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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins11 (25.00 %)
The number (and %) of the tumor suppressors8 (18.18 %)
Total number of binary PPIs (saturation %)104 (10.99 %)
The number (and %) of affected PPIs54 (51.92 %)
The number of possible different fusions8
PPI diameter3
PPI radius2
The average degree of PPI4.045
Assortativity coefficient-0.1776
The network average Clustering coefficient0.419
The number (and %) of a zero Clustering coefficients16 (36.36 %)
The number (and %) of a zero Betweenness Centrality23 (52.27 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SERPINB4,SERPINB3 All fusions
: DD069976;
Proteins found in more fusions USF2 (see 1 fusions); NF2 (see 1 fusions); COPS5 (see 1 fusions); EWSR1 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); SERPINB4/SERPINB3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SERPINB4parental protein250.067787.346Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
2 SERPINB3parental protein300.0641009.880Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
3 ASCC1interactor204.169AKAP7_NLS (PF10469, IPR019510): AKAP7 2'5' RNA ligase-like domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
4 BTRConcoprotein4016.102WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
5 C11orf54interactor21.0000DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
6 C16orf70interactor21.0000UPF0183 (PF03676, IPR005373): Uncharacterised protein family (UPF0183)
7 CCDC92interactor208.983Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
CCDC92 (PF14916): Coiled-coil domain of unknown function
8 CCDC94interactor100DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
9 COPS5protein found in more fusions90.50029.070JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
10 CTSGinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
11 CTSKinteractor100Inhibitor_I29 (PF08246, IPR013201, SM00848): Cathepsin propeptide inhibitor domain (I29)
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
12 CTSLoncoprotein100Inhibitor_I29 (PF08246, IPR013201, SM00848): Cathepsin propeptide inhibitor domain (I29)
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
13 CTSSinteractor100Inhibitor_I29 (PF08246, IPR013201, SM00848): Cathepsin propeptide inhibitor domain (I29)
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
14 CUL2suppressor60.60023.867Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
15 CUL5suppressor40.8332.708Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
16 DDX19Binteractor31.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
17 EGFRoncoprotein70.26730.803Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
18 EIF2B1interactor303.419IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
19 ESR1suppressor80.33332.351Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
20 EWSR1oncoprotein100.33348.771RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
21 FOXH1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
22 GPR18interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
23 HDLBPoncoprotein40.5007.455BMC (PF00936, IPR000249, SM00877): BMC domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
KH_5 (PF13184, IPR025249): NusA-like KH domain
SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
24 HLA-DPA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
25 HOXD10interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
26 KIR3DS1interactor21.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
27 MAPK8oncoprotein60.40021.476DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
28 MCM2oncoprotein41.0000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
29 METTL13interactor100Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
Methyltransf_23 (PF13489): Methyltransferase domain
30 NF2suppressor200ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
31 PSMA3interactor50.50013.067Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
32 RASSF10suppressor21.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
33 RASSF7interactor30.6671.000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SlyX (PF04102, IPR007236): SlyX
Tryp_alpha_amyl (PF00234, IPR016140, SM00499): Protease inhibitor/seed storage/LTP family
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
34 RASSF9interactor30.66710.733RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB)
DUF3087 (PF11286, IPR021438): Protein of unknown function (DUF3087)
35 SH3GLB1suppressor31.0000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
36 SIRT1suppressor50.5004.041DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
37 SUSD3oncoprotein21.0000IncA (PF04156, IPR007285): IncA protein
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
38 TPI1interactor80.38125.113TIM (PF00121, IPR000652): Triosephosphate isomerase
39 UCHL5oncoprotein50.50017.778Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
40 UCP2interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
41 UGT1A10interactor100UDPGT (PF00201, IPR002213): UDP-glucoronosyl and UDP-glucosyl transferase
42 USF2protein found in more fusions31.0000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
43 WWOXsuppressor40.33311.867adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
44 ZSCAN20interactor21.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Glyco_trans_1_2 (PF13524): Glycosyl transferases group 1
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type

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