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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SOX5 (from a repository: Tue Dec 6 16:00:07 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins8 (27.59 %)
The number (and %) of the tumor suppressors2 (6.90 %)
Total number of binary PPIs (saturation %)59 (14.53 %)
The number (and %) of affected PPIs29 (49.15 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.103
Assortativity coefficient-0.4259
The network average Clustering coefficient0.456
The number (and %) of a zero Clustering coefficients11 (37.93 %)
The number (and %) of a zero Betweenness Centrality20 (68.97 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SOX5 All fusions
Proteins found in more fusions APP (see 4 fusions); KAT5 (see 3 fusions); AES (see 3 fusions); CDK6 (see 1 fusions); SOX5 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SOX5parental protein290.045690.333HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
2 AESprotein found in more fusions60.4006.000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3 APPprotein found in more fusions80.28614.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARID5Aoncoprotein100ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
5 CBX8interactor40.6670.667Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
6 CDC23interactor31.0000ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
7 CDC25Aoncoprotein40.5003.000M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
8 CDK6suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
9 CEP85interactor100DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
10 CRXinteractor21.0000TF_Otx (PF03529, IPR013851): Otx1 transcription factor
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
11 FAM46Binteractor100NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
12 FTH1interactor31.0000Coat_F (PF07875, IPR012851): Coat F domain
Ferritin (PF00210, IPR008331): Ferritin-like domain
13 KAT5suppressor40.6670.667MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
14 KIFC3oncoprotein50.5002.667Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
15 LMO1oncoprotein21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
16 LMO2oncoprotein40.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
17 MED27interactor100Med27 (PF11571, IPR021627): Mediator complex subunit 27
18 MORN3interactor100MORN (PF02493, IPR003409, SM00698): MORN repeat
TFIIIC_sub6 (PF10419, IPR019481): TFIIIC subunit
19 PRR20Ainteractor200PRR20 (PF15708, IPR031439): Proline-rich protein family 20
20 RPS2interactor100Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
21 SMAD1interactor50.5003.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
22 SMAD5interactor21.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
23 SMAD7interactor21.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
24 SOX2oncoprotein31.0000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
25 SUMO1P1interactor200NA
26 TAF6interactor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
27 TTC1interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
28 UQCRFS1interactor100Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
29 ZNF581interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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