Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SIAH1 (from a repository: Wed Nov 16 13:23:06 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)158
The number (and %) of the onco-proteins45 (28.48 %)
The number (and %) of the tumor suppressors20 (12.66 %)
Total number of binary PPIs (saturation %)533 (4.30 %)
The number (and %) of affected PPIs158 (29.64 %)
The number of possible different fusions37
PPI diameter2
PPI radius1
The average degree of PPI5.810
Assortativity coefficient-0.4055
The network average Clustering coefficient0.487
The number (and %) of a zero Clustering coefficients36 (22.78 %)
The number (and %) of a zero Betweenness Centrality73 (46.20 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

Proteins found in more fusions AFF1 (see 1 fusions); RARA/PML (see 20 fusions); PUF60 (see 2 fusions); PKD1 (see 1 fusions); HIPK2 (see 1 fusions); NPM1 (see 1 fusions); BCL6 (see 2 fusions); SIAH1 (see 1 fusions); RBBP8 (see 1 fusions); UBE2N (see 1 fusions); EEF1D (see 3 fusions); PIAS2 (see 2 fusions); RUNX1 (see 1 fusions); STAT3 (see 2 fusions); UBE2D2 (see 2 fusions); UBE2L6 (see 2 fusions); SH3RF1 (see 1 fusions); UBE2E2 (see 1 fusions); HIF1AN (see 1 fusions); RARA/NPM1 (see 1 fusions); PIAS1 (see 2 fusions); SNCAIP (see 1 fusions); RARA (see 4 fusions); MCM2 (see 1 fusions); APC (see 1 fusions); HTT (see 1 fusions); COPS5 (see 1 fusions); SIAH2 (see 1 fusions); ATN1 (see 1 fusions); PFKM (see 1 fusions); PYGB (see 1 fusions); MAP3K5 (see 1 fusions); PML (see 4 fusions); TBL1X (see 2 fusions); PSMC5 (see 2 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SIAH1parental protein1580.02521774.521Sina (PF03145, IPR018121): Seven in absentia protein family
2 AASDHPPTinteractor21.0000ACPS (PF01648, IPR008278): 4'-phosphopantetheinyl transferase superfamily
3 AFF1oncoprotein60.5004.400AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
4 AFF4oncoprotein31.0000AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
5 APCsuppressor60.6003.000APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
6 AQP1interactor40.6671.000MIP (PF00230, IPR000425): Major intrinsic protein
7 ARMC9interactor100CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
AP3D1 (PF06375): AP-3 complex subunit delta-1
8 ATN1protein found in more fusions60.4004.000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
9 ATXN7interactor80.46412.067DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
10 BAG1oncoprotein60.4008.333BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
11 BCL6oncoprotein60.5004.667BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
12 C14orf105interactor21.0000DUF4619 (PF15398, IPR029235): Domain of unknown function (DUF4619)
13 CACYBPinteractor60.6003.000CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
14 CAPGsuppressor100Gelsolin (PF00626, IPR007123): Gelsolin repeat
15 CDC23interactor31.0000ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
16 CDC34oncoprotein40.6671.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
17 CDK5R1oncoprotein21.0000CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
18 COPS5protein found in more fusions140.21852.833JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
19 CTNNB1oncoprotein140.23163.417Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
20 DAB1interactor50.6003.667PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
21 DCCsuppressor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
22 DDX41interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
zf-CCHC (PF00098, IPR001878): Zinc knuckle
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 DLDinteractor21.0000Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
24 DNAJC15interactor200DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF3918 (PF13056, IPR025029): Protein of unknown function (DUF3918)
25 DNALI1interactor31.0000Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
26 EEF1Dprotein found in more fusions70.4674.741EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
27 ELL2interactor31.0000Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
28 EXOC3-AS1interactor21.0000NA
29 FAM90A1interactor21.0000zf-CCHC_6 (PF15288): Zinc knuckle
30 FLI1oncoprotein41.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
31 FLT3suppressor31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
32 FZD9interactor100Frizzled (PF01534, IPR000539): Frizzled/Smoothened family membrane region
Fz (PF01392, IPR020067, SM00063): Fz domain
33 GAPDHoncoprotein100.38917.250Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
34 GDPD5interactor100DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
MgtE (PF01769, IPR006667): Divalent cation transporter
GDPD_2 (PF13653): Glycerophosphoryl diester phosphodiesterase family
35 GRM5interactor1007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
36 HERPUD1oncoprotein50.5004.333Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
37 HIF1ANprotein found in more fusions200Cupin_8 (PF13621): Cupin-like domain
38 HIPK1interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
39 HIPK2suppressor60.8001.167Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
40 HIPK3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
41 HIST4H4interactor40.5001.139CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
42 HTTprotein found in more fusions100.27820.667HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
43 INHAoncoprotein100TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
44 JSRP1interactor100SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
JSRP (PF15312, IPR026178): Junctional sarcoplasmic reticulum protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
45 KATNAL1interactor200AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_24 (PF13479): AAA domain
46 KCNJ10interactor21.0000IRK (PF01007, IPR016449): Inward rectifier potassium channel
47 KHDRBS3interactor31.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
48 KIAA0319Linteractor100EGF_2 (PF07974, IPR013111): EGF-like domain
PKD (PF00801, IPR000601, SM00089): PKD domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
Fungus-induced (PF10917, IPR024415): Fungus-induced protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
DUF4625 (PF15418, IPR027829): Domain of unknown function (DUF4625)
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
49 KIAA1217interactor100AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
50 KIAA1683interactor30.6670.500IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
51 KIF1Bsuppressor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
KIF1B (PF12423, IPR022140): Kinesin protein 1B
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
DUF3694 (PF12473, IPR022164): Kinesin protein
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
52 KIF22interactor100Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
53 KIFC3oncoprotein60.5004.000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
54 KLF10suppressor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
AAA_33 (PF13671): AAA domain
55 LACTB2interactor100E2_bind (PF08825, IPR014929): E2 binding domain
Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
56 LATS2suppressor80.42910.167Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
57 MAB21L1interactor100Mab-21 (PF03281, IPR024810): Mab-21 protein
58 MAP3K5oncoprotein50.6671.167Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
59 MAPK12oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
Peripla_BP_5 (PF13433): Periplasmic binding protein domain
60 MAPKBP1interactor21.0000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
61 MAPRE3interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
62 MCM2oncoprotein180.22178.372AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
63 MOB3Cinteractor21.0000Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
64 MTIF3interactor100IF3_C (PF00707, IPR019815): Translation initiation factor IF-3, C-terminal domain
IF3_N (PF05198, IPR019814): Translation initiation factor IF-3, N-terminal domain
65 MX1interactor41.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
66 MYD88oncoprotein40.6670.500Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
67 NECTIN2interactor200C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
68 NELFAinteractor100CathepsinC_exc (PF08773, IPR014882): Cathepsin C exclusion domain
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
69 NOL6interactor40.5001.500Nrap (PF03813, IPR005554): Nrap protein
70 NPM1suppressor140.29545.417Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
71 NUMBsuppressor21.0000NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
72 NUMBLinteractor100DUF1932 (PF09130, IPR015814): Domain of unknown function (DUF1932)
NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
73 OPRD1interactor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
74 OPRK1interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
75 OPRM1interactor40.6671.6677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4231 (PF14015, IPR025325): Protein of unknown function (DUF4231)
DMRT-like (PF15791, IPR031577): Doublesex-and mab-3-related transcription factor C1 and C2
76 OTUB2interactor50.5003.250Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
77 PARD3interactor40.8330.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
78 PEG10oncoprotein60.3338.952CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
Asp_protease_2 (PF13650): Aspartyl protease
zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
PRIMA1 (PF16101): Proline-rich membrane anchor 1
DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
79 PEG3suppressor31.0000C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Fer4_10 (PF13237, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-Mss51 (PF13824, IPR032717): Zinc-finger of mitochondrial splicing suppressor 51
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
80 PFKMprotein found in more fusions200PFK (PF00365, IPR000023): Phosphofructokinase
81 PHC1interactor60.6003.000GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
FSA_C (PF10479, IPR018863): Fragile site-associated protein C-terminus
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
82 PHC2interactor90.28615.389SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
83 PIAS1suppressor130.42424.167Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
84 PIAS2protein found in more fusions100.6117.433SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
85 PIAS3oncoprotein60.5333.450SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
86 PKD1suppressor31.0000Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
PKD (PF00801, IPR000601, SM00089): PKD domain
PKD_channel (PF08016, IPR013122): Polycystin cation channel
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
REJ (PF02010, IPR002859): REJ domain
WSC (PF01822, IPR002889, SM00321): WSC domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
87 PLCE1suppressor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
88 PMLsuppressor150.34146.667zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
89 POU2AF1oncoprotein100PD-C2-AF1 (PF09310, IPR015389): POU domain, class 2, associating factor 1
90 PRPF31interactor80.28612.667Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
91 PRR20Ainteractor41.0000PRR20 (PF15708, IPR031439): Proline-rich protein family 20
92 PSMC5protein found in more fusions80.38111.000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
93 PSMC6interactor50.6671.667AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
94 PTPMT1interactor40.6670.667DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
95 PUF60protein found in more fusions80.28612.417RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
96 PYGBprotein found in more fusions41.0000Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
97 QRICH1interactor31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
98 RAB33Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
99 RAD51AP1interactor100RAD51_interact (PF15696, IPR031419): RAD51 interacting motif
100 RAD54L2interactor40.6671.000SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
101 RAPH1oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
FAM76 (PF16046, IPR032017): FAM76 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
102 RARAoncoprotein70.5335.833zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
103 RBBP8suppressor40.6671.000ZapB (PF06005, IPR009252): Cell division protein ZapB
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
104 RLIMinteractor80.3335.972DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
105 RNF2interactor210.153130.972zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
106 RPL27Ainteractor50.6001.639Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
107 RPS19BP1interactor21.0000AROS (PF15684, IPR023262): Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
108 RUNX1suppressor70.4676.833Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
109 SDCBPinteractor80.25019.167PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
110 SEPT4suppressor30.6671.000Septin (PF00735, IPR000038): Septin
111 SH3RF1protein found in more fusions70.4675.682zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
112 SIAH2oncoprotein350.100471.434Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
113 SNCAinteractor70.4677.000Synuclein (PF01387, IPR001058): Synuclein
114 SNCAIPprotein found in more fusions50.8330.500Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
115 SPATA4interactor100CH_2 (PF06294, IPR010441): CH-like domain in sperm protein
116 SPATC1Linteractor30.6670.333Speriolin_N (PF15058, IPR029385): Speriolin N terminus
Speriolin_C (PF15059, IPR029384): Speriolin C-terminus
117 STAT3suppressor60.6002.567SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
118 SYPinteractor100MARVEL (PF01284, IPR008253): Membrane-associating domain
119 SYT7interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
SCIMP (PF15050, IPR028181): SCIMP protein
120 TBC1D22Binteractor40.6671.000RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF4502 (PF14950, IPR028026): Domain of unknown function (DUF4502)
121 TBL1Xprotein found in more fusions80.4299.286K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
122 TERF2interactor60.5004.000Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
123 TFDP1oncoprotein30.6670.500DP (PF08781, IPR014889, SM01138): Transcription factor DP
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
124 TMEM43interactor100TMEM43 (PF07787, IPR012430): Transmembrane protein 43
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
125 TNK2interactor40.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
126 TOLLIPinteractor90.35716.619C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
127 TP53BP2suppressor80.28616.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
128 TRIB3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
129 TRIM23interactor160.26759.368Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
130 TRIM27oncoprotein340.121402.558IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
131 TRIM7oncoprotein50.6670.382IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
TMPIT (PF07851, IPR012926): TMPIT-like protein
YojJ (PF10372, IPR019457): Bacterial membrane-spanning protein N-terminus
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
132 TRIM8interactor100.38910.539dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
133 TXNoncoprotein90.44416.083Thioredoxin (PF00085, IPR013766): Thioredoxin
134 UBE2D1interactor150.31934.746UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
135 UBE2D2oncoprotein160.34342.698UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
136 UBE2D3interactor120.27316.913UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
137 UBE2D4interactor80.3814.075UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
138 UBE2E2protein found in more fusions70.4672.469UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
139 UBE2E3interactor60.5002.900UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
140 UBE2Iinteractor260.187206.519UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
141 UBE2Kinteractor80.5009.067UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
142 UBE2L6protein found in more fusions90.32112.436UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
143 UBE2Nprotein found in more fusions80.4298.367UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
144 UBE2V2interactor40.6670.750UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
145 UPP2interactor200PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
146 USP19interactor50.4003.155CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
147 UXTinteractor21.0000Prefoldin (PF02996, IPR004127): Prefoldin subunit
148 VAV1oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
149 WDYHV1interactor60.4676.867Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
150 XIAPinteractor160.21956.891BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
151 ZBP1interactor100z-alpha (PF02295, IPR000607, SM00550): Adenosine deaminase z-alpha domain
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
152 ZCCHC10interactor30.6671.000Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-CCHC_3 (PF13917): Zinc knuckle
153 ZCCHC13interactor100DUF1815 (PF08844, IPR014943): Domain of unknown function (DUF1815)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
154 ZFYVE21interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
ZFYVE21_C (PF16696, IPR032031): Zinc finger FYVE domain-containing protein 21 C-terminus
155 ZMAT3interactor100zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-met (PF12874): Zinc-finger of C2H2 type
156 ZNF148interactor100DUF680 (PF05079, IPR007771): Protein of unknown function (DUF680)
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
157 ZNF512Binteractor30.6671.000YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger
158 ZNF671interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

B a c k    t o    T o p ⇑


List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AASDHPPTinteractorACPS (PF01648, IPR008278): 4'-phosphopantetheinyl transferase superfamilyAW390258
2 AQP1interactorMIP (PF00230, IPR000425): Major intrinsic proteinAW390258
3 ATN1interactorAtrophin-1 (PF03154, IPR002951): Atrophin-1 familyAW390258
4 C14orf105interactorDUF4619 (PF15398, IPR029235): Domain of unknown function (DUF4619)AW390258
5 CAPGsuppressorGelsolin (PF00626, IPR007123): Gelsolin repeatAW390258
6 COPS5interactorJAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin proteaseAW390258
7 DNALI1interactorAx_dynein_light (PF10211, IPR019347): Axonemal dynein light chainAW390258
8 EXOC3-AS1interactorNAAW390258
9 HIF1ANinteractorCupin_8 (PF13621): Cupin-like domainAW390258
10 HIPK1interactorPkinase (PF00069, IPR000719): Protein kinase domainAW390258
11 HIPK3interactorPkinase (PF00069, IPR000719): Protein kinase domainAW390258
12 KCNJ10interactorIRK (PF01007, IPR016449): Inward rectifier potassium channelAW390258
13 KIAA1683interactorIQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motifAW390258
14 MAB21L1interactorMab-21 (PF03281, IPR024810): Mab-21 proteinAW390258
15 MOB3CinteractorMob1_phocein (PF03637, IPR005301): Mob1/phocein familyAW390258
16 OPRD1interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)AW390258
17 OPRK1interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)AW390258
18 OTUB2interactorPeptidase_C65 (PF10275, IPR019400): Peptidase C65 OtubainAW390258
19 PRR20AinteractorPRR20 (PF15708, IPR031439): Proline-rich protein family 20AW390258
20 PTPMT1interactorDSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domainAW390258
21 RAB33AoncoproteinRas (PF00071, IPR001806, SM00173): Ras familyAW390258
22 RPL27AinteractorRibosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27AAW390258
23 RPS19BP1interactorAROS (PF15684, IPR023262): Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1AW390258
24 SDCBPinteractorPDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)AW390258
25 SIAH1parental proteinSina (PF03145, IPR018121): Seven in absentia protein familyAW390258
26 SYPinteractorMARVEL (PF01284, IPR008253): Membrane-associating domainAW390258
27 TRIB3interactorPkinase (PF00069, IPR000719): Protein kinase domainAW390258
28 TXNoncoproteinThioredoxin (PF00085, IPR013766): ThioredoxinAW390258
29 UXTinteractorPrefoldin (PF02996, IPR004127): Prefoldin subunitAW390258

B a c k    t o    T o p ⇑