Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SGK1 (from a repository: Sat Nov 12 16:46:49 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)56
The number (and %) of the onco-proteins21 (37.50 %)
The number (and %) of the tumor suppressors10 (17.86 %)
Total number of binary PPIs (saturation %)207 (13.44 %)
The number (and %) of affected PPIs56 (27.05 %)
The number of possible different fusions17
PPI diameter2
PPI radius1
The average degree of PPI6.464
Assortativity coefficient-0.2593
The network average Clustering coefficient0.526
The number (and %) of a zero Clustering coefficients10 (17.86 %)
The number (and %) of a zero Betweenness Centrality21 (37.50 %)


List of the fusions

PPI for parental proteins: SGK1 All fusions
Proteins found in more fusions NEDD4L (see 3 fusions); FANCA (see 1 fusions); COMMD1 (see 1 fusions); CD40 (see 2 fusions); TSC22D3 (see 2 fusions); UBC (see 1 fusions); CDC37 (see 2 fusions); MTOR (see 1 fusions); SGK1 (see 2 fusions); RPTOR (see 3 fusions); VCP (see 4 fusions); HSP90AA1 (see 2 fusions); YWHAZ (see 1 fusions); NEDD4 (see 1 fusions); STUB1 (see 1 fusions); MAPT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 SGK1parental protein560.0852220.846Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
2 AKT1S1interactor60.9000.500Pap_E4 (PF02711, IPR003861): E4 protein
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
3 ARL5Binteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
4 CAMKK2oncoprotein30.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
5 CARHSP1interactor21.0000DUF4339 (PF14237, IPR025640): Domain of unknown function (DUF4339)
6 CD40protein found in more fusions40.6671.000Glycophorin_A (PF01102, IPR001195): Glycophorin A
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
7 CDC37protein found in more fusions110.5569.186CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
8 CDKN1Bsuppressor70.5714.900CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
9 COMMD1protein found in more fusions50.6671.333COMMD1_N (PF17221): COMMD1 N-terminal domain
COMM_domain (PF07258): COMM domain
10 ELAVL1oncoprotein80.3819.686RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 FANCAoncoprotein31.0000Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
12 FKBP5interactor50.9000.222FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NuDC (PF16273, IPR032572): Nuclear distribution C domain
13 GADD45Gsuppressor21.0000Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
14 HSP90AA1oncoprotein150.35247.641HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
15 HSPA4interactor160.32559.719Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
16 IARSinteractor21.0000Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
17 IGHA1interactor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4333 (PF14230, IPR025637): Domain of unknown function (DUF4333)
18 IKBKGinteractor120.38224.422CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
19 KPNA2interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
20 LTFsuppressor21.0000Transferrin (PF00405, IPR001156, SM00094): Transferrin
21 MAGEA1interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
22 MAPK7oncoprotein70.7331.389Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
23 MAPTprotein found in more fusions80.4765.200Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
24 MLLT3oncoprotein100Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
NKAP (PF15692): NF-kappa-B-activating protein
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
25 MTORoncoprotein140.39733.508DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
26 MYH14interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
27 NDRG1suppressor41.0000Ndr (PF03096, IPR004142): Ndr family
28 NEDD4suppressor70.4007.452Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
29 NEDD4Lsuppressor110.46715.586WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
30 PA2G4interactor60.6004.400Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
31 PCCAinteractor100Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
SLT_beta (PF02258, IPR003189): Shiga-like toxin beta subunit
32 PDK1interactor41.0000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
33 PDPK1interactor50.5002.667Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
34 PIGRoncoprotein100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
35 PIK3CAoncoprotein21.0000PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
36 PIN1suppressor60.4006.800Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
37 PPP2CAsuppressor50.6002.186Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
38 RABAC1interactor200PRA1 (PF03208, IPR004895): PRA1 family protein
39 RAF1oncoprotein160.37147.108Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
40 RAP2Aoncoprotein40.5002.500Ras (PF00071, IPR001806, SM00173): Ras family
41 RICTORinteractor50.7002.167RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
42 RPTORprotein found in more fusions90.5717.333HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
43 SCNN1Boncoprotein60.6004.500ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
44 SLC9A3R2interactor21.0000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
45 STUB1suppressor100.5837.308U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
46 SYVN1interactor31.0000Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
47 TMEM184Cinteractor100Solute_trans_a (PF03619, IPR005178): Organic solute transporter Ostalpha
48 TSC22D3protein found in more fusions70.6672.352TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
49 TUFMinteractor30.6670.400GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
50 UBCprotein found in more fusions140.25646.938ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
51 VCPprotein found in more fusions180.33166.008AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
52 WNK1interactor70.7332.286SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist
Pkinase (PF00069, IPR000719): Protein kinase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
53 WNK2suppressor31.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Pkinase (PF00069, IPR000719): Protein kinase domain
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
54 WNK4interactor40.6671.067Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
55 YWHAQinteractor140.37439.88614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
56 YWHAZprotein found in more fusions140.42328.83814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k    t o    T o p ⇑