Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SKI (from a repository: Sun Dec 4 09:16:53 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 120 The number (and %) of the onco-proteins 49 (40.83 %) The number (and %) of the tumor suppressors 21 (17.50 %) Total number of binary PPIs (saturation %) 682 (9.55 %) The number (and %) of affected PPIs 120 (17.60 %) The number of possible different fusions 34 PPI diameter 2 PPI radius 1 The average degree of PPI 10.583 Assortativity coefficient -0.3001 The network average Clustering coefficient 0.556 The number (and %) of a zero Clustering coefficients 10 (8.33 %) The number (and %) of a zero Betweenness Centrality 27 (22.50 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SKI	All fusions : AI949581;
Proteins found in more fusions	MERTK (see 1 fusions); RARA/PML (see 21 fusions); SMAD4 (see 2 fusions); SKI/LDHA (see 3 fusions); PRMT5 (see 2 fusions); TRIM28 (see 1 fusions); HIPK2 (see 1 fusions); PABPC1 (see 2 fusions); HSP90AB1 (see 1 fusions); COPB1 (see 2 fusions); AHNAK (see 2 fusions); SQSTM1 (see 5 fusions); NFIX (see 3 fusions); RNF111 (see 1 fusions); ACTB (see 3 fusions); PRKDC (see 3 fusions); PRDX1 (see 1 fusions); RANBP9 (see 2 fusions); RARA (see 4 fusions); RACK1 (see 3 fusions); SKI (see 1 fusions); SIAH2 (see 1 fusions); NLK (see 4 fusions); PYGB (see 1 fusions); PCNA (see 1 fusions); DDX5 (see 1 fusions); ATP5A1 (see 1 fusions); PML (see 4 fusions); NCL (see 3 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions); SNW1 (see 1 fusions); HSPA8/HSPD1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SKI	parental protein	120	0.073	9743.164	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
2	ACTB	oncoprotein	10	0.639	3.697	Actin (PF00022, IPR004000, SM00268): Actin
3	ACTBL2	interactor	2	1.000	0	Actin (PF00022, IPR004000, SM00268): Actin
4	AGRN	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain Laminin_G_1 (PF00054, IPR001791): Laminin G domain NtA (PF03146, IPR004850): Agrin NtA domain SEA (PF01390, IPR000082, SM00200): SEA domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain hEGF (PF12661, IPR013032): Human growth factor-like EGF EGF_3 (PF12947, IPR024731): EGF domain
5	AHNAK	suppressor	6	0.500	1.136	DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945) ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993) DUF4097 (PF13349, IPR025164): Putative adhesin Ntox37 (PF15535, IPR029108): Bacterial toxin 37
6	AKT1	oncoprotein	20	0.310	67.494	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
7	AKT2	oncoprotein	3	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8	ATP1A1	interactor	5	0.600	2.167	Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase Tetraspannin (PF00335, IPR018499): Tetraspanin family Cation_ATPase (PF13246): Cation transport ATPase (P-type)
9	ATP2A2	interactor	1	0	0	Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase HAD (PF12710): haloacid dehalogenase-like hydrolase Cation_ATPase (PF13246): Cation transport ATPase (P-type)
10	ATP5A1	protein found in more fusions	12	0.491	15.248	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
11	ATP5B	interactor	10	0.511	12.164	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain NACHT (PF05729): NACHT domain
12	ATP5O	interactor	4	1.000	0	OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
13	AXIN1	suppressor	6	0.800	0.429	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
14	CAD	oncoprotein	13	0.359	29.184	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain GATase (PF00117, IPR017926): Glutamine amidotransferase class-I MGS (PF02142, IPR011607, SM00851): MGS-like domain OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
15	CCT3	interactor	10	0.444	14.119	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16	COPB1	protein found in more fusions	6	0.600	2.556	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform
17	DCAF7	interactor	10	0.444	18.267	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
18	DDX5	oncoprotein	13	0.530	15.041	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
19	DIAPH1	interactor	4	0.667	1.286	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Drf_DAD (PF06345, IPR010465): DRF Autoregulatory Domain Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1 Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain Glucan_synthase (PF02364, IPR003440): 1,3-beta-glucan synthase component Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
20	DYNC1H1	interactor	6	0.400	5.317	AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily) DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1 DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1 AAA_7 (PF12775): P-loop containing dynein motor region D3 MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4 AAA_9 (PF12781): ATP-binding dynein motor region D5
21	DYRK1B	oncoprotein	6	0.600	1.900	Pkinase (PF00069, IPR000719): Protein kinase domain
22	EPPK1	interactor	4	0.500	1.000	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HupF_HypC (PF01455, IPR001109): HupF/HypC family Plectin (PF00681, IPR001101, SM00250): Plectin repeat RPA_interact_N (PF14766, IPR028158): Replication protein A interacting N-terminal
23	ESR1	suppressor	42	0.235	392.778	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
24	EYA3	interactor	1	0	0	NA
25	GATA1	oncoprotein	5	0.800	0.786	GATA (PF00320, IPR000679, SM00401): GATA zinc finger Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
26	GLI2	oncoprotein	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
27	GLI3	oncoprotein	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
28	HADHA	interactor	3	1.000	0	3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
29	HADHB	interactor	7	0.524	7.389	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
30	HDAC3	suppressor	20	0.322	66.074	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
31	HIPK2	suppressor	16	0.400	40.648	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
32	HNRNPM	interactor	15	0.562	22.361	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
33	HSP90AB1	oncoprotein	23	0.312	90.766	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
34	HSPA1L	interactor	7	0.714	2.452	HSP70 (PF00012, IPR013126): Hsp70 protein
35	HSPA5	oncoprotein	20	0.368	54.805	HSP70 (PF00012, IPR013126): Hsp70 protein
36	HSPA6	interactor	5	0.900	0.400	HSP70 (PF00012, IPR013126): Hsp70 protein
37	HSPA8	oncoprotein	19	0.427	44.187	HSP70 (PF00012, IPR013126): Hsp70 protein
38	HSPA9	oncoprotein	9	0.417	10.112	HSP70 (PF00012, IPR013126): Hsp70 protein
39	HSPD1	suppressor	8	0.679	2.167	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
40	HSPG2	oncoprotein	1	0	0	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain EGF (PF00008, IPR000742, SM00181): EGF-like domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Laminin_B (PF00052, IPR000034): Laminin B (Domain IV) Laminin_G_1 (PF00054, IPR001791): Laminin G domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A hEGF (PF12661, IPR013032): Human growth factor-like EGF Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
41	ITGB4	oncoprotein	4	0.667	1.000	Calx-beta (PF03160, IPR003644, SM00237): Calx-beta domain EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain SEA (PF01390, IPR000082, SM00200): SEA domain STOP (PF05217, IPR024963): STOP protein Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain
42	JUN	oncoprotein	18	0.412	37.236	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
43	LATS2	suppressor	9	0.393	13.900	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
44	LDHA	protein found in more fusions	8	0.381	7.233	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
45	LTBR	oncoprotein	2	0	0	Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
46	MECP2	interactor	5	0.600	1.619	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
47	MERTK	oncoprotein	2	0	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain
48	MOB1A	suppressor	6	0.667	3.333	Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
49	MOB1B	suppressor	6	0.667	3.333	Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
50	MVP	oncoprotein	8	0.619	3.071	Vault (PF01505, IPR002499): Major Vault Protein repeat DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543) MVP_shoulder (PF11978, IPR021870): Shoulder domain
51	MYB	oncoprotein	10	0.467	12.200	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
52	NCL	protein found in more fusions	13	0.621	14.789	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
53	NCOR1	oncoprotein	19	0.409	55.149	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
54	NFIX	oncoprotein	5	0.833	0.333	CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus MH1 (PF03165, IPR003619, SM00523): MH1 domain
55	NLK	protein found in more fusions	6	0.600	1.283	Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
56	PABPC1	oncoprotein	16	0.629	13.853	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
57	PABPC4	interactor	4	0.500	2.333	ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
58	PCNA	oncoprotein	5	0.667	0.833	PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
59	PFKP	interactor	2	1.000	0	PFK (PF00365, IPR000023): Phosphofructokinase Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
60	PLEC	oncoprotein	4	0.500	1.100	CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family FUSC (PF04632, IPR006726): Fusaric acid resistance protein family RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25 S10_plectin (PF03501, IPR005326): Plectin/S10 domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229) Plectin (PF00681, IPR001101, SM00250): Plectin repeat YlqD (PF11068, IPR021297): YlqD protein Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
61	PML	suppressor	22	0.390	68.576	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
62	PPM1B	interactor	2	1.000	0	PP2C (PF00481, IPR001932): Protein phosphatase 2C PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
63	PRDM16	oncoprotein	3	1.000	0	SET (PF00856, IPR001214, SM00317): SET domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
64	PRDX1	oncoprotein	3	1.000	0	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
65	PRKDC	protein found in more fusions	16	0.448	36.048	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
66	PRMT5	protein found in more fusions	6	0.600	2.800	PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
67	PYGB	protein found in more fusions	2	0	0	Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
68	RACK1	suppressor	12	0.564	12.282	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
69	RANBP9	suppressor	13	0.424	26.065	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator LisH (PF08513, IPR013720, SM00667): LisH SPRY (PF00622, IPR003877, SM00449): SPRY domain CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
70	RARA	oncoprotein	11	0.533	8.536	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
71	RB1	suppressor	13	0.423	25.010	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
72	RB1CC1	suppressor	4	0.667	0.429	Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II DHC (PF09626, IPR018588): Dihaem cytochrome c DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) ATG11 (PF10377, IPR019460): Autophagy-related protein 11 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Jag_N (PF14804, IPR032782): Jag N-terminus NPBW (PF15180, IPR013297): Neuropeptides B and W HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
73	RNF111	suppressor	9	0.607	4.448	zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
74	RPL12	interactor	14	0.802	5.832	Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
75	RPL14	interactor	17	0.699	12.974	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14 UPF0688 (PF15772, IPR031530): UPF0688 family
76	RPL18	interactor	19	0.561	42.906	Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
77	RPL30	interactor	11	0.964	0.400	NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
78	RPL4	interactor	18	0.614	26.581	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
79	RPLP0	interactor	17	0.691	12.487	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
80	RPS16	interactor	19	0.602	25.450	Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
81	RPS3	interactor	18	0.542	32.472	KH_2 (PF07650, IPR004044): KH domain Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
82	RPS4X	interactor	17	0.713	11.081	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain S4 (PF01479, IPR002942, SM00363): S4 domain 40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
83	SAV1	oncoprotein	5	0.800	1.333	WW (PF00397, IPR001202, SM00456): WW domain
84	SIAH2	oncoprotein	6	0.800	0.848	Sina (PF03145, IPR018121): Seven in absentia protein family zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
85	SIN3A	oncoprotein	13	0.474	21.213	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
86	SIRT1	suppressor	18	0.412	41.410	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
87	SIX1	oncoprotein	1	0	0	KilA-N (PF04383, IPR018004): KilA-N domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
88	SKIL	suppressor	18	0.419	38.324	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
89	SLC25A13	interactor	1	0	0	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
90	SLC25A4	interactor	2	1.000	0	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
91	SLC25A5	interactor	10	0.711	10.200	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
92	SLC25A6	interactor	2	1.000	0	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
93	SMAD1	interactor	10	0.611	9.412	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
94	SMAD2	suppressor	26	0.263	144.644	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
95	SMAD3	oncoprotein	29	0.278	163.415	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
96	SMAD4	suppressor	15	0.429	29.397	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
97	SMAD5	interactor	5	1.000	0	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
98	SNW1	protein found in more fusions	33	0.198	258.737	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
99	SPI1	suppressor	9	0.556	8.533	Ets (PF00178, IPR000418, SM00413): Ets-domain p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
100	SQRDL	interactor	3	1.000	0	Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
101	SQSTM1	oncoprotein	12	0.382	22.133	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
102	STK38	interactor	4	1.000	0	MEKHLA (PF08670, IPR013978): MEKHLA domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
103	STK38L	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
104	TBL1XR1	oncoprotein	6	0.800	0.915	LisH (PF08513, IPR013720, SM00667): LisH WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
105	TCP1	interactor	11	0.491	12.438	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
106	TEAD1	interactor	2	1.000	0	TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
107	TEAD4	interactor	3	0.667	1.000	TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
108	TGFBR1	oncoprotein	6	0.867	0.733	Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain Pkinase (PF00069, IPR000719): Protein kinase domain TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
109	TP53	suppressor	56	0.186	853.716	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
110	TRIM28	protein found in more fusions	10	0.611	5.606	ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PHD (PF00628, IPR019787, SM00249): PHD-finger FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
111	TUBA1A	oncoprotein	13	0.462	24.162	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
112	TUBA1B	interactor	9	0.417	11.352	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
113	TUBA4A	interactor	9	0.611	6.994	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
114	TUBB	interactor	12	0.576	11.889	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
115	TUBB2A	interactor	9	0.500	10.550	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
116	TUBB6	interactor	7	0.429	8.833	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
117	TUFM	interactor	8	0.464	10.367	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
118	UBE2I	interactor	21	0.374	59.038	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
119	UQCRC2	oncoprotein	14	0.275	46.733	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
120	WDR26	interactor	2	1.000	0	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1

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