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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SORD (from a repository: Thu Jul 5 23:16:53 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins11 (20.00 %)
The number (and %) of the tumor suppressors5 (9.09 %)
Total number of binary PPIs (saturation %)205 (13.80 %)
The number (and %) of affected PPIs55 (26.83 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI6.800
Assortativity coefficient-0.2297
The network average Clustering coefficient0.571
The number (and %) of a zero Clustering coefficients6 (10.91 %)
The number (and %) of a zero Betweenness Centrality18 (32.73 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SORD All fusions
Proteins found in more fusions TPM1 (see 2 fusions); RANGAP1 (see 2 fusions); NAGK (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SORDparental protein550.0932081.829ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
2 ABATinteractor100.37819.786Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
3 ACOT7interactor30.6671.0004HBT (PF03061, IPR006683): Thioesterase superfamily
NINJA_B (PF16136, IPR032310): Putative nuclear localisation signal
4 AKR1B1suppressor60.4005.705Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
5 ALDH7A1interactor60.5334.633Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
6 ANLNoncoprotein31.0000Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
7 BCCIPinteractor90.6396.852DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
8 BROXinteractor21.0000BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
9 C12orf10interactor50.5004.333UPF0160 (PF03690, IPR003226): Uncharacterised protein family (UPF0160)
10 CATsuppressor100.58310.086Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
11 CFAP97interactor21.0000DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
KIAA1430 (PF13879, IPR029488): KIAA1430 homologue
GH97_C (PF14509, IPR029483): Glycosyl-hydrolase 97 C-terminal, oligomerisation
12 CHORDC1interactor70.6672.833CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
13 CRYABoncoprotein40.6671.000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
14 DDX39Ainteractor70.6004.233DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15 ETFAinteractor80.50010.200ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
ETF_alpha (PF00766, IPR014731): Electron transfer flavoprotein FAD-binding domain
16 FAHinteractor41.0000FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
17 FAHD1interactor60.6673.086FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
18 FAHD2Ainteractor31.0000FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
19 FDPSinteractor50.7001.833polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
20 FLAD1interactor31.0000MoCF_biosynth (PF00994, IPR001453, SM00852): Probable molybdopterin binding domain
PAPS_reduct (PF01507, IPR002500): Phosphoadenosine phosphosulfate reductase family
21 GCLMinteractor21.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
22 GDAinteractor80.5369.333Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
23 GPIinteractor50.8000.733PGI (PF00342, IPR001672): Phosphoglucose isomerase
24 LDHAinteractor210.32688.176Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
25 LDHAL6Ainteractor50.4002.157Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
26 LDHAL6Binteractor100.51112.210Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
27 LDHBinteractor140.48722.010Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
28 LOC440434interactor100NA
29 METTL26interactor100DUF938 (PF06080, IPR010342): Protein of unknown function (DUF938)
30 MYH9suppressor50.6003.333IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
31 NAGKprotein found in more fusions100.55611.519BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
32 NIT2suppressor51.0000CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
33 NME1suppressor50.5001.733NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
34 NTRK1oncoprotein220.229141.052I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
35 NUDCD2interactor30.6670.667CS (PF04969, IPR007052): CS domain
DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
36 PDLIM7interactor31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
37 PFDN4interactor100Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
38 PGDoncoprotein90.44416.4006PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
39 PGM1interactor120.53016.176PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
40 PIEZO1interactor100CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
Piezo_RRas_bdg (PF12166, IPR027272): Piezo non-specific cation channel, R-Ras-binding domain
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PIEZO (PF15917, IPR031805): Piezo
41 PLS3interactor60.6672.305CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
42 PRR11interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PRIMA1 (PF16101): Proline-rich membrane anchor 1
43 RAD23Aoncoprotein200UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
44 RANGAP1protein found in more fusions31.0000RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
45 RELAoncoprotein31.0000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
46 SHBGoncoprotein31.0000Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
47 SMSinteractor120.43928.419Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
48 SOD1interactor120.30928.000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
49 TALDO1interactor110.45518.500TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
50 TCEA1oncoprotein50.8000.833Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
51 THOP1interactor70.5247.233Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
52 TIPRLinteractor30.6670.500TIP41 (PF04176, IPR007303): TIP41-like family
53 TKFCinteractor40.5002.667Dak1 (PF02733, IPR004006): Dak1 domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
54 TPI1interactor110.48912.633TIM (PF00121, IPR000652): Triosephosphate isomerase
55 TPM1protein found in more fusions80.38112.000Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like

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