Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: SLC9A3R1 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 75 The number (and %) of the onco-proteins 28 (37.33 %) The number (and %) of the tumor suppressors 2 (2.67 %) Total number of binary PPIs (saturation %) 288 (10.38 %) The number (and %) of affected PPIs 75 (26.04 %) The number of possible different fusions 16 PPI diameter 2 PPI radius 1 The average degree of PPI 6.960 Assortativity coefficient -0.3307 The network average Clustering coefficient 0.495 The number (and %) of a zero Clustering coefficients 16 (21.33 %) The number (and %) of a zero Betweenness Centrality 27 (36.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SLC9A3R1	All fusions : BE697345;
Proteins found in more fusions	NF2 (see 1 fusions); CLCN3 (see 2 fusions); MME (see 1 fusions); EZR (see 2 fusions); PAG1 (see 1 fusions); TCF3 (see 3 fusions); YWHAZ (see 1 fusions); RACK1 (see 3 fusions); G6PD (see 3 fusions); U2AF2 (see 2 fusions); PLCB1 (see 1 fusions); PPME1 (see 1 fusions); ECHS1 (see 1 fusions); SLC9A3R1 (see 2 fusions); TGM2 (see 4 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SLC9A3R1	parental protein	75	0.069	4285.437	EBP50_C (PF09007, IPR015098): EBP50, C-terminal PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
2	ABCC2	interactor	3	0.667	1.000	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter DUF805 (PF05656, IPR008523): Protein of unknown function (DUF805) DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
3	ABCC4	interactor	3	1.000	0	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
4	ADRB2	interactor	3	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5	AKT1	oncoprotein	12	0.218	36.833	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
6	BCL10	oncoprotein	3	1.000	0	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
7	CAPN1	interactor	8	0.643	6.190	Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8	CDCA5	interactor	2	0	0	Sororin (PF09666, IPR018605): Sororin protein
9	CFTR	suppressor	12	0.236	38.233	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
10	CKB	interactor	12	0.591	14.010	ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
11	CLCN3	protein found in more fusions	4	1.000	0	CBS (PF00571, IPR000644, SM00116): CBS domain Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
12	CNDP2	suppressor	15	0.467	30.113	Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
13	CSE1L	oncoprotein	14	0.473	27.591	CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus Cse1 (PF08506, IPR013713): Cse1 IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein
14	CTNNB1	oncoprotein	9	0.528	10.967	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
15	ECHS1	protein found in more fusions	9	0.750	2.119	ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
16	EPHB1	interactor	2	1.000	0	EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
17	EZR	protein found in more fusions	11	0.378	21.967	DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
18	FTO	interactor	6	0.800	1.400	FTO_NTD (PF12933, IPR024367): FTO catalytic domain FTO_CTD (PF12934, IPR024366): FTO C-terminal domain
19	G6PD	protein found in more fusions	12	0.673	6.991	G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
20	GDA	interactor	6	0.600	4.667	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
21	GNA11	oncoprotein	3	0.667	1.000	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
22	IREB2	interactor	1	0	0	Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase) Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
23	KCNJ1	interactor	2	1.000	0	IRK (PF01007, IPR016449): Inward rectifier potassium channel
24	LDHAL6B	interactor	5	0.500	3.500	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
25	LDHB	interactor	17	0.433	42.843	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
26	MDH1	interactor	6	0.400	6.900	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
27	MME	oncoprotein	2	0	0	Peptidase_M13 (PF01431, IPR018497): Peptidase family M13 Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
28	MSN	oncoprotein	5	0.833	0.400	DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
29	NANS	interactor	8	0.679	3.948	NeuB (PF03102, IPR013132): NeuB family SAF (PF08666, IPR013974, SM00858): SAF domain
30	NF2	oncoprotein	7	0.400	6.000	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
31	NOS2	interactor	6	0.700	2.000	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
32	NPEPPS	interactor	14	0.516	24.138	Peptidase_M1 (PF01433, IPR014782): Peptidase family M1 ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
33	NTRK1	oncoprotein	28	0.239	200.465	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34	OPRK1	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
35	P2RY1	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
36	PAG1	protein found in more fusions	2	0	0	PAG (PF15347, IPR032748): Phosphoprotein associated with glycosphingolipid-enriched
37	PALM2	interactor	1	0	0	Paralemmin (PF03285, IPR004965): Paralemmin Phage_int_SAM_5 (PF13102, IPR025269): Phage integrase SAM-like domain AKAP2_C (PF15304, IPR029304): A-kinase anchor protein 2 C-terminus SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
38	PCYOX1	interactor	1	0	0	Prenylcys_lyase (PF07156, IPR010795): Prenylcysteine lyase NAD_binding_8 (PF13450): NAD(P)-binding Rossmann-like domain
39	PDGFRA	oncoprotein	5	0.833	0.333	Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain LAT (PF15234, IPR008359): Linker for activation of T-cells
40	PDGFRB	oncoprotein	5	0.833	0.333	I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase V-set (PF07686, IPR013106): Immunoglobulin V-set domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain Ig_3 (PF13927): Immunoglobulin domain TonB_N (PF16031): TonB N-terminal region
41	PDIA3	interactor	11	0.491	17.815	Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
42	PDZK1	interactor	7	0.381	12.667	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
43	PHLPP2	oncoprotein	2	1.000	0	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PH (PF00169, IPR001849, SM00233): PH domain PP2C (PF00481, IPR001932): Protein phosphatase 2C SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
44	PLCB1	oncoprotein	3	1.000	0	DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987) zf-C2H2_assoc (PF16606): Unstructured conserved, between two C2H2-type zinc-fingers
45	PPME1	protein found in more fusions	7	0.667	2.122	Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
46	PPP4R3B	interactor	9	0.611	6.486	Diphtheria_T (PF02764, IPR022405): Diphtheria toxin, T domain SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1 IGF2_C (PF08365, IPR013576): Insulin-like growth factor II E-peptide WH1 (PF00568, IPR000697, SM00461): WH1 domain
47	PRKCA	interactor	8	0.619	4.133	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
48	PTEN	oncoprotein	10	0.289	27.833	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
49	PTH1R	interactor	1	0	0	7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family) HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
50	RACK1	oncoprotein	8	0.429	9.233	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
51	RNASET2	interactor	1	0	0	Ribonuclease_T2 (PF00445, IPR001568): Ribonuclease T2 family DHODB_Fe-S_bind (PF10418, IPR019480): Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
52	RPL23	interactor	7	0.476	8.567	Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
53	RPS3	interactor	8	0.429	11.333	KH_2 (PF07650, IPR004044): KH domain Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
54	RPS6KA3	interactor	7	0.714	2.848	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
55	SCN4A	interactor	1	0	0	Ion_trans (PF00520, IPR005821): Ion transport protein IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363) GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
56	SKP2	oncoprotein	4	0.500	2.667	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
57	SLC4A7	interactor	4	0.667	1.333	Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain DUF2628 (PF10947, IPR024399): Protein of unknown function (DUF2628) FAM176 (PF14851): FAM176 family DUF4519 (PF15012, IPR027960): Domain of unknown function (DUF4519)
58	SLC4A8	interactor	1	0	0	Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family Mu-transpos_C (PF09299, IPR015378): Mu transposase, C-terminal
59	SLC9A3	interactor	2	1.000	0	Na_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
60	SMS	interactor	10	0.511	14.467	Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
61	TACC1	interactor	1	0	0	TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC) DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
62	TBC1D10A	interactor	1	0	0	LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain TonB_N (PF16031): TonB N-terminal region
63	TCF3	oncoprotein	3	1.000	0	CDC45 (PF02724, IPR003874): CDC45-like protein HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
64	TGM2	protein found in more fusions	14	0.577	14.087	Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
65	TKFC	interactor	7	0.571	5.067	Dak1 (PF02733, IPR004006): Dak1 domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
66	U2AF2	protein found in more fusions	8	0.524	6.300	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
67	UBFD1	interactor	9	0.833	1.635	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
68	UQCRFS1	interactor	3	0.667	1.000	Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
69	UQCRFS1P1	interactor	1	0	0	NA
70	YAP1	oncoprotein	5	0.700	2.167	Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181
71	YES1	oncoprotein	2	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain YdjC (PF04794, IPR006879): YdjC-like protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
72	YWHAB	interactor	11	0.473	22.167	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
73	YWHAQ	interactor	16	0.433	39.961	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
74	YWHAZ	protein found in more fusions	15	0.418	34.734	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
75	ZNF468	interactor	1	0	0	DUF1033 (PF06279, IPR010434): Protein of unknown function (DUF1033) KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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