Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SGK1 (from a repository: Sat Nov 12 16:46:49 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 56 The number (and %) of the onco-proteins 21 (37.50 %) The number (and %) of the tumor suppressors 10 (17.86 %) Total number of binary PPIs (saturation %) 207 (13.44 %) The number (and %) of affected PPIs 56 (27.05 %) The number of possible different fusions 17 PPI diameter 2 PPI radius 1 The average degree of PPI 6.464 Assortativity coefficient -0.2593 The network average Clustering coefficient 0.526 The number (and %) of a zero Clustering coefficients 10 (17.86 %) The number (and %) of a zero Betweenness Centrality 21 (37.50 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SGK1	All fusions
Proteins found in more fusions	NEDD4L (see 3 fusions); FANCA (see 1 fusions); COMMD1 (see 1 fusions); CD40 (see 2 fusions); TSC22D3 (see 2 fusions); UBC (see 1 fusions); CDC37 (see 2 fusions); MTOR (see 1 fusions); SGK1 (see 2 fusions); RPTOR (see 3 fusions); VCP (see 4 fusions); HSP90AA1 (see 2 fusions); YWHAZ (see 1 fusions); NEDD4 (see 1 fusions); STUB1 (see 1 fusions); MAPT (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SGK1	parental protein	56	0.085	2220.846	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain
2	AKT1S1	interactor	6	0.900	0.500	Pap_E4 (PF02711, IPR003861): E4 protein PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
3	ARL5B	interactor	1	0	0	Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
4	CAMKK2	oncoprotein	3	0.667	0.667	Pkinase (PF00069, IPR000719): Protein kinase domain
5	CARHSP1	interactor	2	1.000	0	DUF4339 (PF14237, IPR025640): Domain of unknown function (DUF4339)
6	CD40	protein found in more fusions	4	0.667	1.000	Glycophorin_A (PF01102, IPR001195): Glycophorin A TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
7	CDC37	protein found in more fusions	11	0.556	9.186	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
8	CDKN1B	suppressor	7	0.571	4.900	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
9	COMMD1	protein found in more fusions	5	0.667	1.333	COMMD1_N (PF17221): COMMD1 N-terminal domain COMM_domain (PF07258): COMM domain
10	ELAVL1	oncoprotein	8	0.381	9.686	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11	FANCA	oncoprotein	3	1.000	0	Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
12	FKBP5	interactor	5	0.900	0.222	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
13	GADD45G	suppressor	2	1.000	0	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
14	HSP90AA1	oncoprotein	15	0.352	47.641	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
15	HSPA4	interactor	16	0.325	59.719	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
16	IARS	interactor	2	1.000	0	Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
17	IGHA1	interactor	1	0	0	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain Ig_3 (PF13927): Immunoglobulin domain DUF4333 (PF14230, IPR025637): Domain of unknown function (DUF4333)
18	IKBKG	interactor	12	0.382	24.422	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
19	KPNA2	interactor	1	0	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
20	LTF	suppressor	2	1.000	0	Transferrin (PF00405, IPR001156, SM00094): Transferrin
21	MAGEA1	interactor	1	0	0	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
22	MAPK7	oncoprotein	7	0.733	1.389	Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
23	MAPT	protein found in more fusions	8	0.476	5.200	Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
24	MLLT3	oncoprotein	1	0	0	Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Sox_N (PF12444, IPR022151): Sox developmental protein N terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal NKAP (PF15692): NF-kappa-B-activating protein BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
25	MTOR	oncoprotein	14	0.397	33.508	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
26	MYH14	interactor	1	0	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
27	NDRG1	suppressor	4	1.000	0	Ndr (PF03096, IPR004142): Ndr family
28	NEDD4	suppressor	7	0.400	7.452	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
29	NEDD4L	suppressor	11	0.467	15.586	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
30	PA2G4	interactor	6	0.600	4.400	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein TraC (PF07820, IPR012930): TraC-like protein
31	PCCA	interactor	1	0	0	Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain SLT_beta (PF02258, IPR003189): Shiga-like toxin beta subunit
32	PDK1	interactor	4	1.000	0	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
33	PDPK1	interactor	5	0.500	2.667	Pkinase (PF00069, IPR000719): Protein kinase domain PH_3 (PF14593): PH domain
34	PIGR	oncoprotein	1	0	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
35	PIK3CA	oncoprotein	2	1.000	0	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
36	PIN1	suppressor	6	0.400	6.800	Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain
37	PPP2CA	suppressor	5	0.600	2.186	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
38	RABAC1	interactor	2	0	0	PRA1 (PF03208, IPR004895): PRA1 family protein
39	RAF1	oncoprotein	16	0.371	47.108	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
40	RAP2A	oncoprotein	4	0.500	2.500	Ras (PF00071, IPR001806, SM00173): Ras family
41	RICTOR	interactor	5	0.700	2.167	RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
42	RPTOR	protein found in more fusions	9	0.571	7.333	HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
43	SCNN1B	oncoprotein	6	0.600	4.500	ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
44	SLC9A3R2	interactor	2	1.000	0	EBP50_C (PF09007, IPR015098): EBP50, C-terminal GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
45	STUB1	suppressor	10	0.583	7.308	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
46	SYVN1	interactor	3	1.000	0	Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
47	TMEM184C	interactor	1	0	0	Solute_trans_a (PF03619, IPR005178): Organic solute transporter Ostalpha
48	TSC22D3	protein found in more fusions	7	0.667	2.352	TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
49	TUFM	interactor	3	0.667	0.400	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
50	UBC	protein found in more fusions	14	0.256	46.938	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
51	VCP	protein found in more fusions	18	0.331	66.008	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
52	WNK1	interactor	7	0.733	2.286	SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist Pkinase (PF00069, IPR000719): Protein kinase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
53	WNK2	suppressor	3	1.000	0	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pkinase (PF00069, IPR000719): Protein kinase domain PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
54	WNK4	interactor	4	0.667	1.067	Pkinase (PF00069, IPR000719): Protein kinase domain OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
55	YWHAQ	interactor	14	0.374	39.886	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
56	YWHAZ	protein found in more fusions	14	0.423	28.838	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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