Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SH3GL2 (from a repository: Tue Nov 15 22:02:21 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 58 The number (and %) of the onco-proteins 14 (24.14 %) The number (and %) of the tumor suppressors 4 (6.90 %) Total number of binary PPIs (saturation %) 165 (9.98 %) The number (and %) of affected PPIs 58 (35.15 %) The number of possible different fusions 10 PPI diameter 2 PPI radius 1 The average degree of PPI 4.966 Assortativity coefficient -0.4454 The network average Clustering coefficient 0.535 The number (and %) of a zero Clustering coefficients 15 (25.86 %) The number (and %) of a zero Betweenness Centrality 33 (56.90 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SH3GL2	All fusions : BF934809;
Proteins found in more fusions	CD2AP (see 1 fusions); APP (see 4 fusions); LRRK2 (see 1 fusions); SH3KBP1 (see 1 fusions); ACTG1 (see 4 fusions); EGFR (see 2 fusions); CBL (see 1 fusions); SH3GL2 (see 1 fusions); F13A1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SH3GL2	parental protein	58	0.055	2668.467	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain
2	ACTG1	protein found in more fusions	3	1.000	0	Actin (PF00022, IPR004000, SM00268): Actin
3	ADAM15	interactor	1	0	0	CD20 (PF04103, IPR007237): CD20-like family Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
4	ADAM19	interactor	1	0	0	Adeno_E3_CR2 (PF02439, IPR003470): Adenovirus E3 region protein CR2 EGF_2 (PF07974, IPR013111): EGF-like domain Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
5	ADAM9	oncoprotein	1	0	0	EB (PF01683, IPR006149): EB module Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
6	AMPH	oncoprotein	8	0.429	13.733	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
7	APP	protein found in more fusions	15	0.176	73.833	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8	ARHGAP8	interactor	3	1.000	0	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
9	ARNT2	interactor	2	1.000	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
10	ATXN2	interactor	4	1.000	0	LsmAD (PF06741, IPR009604): LsmAD domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Spt20 (PF12090, IPR021950): Spt20 family SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain
11	AZU1	interactor	2	1.000	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
12	CBL	suppressor	10	0.472	13.633	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
13	CD2AP	protein found in more fusions	7	0.800	1.133	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
14	CLEC3B	interactor	2	1.000	0	Chordopox_A33R (PF05966, IPR009238): Chordopoxvirus A33R protein Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
15	DACT1	suppressor	1	0	0	Dapper (PF15268, IPR024843): Dapper
16	DLGAP4	interactor	1	0	0	GKAP (PF03359, IPR005026): Guanylate-kinase-associated protein (GKAP) protein
17	DNM1	interactor	9	0.500	9.633	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
18	DNM2	interactor	10	0.422	20.633	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
19	DNM3	interactor	4	0.667	1.000	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
20	DPPA4	interactor	5	0.833	0.667	Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family DCR (PF14047, IPR025891): Dppa2/4 conserved region Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
21	DPYSL4	interactor	3	1.000	0	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
22	DYRK1A	oncoprotein	5	0.667	1.333	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X
23	EGFL6	oncoprotein	2	1.000	0	C_tripleX (PF02363, IPR003341): Cysteine rich repeat EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
24	EGFR	oncoprotein	16	0.305	60.700	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25	EMD	interactor	6	0.600	3.333	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
26	ERH	interactor	3	1.000	0	ER (PF01133, IPR000781): Enhancer of rudimentary
27	F13A1	protein found in more fusions	2	0	0	Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
28	GCH1	interactor	2	0	0	GTP_cyclohydroI (PF01227, IPR020602): GTP cyclohydrolase I
29	GSTM3	interactor	2	0	0	GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
30	HLA-DQA1	interactor	1	0	0	MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
31	IGHM	interactor	2	1.000	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
32	IL6	oncoprotein	1	0	0	IL6 (PF00489, IPR003573, SM00126): Interleukin-6/G-CSF/MGF family
33	IPO11	interactor	2	1.000	0	DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein HEAT_2 (PF13646): HEAT repeats
34	ITCH	interactor	7	0.600	3.333	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
35	ITSN1	interactor	10	0.528	10.500	C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain
36	LCP2	interactor	4	0.833	0.667	SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SDA1 (PF05285, IPR007949): SDA1 SH2 (PF00017, IPR000980, SM00252): SH2 domain
37	LRRK2	oncoprotein	7	0.400	7.000	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
38	MAST2	oncoprotein	2	1.000	0	DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain
39	PAXIP1	interactor	4	0.667	1.667	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
40	PDCD6IP	interactor	9	0.500	8.367	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
41	PPP1R21	interactor	1	0	0	TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein TTKRSYEDQ (PF10212, IPR019348): Predicted coiled-coil domain-containing protein
42	PPP6R1	interactor	2	1.000	0	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
43	PRR14	interactor	2	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
44	PTPN23	suppressor	4	0.667	1.000	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase SOGA (PF11365, IPR027881): Protein SOGA ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
45	SH3GL1	oncoprotein	11	0.289	26.567	BAR (PF03114, IPR004148, SM00721): BAR domain PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
46	SH3GL3	interactor	15	0.264	59.900	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain
47	SH3KBP1	protein found in more fusions	13	0.424	27.267	Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
48	SYNJ1	interactor	5	0.600	1.967	DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866) Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family Syja_N (PF02383, IPR002013): SacI homology domain YppG (PF14179, IPR025555): YppG-like protein
49	SYNM	suppressor	3	0.667	0.667	Filament (PF00038, IPR001664): Intermediate filament protein CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
50	TANGO2	interactor	1	0	0	TANGO2 (PF05742, IPR008551): Transport and Golgi organisation 2
51	TCEA2	interactor	2	1.000	0	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS) TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
52	TERF1	interactor	4	0.667	1.000	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
53	TIAM2	interactor	2	1.000	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PH (PF00169, IPR001849, SM00233): PH domain RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PH_6 (PF15406): Pleckstrin homology domain
54	TMEM108	interactor	1	0	0	TMEM108 (PF15759, IPR031508): TMEM108 family
55	TYMS	interactor	1	0	0	Thymidylat_synt (PF00303, IPR000398): Thymidylate synthase
56	ZNF219	interactor	2	1.000	0	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
57	ZNF580	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
58	ZXDC	interactor	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon

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