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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)75
The number (and %) of the onco-proteins28 (37.33 %)
The number (and %) of the tumor suppressors2 (2.67 %)
Total number of binary PPIs (saturation %)288 (10.38 %)
The number (and %) of affected PPIs75 (26.04 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI6.960
Assortativity coefficient-0.3307
The network average Clustering coefficient0.495
The number (and %) of a zero Clustering coefficients16 (21.33 %)
The number (and %) of a zero Betweenness Centrality27 (36.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SLC9A3R1 All fusions
: BE697345;
Proteins found in more fusions NF2 (see 1 fusions); CLCN3 (see 2 fusions); MME (see 1 fusions); EZR (see 2 fusions); PAG1 (see 1 fusions); TCF3 (see 3 fusions); YWHAZ (see 1 fusions); RACK1 (see 3 fusions); G6PD (see 3 fusions); U2AF2 (see 2 fusions); PLCB1 (see 1 fusions); PPME1 (see 1 fusions); ECHS1 (see 1 fusions); SLC9A3R1 (see 2 fusions); TGM2 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLC9A3R1parental protein750.0694285.437EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
2 ABCC2interactor30.6671.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
DUF805 (PF05656, IPR008523): Protein of unknown function (DUF805)
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
3 ABCC4interactor31.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
4 ADRB2interactor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 AKT1oncoprotein120.21836.833PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
6 BCL10oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
7 CAPN1interactor80.6436.190Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 CDCA5interactor200Sororin (PF09666, IPR018605): Sororin protein
9 CFTRsuppressor120.23638.233ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
10 CKBinteractor120.59114.010ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
11 CLCN3protein found in more fusions41.0000CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
12 CNDP2suppressor150.46730.113Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
13 CSE1Loncoprotein140.47327.591CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
14 CTNNB1oncoprotein90.52810.967Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
15 ECHS1protein found in more fusions90.7502.119ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
16 EPHB1interactor21.0000EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
17 EZRprotein found in more fusions110.37821.967DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
18 FTOinteractor60.8001.400FTO_NTD (PF12933, IPR024367): FTO catalytic domain
FTO_CTD (PF12934, IPR024366): FTO C-terminal domain
19 G6PDprotein found in more fusions120.6736.991G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
20 GDAinteractor60.6004.667Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
21 GNA11oncoprotein30.6671.000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
22 IREB2interactor100Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
23 KCNJ1interactor21.0000IRK (PF01007, IPR016449): Inward rectifier potassium channel
24 LDHAL6Binteractor50.5003.500Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
25 LDHBinteractor170.43342.843Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
26 MDH1interactor60.4006.900Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
27 MMEoncoprotein200Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
28 MSNoncoprotein50.8330.400DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
29 NANSinteractor80.6793.948NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
30 NF2oncoprotein70.4006.000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
31 NOS2interactor60.7002.000FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
32 NPEPPSinteractor140.51624.138Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
33 NTRK1oncoprotein280.239200.465I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34 OPRK1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
35 P2RY1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
36 PAG1protein found in more fusions200PAG (PF15347, IPR032748): Phosphoprotein associated with glycosphingolipid-enriched
37 PALM2interactor100Paralemmin (PF03285, IPR004965): Paralemmin
Phage_int_SAM_5 (PF13102, IPR025269): Phage integrase SAM-like domain
AKAP2_C (PF15304, IPR029304): A-kinase anchor protein 2 C-terminus
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
38 PCYOX1interactor100Prenylcys_lyase (PF07156, IPR010795): Prenylcysteine lyase
NAD_binding_8 (PF13450): NAD(P)-binding Rossmann-like domain
39 PDGFRAoncoprotein50.8330.333Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
40 PDGFRBoncoprotein50.8330.333I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
41 PDIA3interactor110.49117.815Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
42 PDZK1interactor70.38112.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
43 PHLPP2oncoprotein21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
44 PLCB1oncoprotein31.0000DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
zf-C2H2_assoc (PF16606): Unstructured conserved, between two C2H2-type zinc-fingers
45 PPME1protein found in more fusions70.6672.122Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
46 PPP4R3Binteractor90.6116.486Diphtheria_T (PF02764, IPR022405): Diphtheria toxin, T domain
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
IGF2_C (PF08365, IPR013576): Insulin-like growth factor II E-peptide
WH1 (PF00568, IPR000697, SM00461): WH1 domain
47 PRKCAinteractor80.6194.133C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
48 PTENoncoprotein100.28927.833DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
49 PTH1Rinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
50 RACK1oncoprotein80.4299.233WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
51 RNASET2interactor100Ribonuclease_T2 (PF00445, IPR001568): Ribonuclease T2 family
DHODB_Fe-S_bind (PF10418, IPR019480): Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
52 RPL23interactor70.4768.567Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
53 RPS3interactor80.42911.333KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
54 RPS6KA3interactor70.7142.848Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
55 SCN4Ainteractor100Ion_trans (PF00520, IPR005821): Ion transport protein
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
56 SKP2oncoprotein40.5002.667LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
57 SLC4A7interactor40.6671.333Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
DUF2628 (PF10947, IPR024399): Protein of unknown function (DUF2628)
FAM176 (PF14851): FAM176 family
DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
58 SLC4A8interactor100Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family
Mu-transpos_C (PF09299, IPR015378): Mu transposase, C-terminal
59 SLC9A3interactor21.0000Na_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
60 SMSinteractor100.51114.467Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
61 TACC1interactor100TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
62 TBC1D10Ainteractor100LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
TonB_N (PF16031): TonB N-terminal region
63 TCF3oncoprotein31.0000CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
64 TGM2protein found in more fusions140.57714.087Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
65 TKFCinteractor70.5715.067Dak1 (PF02733, IPR004006): Dak1 domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
66 U2AF2protein found in more fusions80.5246.300RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
67 UBFD1interactor90.8331.635ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
68 UQCRFS1interactor30.6671.000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
69 UQCRFS1P1interactor100NA
70 YAP1oncoprotein50.7002.167Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
71 YES1oncoprotein21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
72 YWHABinteractor110.47322.16714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
73 YWHAQinteractor160.43339.96114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
74 YWHAZprotein found in more fusions150.41834.73414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
75 ZNF468interactor100DUF1033 (PF06279, IPR010434): Protein of unknown function (DUF1033)
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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