Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SMARCB1 (from a repository: Tue Nov 15 21:21:07 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 107 The number (and %) of the onco-proteins 37 (34.58 %) The number (and %) of the tumor suppressors 28 (26.17 %) Total number of binary PPIs (saturation %) 837 (14.76 %) The number (and %) of affected PPIs 107 (12.78 %) The number of possible different fusions 22 PPI diameter 2 PPI radius 1 The average degree of PPI 14.897 Assortativity coefficient -0.1949 The network average Clustering coefficient 0.578 The number (and %) of a zero Clustering coefficients 4 (3.74 %) The number (and %) of a zero Betweenness Centrality 13 (12.15 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SMARCB1	All fusions : BE932674; BE932597; BG390166; BE933271; BE719306; BF355240; BF088188; BF088153; BE932658; BE933287; CN272300;
Proteins found in more fusions	APP (see 4 fusions); MED21 (see 1 fusions); PRMT5 (see 2 fusions); ZDHHC17 (see 2 fusions); HSF1 (see 3 fusions); CUL3 (see 1 fusions); SMARCB1 (see 12 fusions); CALR (see 6 fusions); MYC (see 1 fusions); RUNX1 (see 1 fusions); CREBBP (see 5 fusions); KAT2B (see 1 fusions); KMT2A (see 16 fusions); POLR2A (see 2 fusions); COPS5 (see 1 fusions); SMARCC1 (see 2 fusions); EPAS1 (see 1 fusions); ZAK (see 2 fusions); TBL1X (see 2 fusions); SS18 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SMARCB1	parental protein	107	0.124	5558.897	SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
2	ACTA1	interactor	6	0.667	1.789	Actin (PF00022, IPR004000, SM00268): Actin
3	ACTL6A	interactor	29	0.473	81.344	Actin (PF00022, IPR004000, SM00268): Actin
4	AKT1	oncoprotein	14	0.372	27.166	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5	APP	protein found in more fusions	20	0.146	113.300	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6	ARID1A	suppressor	27	0.556	43.258	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family YscJ_FliF_C (PF08345, IPR013556): Flagellar M-ring protein C-terminal TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
7	ARID1B	oncoprotein	20	0.753	12.420	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin (PF01080, IPR001108): Presenilin DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa Spt20 (PF12090, IPR021950): Spt20 family
8	ARID2	suppressor	12	0.788	3.791	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
9	ATM	suppressor	10	0.556	9.373	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
10	BCL2L11	suppressor	2	1.000	0	Bclx_interact (PF08945, IPR015040): Bcl-x interacting, BH3 domain Bim_N (PF06773, IPR014771): Bim protein N-terminus
11	BCL7A	suppressor	15	0.848	3.372	BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 UPF0561 (PF10573, IPR018888): Uncharacterised protein family UPF0561
12	BCL7B	suppressor	12	0.970	0.236	BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
13	BCL7C	suppressor	18	0.778	12.586	BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
14	BRCA1	suppressor	24	0.451	57.174	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
15	CALR	oncoprotein	4	0.667	1.000	Calreticulin (PF00262, IPR001580): Calreticulin family DDHD (PF02862, IPR004177, SM01127): DDHD domain
16	CAND1	interactor	15	0.495	20.486	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
17	CARM1	oncoprotein	15	0.571	13.736	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
18	CCNE1	oncoprotein	7	0.810	0.888	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
19	CDK8	interactor	15	0.692	7.614	Pkinase (PF00069, IPR000719): Protein kinase domain
20	CDX2	suppressor	4	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Caudal_act (PF04731, IPR006820): Caudal like protein activation region Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
21	CDYL	interactor	6	0.933	0.200	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase ECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
22	CEBPB	oncoprotein	16	0.676	9.603	RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
23	CHFR	suppressor	7	0.867	0.287	FHA (PF00498, IPR000253, SM00240): FHA domain Glyco_hydro_92 (PF07971, IPR012939): Glycosyl hydrolase family 92 zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) LAX (PF15681, IPR031393): Lymphocyte activation family X
24	CHMP4A	interactor	2	0	0	Snf7 (PF03357, IPR005024): Snf7
25	COPS5	protein found in more fusions	15	0.407	27.351	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
26	CPSF6	interactor	9	0.472	10.411	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
27	CREBBP	suppressor	30	0.337	125.783	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
28	CUL3	protein found in more fusions	27	0.335	124.678	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
29	DPF1	interactor	7	1.000	0	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. PHD_4 (PF16866, IPR019787): PHD-finger
30	DPF2	interactor	21	0.667	26.265	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
31	DPF3	interactor	18	0.837	5.097	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. Lar_restr_allev (PF14354): Restriction alleviation protein Lar
32	EIF4A3	interactor	9	0.429	11.817	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
33	EMD	interactor	11	0.556	7.852	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
34	EPAS1	suppressor	14	0.564	11.795	Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 PAS_11 (PF14598): PAS domain
35	FOXN1	interactor	5	0.800	0.202	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
36	GADD45G	suppressor	2	1.000	0	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
37	GATA1	oncoprotein	11	0.636	9.128	GATA (PF00320, IPR000679, SM00401): GATA zinc finger Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
38	HDAC1	suppressor	44	0.287	302.701	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
39	HDAC2	suppressor	30	0.411	80.090	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
40	HSF1	protein found in more fusions	7	0.933	0.222	DUF247 (PF03140, IPR004158): Plant protein of unknown function Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
41	ING1	suppressor	14	0.670	6.773	PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
42	ING2	suppressor	11	0.618	6.271	PHD (PF00628, IPR019787, SM00249): PHD-finger S1FA (PF04689, IPR006779): DNA binding protein S1FA ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
43	JUN	oncoprotein	19	0.412	42.383	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
44	KAT2B	protein found in more fusions	16	0.457	23.053	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
45	KLF1	interactor	10	0.800	1.493	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1 EKLF_TAD2 (PF16833, IPR031784): Erythroid krueppel-like transcription factor, transactivation 2
46	KMT2A	oncoprotein	16	0.571	19.778	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
47	KMT2B	oncoprotein	1	0	0	FLO_LFY (PF01698, IPR002910): Floricaula / Leafy protein FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus GRP (PF07172, IPR010800): Glycine rich protein family PHD (PF00628, IPR019787, SM00249): PHD-finger SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Fer4_2 (PF12797, IPR001450): 4Fe-4S binding domain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
48	KMT2C	suppressor	2	1.000	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus SLC12 (PF03522, IPR018491): Solute carrier family 12 MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family PHD (PF00628, IPR019787, SM00249): PHD-finger SET (PF00856, IPR001214, SM00317): SET domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box zf-HC5HC2H (PF13771): PHD-like zinc-binding domain zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
49	MAP1LC3B	interactor	4	0.667	0.382	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
50	MAPK8IP2	interactor	3	1.000	0	BUD22 (PF09073, IPR015158): BUD22 CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal SH3_9 (PF14604, IPR001452): Variant SH3 domain
51	MCPH1	suppressor	6	0.733	1.633	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain MSP (PF01716, IPR002628): Manganese-stabilising protein / photosystem II polypeptide Spectrin (PF00435, IPR002017): Spectrin repeat Microcephalin (PF12258, IPR022047): Microcephalin protein PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
52	MECP2	interactor	8	0.714	4.300	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
53	MED21	protein found in more fusions	8	0.905	0.336	Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
54	MLLT10	oncoprotein	4	0.667	0.667	SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal PHD_2 (PF13831): PHD-finger zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain Tnp_zf-ribbon_2 (PF13842, IPR032718): DDE_Tnp_1-like zinc-ribbon CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106 DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718) DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887) AP3D1 (PF06375): AP-3 complex subunit delta-1
55	MYC	oncoprotein	26	0.420	85.206	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
56	NCOR1	oncoprotein	24	0.406	66.522	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
57	NCSTN	interactor	7	0.476	6.272	Nicastrin (PF05450, IPR008710): Nicastrin Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
58	NFATC1	oncoprotein	8	0.714	1.586	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
59	NONO	oncoprotein	20	0.409	46.360	GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAS_7 (PF12860): PAS fold SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
60	NR0B2	suppressor	8	0.750	1.371	Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
61	PBRM1	suppressor	13	0.667	14.148	BAH (PF01426, IPR001025, SM00439): BAH domain BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen Bromodomain (PF00439, IPR001487, SM00297): Bromodomain HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
62	PDPK1	interactor	6	0.500	3.667	Pkinase (PF00069, IPR000719): Protein kinase domain PH_3 (PF14593): PH domain
63	PHF10	interactor	9	1.000	0	Herpes_MCP (PF03122, IPR000912): Herpes virus major capsid protein PHD (PF00628, IPR019787, SM00249): PHD-finger MRI (PF15325, IPR028278): Modulator of retrovirus infection
64	POLR2A	protein found in more fusions	17	0.425	30.030	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
65	PPP1CA	suppressor	18	0.373	54.878	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
66	PPP1CB	interactor	10	0.556	7.617	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
67	PPP1CC	oncoprotein	14	0.396	31.538	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
68	PPP1R15A	interactor	8	0.571	5.902	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region PP1c_bdg (PF10488, IPR019523): Phosphatase-1 catalytic subunit binding region SCHIP-1 (PF10148, IPR015649): Schwannomin-interacting protein 1 CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
69	PRMT5	protein found in more fusions	15	0.484	24.893	PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
70	QSOX2	interactor	1	0	0	Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain Evr1_Alr (PF04777, IPR017905): Erv1 / Alr family Thioredoxin (PF00085, IPR013766): Thioredoxin zf-HYPF (PF07503, IPR011125): HypF finger Thioredoxin_2 (PF13098, IPR012336): Thioredoxin-like domain
71	RAN	oncoprotein	9	0.417	14.008	Ras (PF00071, IPR001806, SM00173): Ras family
72	RB1CC1	suppressor	2	1.000	0	Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II DHC (PF09626, IPR018588): Dihaem cytochrome c DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) ATG11 (PF10377, IPR019460): Autophagy-related protein 11 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Jag_N (PF14804, IPR032782): Jag N-terminus NPBW (PF15180, IPR013297): Neuropeptides B and W HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
73	RBBP4	oncoprotein	16	0.633	11.758	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
74	RELB	oncoprotein	9	0.778	2.846	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain RelB_leu_zip (PF16180, IPR032399): RelB leucine zipper RelB_transactiv (PF16181, IPR032400): RelB transactivation domain
75	RPS6KA5	interactor	5	0.500	2.686	Choline_kinase (PF01633): Choline/ethanolamine kinase Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
76	RUNX1	suppressor	14	0.718	4.698	Runt (PF00853, IPR013524): Runt domain RunxI (PF08504, IPR013711): Runx inhibition domain DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
77	SAP18	interactor	8	0.429	11.583	SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
78	SIN3A	oncoprotein	29	0.392	104.864	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
79	SIN3B	interactor	10	0.800	1.671	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
80	SMARCA2	suppressor	45	0.326	287.553	DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain YL1 (PF05764, IPR008895): YL1 nuclear protein BRK (PF07533, IPR006576, SM00592): BRK domain DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
81	SMARCA4	suppressor	56	0.276	511.170	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
82	SMARCAD1	interactor	13	0.731	4.954	CUE (PF02845, IPR003892, SM00546): CUE domain Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
83	SMARCC1	suppressor	54	0.289	378.833	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
84	SMARCC2	interactor	49	0.291	357.932	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain SWIRM (PF04433, IPR007526): SWIRM domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
85	SMARCD1	interactor	35	0.407	140.479	ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit DivIC (PF04977, IPR007060): Septum formation initiator SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
86	SMARCD2	interactor	23	0.609	30.141	SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
87	SMARCD3	interactor	19	0.719	15.456	SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
88	SMARCE1	interactor	40	0.355	195.574	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
89	SON	interactor	5	0.600	2.233	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region G-patch (PF01585, IPR000467, SM00443): G-patch domain tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1 GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer RSRP (PF17069): Arginine/Serine-Rich protein 1
90	SOX2	oncoprotein	19	0.490	35.750	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor
91	SS18	oncoprotein	25	0.627	41.187	SSXT (PF05030, IPR007726): SSXT protein (N-terminal region) Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
92	TACC2	interactor	5	0.500	3.167	TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
93	TAF1D	interactor	1	0	0	TAF1D (PF15333, IPR027976): TATA box-binding protein-associated factor 1D
94	TAF6	interactor	13	0.667	9.570	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
95	TBL1X	protein found in more fusions	10	0.528	5.112	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain LisH (PF08513, IPR013720, SM00667): LisH WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
96	TBL1XR1	oncoprotein	13	0.628	8.347	LisH (PF08513, IPR013720, SM00667): LisH WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
97	TFAP4	oncoprotein	11	0.564	8.393	DivIC (PF04977, IPR007060): Septum formation initiator HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
98	TOP2B	oncoprotein	12	0.652	11.953	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DASH_Spc19 (PF08287, IPR013251): Spc19 DNA_gyraseB (PF00204, IPR013506): DNA gyrase B DTHCT (PF08070, IPR012542): DTHCT (NUC029) region HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim (PF01751, IPR006171, SM00493): Toprim domain Anophelin (PF10731, IPR018932): Thrombin inhibitor from mosquito DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
99	TP53	suppressor	38	0.275	253.180	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
100	TRA2A	interactor	7	0.524	6.050	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
101	UBQLN4	interactor	3	1.000	0	CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Arm_2 (PF04826, IPR006911): Armadillo-like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
102	VTN	interactor	5	0.500	2.952	Hemopexin (PF00045, IPR018487, SM00120): Hemopexin Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
103	XPC	oncoprotein	5	0.600	1.967	Rad4 (PF03835, IPR018325): Rad4 transglutaminase-like domain BHD_1 (PF10403, IPR018326, SM01030): Rad4 beta-hairpin domain 1 BHD_2 (PF10404, IPR018327, SM01031): Rad4 beta-hairpin domain 2 BHD_3 (PF10405, IPR018328, SM01032): Rad4 beta-hairpin domain 3 Macoilin (PF09726, IPR019130): Transmembrane protein SOG2 (PF10428, IPR019487): RAM signalling pathway protein Abdominal-A (PF12407, IPR022132): Homeobox protein DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
104	XPO1	interactor	16	0.217	61.722	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
105	YEATS4	interactor	6	0.467	6.452	YEATS (PF03366, IPR005033): YEATS family SOGA (PF11365, IPR027881): Protein SOGA
106	ZAK	protein found in more fusions	5	0.667	1.400	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
107	ZDHHC17	protein found in more fusions	6	0.400	3.383	zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_4 (PF13637): Ankyrin repeats (many copies)

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