Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SNX1 (from a repository: Mon Dec 5 21:58:19 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins15 (25.86 %)
The number (and %) of the tumor suppressors3 (5.17 %)
Total number of binary PPIs (saturation %)232 (14.04 %)
The number (and %) of affected PPIs58 (25.00 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI7.241
Assortativity coefficient-0.3393
The network average Clustering coefficient0.577
The number (and %) of a zero Clustering coefficients8 (13.79 %)
The number (and %) of a zero Betweenness Centrality18 (31.03 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SNX1 All fusions
: BE831969;
Proteins found in more fusions APP (see 4 fusions); ATP6V1C1 (see 3 fusions); VPS26A (see 1 fusions); EGFR (see 2 fusions); VPS35 (see 2 fusions); MCM2 (see 1 fusions); STAT1 (see 1 fusions); SNX1 (see 1 fusions); CTTN (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SNX1parental protein580.0962189.129PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
2 ACVR1Boncoprotein40.8330.667Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3 ACVR2Binteractor40.8330.667Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
4 AGTRAPinteractor31.0000AGTRAP (PF06396, IPR009436, SM00805): Angiotensin II, type I receptor-associated protein (AGTRAP)
5 APPprotein found in more fusions160.23857.157APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARFIP2interactor70.5335.467Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
7 ARL6IP1interactor50.6671.167Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
8 ATG7interactor140.56019.755ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
9 ATP6V1C1protein found in more fusions140.57715.707V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
10 ATXN7interactor100DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
11 BIN3interactor30.6670.667BAR (PF03114, IPR004148, SM00721): BAR domain
12 CCNL2interactor21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
13 CMTM5suppressor21.0000MARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
14 CTTNoncoprotein130.62112.974FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
15 DNAJC13interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Arm_2 (PF04826, IPR006911): Armadillo-like
DUF4339 (PF14237, IPR025640): Domain of unknown function (DUF4339)
16 DNM3interactor40.8330.667Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
17 EGFRoncoprotein100.5836.352Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
18 F2Rinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF412 (PF04217, IPR007334): Protein of unknown function, DUF412
19 FAM90A1interactor40.6670.600zf-CCHC_6 (PF15288): Zinc knuckle
20 FUNDC1interactor100FUN14 (PF04930, IPR007014): FUN14 family
21 GARSinteractor50.7002.667HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
22 GNAT2interactor40.6670.600G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
23 GSPT1oncoprotein70.9050.450GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
24 GSPT2interactor100.7114.619GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
25 HGSinteractor130.41029.469FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
26 INSRinteractor50.8000.583fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
27 LEPRoncoprotein31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
28 LSM2interactor100LSM (PF01423, IPR001163): LSM domain
29 MAT2Binteractor60.6003.400RmlD_sub_bind (PF04321, IPR005913): RmlD substrate binding domain
30 MCM2oncoprotein50.6670.650AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
31 MED4interactor21.0000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
32 MOV10interactor100.35623.167AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
33 NASPinteractor70.7142.517Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
SlyX (PF04102, IPR007236): SlyX
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
XhlA (PF10779, IPR019715): Haemolysin XhlA
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
34 NTRK1oncoprotein250.239157.726I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
35 NXF1interactor80.3819.633NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
36 PDGFRBoncoprotein51.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
37 RABAC1interactor200PRA1 (PF03208, IPR004895): PRA1 family protein
38 REEP6interactor200TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
39 RTN3interactor31.0000Reticulon (PF02453, IPR003388): Reticulon
40 RTN4suppressor60.5004.167CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
41 RUVBL2oncoprotein60.5001.750TIP49 (PF06068, IPR010339): TIP49 C-terminus
42 SHMT2interactor150.41942.971SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
43 SMYD2interactor30.6670.400Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
SET (PF00856, IPR001214, SM00317): SET domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
44 SNX2interactor270.242200.793PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
45 SNX32interactor100DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
46 SNX5oncoprotein80.42912.167PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
47 SNX6interactor140.38537.740PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
48 STAT1suppressor130.6528.657SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
49 TK1oncoprotein40.6670.400TK (PF00265, IPR001267, SM00203): Thymidine kinase
50 TMOD1interactor21.0000Tropomodulin (PF03250, IPR004934): Tropomodulin
51 UFD1Linteractor30.6670.667UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
52 UGDHinteractor70.7332.5673HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
UDPG_MGDP_dh (PF00984, IPR014026): UDP-glucose/GDP-mannose dehydrogenase family, central domain
UDPG_MGDP_dh_C (PF03720, IPR014027, SM00984): UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
UDPG_MGDP_dh_N (PF03721, IPR001732): UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
53 VPS26Aprotein found in more fusions80.8570.983Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
54 VPS26Binteractor80.6794.200Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
55 VPS29interactor90.6674.883Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
56 VPS35protein found in more fusions140.52617.200FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35
57 WDFY1interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ELYS-bb (PF16687, IPR032040): beta-propeller of ELYS nucleoporin
58 ZNF397interactor100SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

B a c k    t o    T o p ⇑