Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SNRNP200 (from a repository: Sat Dec 3 13:05:25 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 152 The number (and %) of the onco-proteins 45 (29.61 %) The number (and %) of the tumor suppressors 23 (15.13 %) Total number of binary PPIs (saturation %) 2109 (18.38 %) The number (and %) of affected PPIs 152 (7.21 %) The number of possible different fusions 33 PPI diameter 2 PPI radius 1 The average degree of PPI 26.961 Assortativity coefficient -0.1511 The network average Clustering coefficient 0.508 The number (and %) of a zero Clustering coefficients 4 (2.63 %) The number (and %) of a zero Betweenness Centrality 10 (6.58 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SNRNP200	All fusions : BE085358; W22071;
Proteins found in more fusions	PRPF19 (see 2 fusions); U2AF2 (see 2 fusions); GRB2 (see 1 fusions); APC (see 1 fusions); HDAC5 (see 1 fusions); RPA1 (see 1 fusions); SUZ12 (see 2 fusions); SNW1 (see 1 fusions); ZMYND11 (see 1 fusions); HSPB1/OBSL1 (see 1 fusions); HSP90AA1 (see 2 fusions); HUWE1 (see 2 fusions); SNRNP200 (see 3 fusions); PRPF8 (see 3 fusions); HSPB1 (see 4 fusions); PRPF6 (see 1 fusions); EZH2 (see 1 fusions); PSMC2 (see 1 fusions); STAU1 (see 2 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); COPS5 (see 1 fusions); TSC22D1 (see 5 fusions); FN1/YWHAG (see 1 fusions); YWHAG (see 1 fusions); CRY2 (see 3 fusions); LUC7L2 (see 2 fusions); PABPC1 (see 2 fusions); MCM2 (see 1 fusions); SRSF1 (see 1 fusions); HNRNPC (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SNRNP200	parental protein	152	0.168	8533.671	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603 Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
2	AAR2	interactor	8	0.607	4.626	AAR2 (PF05282, IPR007946): AAR2 protein
3	APC	suppressor	5	0.500	0.583	APC_15aa (PF05972, IPR009240): APC 15 residue motif APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EB1_binding (PF05937, IPR009232): EB-1 Binding Domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4 Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4	BARD1	suppressor	17	0.408	27.907	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
5	BCAS2	interactor	24	0.656	12.589	BCAS2 (PF05700, IPR008409): Breast carcinoma amplified sequence 2 (BCAS2) ZapB (PF06005, IPR009252): Cell division protein ZapB
6	BLM	suppressor	15	0.418	9.011	BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain DEAD (PF00270, IPR011545): DEAD/DEAH box helicase HRDC (PF00570, IPR002121, SM00341): HRDC domain RQC (PF09382, IPR018982, SM00956): RQC domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain ALMT (PF11744, IPR020966): Aluminium activated malate transporter RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
7	BPTF	interactor	7	0.429	7.545	Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT DDT (PF02791, IPR004022, SM00571): DDT domain DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) GRP (PF07172, IPR010800): Glycine rich protein family OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PHD (PF00628, IPR019787, SM00249): PHD-finger SDA1 (PF05285, IPR007949): SDA1 Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Bromodomain (PF00439, IPR001487, SM00297): Bromodomain WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1 WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
8	BRCA1	suppressor	24	0.312	70.719	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
9	CAND1	interactor	55	0.432	189.075	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
10	CCDC8	interactor	28	0.467	39.064	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
11	CD2BP2	interactor	15	0.667	12.189	GYF (PF02213, IPR003169, SM00444): GYF domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
12	CDC5L	interactor	66	0.437	284.930	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
13	CDKN1A	suppressor	7	0.714	1.832	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
14	CHMP1B	interactor	2	0	0	Snf7 (PF03357, IPR005024): Snf7
15	COPS5	protein found in more fusions	44	0.474	110.137	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
16	CPT1A	interactor	7	0.381	2.657	Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase CPT_N (PF16484, IPR032476): Carnitine O-palmitoyltransferase N-terminus
17	CRNKL1	interactor	21	0.581	19.332	NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference HAT (PF02184, IPR003107, SM00386): HAT (Half-A-TPR) repeat Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1 Suf (PF05843, IPR008847): Suppressor of forked protein (Suf) U3_assoc_6 (PF08640, IPR013949): U3 small nucleolar RNA-associated protein 6 TPR_14 (PF13428): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat
18	CRY2	protein found in more fusions	13	0.439	8.496	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
19	CUL2	suppressor	29	0.564	24.982	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
20	CUL3	protein found in more fusions	67	0.386	384.047	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
21	CUL5	suppressor	26	0.597	20.289	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22	CUL7	protein found in more fusions	52	0.456	142.949	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
23	DCUN1D1	interactor	18	0.739	5.988	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
24	DDX23	interactor	39	0.393	135.844	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase FUSC (PF04632, IPR006726): Fusaric acid resistance protein family Transformer (PF06495, IPR010519): Fruit fly transformer protein Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF3698 (PF12479, IPR022167): Protein of unknown function (DUF3698) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
25	DHX15	interactor	54	0.412	173.939	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
26	EAPP	interactor	6	0.600	1.242	Serglycin (PF04360, IPR007455): Serglycin Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
27	ECT2	suppressor	8	0.464	6.711	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
28	EED	suppressor	40	0.493	112.413	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
29	EFTUD2	interactor	79	0.297	766.403	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
30	EIF4A3	interactor	52	0.523	91.806	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
31	ELP3	interactor	2	1.000	0	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family Radical_SAM (PF04055, IPR007197): Radical SAM superfamily Radical_SAM_C (PF16199, IPR032432): Radical_SAM C-terminal domain
32	EMD	interactor	18	0.346	20.608	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
33	ERG	oncoprotein	15	0.543	7.313	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
34	EZH2	suppressor	25	0.489	34.654	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
35	FBXO6	interactor	25	0.423	32.509	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
36	FERMT3	interactor	5	0.600	1.070	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
37	FN1	oncoprotein	39	0.421	85.952	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
38	FOXG1	oncoprotein	1	0	0	SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SPX (PF03105, IPR004331): SPX domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
39	FOXK2	interactor	7	0.333	10.919	FHA (PF00498, IPR000253, SM00240): FHA domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
40	FOXM1	oncoprotein	6	0.600	2.265	EspF (PF04806, IPR006891): EspF protein repeat Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
41	FOXQ1	interactor	8	0.536	5.363	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
42	GCFC2	interactor	5	0.900	0.105	DUF1676 (PF07898, IPR012464): Protein of unknown function (DUF1676) GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
43	GRB2	oncoprotein	18	0.500	26.964	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
44	HDAC5	protein found in more fusions	29	0.497	50.549	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
45	HNRNPA1	interactor	56	0.444	138.247	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
46	HNRNPC	protein found in more fusions	50	0.373	176.149	APG6 (PF04111, IPR007243): Autophagy protein Apg6 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
47	HNRNPR	interactor	53	0.481	140.549	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
48	HNRNPU	interactor	61	0.390	248.305	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
49	HSP90AA1	oncoprotein	42	0.340	213.201	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
50	HSPB1	oncoprotein	34	0.441	72.446	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
51	HUWE1	oncoprotein	36	0.424	82.468	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
52	IRAK1	interactor	11	0.489	12.141	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
53	IRAK2	oncoprotein	5	0.800	1.333	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
54	ISG15	suppressor	7	0.619	1.148	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
55	ITGA4	interactor	30	0.507	46.464	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
56	KIAA1033	interactor	7	0.667	4.815	WASH-7_mid (PF14744, IPR028282): WASH complex subunit 7 WASH-7_N (PF14745, IPR028191): WASH complex subunit 7, N-terminal WASH-7_C (PF14746, IPR028283): WASH complex subunit 7, C-terminal
57	KIAA1429	interactor	9	0.472	8.192	Mpp10 (PF04006, IPR007151): Mpp10 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus VIR_N (PF15912, IPR031801): Virilizer, N-terminal
58	LGR4	interactor	11	0.400	7.763	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
59	LSM8	interactor	10	0.356	9.594	LSM (PF01423, IPR001163): LSM domain
60	LUC7L2	protein found in more fusions	32	0.538	33.580	LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
61	MAGOH	interactor	36	0.517	51.737	Mago_nashi (PF02792, IPR004023): Mago nashi protein
62	MCC	suppressor	1	0	0	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding EF-hand_7 (PF13499, IPR011992): EF-hand domain pair FAM76 (PF16046, IPR032017): FAM76 protein
63	MCM2	oncoprotein	39	0.425	89.246	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
64	MCM5	oncoprotein	32	0.472	56.369	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
65	MED12	oncoprotein	6	0.733	1.232	Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12 Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877) Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
66	MEGF10	interactor	1	0	0	DSL (PF01414, IPR001774, SM00051): Delta serrate ligand EGF_2 (PF07974, IPR013111): EGF-like domain Syndecan (PF01034, IPR027789): Syndecan domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
67	MEPCE	interactor	27	0.527	31.810	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
68	MYC	oncoprotein	26	0.427	42.319	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
69	NTRK1	oncoprotein	68	0.332	516.669	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
70	OBSL1	protein found in more fusions	55	0.451	133.827	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
71	PABPC1	oncoprotein	40	0.449	77.963	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
72	PARK2	suppressor	17	0.417	17.228	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
73	PDCD7	interactor	4	0.500	0.554	PDCD7 (PF16021, IPR031974): Programmed cell death protein 7
74	PHF6	suppressor	8	0.821	0.338	zf-HC5HC2H (PF13771): PHD-like zinc-binding domain YqfQ (PF14181, IPR025571): YqfQ-like protein
75	PIN1	suppressor	16	0.608	12.113	Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain
76	POLR2H	interactor	7	0.467	3.186	RNA_pol_Rpb8 (PF03870, IPR005570, SM00658): RNA polymerase Rpb8
77	PRKAB1	oncoprotein	3	0.667	0.333	AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
78	PRPF19	protein found in more fusions	55	0.497	132.570	Prp19 (PF08606, IPR013915): Prp19/Pso4-like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
79	PRPF31	interactor	32	0.587	36.943	Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
80	PRPF4	interactor	34	0.581	46.699	PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
81	PRPF4B	oncoprotein	23	0.585	15.110	Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking Ureide_permease (PF07168, IPR009834): Ureide permease Pkinase (PF00069, IPR000719): Protein kinase domain Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
82	PRPF6	protein found in more fusions	45	0.446	144.154	PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal Suf (PF05843, IPR008847): Suppressor of forked protein (Suf) TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
83	PRPF8	oncoprotein	85	0.311	799.842	PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain PROCN (PF08083, IPR012592): PROCN (NUC071) domain PROCT (PF08084, IPR012984): PROCT (NUC072) domain RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8 U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8 U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8 JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
84	PSMC2	protein found in more fusions	16	0.467	12.142	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
85	RAB4B	oncoprotein	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
86	RANBP2	oncoprotein	27	0.348	72.248	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
87	RBM39	oncoprotein	40	0.495	81.484	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
88	RBM5	suppressor	10	0.644	3.489	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) G-patch (PF01585, IPR000467, SM00443): G-patch domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others GSIII_N (PF12437, IPR022147): Glutamine synthetase type III N terminal PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
89	RNF113A	interactor	3	0.667	0.080	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8 zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
90	RNF2	interactor	49	0.410	201.070	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
91	RNPS1	interactor	34	0.560	38.472	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) Macoilin (PF09726, IPR019130): Transmembrane protein
92	RNU11	interactor	13	0.654	7.184	NA
93	RNU12	interactor	13	0.654	7.184	NA
94	RNU4ATAC	interactor	8	1.000	0	NA
95	RNU6ATAC	interactor	8	1.000	0	NA
96	RPA1	suppressor	41	0.445	99.103	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
97	RPA2	oncoprotein	37	0.416	104.238	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
98	RPA3	interactor	35	0.417	88.872	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
99	SART1	interactor	49	0.501	137.895	SART-1 (PF03343, IPR005011): SART-1 family Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
100	SF3A1	interactor	48	0.524	91.269	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
101	SF3A2	interactor	44	0.518	93.175	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
102	SF3A3	interactor	40	0.499	82.822	DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449) SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain Telomere_Sde2_2 (PF13297): Telomere stability C-terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
103	SF3B1	oncoprotein	63	0.412	283.590	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
104	SF3B2	interactor	44	0.389	160.853	DUF382 (PF04037, IPR007180): Domain of unknown function (DUF382) PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region PSP (PF04046, IPR006568, SM00581): PSP SAP (PF02037, IPR003034, SM00513): SAP domain Usp (PF00582, IPR006016): Universal stress protein family Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
105	SF3B3	interactor	64	0.431	238.005	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
106	SIRT6	suppressor	5	0.700	1.202	SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
107	SIRT7	interactor	34	0.307	141.073	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
108	SMNDC1	interactor	7	0.905	0.171	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
109	SNCA	interactor	15	0.363	25.014	Synuclein (PF01387, IPR001058): Synuclein
110	SNRNP40	interactor	32	0.494	62.303	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
111	SNRNP70	interactor	42	0.502	70.351	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
112	SNRPA1	interactor	43	0.543	72.633	LRR_9 (PF14580): Leucine-rich repeat
113	SNRPB	interactor	32	0.419	63.493	LSM (PF01423, IPR001163): LSM domain
114	SNRPB2	interactor	23	0.561	14.855	DUF1027 (PF06265, IPR009370): Protein of unknown function (DUF1027) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
115	SNRPD1	interactor	52	0.478	128.810	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) LSM (PF01423, IPR001163): LSM domain
116	SNRPD2	interactor	51	0.450	136.459	LSM (PF01423, IPR001163): LSM domain
117	SNRPD3	interactor	46	0.510	76.911	LSM (PF01423, IPR001163): LSM domain
118	SNRPE	interactor	23	0.621	16.310	LSM (PF01423, IPR001163): LSM domain
119	SNW1	protein found in more fusions	59	0.475	153.547	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
120	SRRM1	interactor	35	0.499	70.641	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
121	SRRM2	interactor	46	0.548	85.461	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
122	SRSF1	protein found in more fusions	49	0.480	120.730	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
123	STAU1	protein found in more fusions	27	0.625	13.295	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
124	SUZ12	suppressor	39	0.492	77.793	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
125	TARDBP	interactor	42	0.467	105.085	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
126	TCEA1	oncoprotein	7	0.619	0.877	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS) TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
127	TFAP4	oncoprotein	5	0.500	4.333	DivIC (PF04977, IPR007060): Septum formation initiator HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
128	THOC6	interactor	10	0.533	2.388	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
129	TIRAP	interactor	4	1.000	0	TIR_2 (PF13676, IPR000157): TIR domain
130	TOP1	oncoprotein	36	0.538	49.452	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region
131	TOP2B	oncoprotein	15	0.419	11.546	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DASH_Spc19 (PF08287, IPR013251): Spc19 DNA_gyraseB (PF00204, IPR013506): DNA gyrase B DTHCT (PF08070, IPR012542): DTHCT (NUC029) region HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim (PF01751, IPR006171, SM00493): Toprim domain Anophelin (PF10731, IPR018932): Thrombin inhibitor from mosquito DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
132	TSC22D1	suppressor	4	0.667	0.118	SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TSC22 (PF01166, IPR000580): TSC-22/dip/bun family ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
133	TSSC4	suppressor	14	0.593	10.534	TSSC4 (PF15264, IPR029338): Tumour suppressing sub-chromosomal transferable candidate 4
134	TUBA1B	interactor	16	0.442	13.604	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
135	TUBB	interactor	38	0.343	123.550	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
136	U2AF2	protein found in more fusions	55	0.502	139.362	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
137	UBE2I	interactor	19	0.405	28.042	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
138	UBR4	interactor	11	0.418	17.610	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Pheromone (PF08015, IPR012597): Fungal mating-type pheromone RecR (PF02132, IPR023628): RecR protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) DZR (PF12773, IPR025874): Double zinc ribbon E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4 FAM176 (PF14851): FAM176 family
139	USP19	interactor	5	0.600	0.946	CS (PF04969, IPR007052): CS domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP19_linker (PF16602): Linker region of USP19 deubiquitinase
140	USP34	interactor	4	0.667	1.667	Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517)
141	USP37	interactor	16	0.467	20.054	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase UCH_N (PF16674, IPR032069): N-terminal of ubiquitin carboxyl-terminal hydrolase 37
142	USP39	oncoprotein	29	0.539	43.020	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
143	USP9X	interactor	18	0.386	41.116	DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722) UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
144	VCAM1	interactor	27	0.453	43.390	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
145	WDHD1	interactor	11	0.491	13.663	PVL_ORF50 (PF07768, IPR011688): PVL ORF-50-like family WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Mcl1_mid (PF12341, IPR022100): Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
146	WWOX	suppressor	26	0.505	40.261	adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain
147	XAB2	interactor	24	0.598	14.946	NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference HAT (PF02184, IPR003107, SM00386): HAT (Half-A-TPR) repeat Suf (PF05843, IPR008847): Suppressor of forked protein (Suf) TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
148	YBX1	oncoprotein	36	0.394	76.947	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
149	YEATS2	interactor	2	1.000	0	YEATS (PF03366, IPR005033): YEATS family
150	YWHAG	protein found in more fusions	25	0.467	27.036	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
151	ZBTB10	interactor	4	0.500	1.667	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
152	ZMYND11	suppressor	10	0.583	2.677	DUF1002 (PF06207, IPR009343): Protein of unknown function (DUF1002) DUF1353 (PF07087, IPR010767): Protein of unknown function (DUF1353) PWWP (PF00855, IPR000313, SM00293): PWWP domain zf-MYND (PF01753, IPR002893): MYND finger zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) Bromodomain (PF00439, IPR001487, SM00297): Bromodomain

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