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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SNCAIP (from a repository: Sun Dec 4 11:04:49 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins10 (41.67 %)
The number (and %) of the tumor suppressors5 (20.83 %)
Total number of binary PPIs (saturation %)61 (22.10 %)
The number (and %) of affected PPIs24 (39.34 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI4.083
Assortativity coefficient-0.2954
The network average Clustering coefficient0.621
The number (and %) of a zero Clustering coefficients3 (12.50 %)
The number (and %) of a zero Betweenness Centrality11 (45.83 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions ARIH1 (see 4 fusions); NUDT21 (see 2 fusions); YWHAH (see 2 fusions); PINK1 (see 3 fusions); SNCAIP (see 1 fusions); CSNK2A1 (see 1 fusions); SIAH2 (see 1 fusions); SIAH1 (see 4 fusions); GSK3B (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SNCAIPparental protein240.103401.000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
2 ARIH1protein found in more fusions31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
3 C11orf58interactor30.6670.667DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
4 CSNK2A1oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
5 GET4interactor100DUF410 (PF04190, IPR007317): Protein of unknown function (DUF410)
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
6 GSK3Bsuppressor60.4006.000Pkinase (PF00069, IPR000719): Protein kinase domain
7 HERPUD1oncoprotein31.0000Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
8 KALRNoncoprotein100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Spectrin (PF00435, IPR002017): Spectrin repeat
UPF0302 (PF08864, IPR014963): UPF0302 domain
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
9 NUB1interactor21.0000Glyphos_transf (PF04464, IPR007554): CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
TPR_12 (PF13424): Tetratricopeptide repeat
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
10 NUDT21protein found in more fusions40.6670.667NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
11 PARK2suppressor70.4009.000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
12 PIN1suppressor31.0000Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
13 PINK1protein found in more fusions41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
14 PPHLN1interactor21.0000Lge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
15 PPP1CAsuppressor40.5003.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
16 PPP1CConcoprotein40.5003.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
17 PSMC4interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
18 PTNoncoprotein50.5002.667PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
19 RNF19Ainteractor30.6670.667IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
20 SH2D3Cinteractor100RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
21 SIAH1suppressor50.8330.667Sina (PF03145, IPR018121): Seven in absentia protein family
22 SIAH2oncoprotein50.6672.000Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
23 SNCAinteractor100.33323.667Synuclein (PF01387, IPR001058): Synuclein
24 YWHAHprotein found in more fusions40.6671.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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