Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SOD2 (from a repository: Sat Nov 26 09:47:56 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins4 (10.53 %)
The number (and %) of the tumor suppressors5 (13.16 %)
Total number of binary PPIs (saturation %)112 (15.93 %)
The number (and %) of affected PPIs38 (33.93 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI5.368
Assortativity coefficient-0.3903
The network average Clustering coefficient0.542
The number (and %) of a zero Clustering coefficients6 (15.79 %)
The number (and %) of a zero Betweenness Centrality12 (31.58 %)


List of the fusions

PPI for parental proteins: SOD2 All fusions
: BQ317034; AW838142; AW838473;
Proteins found in more fusions TKT (see 5 fusions); APP (see 4 fusions); SOD2 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 SOD2parental protein380.0981003.567Sod_Fe_C (PF02777, IPR019832): Iron/manganese superoxide dismutases, C-terminal domain
Sod_Fe_N (PF00081, IPR019831): Iron/manganese superoxide dismutases, alpha-hairpin domain
2 ABATinteractor21.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
3 ACO2interactor60.4676.667Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
4 ALDH1B1interactor40.6672.000Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
5 ALDH2oncoprotein30.6670.500Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
6 ALDH4A1interactor50.8330.400Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
7 ALDH5A1interactor40.6671.500Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
8 ALDOAinteractor90.5369.167Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
9 ALDOCinteractor60.5335.000Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
10 APPprotein found in more fusions140.21856.333APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
11 AURKAoncoprotein40.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
12 CATsuppressor70.7332.000Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
13 CYP4F12interactor100p450 (PF00067, IPR001128): Cytochrome P450
14 ENO3interactor90.5839.233Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
15 FHsuppressor60.5335.833Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
16 GPT2interactor21.0000Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
17 GPX4interactor80.5719.167GSHPx (PF00255, IPR000889): Glutathione peroxidase
18 H2AFXsuppressor31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
19 HSPE1interactor110.38229.667Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
20 MDH1interactor21.0000Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
21 NABP2interactor100tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
22 NOL12interactor30.6670.500DUF2357 (PF09823, IPR018633): Domain of unknown function (DUF2357)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
23 OATinteractor30.6671.000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
24 PEBP1suppressor50.6002.833PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
25 PEPDinteractor21.0000AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
26 PRDX5interactor70.42910.333Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
27 RPS3Ainteractor40.5002.000Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
28 SOD1interactor100.52813.000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
29 STX7interactor21.0000SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
30 TBL2suppressor100eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
FdsD (PF11390, IPR021074): NADH-dependant formate dehydrogenase delta subunit FdsD
31 TKTprotein found in more fusions120.40026.333Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
32 TPI1interactor50.8330.400TIM (PF00121, IPR000652): Triosephosphate isomerase
33 UBL4Ainteractor40.5002.500ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
34 UBR2interactor100ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
35 UCHL3interactor40.6670.500Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
36 USP36interactor100TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
37 VAPAinteractor40.6671.067DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
38 ZC3H11Ainteractor100Bul1_C (PF04426, IPR022794): Bul1 C terminus
Sec62 (PF03839, IPR004728): Translocation protein Sec62
zf-CCCH_3 (PF15663): Zinc-finger containing family

B a c k    t o    T o p ⇑