Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins SFPQ (from a repository: Sat Dec 3 23:26:30 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 162 The number (and %) of the onco-proteins 63 (38.89 %) The number (and %) of the tumor suppressors 20 (12.35 %) Total number of binary PPIs (saturation %) 2030 (15.57 %) The number (and %) of affected PPIs 162 (7.98 %) The number of possible different fusions 35 PPI diameter 2 PPI radius 1 The average degree of PPI 24.210 Assortativity coefficient -0.1756 The network average Clustering coefficient 0.472 The number (and %) of a zero Clustering coefficients 1 (0.62 %) The number (and %) of a zero Betweenness Centrality 12 (7.41 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SFPQ	All fusions : BF089022; BE276277; BE926576; BE385898; BE408250;
Proteins found in more fusions	STAU1 (see 2 fusions); MAPK1 (see 1 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); CSNK2A1/ELAVL1 (see 1 fusions); RAC1 (see 1 fusions); HNRNPA3/NONO (see 1 fusions); IMMT (see 4 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); UBC (see 1 fusions); PRPF40A (see 2 fusions); RPA1 (see 1 fusions); SNW1 (see 1 fusions); AP2M1 (see 3 fusions); PTBP1 (see 1 fusions); SREK1 (see 4 fusions); SFPQ (see 6 fusions); NR3C1 (see 8 fusions); HUWE1 (see 2 fusions); SERBP1 (see 1 fusions); SP1 (see 1 fusions); HNRNPL (see 2 fusions); GAS7 (see 1 fusions); HNRNPD (see 1 fusions); NDUFS3 (see 1 fusions); KHDRBS1 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); CSNK2A1 (see 1 fusions); PFKM (see 1 fusions); HNRNPC (see 1 fusions); DDX17 (see 3 fusions); NTRK1/TPR (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SFPQ	parental protein	162	0.140	10233.904	GRP (PF07172, IPR010800): Glycine rich protein family Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
2	ACAT1	interactor	14	0.410	17.291	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3	AHSA1	interactor	11	0.509	7.275	Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
4	AP2M1	protein found in more fusions	12	0.509	5.727	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5	APBB1	interactor	15	0.396	13.526	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) WW (PF00397, IPR001202, SM00456): WW domain RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
6	APEX1	interactor	12	0.409	9.076	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
7	AR	oncoprotein	20	0.339	49.040	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
8	ARRB2	interactor	27	0.368	50.721	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9	ASB12	interactor	1	0	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat SOCS_box (PF07525, IPR001496): SOCS box
10	ASB18	interactor	3	0.667	0.133	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
11	ASB3	interactor	4	0.667	0.333	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
12	BTK	suppressor	4	0.667	0.500	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13	CARS	oncoprotein	3	1.000	0	tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
14	CBLL1	oncoprotein	2	1.000	0	Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
15	CCDC8	interactor	31	0.423	49.580	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
16	CD81	interactor	17	0.450	12.161	Tetraspannin (PF00335, IPR018499): Tetraspanin family
17	CDC5L	interactor	64	0.354	358.042	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
18	CDK2	suppressor	36	0.345	130.818	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
19	CEBPA	suppressor	12	0.509	7.405	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
20	COPS5	protein found in more fusions	48	0.342	229.495	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
21	COX5A	interactor	5	0.500	2.778	COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
22	CRY1	interactor	13	0.288	12.348	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
23	CSNK2A1	oncoprotein	37	0.375	96.808	Pkinase (PF00069, IPR000719): Protein kinase domain
24	CUL7	protein found in more fusions	60	0.319	308.267	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
25	DDX17	protein found in more fusions	49	0.360	164.116	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
26	DDX21	interactor	34	0.408	55.893	CRT10 (PF08728, IPR014839): CRT10 DEAD (PF00270, IPR011545): DEAD/DEAH box helicase GUCT (PF08152, IPR012562): GUCT (NUC152) domain Sulfatase (PF00884, IPR000917): Sulfatase MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
27	DNAJC19	interactor	2	1.000	0	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
28	DPH5	interactor	4	0.500	0.408	TP_methylase (PF00590, IPR000878): Tetrapyrrole (Corrin/Porphyrin) Methylases
29	EED	suppressor	52	0.297	270.467	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
30	EFTUD2	interactor	41	0.409	97.438	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
31	EGFR	oncoprotein	31	0.216	161.185	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
32	ELAVL1	oncoprotein	48	0.317	293.688	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
33	ERG	oncoprotein	17	0.456	12.157	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
34	ESR1	suppressor	53	0.249	405.188	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
35	EXOSC5	interactor	2	1.000	0	RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1 RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
36	FHL2	oncoprotein	9	0.536	4.769	LIM (PF00412, IPR001781, SM00132): LIM domain zf-ribbon_3 (PF13248): zinc-ribbon domain
37	FN1	oncoprotein	42	0.330	132.891	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
38	FUS	suppressor	41	0.405	123.108	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
39	GAS7	oncoprotein	4	0.667	0.125	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain WW (PF00397, IPR001202, SM00456): WW domain YscO (PF07321, IPR009929): Type III secretion protein YscO SH3_9 (PF14604, IPR001452): Variant SH3 domain WW_FCH_linker (PF16623): Unstructured linker region between on GAS7 protein
40	HDAC1	suppressor	36	0.286	183.040	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
41	HDAC2	suppressor	36	0.299	160.051	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
42	HDAC5	protein found in more fusions	34	0.388	71.584	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
43	HIST3H3	interactor	18	0.556	14.633	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
44	HN1	interactor	2	1.000	0	JUPITER (PF17054): Microtubule-Associated protein Jupiter
45	HNRNPA1	interactor	63	0.356	357.235	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
46	HNRNPA2B1	oncoprotein	48	0.362	173.356	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
47	HNRNPA3	oncoprotein	41	0.432	94.059	IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
48	HNRNPC	protein found in more fusions	46	0.383	144.106	APG6 (PF04111, IPR007243): Autophagy protein Apg6 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
49	HNRNPD	oncoprotein	44	0.378	118.749	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
50	HNRNPL	protein found in more fusions	39	0.484	100.013	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
51	HNRNPM	interactor	57	0.328	306.389	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
52	HNRNPR	interactor	54	0.370	249.429	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
53	HTATSF1	interactor	12	0.379	11.796	BUD22 (PF09073, IPR015158): BUD22 Conotoxin (PF02950, IPR004214): Conotoxin Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
54	HUWE1	oncoprotein	34	0.312	118.778	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
55	ILF3	oncoprotein	44	0.356	138.630	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
56	IMMT	protein found in more fusions	17	0.350	28.469	Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
57	ITGA4	interactor	39	0.377	110.199	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
58	KHDRBS1	protein found in more fusions	28	0.342	104.527	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
59	KRAS	oncoprotein	15	0.396	15.732	Ras (PF00071, IPR001806, SM00173): Ras family
60	LMO7	oncoprotein	12	0.530	9.886	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF2072 (PF09845, IPR018645): Zn-ribbon containing protein AAA_23 (PF13476): AAA domain DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757)
61	MAPK1	oncoprotein	16	0.314	29.616	Pkinase (PF00069, IPR000719): Protein kinase domain
62	MCM2	oncoprotein	53	0.324	336.803	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
63	MCM5	oncoprotein	31	0.475	60.346	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
64	MDM2	oncoprotein	34	0.294	146.891	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
65	MOV10	interactor	25	0.347	62.666	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
66	MUS81	suppressor	3	0.667	0.133	ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain MutL (PF13941, IPR006230): MutL protein HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
67	NDUFS3	protein found in more fusions	18	0.390	23.451	Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
68	NONO	oncoprotein	68	0.221	779.624	GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAS_7 (PF12860): PAS fold SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
69	NR2C1	interactor	7	0.905	0.333	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
70	NR3C1	protein found in more fusions	20	0.298	45.752	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
71	NR4A2	oncoprotein	6	0.533	2.444	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
72	NTRK1	oncoprotein	78	0.236	827.275	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
73	NUP210	interactor	11	0.400	11.417	Big_2 (PF02368, IPR003343, SM00635): Bacterial Ig-like domain (group 2)
74	NXF1	interactor	34	0.273	145.268	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
75	OBSL1	interactor	55	0.347	225.295	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
76	ORC6	interactor	6	0.733	0.415	ORC6 (PF05460, IPR008721): Origin recognition complex subunit 6 (ORC6)
77	PAN2	interactor	22	0.394	27.080	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
78	PARK2	suppressor	24	0.312	61.735	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
79	PARK7	suppressor	15	0.341	27.206	DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
80	PFKM	protein found in more fusions	10	0.444	7.819	PFK (PF00365, IPR000023): Phosphofructokinase
81	PGK1	interactor	19	0.550	16.008	PGK (PF00162, IPR001576): Phosphoglycerate kinase
82	PHF5A	interactor	6	0.733	0.352	PHF5 (PF03660, IPR005345): PHF5-like protein
83	PIN1	suppressor	17	0.441	23.840	Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain
84	PITX3	interactor	3	1.000	0	OAR (PF03826, IPR003654): OAR domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
85	POT1	interactor	6	0.400	2.222	POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
86	PPARG	suppressor	15	0.352	34.557	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
87	PPARGC1A	interactor	9	0.472	8.312	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
88	PPP1CA	suppressor	27	0.345	56.309	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
89	PRKCI	interactor	2	1.000	0	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
90	PRPF40A	protein found in more fusions	32	0.501	39.903	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
91	PTBP1	oncoprotein	42	0.428	107.870	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
92	RAC1	oncoprotein	9	0.500	1.801	Ras (PF00071, IPR001806, SM00173): Ras family
93	RAD21	oncoprotein	19	0.444	25.107	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
94	RNF43	oncoprotein	3	1.000	0	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
95	RPA1	suppressor	45	0.428	120.715	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
96	RPA2	oncoprotein	41	0.377	114.945	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
97	RPA3	interactor	37	0.395	77.679	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
98	RPS6KB2	interactor	12	0.394	14.873	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
99	SART1	interactor	34	0.455	96.560	SART-1 (PF03343, IPR005011): SART-1 family Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
100	SCARNA22	interactor	21	0.505	11.486	NA
101	SERBP1	protein found in more fusions	20	0.333	28.653	HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
102	SF3A1	interactor	45	0.390	166.073	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
103	SF3B1	oncoprotein	50	0.372	190.813	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
104	SF3B3	interactor	50	0.355	209.888	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
105	SFN	suppressor	19	0.386	25.744	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
106	SIN3A	oncoprotein	22	0.368	56.882	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
107	SIRT7	interactor	41	0.273	200.673	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
108	SLTM	interactor	6	0.400	5.554	DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Podoplanin (PF05808, IPR008783): Podoplanin RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
109	SMAD5	interactor	8	0.679	1.607	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
110	SMARCA2	suppressor	18	0.431	30.609	DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain YL1 (PF05764, IPR008895): YL1 nuclear protein BRK (PF07533, IPR006576, SM00592): BRK domain DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
111	SMARCA5	interactor	22	0.514	20.001	HAND (PF09110, IPR015194): HAND SLIDE (PF09111, IPR015195): SLIDE SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DBINO (PF13892, IPR020838): DNA-binding domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
112	SMARCD1	interactor	10	0.600	3.381	ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit DivIC (PF04977, IPR007060): Septum formation initiator SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
113	SMC3	oncoprotein	24	0.464	29.697	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
114	SMN1	interactor	20	0.392	23.639	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
115	SNRPA	interactor	22	0.500	23.220	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
116	SNRPA1	interactor	33	0.436	75.849	LRR_9 (PF14580): Leucine-rich repeat
117	SNRPD2	interactor	28	0.405	48.853	LSM (PF01423, IPR001163): LSM domain
118	SNW1	protein found in more fusions	48	0.398	186.243	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
119	SON	interactor	19	0.678	6.443	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region G-patch (PF01585, IPR000467, SM00443): G-patch domain tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1 GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer RSRP (PF17069): Arginine/Serine-Rich protein 1
120	SP1	protein found in more fusions	14	0.436	19.836	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
121	SP3	interactor	5	1.000	0	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
122	SREK1	protein found in more fusions	21	0.421	27.988	Ureide_permease (PF07168, IPR009834): Ureide permease RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
123	SRRM1	interactor	33	0.420	74.375	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
124	SRRM2	interactor	45	0.441	123.527	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
125	SRSF3	oncoprotein	29	0.357	70.832	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
126	SRSF4	interactor	14	0.440	16.789	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
127	SRSF5	interactor	33	0.428	77.962	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
128	SRSF7	interactor	28	0.511	29.959	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP2 (PF01254, IPR000678): Nuclear transition protein 2 zf-CCHC (PF00098, IPR001878): Zinc knuckle
129	SSR4	interactor	9	0.500	8.348	TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta) OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
130	STAG2	oncoprotein	9	0.750	1.233	AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain STAG (PF08514, IPR013721): STAG domain Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
131	STAT6	oncoprotein	2	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT6_C (PF14596, IPR028187): STAT6 C-terminal
132	STAU1	protein found in more fusions	30	0.466	39.171	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
133	TADA2A	interactor	17	0.449	18.291	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
134	TARS	interactor	13	0.551	4.595	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain TGS (PF02824, IPR004095): TGS domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
135	TCERG1	interactor	21	0.519	17.524	FF (PF01846, IPR002713, SM00441): FF domain WW (PF00397, IPR001202, SM00456): WW domain Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807) DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO FAM150 (PF15129, IPR029364): FAM150 family
136	THRAP3	oncoprotein	25	0.310	83.363	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228) THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
137	TIMM10	interactor	5	0.600	2.567	zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
138	TIMM23B	interactor	2	1.000	0	Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
139	TIMM9	interactor	5	0.500	3.091	zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
140	TOMM40	interactor	3	0.667	0.333	Porin_3 (PF01459, IPR027246): Eukaryotic porin
141	TOP1	oncoprotein	39	0.506	62.384	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region
142	TOP2B	oncoprotein	18	0.366	19.428	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DASH_Spc19 (PF08287, IPR013251): Spc19 DNA_gyraseB (PF00204, IPR013506): DNA gyrase B DTHCT (PF08070, IPR012542): DTHCT (NUC029) region HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim (PF01751, IPR006171, SM00493): Toprim domain Anophelin (PF10731, IPR018932): Thrombin inhibitor from mosquito DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
143	TOPORS	suppressor	11	0.509	5.230	Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
144	TPR	oncoprotein	23	0.474	24.447	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus ZapB (PF06005, IPR009252): Cell division protein ZapB Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 XhlA (PF10779, IPR019715): Haemolysin XhlA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373) DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
145	TSG101	suppressor	11	0.511	5.511	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Laminin_II (PF06009, IPR010307): Laminin Domain II UEV (PF05743, IPR008883): UEV domain Vps23_core (PF09454, IPR017916): Vps23 core domain
146	TXN	oncoprotein	12	0.303	16.474	Thioredoxin (PF00085, IPR013766): Thioredoxin
147	U2AF1	oncoprotein	22	0.688	9.991	DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509) KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
148	U2AF2	protein found in more fusions	55	0.414	194.643	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
149	UBC	protein found in more fusions	41	0.374	157.664	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
150	UBE2I	interactor	31	0.287	122.620	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
151	UNK	interactor	17	0.243	50.572	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
152	UQCRC2	oncoprotein	12	0.439	9.210	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
153	UQCRFS1P1	interactor	3	0.667	0.400	NA
154	UTP14A	interactor	14	0.626	3.944	Utp14 (PF04615, IPR006709): Utp14 protein
155	VCAM1	interactor	32	0.381	64.741	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
156	VTN	interactor	14	0.747	2.549	Hemopexin (PF00045, IPR018487, SM00120): Hemopexin Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
157	WBP11	interactor	10	0.467	7.010	BUD22 (PF09073, IPR015158): BUD22 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SspB (PF04386, IPR007481): Stringent starvation protein B Wbp11 (PF09429, IPR019007): WW domain binding protein 11 ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal
158	WBP4	interactor	13	0.423	11.144	CDC45 (PF02724, IPR003874): CDC45-like protein WW (PF00397, IPR001202, SM00456): WW domain zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger TMCO5 (PF14992, IPR026617): TMCO5 family
159	WWOX	suppressor	21	0.410	17.887	adh_short (PF00106, IPR002198): short chain dehydrogenase WW (PF00397, IPR001202, SM00456): WW domain
160	YTHDF2	interactor	13	0.513	12.286	YTH (PF04146, IPR007275): YT521-B-like domain DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
161	ZC3HAV1	interactor	7	0.571	4.747	PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain WWE (PF02825, IPR004170, SM00678): WWE domain
162	ZMYM2	oncoprotein	8	0.571	2.077	YHS (PF04945, IPR007029): YHS domain zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504) SOBP (PF15279, IPR026092): Sine oculis-binding protein

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