Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SNAP29 (from a repository: Thu Nov 10 14:59:26 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)66
The number (and %) of the onco-proteins15 (22.73 %)
The number (and %) of the tumor suppressors3 (4.55 %)
Total number of binary PPIs (saturation %)201 (9.37 %)
The number (and %) of affected PPIs66 (32.84 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI5.333
Assortativity coefficient-0.3593
The network average Clustering coefficient0.561
The number (and %) of a zero Clustering coefficients13 (19.70 %)
The number (and %) of a zero Betweenness Centrality31 (46.97 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SNAP29 All fusions
: AW391811;
Proteins found in more fusions ITSN2 (see 1 fusions); TRAF6 (see 1 fusions); EWSR1 (see 2 fusions); RNF40 (see 2 fusions); NDEL1 (see 1 fusions); NDE1 (see 3 fusions); SNAP29 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SNAP29parental protein660.0533653.479DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
2 ATF4oncoprotein200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
3 C1orf122interactor21.0000DUF4726 (PF15855, IPR031714): Domain of unknown function (DUF4726)
4 CCHCR1interactor50.6671.500HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
5 COQ9interactor31.0000COQ9 (PF08511, IPR013718): COQ9
6 COX6B1interactor200COX6B (PF02297, IPR003213): Cytochrome oxidase c subunit VIb
7 EHD1interactor60.6003.667Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
8 EHD3suppressor41.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
9 EWSR1oncoprotein70.3339.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
10 EXOC1interactor40.6672.000FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
Sec3-PIP2_bind (PF15277, IPR028258): Exocyst complex component SEC3 N-terminal PIP2 binding PH
11 EXOC4oncoprotein31.0000DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Vps51 (PF08700): Vps51/Vps67
12 FAAP100interactor30.6671.000FANCAA (PF15146, IPR029251): Fanconi anemia-associated
13 FAM9Binteractor31.0000Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
14 FKBP15interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
WH1 (PF00568, IPR000697, SM00461): WH1 domain
SOSSC (PF15925, IPR031821): SOSS complex subunit C
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
15 FMC1interactor100Complex1_LYR_2 (PF13233): Complex1_LYR-like
16 IGF1Roncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
17 ITPR3interactor100DUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
18 ITSN2protein found in more fusions40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
19 KIFC3oncoprotein50.5002.500Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
20 LURAP1interactor100LURAP (PF14854): Leucine rich adaptor protein
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
21 LURAP1Linteractor100Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
LURAP (PF14854): Leucine rich adaptor protein
22 MACF1oncoprotein30.6671.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
CTV_P33 (PF07184, IPR010803): Citrus tristeza virus P33 protein
DnaI_N (PF07319, IPR009928): Primosomal protein DnaI N-terminus
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF19 (PF01579, IPR002542): Domain of unknown function (DUF19)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
Peptidase_S49 (PF01343, IPR002142): Peptidase family S49
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
SYF2 (PF08231, IPR013260): SYF2 splicing factor
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF3813 (PF12758, IPR024217): Protein of unknown function (DUF3813)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
TEX12 (PF15219, IPR029193): Testis-expressed 12
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
23 MED4interactor90.27825.000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
24 NAPAoncoprotein100.60012.752SNAP (PF14938): Soluble NSF attachment protein, SNAP
25 NDE1protein found in more fusions70.3339.500NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
26 NDEL1protein found in more fusions60.4005.000HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
27 NDUFA4interactor200B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
28 NSFinteractor71.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
ATPase (PF06745, IPR014774): KaiC
AAA_19 (PF13245): Part of AAA domain
29 PTPMT1interactor31.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
30 PTRFinteractor100PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
31 RASSF7interactor21.0000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SlyX (PF04102, IPR007236): SlyX
Tryp_alpha_amyl (PF00234, IPR016140, SM00499): Protease inhibitor/seed storage/LTP family
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
32 RNF20interactor40.6671.000Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein
Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
33 RNF40protein found in more fusions50.5003.000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
FlgN (PF05130, IPR007809): FlgN protein
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE)
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
34 SGF29interactor40.5003.000DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain
Filament (PF00038, IPR001664): Intermediate filament protein
35 SKA1interactor31.0000SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
36 SPC25interactor21.0000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spindle_Spc25 (PF08234, IPR013255): Chromosome segregation protein Spc25
37 STRN4interactor100CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Striatin (PF08232, IPR013258): Striatin family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
38 STX12interactor140.48428.171PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776)
Syntaxin_2 (PF14523): Syntaxin-like protein
39 STX17interactor21.0000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
Gly-zipper_YMGG (PF13441, IPR027367): YMGG-like Gly-zipper
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
40 STX18interactor70.7143.952Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
Phage_Integr_2 (PF13009, IPR024965): Putative phage integrase
41 STX1Ainteractor90.28613.619Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
4HB_MCP_1 (PF12729, IPR024478): Four helix bundle sensory module for signal transduction
42 STX3interactor100.57810.305XhlA (PF10779, IPR019715): Haemolysin XhlA
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
43 STX4oncoprotein150.46235.260Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
44 STX5interactor110.54519.856Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
45 STX6interactor140.52727.327Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
46 STX7interactor150.50530.560SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
47 STXBP5interactor70.7142.308Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
Synaptobrevin (PF00957, IPR001388): Synaptobrevin
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
WD40_like (PF17005, IPR031544): WD40-like domain
48 TACC3oncoprotein21.0000TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
49 TMEM120Ainteractor100TMPIT (PF07851, IPR012926): TMPIT-like protein
50 TRAF3oncoprotein31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
51 TRAF6protein found in more fusions200SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
52 TRIM62interactor100Laminin_II (PF06009, IPR010307): Laminin Domain II
Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3416 (PF11896, IPR021828): Domain of unknown function (DUF3416)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
53 TRPM7interactor200Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Ion_trans (PF00520, IPR005821): Ion transport protein
DUF3893 (PF13032, IPR024996): Domain of unknown function (DUF3893)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
54 TSNARE1interactor21.0000SNARE (PF05739, IPR000727, SM00397): SNARE domain
Myb_DNA-bind_5 (PF13873, IPR028002): Myb/SANT-like DNA-binding domain
Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1
Syntaxin_2 (PF14523): Syntaxin-like protein
55 TSSC1suppressor41.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
56 VAMP1interactor30.6670.286Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
57 VAMP2interactor70.7142.141Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
58 VAMP4interactor80.7144.222Synaptobrevin (PF00957, IPR001388): Synaptobrevin
59 VAMP5interactor30.6670.286RAMP (PF04901, IPR006985): Receptor activity modifying family
Synaptobrevin (PF00957, IPR001388): Synaptobrevin
ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18
60 VAMP7interactor70.7142.308Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
61 VCAM1interactor50.4005.667C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
62 VPS50interactor41.0000Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
63 VPS51interactor50.8001.333DUF1736 (PF08409, IPR013618): Domain of unknown function (DUF1736)
Vps51 (PF08700): Vps51/Vps67
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
Sec5 (PF15469): Exocyst complex component Sec5
64 VPS53suppressor70.6674.000Vps53_N (PF04100, IPR007234): Vps53-like, N-terminal
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
VPS53_C (PF16854, IPR031745): Vacuolar protein sorting-associated protein 53 C-terminus
65 XPO1interactor50.4006.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
66 ZWINTinteractor60.4005.333Zwint (PF15556, IPR029092): ZW10 interactor

B a c k    t o    T o p ⇑