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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SOD2 (from a repository: Sat Nov 26 09:47:56 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins4 (10.53 %)
The number (and %) of the tumor suppressors5 (13.16 %)
Total number of binary PPIs (saturation %)112 (15.93 %)
The number (and %) of affected PPIs38 (33.93 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI5.368
Assortativity coefficient-0.3903
The network average Clustering coefficient0.542
The number (and %) of a zero Clustering coefficients6 (15.79 %)
The number (and %) of a zero Betweenness Centrality12 (31.58 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SOD2 All fusions
: BQ317034; AW838142; AW838473;
Proteins found in more fusions TKT (see 5 fusions); APP (see 4 fusions); SOD2 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SOD2parental protein380.0981003.567Sod_Fe_C (PF02777, IPR019832): Iron/manganese superoxide dismutases, C-terminal domain
Sod_Fe_N (PF00081, IPR019831): Iron/manganese superoxide dismutases, alpha-hairpin domain
2 ABATinteractor21.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
3 ACO2interactor60.4676.667Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
4 ALDH1B1interactor40.6672.000Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
5 ALDH2oncoprotein30.6670.500Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
6 ALDH4A1interactor50.8330.400Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
7 ALDH5A1interactor40.6671.500Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
8 ALDOAinteractor90.5369.167Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
9 ALDOCinteractor60.5335.000Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
10 APPprotein found in more fusions140.21856.333APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
11 AURKAoncoprotein40.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
12 CATsuppressor70.7332.000Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
13 CYP4F12interactor100p450 (PF00067, IPR001128): Cytochrome P450
14 ENO3interactor90.5839.233Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
15 FHsuppressor60.5335.833Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
16 GPT2interactor21.0000Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
17 GPX4interactor80.5719.167GSHPx (PF00255, IPR000889): Glutathione peroxidase
18 H2AFXsuppressor31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
19 HSPE1interactor110.38229.667Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
20 MDH1interactor21.0000Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
21 NABP2interactor100tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
22 NOL12interactor30.6670.500DUF2357 (PF09823, IPR018633): Domain of unknown function (DUF2357)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
23 OATinteractor30.6671.000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
24 PEBP1suppressor50.6002.833PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
25 PEPDinteractor21.0000AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
26 PRDX5interactor70.42910.333Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
27 RPS3Ainteractor40.5002.000Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
28 SOD1interactor100.52813.000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
29 STX7interactor21.0000SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
30 TBL2suppressor100eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
FdsD (PF11390, IPR021074): NADH-dependant formate dehydrogenase delta subunit FdsD
31 TKTprotein found in more fusions120.40026.333Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
32 TPI1interactor50.8330.400TIM (PF00121, IPR000652): Triosephosphate isomerase
33 UBL4Ainteractor40.5002.500ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
34 UBR2interactor100ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
35 UCHL3interactor40.6670.500Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
36 USP36interactor100TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
37 VAPAinteractor40.6671.067DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
38 ZC3H11Ainteractor100Bul1_C (PF04426, IPR022794): Bul1 C terminus
Sec62 (PF03839, IPR004728): Translocation protein Sec62
zf-CCCH_3 (PF15663): Zinc-finger containing family

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