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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SNAP23 (from a repository: Sun Dec 4 20:15:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins11 (19.30 %)
The number (and %) of the tumor suppressors2 (3.51 %)
Total number of binary PPIs (saturation %)239 (14.97 %)
The number (and %) of affected PPIs57 (23.85 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI7.684
Assortativity coefficient-0.3542
The network average Clustering coefficient0.586
The number (and %) of a zero Clustering coefficients6 (10.53 %)
The number (and %) of a zero Betweenness Centrality18 (31.58 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions SNAP23 (see 1 fusions); ZDHHC17 (see 2 fusions); UBQLN2 (see 2 fusions); PSAP (see 6 fusions); SRSF1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SNAP23parental protein570.1062199.499DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SNAP-25 (PF00835, IPR000928): SNAP-25 family
DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089)
2 ABCE1interactor50.5002.200ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 ABI2suppressor200Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 ABI3interactor200Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
SH3_9 (PF14604, IPR001452): Variant SH3 domain
5 ANXA3interactor21.0000Annexin (PF00191, IPR018502, SM00335): Annexin
RPT (PF13446, IPR025305): A repeated domain in UCH-protein
6 C12orf57interactor100P_C10 (PF14974, IPR026317): Protein C10
7 CCDC8interactor100.41714.686Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
8 CCP110interactor30.6671.000DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
CALM_bind (PF16025): Calcium-dependent calmodulin binding
9 CEP97interactor21.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
10 CFTRsuppressor50.5003.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
11 ELAVL1oncoprotein170.20082.286RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 FAM3Cinteractor100ILEI (PF15711): Interleukin-like EMT inducer
13 FN1oncoprotein120.33335.467fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
14 FXR2interactor31.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
15 HNRNPABinteractor31.0000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
GRP (PF07172, IPR010800): Glycine rich protein family
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
16 ILF2interactor70.5247.167DZF (PF07528, IPR006561, SM00572): DZF domain
17 ITSN1interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
18 KIF5Binteractor30.6671.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
19 KRASoncoprotein50.6671.400Ras (PF00071, IPR001806, SM00173): Ras family
20 MATR3interactor50.8330.333DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
21 NAPAoncoprotein120.56117.614SNAP (PF14938): Soluble NSF attachment protein, SNAP
22 NAPBinteractor80.6074.851SNAP (PF14938): Soluble NSF attachment protein, SNAP
23 NSFinteractor90.7143.300AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
ATPase (PF06745, IPR014774): KaiC
AAA_19 (PF13245): Part of AAA domain
24 PSAPoncoprotein31.0000SapA (PF02199, IPR003119, SM00162): Saposin A-type domain
SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
SapB_2 (PF03489, IPR008138): Saposin-like type B, region 2
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
25 SCAMP1interactor70.4676.600SCAMP (PF04144, IPR007273): SCAMP family
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
26 SCAMP2interactor31.0000SCAMP (PF04144, IPR007273): SCAMP family
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
27 SCFD1interactor90.5568.956Sec1 (PF00995, IPR001619): Sec1 family
28 SCGNinteractor21.0000EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_10 (PF14788): EF hand
29 SNAPINinteractor100Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
30 SNTG1interactor21.0000Marek_SORF3 (PF07153, IPR009823): Marek's disease-like virus SORF3 protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
31 SRSF1protein found in more fusions50.8330.500Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
32 STX11interactor50.6670.667KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
33 STX12interactor170.52923.179PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776)
Syntaxin_2 (PF14523): Syntaxin-like protein
34 STX18interactor80.8211.408Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
Phage_Integr_2 (PF13009, IPR024965): Putative phage integrase
35 STX19interactor50.7000.821DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
36 STX1Ainteractor100.30614.757Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
4HB_MCP_1 (PF12729, IPR024478): Four helix bundle sensory module for signal transduction
37 STX1Binteractor21.0000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
38 STX2interactor60.6002.567Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
39 STX3interactor110.6555.510XhlA (PF10779, IPR019715): Haemolysin XhlA
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
40 STX4oncoprotein200.38074.596Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
41 STX5interactor130.61510.602Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
42 STX6interactor170.55122.788Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
43 STX7interactor180.52928.211SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
44 STXBP3interactor60.5335.300Sec1 (PF00995, IPR001619): Sec1 family
45 STXBP5interactor80.5714.318Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
Synaptobrevin (PF00957, IPR001388): Synaptobrevin
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
WD40_like (PF17005, IPR031544): WD40-like domain
46 SYNCRIPinteractor60.6004.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
47 TMEM17interactor140.40737.950Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
48 TMEM216interactor120.51517.854Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
49 UBQLN2protein found in more fusions31.0000Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
50 VAMP2interactor170.38252.718Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
51 VAMP3interactor130.59014.141Synaptobrevin (PF00957, IPR001388): Synaptobrevin
52 VAMP5interactor30.6670.250RAMP (PF04901, IPR006985): Receptor activity modifying family
Synaptobrevin (PF00957, IPR001388): Synaptobrevin
ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18
53 VAMP7interactor80.6792.690Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
54 VAMP8oncoprotein160.46733.581Synaptobrevin (PF00957, IPR001388): Synaptobrevin
55 WASH2Pinteractor100NA
56 YES1oncoprotein60.4676.233Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
57 ZDHHC17protein found in more fusions41.0000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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