1 |
SGK1 | parental protein | 56 | 0.085 | 2220.846 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain |
2 |
AKT1S1 | interactor | 6 | 0.900 | 0.500 | Pap_E4 (PF02711, IPR003861): E4 protein PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1 |
3 |
ARL5B | interactor | 1 | 0 | 0 | Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family |
4 |
CAMKK2 | oncoprotein | 3 | 0.667 | 0.667 | Pkinase (PF00069, IPR000719): Protein kinase domain |
5 |
CARHSP1 | interactor | 2 | 1.000 | 0 | DUF4339 (PF14237, IPR025640): Domain of unknown function (DUF4339) |
6 |
CD40 | protein found in more fusions | 4 | 0.667 | 1.000 | Glycophorin_A (PF01102, IPR001195): Glycophorin A TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
7 |
CDC37 | protein found in more fusions | 11 | 0.556 | 9.186 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
8 |
CDKN1B | suppressor | 7 | 0.571 | 4.900 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH |
9 |
COMMD1 | protein found in more fusions | 5 | 0.667 | 1.333 | COMMD1_N (PF17221): COMMD1 N-terminal domain COMM_domain (PF07258): COMM domain |
10 |
ELAVL1 | oncoprotein | 8 | 0.381 | 9.686 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
11 |
FANCA | oncoprotein | 3 | 1.000 | 0 | Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus |
12 |
FKBP5 | interactor | 5 | 0.900 | 0.222 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain |
13 |
GADD45G | suppressor | 2 | 1.000 | 0 | Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family |
14 |
HSP90AA1 | oncoprotein | 15 | 0.352 | 47.641 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
15 |
HSPA4 | interactor | 16 | 0.325 | 59.719 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
16 |
IARS | interactor | 2 | 1.000 | 0 | Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V) |
17 |
IGHA1 | interactor | 1 | 0 | 0 | ig (PF00047, IPR013151, SM00409): Immunoglobulin domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain Ig_3 (PF13927): Immunoglobulin domain DUF4333 (PF14230, IPR025637): Domain of unknown function (DUF4333) |
18 |
IKBKG | interactor | 12 | 0.382 | 24.422 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
19 |
KPNA2 | interactor | 1 | 0 | 0 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
20 |
LTF | suppressor | 2 | 1.000 | 0 | Transferrin (PF00405, IPR001156, SM00094): Transferrin |
21 |
MAGEA1 | interactor | 1 | 0 | 0 | MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal |
22 |
MAPK7 | oncoprotein | 7 | 0.733 | 1.389 | Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor |
23 |
MAPT | protein found in more fusions | 8 | 0.476 | 5.200 | Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat |
24 |
MLLT3 | oncoprotein | 1 | 0 | 0 | Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Sox_N (PF12444, IPR022151): Sox developmental protein N terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal NKAP (PF15692): NF-kappa-B-activating protein BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation |
25 |
MTOR | oncoprotein | 14 | 0.397 | 33.508 | DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat |
26 |
MYH14 | interactor | 1 | 0 | 0 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
27 |
NDRG1 | suppressor | 4 | 1.000 | 0 | Ndr (PF03096, IPR004142): Ndr family |
28 |
NEDD4 | suppressor | 7 | 0.400 | 7.452 | Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
29 |
NEDD4L | suppressor | 11 | 0.467 | 15.586 | WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
30 |
PA2G4 | interactor | 6 | 0.600 | 4.400 | Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein TraC (PF07820, IPR012930): TraC-like protein |
31 |
PCCA | interactor | 1 | 0 | 0 | Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain SLT_beta (PF02258, IPR003189): Shiga-like toxin beta subunit |
32 |
PDK1 | interactor | 4 | 1.000 | 0 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase |
33 |
PDPK1 | interactor | 5 | 0.500 | 2.667 | Pkinase (PF00069, IPR000719): Protein kinase domain PH_3 (PF14593): PH domain |
34 |
PIGR | oncoprotein | 1 | 0 | 0 | V-set (PF07686, IPR013106): Immunoglobulin V-set domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
35 |
PIK3CA | oncoprotein | 2 | 1.000 | 0 | PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
36 |
PIN1 | suppressor | 6 | 0.400 | 6.800 | Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain |
37 |
PPP2CA | suppressor | 5 | 0.600 | 2.186 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
38 |
RABAC1 | interactor | 2 | 0 | 0 | PRA1 (PF03208, IPR004895): PRA1 family protein |
39 |
RAF1 | oncoprotein | 16 | 0.371 | 47.108 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
40 |
RAP2A | oncoprotein | 4 | 0.500 | 2.500 | Ras (PF00071, IPR001806, SM00173): Ras family |
41 |
RICTOR | interactor | 5 | 0.700 | 2.167 | RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5 |
42 |
RPTOR | protein found in more fusions | 9 | 0.571 | 7.333 | HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain |
43 |
SCNN1B | oncoprotein | 6 | 0.600 | 4.500 | ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel |
44 |
SLC9A3R2 | interactor | 2 | 1.000 | 0 | EBP50_C (PF09007, IPR015098): EBP50, C-terminal GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
45 |
STUB1 | suppressor | 10 | 0.583 | 7.308 | U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat |
46 |
SYVN1 | interactor | 3 | 1.000 | 0 | Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain |
47 |
TMEM184C | interactor | 1 | 0 | 0 | Solute_trans_a (PF03619, IPR005178): Organic solute transporter Ostalpha |
48 |
TSC22D3 | protein found in more fusions | 7 | 0.667 | 2.352 | TSC22 (PF01166, IPR000580): TSC-22/dip/bun family |
49 |
TUFM | interactor | 3 | 0.667 | 0.400 | GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain |
50 |
UBC | protein found in more fusions | 14 | 0.256 | 46.938 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
51 |
VCP | protein found in more fusions | 18 | 0.331 | 66.008 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944) |
52 |
WNK1 | interactor | 7 | 0.733 | 2.286 | SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist Pkinase (PF00069, IPR000719): Protein kinase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal |
53 |
WNK2 | suppressor | 3 | 1.000 | 0 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pkinase (PF00069, IPR000719): Protein kinase domain PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal |
54 |
WNK4 | interactor | 4 | 0.667 | 1.067 | Pkinase (PF00069, IPR000719): Protein kinase domain OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal |
55 |
YWHAQ | interactor | 14 | 0.374 | 39.886 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
56 |
YWHAZ | protein found in more fusions | 14 | 0.423 | 28.838 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |