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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SLC25A11 (from a repository: Sat Jul 13 12:54:17 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins12 (25.00 %)
The number (and %) of the tumor suppressors5 (10.42 %)
Total number of binary PPIs (saturation %)126 (11.17 %)
The number (and %) of affected PPIs48 (38.10 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI4.542
Assortativity coefficient-0.4800
The network average Clustering coefficient0.457
The number (and %) of a zero Clustering coefficients14 (29.17 %)
The number (and %) of a zero Betweenness Centrality24 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SLC25A11 All fusions
Proteins found in more fusions FYN (see 1 fusions); NF2 (see 1 fusions); HDAC5 (see 1 fusions); MCM2 (see 1 fusions); SLC25A11 (see 1 fusions); MYC (see 2 fusions); CEBPA (see 1 fusions); COPA (see 1 fusions); STAU1 (see 2 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLC25A11parental protein480.0571862.400Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
2 AATKinteractor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
3 ACTBL2interactor21.0000Actin (PF00022, IPR004000, SM00268): Actin
4 ADRB2interactor50.6672.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 BABAM1interactor21.0000VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
6 BMI1oncoprotein60.6003.000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
7 CAMKK2oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
8 CEBPAsuppressor31.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
9 CLN3interactor21.0000CLN3 (PF02487, IPR003492): CLN3 protein
10 CLN5interactor21.0000CLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
11 COPAprotein found in more fusions70.4676.233Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
12 COQ9interactor200COQ9 (PF08511, IPR013718): COQ9
13 ECT2suppressor30.6670.500BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
14 FBXO46interactor100BTK (PF00779, IPR001562, SM00107): BTK motif
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
CHORD (PF04968, IPR007051): CHORD
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
F-box-like (PF12937, IPR001810): F-box-like
15 FBXO6interactor50.5004.167FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
16 FBXW4oncoprotein100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
F-box_4 (PF15966, IPR001810): F-box
17 FLOT1interactor30.6670.667CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
18 FYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
19 HDAC5protein found in more fusions50.6671.333Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
20 KRBOX4interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
21 MCM2oncoprotein80.38111.500AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
22 MDC1suppressor50.5004.333FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
23 MMS19interactor50.6002.733DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
24 MRPL58interactor50.5004.000RF-1 (PF00472, IPR000352): RF-1 domain
25 MYConcoprotein70.4008.167HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
26 NDUFA4interactor70.5336.333B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
27 NF2suppressor31.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
28 NTRK1oncoprotein120.32731.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
29 OTUB1interactor70.4769.067Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
30 POTEIinteractor100Actin (PF00022, IPR004000, SM00268): Actin
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
DUF3641 (PF12345, IPR024521): Protein of unknown function (DUF3641)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
31 PPP1R1Aoncoprotein100DARPP-32 (PF05395, IPR008466): Protein phosphatase inhibitor 1/DARPP-32
32 PRG2interactor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
33 PRKCAinteractor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
34 RAPGEF2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
35 RNF2interactor100.36119.500zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
36 SMAP2interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Spore-coat_CotD (PF11122, IPR020108): Inner spore coat protein D
37 STAU1protein found in more fusions80.38111.500dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
38 SUZ12suppressor41.0000DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
39 TEPSINinteractor100ENTH (PF01417, IPR001026, SM00273): ENTH domain
40 UBL4Ainteractor31.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
41 UPF3Binteractor21.0000HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family
TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
DUF2098 (PF09871, IPR019209): Uncharacterized protein conserved in archaea (DUF2098)
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
42 VDAC1interactor80.5009.833Porin_3 (PF01459, IPR027246): Eukaryotic porin
43 VDAC2interactor100.35624.167Porin_3 (PF01459, IPR027246): Eukaryotic porin
44 VDAC3interactor80.50010.567Porin_3 (PF01459, IPR027246): Eukaryotic porin
45 WDR45interactor100CNH (PF00780, IPR001180, SM00036): CNH domain
DUF1736 (PF08409, IPR013618): Domain of unknown function (DUF1736)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
46 YES1oncoprotein40.5002.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
47 YTHDF1interactor40.6671.333YTH (PF04146, IPR007275): YT521-B-like domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
48 ZNF703interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
nlz1 (PF12402, IPR022129): NocA-like zinc-finger protein 1

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