Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: SF1 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 123 The number (and %) of the onco-proteins 40 (32.52 %) The number (and %) of the tumor suppressors 3 (2.44 %) Total number of binary PPIs (saturation %) 795 (10.60 %) The number (and %) of affected PPIs 123 (15.47 %) The number of possible different fusions 25 PPI diameter 2 PPI radius 1 The average degree of PPI 12.081 Assortativity coefficient -0.2019 The network average Clustering coefficient 0.515 The number (and %) of a zero Clustering coefficients 7 (5.69 %) The number (and %) of a zero Betweenness Centrality 17 (13.82 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SF1	All fusions : BG987940;
Proteins found in more fusions	LMNA (see 3 fusions); TKT (see 5 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); PLOD2 (see 1 fusions); WDR77 (see 1 fusions); CUL3 (see 1 fusions); ATXN1 (see 3 fusions); HDAC4 (see 1 fusions); NFKB1 (see 2 fusions); NCOA1 (see 2 fusions); UBE2N (see 1 fusions); FAF1 (see 2 fusions); RBPMS (see 2 fusions); HNRNPL (see 2 fusions); GAS7 (see 1 fusions); EWSR1 (see 2 fusions); STOM (see 1 fusions); SF1 (see 1 fusions); HDAC5 (see 1 fusions); DDX17 (see 3 fusions); PML (see 4 fusions); PRPF40A (see 2 fusions); SUZ12 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SF1	parental protein	123	0.084	9821.524	UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
2	ACTL6A	interactor	5	0.900	0.154	Actin (PF00022, IPR004000, SM00268): Actin
3	ALDOC	interactor	5	0.700	2.667	Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
4	APBB1	interactor	11	0.622	8.096	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) WW (PF00397, IPR001202, SM00456): WW domain RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
5	ATXN1	protein found in more fusions	10	0.333	19.967	AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
6	BCAS2	interactor	9	0.611	5.081	BCAS2 (PF05700, IPR008409): Breast carcinoma amplified sequence 2 (BCAS2) ZapB (PF06005, IPR009252): Cell division protein ZapB
7	CAB39	interactor	4	0.500	2.667	Mo25 (PF08569, IPR013878): Mo25-like
8	CCDC25	interactor	2	1.000	0	DUF814 (PF05670, IPR008532): Domain of unknown function (DUF814) Phage_Mu_Gam (PF07352, IPR009951): Bacteriophage Mu Gam like protein DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
9	CCDC8	interactor	19	0.333	42.166	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
10	CDC42	oncoprotein	4	0.667	1.000	Ras (PF00071, IPR001806, SM00173): Ras family
11	CIAO1	interactor	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
12	CIRBP	oncoprotein	9	0.472	9.116	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13	CNN2	interactor	4	0.667	0.310	Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
14	CSNK2A2	interactor	9	0.306	16.863	Pkinase (PF00069, IPR000719): Protein kinase domain
15	CUL3	protein found in more fusions	43	0.226	379.859	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
16	CUL7	protein found in more fusions	33	0.317	142.592	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
17	DDX17	protein found in more fusions	26	0.520	42.837	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18	EED	suppressor	24	0.364	56.642	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
19	EFTUD2	interactor	21	0.405	33.401	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
20	EIF4B	interactor	9	0.821	1.606	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3774 (PF12609, IPR022251): Wound-induced protein PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
21	EMC2	interactor	9	0.500	7.196	TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_19 (PF14559): Tetratricopeptide repeat Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
22	EWSR1	oncoprotein	29	0.270	170.131	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
23	FAF1	protein found in more fusions	15	0.714	6.829	UBX (PF00789, IPR001012, SM00166): UBX domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family AAA_11 (PF13086): AAA domain UBA_4 (PF14555): UBA-like domain
24	FAM168A	interactor	5	0.833	0.667	TCRP1 (PF14944, IPR029247): Tongue Cancer Chemotherapy Resistant Protein 1
25	FARSB	interactor	12	0.576	11.943	B3_4 (PF03483, IPR005146, SM00873): B3/4 domain B5 (PF03484, IPR005147, SM00874): tRNA synthetase B5 domain
26	FN1	oncoprotein	30	0.232	174.077	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
27	FUS	oncoprotein	26	0.440	66.361	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
28	GART	interactor	16	0.542	20.914	AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain Formyl_trans_N (PF00551, IPR002376): Formyl transferase GARS_A (PF01071, IPR020561): Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_C (PF02843, IPR020560): Phosphoribosylglycinamide synthetase, C domain GARS_N (PF02844, IPR020562): Phosphoribosylglycinamide synthetase, N domain
29	GAS7	oncoprotein	3	1.000	0	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain WW (PF00397, IPR001202, SM00456): WW domain YscO (PF07321, IPR009929): Type III secretion protein YscO SH3_9 (PF14604, IPR001452): Variant SH3 domain WW_FCH_linker (PF16623): Unstructured linker region between on GAS7 protein
30	GFPT1	interactor	7	0.667	5.150	SIS (PF01380, IPR001347): SIS domain GATase_6 (PF13522): Glutamine amidotransferase domain
31	HADH	interactor	3	0.667	1.000	3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
32	HDAC4	oncoprotein	8	0.619	4.567	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
33	HDAC5	protein found in more fusions	18	0.287	49.658	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
34	HIRIP3	interactor	10	0.689	7.047	CHZ (PF09649, IPR019098, SM01082): Histone chaperone domain CHZ
35	HIST1H4A	interactor	16	0.333	49.545	CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
36	HNRNPF	interactor	21	0.510	25.615	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
37	HNRNPH1	oncoprotein	22	0.571	23.013	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
38	HNRNPH2	interactor	19	0.451	44.742	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
39	HNRNPK	oncoprotein	30	0.483	68.752	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
40	HNRNPL	protein found in more fusions	21	0.495	31.259	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
41	HNRNPUL1	interactor	19	0.458	41.997	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
42	HSDL2	interactor	1	0	0	adh_short (PF00106, IPR002198): short chain dehydrogenase SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
43	HSPH1	oncoprotein	13	0.577	14.555	HSP70 (PF00012, IPR013126): Hsp70 protein SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
44	IL7R	interactor	9	0.417	9.464	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
45	ILF3	oncoprotein	25	0.327	99.673	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
46	IREB2	interactor	3	0.667	1.000	Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase) Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
47	ITCH	interactor	9	0.429	11.876	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
48	ITGA4	interactor	23	0.420	53.304	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
49	KLC3	interactor	2	0	0	TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TPR_12 (PF13424): Tetratricopeptide repeat
50	KRTAP26-1	interactor	3	1.000	0	PMG (PF05287, IPR007951): PMG protein
51	LLGL2	interactor	3	1.000	0	Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
52	LMNA	protein found in more fusions	15	0.374	23.279	Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
53	MAPK8	oncoprotein	7	0.333	8.667	DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain
54	METTL22	interactor	1	0	0	Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
55	MKRN3	oncoprotein	5	0.500	2.667	zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal Torus (PF16131, IPR032297): Torus domain zf-3CxxC_2 (PF17180): Zinc-binding domain
56	MPLKIP	interactor	3	0.667	0.286	MPLKIP (PF15502, IPR028265): M-phase-specific PLK1-interacting protein
57	NARS	interactor	13	0.462	24.102	tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N) tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
58	NCOA1	oncoprotein	6	0.600	3.333	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
59	NCOR2	oncoprotein	8	0.571	7.967	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
60	NFKB1	oncoprotein	9	0.464	11.082	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
61	NNT	interactor	4	0.667	0.224	AlaDh_PNT_C (PF01262, IPR007698, SM01002): Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N (PF05222, IPR007886, SM01003): Alanine dehydrogenase/PNT, N-terminal domain PNTB (PF02233, IPR012136): NAD(P) transhydrogenase beta subunit PNTB_4TM (PF12769, IPR024605): 4TM region of pyridine nucleotide transhydrogenase, mitoch
62	NTRK1	oncoprotein	52	0.165	735.365	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
63	OBSL1	interactor	31	0.329	111.324	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
64	OSBP	interactor	8	0.750	2.936	Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein PH (PF00169, IPR001849, SM00233): PH domain Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
65	PARD6B	interactor	5	0.400	5.500	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
66	PGK1	interactor	12	0.485	14.508	PGK (PF00162, IPR001576): Phosphoglycerate kinase
67	PLAA	interactor	3	1.000	0	PFU (PF09070, IPR015155): PFU (PLAA family ubiquitin binding) PUL (PF08324, IPR013535): PUL domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
68	PLOD2	protein found in more fusions	13	0.621	10.587	2OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily Anp1 (PF03452, IPR005109): Anp1 Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
69	PLSCR1	interactor	4	0.500	1.033	Scramblase (PF03803, IPR005552): Scramblase
70	PML	oncoprotein	13	0.273	38.982	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
71	PPARGC1A	interactor	5	0.600	2.400	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
72	PPID	interactor	3	0.667	0.095	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
73	PRMT2	interactor	3	0.667	0.667	PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase SH3_9 (PF14604, IPR001452): Variant SH3 domain
74	PRPF40A	protein found in more fusions	17	0.625	11.981	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
75	PSMA3	interactor	12	0.400	23.081	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
76	RANBP3	oncoprotein	13	0.731	5.852	Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
77	RBM10	interactor	16	0.486	27.234	G-patch (PF01585, IPR000467, SM00443): G-patch domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others GSIII_N (PF12437, IPR022147): Glutamine synthetase type III N terminal G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site zf-C2H2_4 (PF13894): C2H2-type zinc finger DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337) FAM176 (PF14851): FAM176 family
78	RBM17	interactor	6	0.600	1.591	G-patch (PF01585, IPR000467, SM00443): G-patch domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDRGK (PF09756, IPR019153, SM01128): DDRGK domain Slu7 (PF11708, IPR021715): Pre-mRNA splicing Prp18-interacting factor
79	RBM4	suppressor	20	0.542	22.895	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC (PF00098, IPR001878): Zinc knuckle CompInhib_SCIN (PF11546, IPR021612): Staphylococcal complement inhibitor SCIN
80	RBM7	interactor	5	0.900	0.154	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
81	RBPMS	protein found in more fusions	7	0.400	7.133	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
82	RNF41	interactor	2	0	0	Sina (PF03145, IPR018121): Seven in absentia protein family USP8_interact (PF08941, IPR015036): USP8 interacting zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
83	RPL24	interactor	17	0.463	32.803	MAS20 (PF02064, IPR002056): MAS20 protein import receptor Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
84	SAMHD1	interactor	17	0.567	19.875	HD (PF01966, IPR006674): HD domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
85	SBDS	oncoprotein	8	0.429	10.233	SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
86	SEPT11	interactor	5	0.400	5.333	Septin (PF00735, IPR000038): Septin DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
87	SF3A1	interactor	25	0.383	91.255	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
88	SF3A2	interactor	22	0.485	42.901	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
89	SF3B4	interactor	27	0.285	130.422	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
90	SIN3A	oncoprotein	10	0.333	24.384	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
91	SORCS3	interactor	1	0	0	PKD (PF00801, IPR000601, SM00089): PKD domain Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
92	SRP9	interactor	4	0.500	2.400	SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
93	SRPRB	interactor	13	0.295	43.847	MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
94	STIM1	interactor	2	1.000	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SSP160 (PF06933, IPR009701): Special lobe-specific silk protein SSP160 DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446) SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
95	STOM	protein found in more fusions	8	0.571	3.621	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
96	SUPT5H	interactor	14	0.473	21.342	KOW (PF00467, IPR005824, SM00739): KOW motif Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
97	SUZ12	oncoprotein	16	0.410	22.630	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
98	TAF15	oncoprotein	7	0.571	1.228	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) GRP (PF07172, IPR010800): Glycine rich protein family Presenilin (PF01080, IPR001108): Presenilin RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
99	TAGLN	oncoprotein	3	0.667	0.667	Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
100	TCERG1	interactor	13	0.615	6.801	FF (PF01846, IPR002713, SM00441): FF domain WW (PF00397, IPR001202, SM00456): WW domain Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807) DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO FAM150 (PF15129, IPR029364): FAM150 family
101	TKT	protein found in more fusions	11	0.467	12.326	Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
102	TMED4	interactor	2	1.000	0	EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
103	TOMM40	interactor	8	0.393	15.500	Porin_3 (PF01459, IPR027246): Eukaryotic porin
104	TRIM23	interactor	4	0.667	1.000	Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family FemAB (PF02388, IPR003447): FemAB family zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
105	TRIM69	interactor	3	1.000	0	DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) SPRY (PF00622, IPR003877, SM00449): SPRY domain PRY (PF13765, IPR006574, SM00589): SPRY-associated domain DZR (PF12773, IPR025874): Double zinc ribbon zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
106	TROVE2	interactor	11	0.727	5.187	TROVE (PF05731, IPR008858): TROVE domain DUF2201 (PF09967, IPR018698): VWA-like domain (DUF2201)
107	U2AF2	protein found in more fusions	32	0.357	143.694	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
108	UBE2L3	interactor	8	0.333	11.333	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
109	UBE2N	protein found in more fusions	7	0.333	8.772	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
110	VAMP2	interactor	2	1.000	0	Synaptobrevin (PF00957, IPR001388): Synaptobrevin PRIMA1 (PF16101): Proline-rich membrane anchor 1
111	VCAM1	interactor	22	0.316	73.671	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
112	VDAC1	interactor	8	0.464	7.872	Porin_3 (PF01459, IPR027246): Eukaryotic porin
113	VDAC3	interactor	9	0.444	10.248	Porin_3 (PF01459, IPR027246): Eukaryotic porin
114	WBP4	interactor	9	0.722	1.693	CDC45 (PF02724, IPR003874): CDC45-like protein WW (PF00397, IPR001202, SM00456): WW domain zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger TMCO5 (PF14992, IPR026617): TMCO5 family
115	WDR77	oncoprotein	8	0.714	1.543	LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
116	WDR83	interactor	4	0.500	1.556	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
117	WWP2	interactor	7	0.600	4.167	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
118	XPO7	interactor	16	0.525	27.517	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
119	XRCC5	suppressor	20	0.380	41.491	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
120	ZC3H11A	interactor	5	0.500	0.553	Bul1_C (PF04426, IPR022794): Bul1 C terminus Sec62 (PF03839, IPR004728): Translocation protein Sec62 zf-CCCH_3 (PF15663): Zinc-finger containing family
121	ZFP41	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
122	ZFR	interactor	5	0.700	0.333	DZF (PF07528, IPR006561, SM00572): DZF domain K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence zf-met (PF12874): Zinc-finger of C2H2 type
123	ZNF461	interactor	1	0	0	Fer4 (PF00037, IPR001450): 4Fe-4S binding domain KRAB (PF01352, IPR001909, SM00349): KRAB box zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-trcl (PF13451, IPR025306): Probable zinc-ribbon domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

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