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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SMG6 (from a repository: Sun Dec 4 12:07:44 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins4 (26.67 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)39 (37.14 %)
The number (and %) of affected PPIs15 (38.46 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.667
Assortativity coefficient-0.3026
The network average Clustering coefficient0.579
The number (and %) of a zero Clustering coefficients3 (20.00 %)
The number (and %) of a zero Betweenness Centrality6 (40.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SMG6 All fusions
Proteins found in more fusions PABPC1 (see 2 fusions); SMG6 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SMG6parental protein150.231116.833EST1 (PF10374, IPR019458): Telomerase activating protein Est1
EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain
PIN_4 (PF13638, IPR002716): PIN domain
2 C2orf68interactor100UPF0561 (PF10573, IPR018888): Uncharacterised protein family UPF0561
3 HBBinteractor60.8001.500Globin (PF00042, IPR000971): Globin
4 HDAC8interactor30.6671.000DNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
5 MAGOHinteractor41.0000Mago_nashi (PF02792, IPR004023): Mago nashi protein
6 PABPC1oncoprotein60.7002.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
7 PPP1CConcoprotein21.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
8 PSG1interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
9 RBM8Ainteractor90.6076.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 SMG5interactor50.5004.333EST1 (PF10374, IPR019458): Telomerase activating protein Est1
EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain
PIN_4 (PF13638, IPR002716): PIN domain
11 SMG7interactor41.0000TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
EST1 (PF10374, IPR019458): Telomerase activating protein Est1
EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain
12 SOX2oncoprotein200HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
13 TERToncoprotein30.6670.500RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase)
Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
14 UPF1interactor80.6076.500UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
15 UPF3Binteractor50.9000.500HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family
TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
DUF2098 (PF09871, IPR019209): Uncharacterized protein conserved in archaea (DUF2098)
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)

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