Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SP100 (from a repository: Tue Dec 6 04:40:17 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 51 The number (and %) of the onco-proteins 12 (23.53 %) The number (and %) of the tumor suppressors 7 (13.73 %) Total number of binary PPIs (saturation %) 158 (12.39 %) The number (and %) of affected PPIs 51 (32.28 %) The number of possible different fusions 12 PPI diameter 2 PPI radius 1 The average degree of PPI 5.216 Assortativity coefficient -0.4609 The network average Clustering coefficient 0.601 The number (and %) of a zero Clustering coefficients 9 (17.65 %) The number (and %) of a zero Betweenness Centrality 26 (50.98 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SP100	All fusions
Proteins found in more fusions	AMOTL2 (see 1 fusions); TERF2IP (see 1 fusions); AHCYL1 (see 3 fusions); PML (see 4 fusions); LZTR1 (see 2 fusions); SENP1 (see 1 fusions); SP100 (see 1 fusions); L3MBTL3 (see 1 fusions); ACTN2 (see 1 fusions); HIPK2 (see 1 fusions); TRIM29 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SP100	parental protein	51	0.068	2039.955	Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
2	ACTN2	protein found in more fusions	3	1.000	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
3	AGL	interactor	6	0.400	8.333	GDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme hDGE_amylase (PF14701, IPR032792): Glucanotransferase of human glycogen debranching enzyme hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme
4	AHCYL1	suppressor	5	0.500	1.400	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515) Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
5	AMOTL2	protein found in more fusions	2	0	0	HOOK (PF05622, IPR008636): HOOK protein SlyX (PF04102, IPR007236): SlyX Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
6	ARID3A	interactor	2	1.000	0	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain Nop14 (PF04147, IPR007276): Nop14-like family TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
7	CBX1	interactor	6	0.800	1.333	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
8	CBX3	interactor	6	0.800	1.333	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
9	CBX5	suppressor	7	0.667	3.667	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
10	CREM	suppressor	2	1.000	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor pKID (PF02173, IPR003102): pKID domain DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
11	CRTAP	interactor	2	1.000	0	Whi5 (PF08528, IPR013734): Whi5 like YfiO (PF13525): Outer membrane lipoprotein Stomagen (PF16851, IPR031753): Stomagen
12	DNMT3A	suppressor	5	0.500	4.500	DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase PWWP (PF00855, IPR000313, SM00293): PWWP domain
13	DSTN	interactor	1	0	0	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
14	DYRK2	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain
15	ETS1	oncoprotein	2	1.000	0	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
16	GIPC2	interactor	2	0	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
17	HEMGN	interactor	1	0	0	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
18	HIPK2	suppressor	9	0.786	2.055	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
19	IFI16	suppressor	8	0.393	15.800	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
20	IGBP1	interactor	2	1.000	0	TAP42 (PF04177, IPR007304): TAP42-like family
21	L3MBTL3	protein found in more fusions	3	1.000	0	CDC45 (PF02724, IPR003874): CDC45-like protein DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Glyco_hydro_2_N (PF02837, IPR006104): Glycosyl hydrolases family 2, sugar binding domain MBT (PF02820, IPR004092, SM00561): mbt repeat SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type Calci_bind_CcbP (PF11535, IPR020994): Calcium binding Apelin (PF15360, IPR026155): APJ endogenous ligand
22	LTN1	interactor	1	0	0	zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
23	LZTR1	oncoprotein	4	0.667	1.000	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3 Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_4 (PF13418): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
24	MOV10	interactor	6	0.400	5.667	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
25	MX1	interactor	4	1.000	0	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
26	MYB	oncoprotein	6	0.933	0.250	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
27	NIPBL	oncoprotein	3	1.000	0	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Zip (PF02535, IPR003689): ZIP Zinc transporter Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion Nipped-B_C (PF12830, IPR024986): Sister chromatid cohesion C-terminus HEAT_2 (PF13646): HEAT repeats DNA_repr_REX1B (PF14966): DNA repair REX1-B PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
28	NUF2	interactor	1	0	0	Nuf2 (PF03800, IPR005549): Nuf2 family DUF2209 (PF09974, IPR014514): Uncharacterized protein conserved in archaea (DUF2209) ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
29	NXF1	interactor	11	0.289	24.300	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
30	PHC1	interactor	4	1.000	0	GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV) FSA_C (PF10479, IPR018863): Fragile site-associated protein C-terminus zf-CGNR (PF11706, IPR021005): CGNR zinc finger PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
31	PML	suppressor	13	0.470	26.355	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
32	PUS1	interactor	3	1.000	0	PseudoU_synth_1 (PF01416, IPR020097): tRNA pseudouridine synthase
33	RANBP2	oncoprotein	8	0.714	2.402	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
34	RBM39	oncoprotein	2	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
35	RTP5	interactor	2	1.000	0	zf-3CxxC (PF13695, IPR027377): Zinc-binding domain
36	SEC23A	interactor	3	0.667	0.286	Gelsolin (PF00626, IPR007123): Gelsolin repeat Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
37	SENP1	protein found in more fusions	8	0.762	1.602	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
38	SERPINE2	interactor	2	1.000	0	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
39	SUMO1	interactor	12	0.436	20.152	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
40	SUMO2	interactor	12	0.382	25.652	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
41	SUMO3	interactor	9	0.444	13.252	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
42	TERF1	interactor	4	1.000	0	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
43	TERF2	interactor	5	0.667	1.500	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
44	TERF2IP	protein found in more fusions	6	0.500	4.000	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Histone_HNS (PF00816, IPR001801): H-NS histone family Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
45	TOM1L1	interactor	2	1.000	0	GAT (PF03127, IPR004152): GAT domain VHS (PF00790, IPR002014, SM00288): VHS domain
46	TRAF3IP3	interactor	1	0	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) FUSC (PF04632, IPR006726): Fusaric acid resistance protein family HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
47	TRIM29	protein found in more fusions	5	0.667	1.000	MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family TP2 (PF01254, IPR000678): Nuclear transition protein 2 zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
48	UBE2I	interactor	17	0.283	74.536	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
49	USPL1	interactor	6	0.467	3.669	zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain Peptidase_C98 (PF15499, IPR028890): Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF4650 (PF15509, IPR029388): Domain of unknown function (DUF4650)
50	VPS25	interactor	4	1.000	0	ESCRT-II (PF05871, IPR008570): ESCRT-II complex subunit
51	ZC2HC1A	interactor	1	0	0	DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) DZR (PF12773, IPR025874): Double zinc ribbon zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type

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