2 | interactor | 15 | 0.308 | 31.044 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
53 |
EDEM1 | interactor | 1 | 0 | 0 | Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47 |
54 |
EEF1D | protein found in more fusions | 13 | 0.409 | 22.027 | EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region |
55 |
EGLN3 | suppressor | 9 | 0.357 | 10.371 | 2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily |
56 |
EMILIN3 | interactor | 1 | 0 | 0 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) ZapB (PF06005, IPR009252): Cell division protein ZapB EMI (PF07546, IPR011489): EMI domain Erythro-docking (PF09277, IPR015357): Erythronolide synthase, docking FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SlyX (PF04102, IPR007236): SlyX Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term |
57 |
ENC1 | oncoprotein | 6 | 0.700 | 1.150 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain HTH_12 (PF08461, IPR013668): Ribonuclease R winged-helix domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif |
58 |
ENPP1 | interactor | 2 | 1.000 | 0 | Endonuclease_NS (PF01223, IPR001604, SM00892): DNA/RNA non-specific endonuclease Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain |
59 |
EPAS1 | suppressor | 14 | 0.321 | 32.109 | Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 PAS_11 (PF14598): PAS domain |
60 |
EPDR1 | interactor | 1 | 0 | 0 | Ependymin (PF00811, IPR001299, SM00026): Ependymin |
61 |
EPM2A | interactor | 3 | 1.000 | 0 | CBM_20 (PF00686, IPR002044): Starch binding domain DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain |
62 |
FAS | suppressor | 9 | 0.393 | 11.067 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH |
63 |
FHOD3 | interactor | 1 | 0 | 0 | Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region AAA_11 (PF13086): AAA domain DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) |
64 |
FKBP4 | interactor | 11 | 0.418 | 13.669 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat |
65 |
FLNB | oncoprotein | 12 | 0.333 | 29.394 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain |
66 |
FUS | suppressor | 20 | 0.405 | 60.524 | Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
67 |
GABARAP | suppressor | 23 | 0.333 | 76.126 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
68 |
GABARAPL1 | interactor | 25 | 0.323 | 77.150 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III |
69 |
GABARAPL2 | interactor | 24 | 0.333 | 80.376 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
70 |
GAS6 | oncoprotein | 1 | 0 | 0 | EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Laminin_G_1 (PF00054, IPR001791): Laminin G domain Laminin_G_2 (PF02210, IPR001791): Laminin G domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site |
71 |
GBAS | interactor | 18 | 0.438 | 39.140 | NIPSNAP (PF07978, IPR012577): NIPSNAP |
72 |
GBP2 | interactor | 2 | 1.000 | 0 | GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain |
73 |
GEMIN4 | interactor | 6 | 0.500 | 3.733 | NA |
74 |
GFM2 | interactor | 1 | 0 | 0 | EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II |
75 |
GLG1 | interactor | 3 | 0.667 | 0.200 | BAT2_N (PF07001, IPR009738): BAT2 N-terminus Cys_rich_FGFR (PF00839, IPR001893): Cysteine rich repeat |
76 |
GPC4 | interactor | 3 | 0.667 | 0.667 | Glypican (PF01153, IPR001863): Glypican |
77 |
GRIA1 | interactor | 1 | 0 | 0 | ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region Lig_chan (PF00060, IPR001320): Ligand-gated ion channel Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site |
78 |
GTF3C3 | interactor | 6 | 0.667 | 1.212 | BUD22 (PF09073, IPR015158): BUD22 PGA2 (PF07543, IPR011431): Protein trafficking PGA2 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1 DUF3369 (PF11849, IPR021800): Domain of unknown function (DUF3369) ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat TPR_20 (PF14561): Tetratricopeptide repeat |
79 |
HADHA | interactor | 16 | 0.383 | 31.417 | 3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase |
80 |
HADHB | interactor | 16 | 0.375 | 27.660 | Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain |
81 |
HDAC6 | oncoprotein | 27 | 0.302 | 119.882 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein |
82 |
HIF1A | suppressor | 16 | 0.383 | 34.329 | Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 |
83 |
HNRNPA2B1 | oncoprotein | 18 | 0.497 | 25.377 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
84 |
HSPA4 | interactor | 37 | 0.300 | 198.146 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
85 |
HSPA5 | oncoprotein | 30 | 0.377 | 115.556 | HSP70 (PF00012, IPR013126): Hsp70 protein |
86 |
HSPB1 | oncoprotein | 33 | 0.296 | 167.787 | HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
87 |
HTT | protein found in more fusions | 17 | 0.217 | 54.460 | HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
88 |
IFI16 | suppressor | 11 | 0.291 | 26.120 | HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein |
89 |
IKBKG | interactor | 32 | 0.202 | 241.294 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
90 |
INA | interactor | 5 | 0.400 | 1.030 | Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 |
91 |
INSR | interactor | 8 | 0.429 | 12.408 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain |
92 |
IRAK1 | interactor | 23 | 0.325 | 76.659 | Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain |
93 |
IRF8 | suppressor | 4 | 0.667 | 0.500 | IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3 |
94 |
ISG15 | suppressor | 10 | 0.467 | 10.514 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
95 |
KEAP1 | oncoprotein | 27 | 0.200 | 182.717 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif |
96 |
KIAA0753 | interactor | 7 | 0.476 | 6.852 | MNR (PF15718, IPR031447): Protein moonraker |
97 |
KIF5B | interactor | 8 | 0.393 | 8.704 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
98 |
KLHL3 | interactor | 4 | 1.000 | 0 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif |
99 |
LCK | oncoprotein | 13 | 0.227 | 37.827 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
100 |
LDHA | protein found in more fusions | 11 | 0.444 | 14.112 | Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain |
101 |
LGALS3 | oncoprotein | 7 | 0.400 | 8.667 | Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin |
102 |
LIMD1 | suppressor | 6 | 0.400 | 2.621 | LIM (PF00412, IPR001781, SM00132): LIM domain |
103 |
LINC00341 | interactor | 2 | 1.000 | 0 | NA |
104 |
LLGL1 | suppressor | 9 | 0.472 | 7.676 | Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
105 |
LLGL2 | interactor | 8 | 0.381 | 8.522 | Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus |
106 |
MALT1 | oncoprotein | 7 | 0.667 | 1.243 | Peptidase_C14 (PF00656, IPR011600): Caspase domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
107 |
MAP1LC3A | interactor | 31 | 0.189 | 221.809 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
108 |
MAP1LC3B | interactor | 22 | 0.338 | 60.489 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
109 |
MAP1LC3C | interactor | 11 | 0.509 | 7.202 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
110 |
MAP2K5 | oncoprotein | 7 | 0.600 | 2.041 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain |
111 |
MAP3K3 | oncoprotein | 13 | 0.318 | 24.736 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain |
112 |
MAPK1 | oncoprotein | 25 | 0.232 | 144.882 | Pkinase (PF00069, IPR000719): Protein kinase domain |
113 |
MAPK13 | oncoprotein | 3 | 0.667 | 1.000 | Pkinase (PF00069, IPR000719): Protein kinase domain |
114 |
MAPK14 | oncoprotein | 9 | 0.500 | 7.602 | Pkinase (PF00069, IPR000719): Protein kinase domain |
115 |
MAPT | protein found in more fusions | 19 | 0.353 | 57.662 | Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat |
116 |
MBP | interactor | 11 | 0.218 | 30.857 | Myelin_MBP (PF01669, IPR000548): Myelin basic protein |
117 |
MED4 | interactor | 16 | 0.242 | 62.882 | Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4 |
118 |
MEIS2 | protein found in more fusions | 2 | 0 | 0 | Homeobox_KN (PF05920, IPR008422): Homeobox KN domain Meis_PKNOX_N (PF16493, IPR032453): N-terminal of Homeobox Meis and PKNOX1 |
119 |
MLH1 | suppressor | 6 | 0.467 | 3.349 | DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus |
120 |
MLST8 | interactor | 9 | 0.528 | 6.174 | Hira (PF07569, IPR011494): TUP1-like enhancer of split WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 |
121 |
MOV10 | interactor | 31 | 0.232 | 165.963 | AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain |
122 |
MRPL38 | interactor | 5 | 0.900 | 0.095 | PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein DUF3095 (PF11294, IPR021445): Protein of unknown function (DUF3095) |
123 |
MTOR | oncoprotein | 24 | 0.281 | 106.814 | DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat |
124 |
MYC | oncoprotein | 36 | 0.185 | 284.346 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region |
125 |
MYD88 | oncoprotein | 8 | 0.571 | 3.355 | Death (PF00531, IPR000488, SM00005): Death domain TIR (PF01582, IPR000157, SM00255): TIR domain |
126 |
NBR1 | oncoprotein | 17 | 0.250 | 61.557 | CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681) N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene |
127 |
NCOR1 | oncoprotein | 14 | 0.352 | 32.042 | BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region |
128 |
NDUFA5 | interactor | 5 | 0.600 | 2.476 | ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region |
129 |
NDUFS2 | interactor | 9 | 0.639 | 2.413 | Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase |
130 |
NDUFS3 | protein found in more fusions | 15 | 0.462 | 22.099 | Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit |
131 |
NEFM | interactor | 2 | 1.000 | 0 | ATP-synt_E (PF05680, IPR008386): ATP synthase E chain FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637) |
132 |
NFE2L2 | oncoprotein | 10 | 0.444 | 15.173 | bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor |
133 |
NGFR | suppressor | 6 | 0.700 | 1.733 | LHC (PF00556, IPR000066): Antenna complex alpha/beta subunit |
134 |
NIPSNAP1 | interactor | 16 | 0.458 | 20.777 | NIPSNAP (PF07978, IPR012577): NIPSNAP |
135 |
NOD2 | interactor | 7 | 0.933 | 0.250 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
136 |
NPM1 | suppressor | 38 | 0.285 | 250.137 | Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain |
137 |
NSUN4 | interactor | 1 | 0 | 0 | DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) RSRP (PF17069): Arginine/Serine-Rich protein 1 |
138 |
NTRK1 | oncoprotein | 69 | 0.129 | 1387.930 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
139 |
NTRK2 | oncoprotein | 4 | 0.500 | 1.833 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
140 |
NTRK3 | suppressor | 3 | 1.000 | 0 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
141 |
NXF1 | interactor | 45 | 0.184 | 434.154 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
142 |
OPTN | protein found in more fusions | 18 | 0.287 | 46.439 | ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
143 |
OSBPL8 | interactor | 4 | 0.500 | 1.175 | CDC45 (PF02724, IPR003874): CDC45-like protein DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980) Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein PH (PF00169, IPR001849, SM00233): PH domain |
144 |
PAN2 | interactor | 16 | 0.250 | 53.519 | RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain |
145 |
PARK2 | suppressor | 37 | 0.200 | 285.707 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
146 |
PARP10 | interactor | 4 | 0.833 | 0.111 | PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif |
147 |
PAWR | suppressor | 4 | 0.667 | 1.167 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
148 |
PCK1 | interactor | 7 | 0.619 | 3.468 | PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase |
149 |
PDE4A | oncoprotein | 1 | 0 | 0 | NadA (PF02445, IPR003473): Quinolinate synthetase A protein PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c |
150 |
PEX5 | interactor | 4 | 0.667 | 0.236 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat SHNi-TPR (PF10516, IPR019544): SHNi-TPR TPR_12 (PF13424): Tetratricopeptide repeat TPR_15 (PF13429): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
151 |
PIK3CA | oncoprotein | 6 | 0.667 | 2.952 | PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
152 |
PIK3R1 | oncoprotein | 12 | 0.327 | 26.975 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
153 |
PIK3R2 | oncoprotein | 8 | 0.607 | 4.643 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
154 |
PML | suppressor | 23 | 0.294 | 89.569 | zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
155 |
PPHLN1 | interactor | 5 | 0.700 | 1.236 | Lge1 (PF11488): Transcriptional regulatory protein LGE1 HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113 |
156 |
PRKCD | suppressor | 13 | 0.439 | 17.805 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
157 |
PRKCI | interactor | 20 | 0.289 | 80.402 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
158 |
PRKCZ | interactor | 16 | 0.276 | 53.495 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
159 |
PSMC2 | protein found in more fusions | 22 | 0.400 | 52.640 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) |
160 |
PSMD10 | interactor | 11 | 0.582 | 8.266 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) |
161 |
PSMD12 | interactor | 18 | 0.471 | 28.737 | Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain PCI (PF01399, IPR000717, SM00088): PCI domain |
162 |
PSMD3 | interactor | 15 | 0.448 | 18.137 | Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat PCI (PF01399, IPR000717, SM00088): PCI domain Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate |
163 |
PSMD4 | interactor | 21 | 0.395 | 62.497 | UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain |
164 |
PYCARD | suppressor | 5 | 0.667 | 1.667 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain |
165 |
RAD23A | oncoprotein | 14 | 0.500 | 17.610 | UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
166 |
RAD54L2 | interactor | 1 | 0 | 0 | SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase |
167 |
RARA | oncoprotein | 10 | 0.389 | 14.071 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
168 |
RBM45 | interactor | 7 | 0.600 | 3.900 | RNA_bind (PF08675, IPR014789): RNA binding domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
169 |
RCN2 | interactor | 10 | 0.378 | 12.026 | EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
170 |
RELN | interactor | 2 | 0 | 0 | BNR (PF02012, IPR002860): BNR/Asp-box repeat EB (PF01683, IPR006149): EB module EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain Reeler (PF02014, IPR002861): Reeler domain |
171 |
RIPK1 | protein found in more fusions | 14 | 0.359 | 34.535 | Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif |
172 |
RPL37 | interactor | 3 | 1.000 | 0 | Ribosomal_L37e (PF01907, IPR001569): Ribosomal protein L37e |
173 |
RPS6KB1 | interactor | 9 | 0.429 | 6.790 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
174 |
RPTOR | protein found in more fusions | 21 | 0.332 | 67.251 | HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain |
175 |
RRAGB | interactor | 5 | 0.800 | 1.333 | Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region |
176 |
RRAGC | interactor | 6 | 0.733 | 2.833 | Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region |
177 |
SASS6 | interactor | 5 | 0.700 | 0.889 | CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SAS-6_N (PF16531, IPR032396): Centriolar protein SAS N-terminal |
178 |
SCCPDH | interactor | 2 | 1.000 | 0 | Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain |
179 |
SDHA | suppressor | 10 | 0.733 | 2.819 | FAD_binding_2 (PF00890, IPR003953): FAD binding domain Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term |
180 |
SESN1 | interactor | 3 | 0.667 | 0.167 | PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) |
181 |
SESN2 | interactor | 3 | 0.667 | 0.250 | PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) |
182 |
SKI | oncoprotein | 12 | 0.382 | 17.540 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
183 |
SMAD3 | oncoprotein | 20 | 0.287 | 82.765 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
184 |
SNCA | interactor | 19 | 0.327 | 51.311 | Synuclein (PF01387, IPR001058): Synuclein |
185 |
SPRED2 | interactor | 2 | 1.000 | 0 | Sprouty (PF05210, IPR007875): Sprouty protein (Spry) WH1 (PF00568, IPR000697, SM00461): WH1 domain |
186 |
SRRM2 | interactor | 11 | 0.618 | 5.621 | cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) |
187 |
STAT5A | suppressor | 5 | 0.667 | 1.400 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
188 |
STUB1 | suppressor | 29 | 0.291 | 147.187 | U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat |
189 |
STXBP1 | interactor | 3 | 0.667 | 0.182 | Sec1 (PF00995, IPR001619): Sec1 family |
190 |
SYNPO2 | suppressor | 5 | 0.600 | 0.919 | Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
191 |
TARDBP | interactor | 21 | 0.442 | 53.097 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
192 |
TBK1 | interactor | 16 | 0.286 | 44.552 | DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain |
193 |
TGM2 | protein found in more fusions | 8 | 0.429 | 4.756 | Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily |
194 |
TKT | protein found in more fusions | 11 | 0.511 | 11.483 | Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain |
195 |
TMEM17 | interactor | 12 | 0.227 | 34.886 | Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043) |
196 |
TNFRSF10A | suppressor | 4 | 0.667 | 1.167 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region TMIE (PF16038, IPR032006): TMIE protein |
197 |
TNK2 | interactor | 9 | 0.286 | 14.764 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GTPase_binding (PF09027, IPR015116): GTPase binding Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6 UBA_4 (PF14555): UBA-like domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
198 |
TOLLIP | interactor | 12 | 0.364 | 21.287 | C2 (PF00168, IPR000008, SM00239): C2 domain CUE (PF02845, IPR003892, SM00546): CUE domain |
199 |
TP53 | suppressor | 44 | 0.196 | 437.834 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
200 |
TP53INP1 | suppressor | 5 | 0.500 | 1.269 | DOR (PF14839, IPR029431): DOR family |
201 |
TRAF1 | oncoprotein | 10 | 0.500 | 11.686 | HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA SlyX (PF04102, IPR007236): SlyX TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain |
202 |
TRAF6 | protein found in more fusions | 38 | 0.164 | 385.855 | SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
203 |
TRIB3 | interactor | 2 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain |
204 |
TRIM13 | suppressor | 5 | 0.500 | 1.952 | ATP-synt_E_2 (PF08112, IPR012508): ATP synthase epsilon subunit Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
205 |
TRIM21 | interactor | 18 | 0.309 | 57.757 | DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
206 |
TRIM5 | interactor | 7 | 0.600 | 1.747 | Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0) Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger |
207 |
TRIM50 | interactor | 3 | 0.667 | 0.500 | Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif SPRY (PF00622, IPR003877, SM00449): SPRY domain Trm112p (PF03966, IPR005651): Trm112p-like protein zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger |
208 |
TRIM55 | interactor | 6 | 0.600 | 3.333 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein NABP (PF07990, IPR012940): Nucleic acid binding protein NABP zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger |
209 |
TRIM63 | interactor | 6 | 0.600 | 2.500 | DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) KIP1 (PF07765, IPR011684): KIP1-like protein RED_C (PF07807, IPR012492): RED-like protein C-terminal region zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module' |
210 |
TRMT61B | interactor | 1 | 0 | 0 | GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit |
211 |
TTN | interactor | 10 | 0.378 | 18.946 | DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain |
212 |
TUBA1A | oncoprotein | 17 | 0.301 | 44.977 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
213 |
TXNL1 | interactor | 10 | 0.733 | 3.482 | PITH (PF06201, IPR010400): PITH domain Thioredoxin (PF00085, IPR013766): Thioredoxin |
214 |
UBC | protein found in more fusions | 60 | 0.186 | 856.300 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
215 |
UBXN1 | interactor | 10 | 0.722 | 2.711 | Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UBX (PF00789, IPR001012, SM00166): UBX domain |
216 |
ULK1 | protein found in more fusions | 18 | 0.324 | 58.824 | Pkinase (PF00069, IPR000719): Protein kinase domain DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein |
217 |
ULK2 | interactor | 3 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543) |
218 |
WDFY3 | interactor | 10 | 0.400 | 8.422 | Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4 PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704) DUF4800 (PF16057): Domain of unknown function (DUF4800) |
219 |
XPO1 | interactor | 44 | 0.140 | 583.737 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
220 |
YWHAZ | protein found in more fusions | 33 | 0.244 | 224.593 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
221 |
ZFAND5 | interactor | 4 | 1.000 | 0 | zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger FAM53 (PF15242, IPR029356): Family of FAM53 |