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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins11 (45.83 %)
The number (and %) of the tumor suppressors3 (12.50 %)
Total number of binary PPIs (saturation %)56 (20.29 %)
The number (and %) of affected PPIs24 (42.86 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI3.417
Assortativity coefficient-0.3750
The network average Clustering coefficient0.619
The number (and %) of a zero Clustering coefficients5 (20.83 %)
The number (and %) of a zero Betweenness Centrality15 (62.50 %)


List of the fusions

PPI for parental proteins: SETD2 All fusions
Proteins found in more fusions POLR2A (see 2 fusions); LUC7L (see 1 fusions); ATXN1 (see 3 fusions); TP53 (see 3 fusions); SIAH2 (see 1 fusions); SMAD3 (see 3 fusions); GAN (see 1 fusions); SETD2 (see 2 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 SETD2parental protein240.071444.000DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
SET (PF00856, IPR001214, SM00317): SET domain
SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
WW (PF00397, IPR001202, SM00456): WW domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
2 ARHGEF10interactor100DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
3 ATXN1protein found in more fusions40.6671.000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
4 AURKAoncoprotein50.5002.667Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
5 CBX8interactor31.0000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
6 CICsuppressor21.0000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
MRI (PF15325, IPR028278): Modulator of retrovirus infection
DUF4819 (PF16090, IPR032147): Domain of unknown function (DUF4819)
7 CLK2interactor31.0000DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-met (PF12874): Zinc-finger of C2H2 type
8 EIF3Ioncoprotein21.0000ISN1 (PF06437, IPR009453): IMP-specific 5'-nucleotidase
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
9 ELAVL1oncoprotein50.6671.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 GANprotein found in more fusions31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
11 HIST1H3Ainteractor31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12 HIST3H3interactor30.6671.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 HTTprotein found in more fusions31.0000HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
14 IWS1interactor31.0000DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
15 LUC7Lprotein found in more fusions40.6671.000LUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
16 POLR2Aprotein found in more fusions50.8330.667RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
17 RASSF8suppressor100ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
FliD_C (PF07195, IPR010809): Flagellar hook-associated protein 2 C-terminus
PEARLI-4 (PF05278, IPR007942): Arabidopsis phospholipase-like protein (PEARLI 4)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
18 SCARA3interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Filament (PF00038, IPR001664): Intermediate filament protein
Flagellin_C (PF00700, IPR001029): Bacterial flagellin C-terminal helical region
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
19 SIAH2oncoprotein200Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
20 SMAD3oncoprotein31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
21 SOX2oncoprotein31.0000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
22 TP53suppressor60.4005.667DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
23 WDR37interactor100DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
24 XPO1interactor70.38112.333CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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