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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins20 (31.25 %)
The number (and %) of the tumor suppressors20 (31.25 %)
Total number of binary PPIs (saturation %)209 (10.37 %)
The number (and %) of affected PPIs64 (30.62 %)
The number of possible different fusions22
PPI diameter2
PPI radius1
The average degree of PPI5.344
Assortativity coefficient-0.4435
The network average Clustering coefficient0.644
The number (and %) of a zero Clustering coefficients7 (10.94 %)
The number (and %) of a zero Betweenness Centrality27 (42.19 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SIAH2 All fusions
Proteins found in more fusions AFF1 (see 2 fusions); KAT5 (see 3 fusions); STAT3 (see 2 fusions); UBE2D2 (see 2 fusions); SIAH2 (see 1 fusions); ATN1 (see 1 fusions); SETD2 (see 2 fusions); UBE2L6 (see 2 fusions); KAT2B (see 1 fusions); SIAH1 (see 4 fusions); SH3RF1 (see 1 fusions); PML (see 4 fusions); PIAS1 (see 2 fusions); RBBP8 (see 1 fusions); SNCAIP (see 1 fusions); EGLN1 (see 1 fusions); EEF1D (see 3 fusions); MCM2 (see 1 fusions); SKI (see 1 fusions); PIAS2 (see 2 fusions); HIPK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SIAH2parental protein640.0553018.169Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
2 AFF1oncoprotein31.0000AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
3 AKAP1interactor100TUDOR (PF00567, IPR002999, SM00333): Tudor domain
RII_binding_1 (PF10522, IPR018459): RII binding domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
4 AKR1C3oncoprotein100Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
5 ARoncoprotein120.38223.167Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
6 ATN1protein found in more fusions31.0000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
7 CCBE1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
8 CEBPDsuppressor30.6670.333bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
9 CHEK2suppressor40.6670.667FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
10 DCCsuppressor30.6670.250fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
11 DLDinteractor40.5003.000Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
12 DLSToncoprotein40.5003.0002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
13 DYRK2interactor30.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
14 EAF2suppressor100Paf1 (PF03985, IPR007133): Paf1
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
15 EEF1Dprotein found in more fusions50.6672.000EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
16 EGLN1suppressor41.0000zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
17 EGLN2interactor41.00002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
18 EGLN3suppressor50.8330.6672OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
19 HDAC3suppressor100.41716.786Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
20 HIPK2suppressor70.6674.500Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
21 HIPK3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
22 KAT2Bprotein found in more fusions70.4008.067Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
23 KAT5suppressor80.6673.286MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
24 MCM2oncoprotein80.5715.733AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
25 MYD88oncoprotein31.0000Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
26 NFE2L2oncoprotein21.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
27 OPRD1interactor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
28 OPRK1interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
29 OPRM1interactor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4231 (PF14015, IPR025325): Protein of unknown function (DUF4231)
DMRT-like (PF15791, IPR031577): Doublesex-and mab-3-related transcription factor C1 and C2
30 PEG10oncoprotein21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
Asp_protease_2 (PF13650): Aspartyl protease
zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
PRIMA1 (PF16101): Proline-rich membrane anchor 1
DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
31 PEG3suppressor40.6670.500C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Fer4_10 (PF13237, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-Mss51 (PF13824, IPR032717): Zinc-finger of mitochondrial splicing suppressor 51
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
32 PIAS1suppressor80.6675.036Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
33 PIAS2protein found in more fusions80.6675.036SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
34 PIAS3oncoprotein50.8000.583SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
35 PLCE1suppressor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
36 PMLsuppressor120.47319.733zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
37 PPP1CConcoprotein50.4005.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
38 PPP1R12Ainteractor100DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
39 PPP1R13Binteractor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
IncA (PF04156, IPR007285): IncA protein
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
40 PSMD4interactor21.0000UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
41 RBBP8suppressor31.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
42 SETD2suppressor200DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
SET (PF00856, IPR001214, SM00317): SET domain
SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
WW (PF00397, IPR001202, SM00456): WW domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
43 SH3RF1protein found in more fusions50.8330.400zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
44 SIAH1suppressor350.100485.067Sina (PF03145, IPR018121): Seven in absentia protein family
45 SKIoncoprotein60.8001.000c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
46 SNCAinteractor41.0000Synuclein (PF01387, IPR001058): Synuclein
47 SNCAIPprotein found in more fusions50.6671.500Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
48 SPRY2suppressor70.4677.333KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
49 STAT3suppressor80.6673.269SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
50 TINF2interactor31.0000TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
51 TNK2interactor50.6670.650CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
52 TP53BP2suppressor30.6670.500ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
53 TPX2interactor100Aurora-A_bind (PF09041, IPR015128): Aurora-A binding
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259)
TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
54 TRAF2interactor60.4004.667MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
55 TYK2interactor40.6670.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
56 UBE2D1interactor90.39314.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
57 UBE2D2oncoprotein70.6005.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
58 UBE2D3interactor60.6002.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
59 UBE2Iinteractor140.38534.269UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
60 UBE2L6protein found in more fusions50.6671.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
61 USP13interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
62 USP19interactor21.0000CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
63 VAV1oncoprotein30.6670.667PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
64 XAF1suppressor21.0000Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65

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