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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SHQ1 (from a repository: Sun Jul 7 07:23:47 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins2 (20.00 %)
The number (and %) of the tumor suppressors1 (10.00 %)
Total number of binary PPIs (saturation %)24 (53.33 %)
The number (and %) of affected PPIs10 (41.67 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.800
Assortativity coefficient-0.1205
The network average Clustering coefficient0.738
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality3 (30.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SHQ1 All fusions
Proteins found in more fusions DKC1 (see 2 fusions); SHQ1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SHQ1parental protein100.27842.667SHQ1 (PF04925, IPR007009): SHQ1 protein
2 DKC1oncoprotein60.6003.667DKCLD (PF08068, IPR012960, SM01136): DKCLD (NUC011) domain
PUA (PF01472, IPR002478, SM00359): PUA domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
3 ELAVL1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 EXOSC4interactor31.0000RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
5 GAR1interactor30.6671.000Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
6 GMCL1interactor40.6671.000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
7 GMCL1P1interactor21.0000NA
8 NAF1interactor40.8330.667AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
9 WDR48suppressor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
10 XPO1interactor40.6672.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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