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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SH3BP4 (from a repository: Fri Nov 11 23:26:19 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins8 (23.53 %)
The number (and %) of the tumor suppressors3 (8.82 %)
Total number of binary PPIs (saturation %)69 (12.30 %)
The number (and %) of affected PPIs34 (49.28 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.235
Assortativity coefficient-0.5201
The network average Clustering coefficient0.301
The number (and %) of a zero Clustering coefficients18 (52.94 %)
The number (and %) of a zero Betweenness Centrality20 (58.82 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SH3BP4 All fusions
: AA493349;
Proteins found in more fusions SH3BP4 (see 2 fusions); MPHOSPH8 (see 5 fusions); EPS15 (see 1 fusions); MYC (see 1 fusions); YWHAG (see 1 fusions); TFRC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SH3BP4parental protein340.042976.333SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
2 ATP6AP2interactor31.0000Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
3 C2orf73interactor100GDWWSH (PF15667, IPR031365): Protein of unknown function with motif GDWWSH
4 CCT3interactor50.5004.333Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
5 CEP78interactor100Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DUF3122 (PF11320, IPR021469): Protein of unknown function (DUF3122)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
6 CIZ1suppressor100Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
FAM163 (PF15069, IPR029379): FAM163 family
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
7 DNAJA4interactor30.6670.667DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
8 DNM1interactor200Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
9 EPS15oncoprotein50.5002.333Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
10 FKBP4interactor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
11 GAPDHSinteractor100Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
12 GIPC1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
13 GIPC2interactor200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
14 GKAP1interactor200CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
15 HSPA5oncoprotein50.5002.667HSP70 (PF00012, IPR013126): Hsp70 protein
16 MPHOSPH8protein found in more fusions200Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
YqzE (PF14038, IPR025622): YqzE-like protein
17 MRGBPinteractor100Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7
18 MYConcoprotein80.42911.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
19 NFU1interactor100Nfu_N (PF08712, IPR014824, SM00932): Scaffold protein Nfu/NifU N terminal
NifU (PF01106, IPR001075): NifU-like domain
20 PLEKHA1interactor100PH (PF00169, IPR001849, SM00233): PH domain
21 PRR14interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
22 PSMA1interactor40.6671.000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
23 SFNsuppressor60.5005.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
24 TCP1interactor40.8330.667Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
25 TFAP2Asuppressor30.6670.667TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2
CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1
Peptidase_Prp (PF04327): Cysteine protease Prp
26 TFRConcoprotein31.0000PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
DUF3855 (PF12967, IPR024482): Domain of Unknown Function with PDB structure (DUF3855)
27 THBS3oncoprotein200EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
28 TTC1interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
29 TXNL1interactor30.6671.000PITH (PF06201, IPR010400): PITH domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
30 VSIG4interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
31 YWHAEoncoprotein40.8330.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
32 YWHAGprotein found in more fusions50.8330.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
33 YWHAQinteractor60.6005.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
34 ZBTB37interactor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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