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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RPL3P4, SEPTIN11 (from a repository: Sat Jan 18 10:36:56 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)40
The number (and %) of the onco-proteins10 (25.00 %)
The number (and %) of the tumor suppressors3 (7.50 %)
Total number of binary PPIs (saturation %)137 (17.56 %)
The number (and %) of affected PPIs38 (27.74 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI6.400
Assortativity coefficient-0.3037
The network average Clustering coefficient0.596
The number (and %) of a zero Clustering coefficients5 (12.50 %)
The number (and %) of a zero Betweenness Centrality10 (25.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: SEPTIN11,RPL3P4 All fusions
: AL702234;
Proteins found in more fusions OXCT1 (see 1 fusions); SF1 (see 1 fusions); SH3KBP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SEPTIN11parental protein380.1281044.060Septin (PF00735, IPR000038): Septin
DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
2 RPL3P4interactor000NA
3 CDC42EP4interactor100.6896.502PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
4 CFTRsuppressor50.6672.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
5 ELAVL1oncoprotein90.39315.286RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 FERMT2interactor21.0000FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
7 FSCN1oncoprotein21.0000Fascin (PF06268, IPR022768): Fascin domain
8 MAD2L1BPinteractor200p31comet (PF06581, IPR009511): Mad1 and Cdc20-bound-Mad2 binding
9 MPSTinteractor31.0000Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
10 NABP2interactor100tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
11 NDUFS6interactor100Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
12 OXCT1protein found in more fusions70.3339.000CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
13 SEC22Binteractor120.21249.067Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
14 SEC23IPinteractor100DDHD (PF02862, IPR004177, SM01127): DDHD domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
WWE (PF02825, IPR004170, SM00678): WWE domain
15 SEPTIN1interactor110.8222.602Pet20 (PF08692, IPR014804): Mitochondrial protein Pet20
Septin (PF00735, IPR000038): Septin
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
16 SEPTIN12interactor90.8891.333Septin (PF00735, IPR000038): Septin
17 SEPTIN2oncoprotein110.8183.094FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
18 SEPTIN3interactor120.8183.075Septin (PF00735, IPR000038): Septin
19 SEPTIN4suppressor60.8670.472Septin (PF00735, IPR000038): Septin
20 SEPTIN5oncoprotein100.9440.472Septin (PF00735, IPR000038): Septin
21 SEPTIN6oncoprotein130.66713.827Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
22 SEPTIN7interactor120.7278.327Fez1 (PF06818): Fez1
Septin (PF00735, IPR000038): Septin
23 SEPTIN8interactor100.8442.225IMD (PF08397, IPR013606): IRSp53/MIM homology domain
Septin (PF00735, IPR000038): Septin
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
24 SEPTIN9oncoprotein120.43931.175Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
25 SF1protein found in more fusions60.4005.000UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
26 SH3KBP1protein found in more fusions80.7622.150Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 SIN3Aoncoprotein50.6002.833Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
28 SLC9A3R2interactor60.4008.000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
29 SMARCA2suppressor40.8330.500DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
30 STIM1interactor30.6670.667APG6 (PF04111, IPR007243): Autophagy protein Apg6
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SSP160 (PF06933, IPR009701): Special lobe-specific silk protein SSP160
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
31 SUCLG1interactor30.6671.000CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
CoA_binding_2 (PF13380, IPR003781): CoA binding domain
32 TCOF1interactor30.6670.500CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Gal-3-0_sulfotr (PF06990, IPR009729): Galactose-3-O-sulfotransferase
Treacle (PF03546, IPR003993): Treacher Collins syndrome protein Treacle
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
AP3D1 (PF06375): AP-3 complex subunit delta-1
33 TMEM177interactor21.0000NA
34 TMEM189interactor50.6003.167MARVEL (PF01284, IPR008253): Membrane-associating domain
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
35 TMEM9interactor30.6670.500Tmemb_9 (PF05434, IPR008853): TMEM9
36 TOMM40interactor40.5002.333Porin_3 (PF01459, IPR027246): Eukaryotic porin
37 TSTinteractor30.6670.500Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
38 VCAM1interactor50.5004.667C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
39 VDAC2interactor40.6671.667Porin_3 (PF01459, IPR027246): Eukaryotic porin
40 XRCC1interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
SPX (PF03105, IPR004331): SPX domain
XRCC1_N (PF01834, IPR002706): XRCC1 N terminal domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CFTRsuppressorABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
AL702234
2 FERMT2interactorFERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
AL702234
3 FSCN1oncoproteinFascin (PF06268, IPR022768): Fascin domainAL702234
4 MAD2L1BPinteractorp31comet (PF06581, IPR009511): Mad1 and Cdc20-bound-Mad2 bindingAL702234
5 MPSTinteractorRhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domainAL702234
6 NABP2interactortRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domainAL702234
7 NDUFS6interactorThiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
AL702234
8 OXCT1interactorCoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferaseAL702234
9 RPL3P4interactorNAAL702234
10 SEC22BinteractorSynaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
AL702234
11 SEC23IPinteractorDDHD (PF02862, IPR004177, SM01127): DDHD domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
WWE (PF02825, IPR004170, SM00678): WWE domain
AL702234
12 SEPTIN11parental proteinSeptin (PF00735, IPR000038): Septin
DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
AL702234
13 SEPTIN12interactorSeptin (PF00735, IPR000038): SeptinAL702234
14 SEPTIN2oncoproteinFYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
AL702234
15 SEPTIN3interactorSeptin (PF00735, IPR000038): SeptinAL702234
16 SEPTIN4suppressorSeptin (PF00735, IPR000038): SeptinAL702234
17 SEPTIN5oncoproteinSeptin (PF00735, IPR000038): SeptinAL702234
18 SEPTIN7interactorFez1 (PF06818): Fez1
Septin (PF00735, IPR000038): Septin
AL702234
19 SEPTIN9oncoproteinSeptin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
AL702234
20 SF1interactorUPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
AL702234
21 SH3KBP1interactorTmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
AL702234
22 SIN3AoncoproteinSin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
AL702234
23 SLC9A3R2interactorEBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
AL702234
24 SMARCA2suppressorDUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
AL702234
25 STIM1interactorAPG6 (PF04111, IPR007243): Autophagy protein Apg6
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SSP160 (PF06933, IPR009701): Special lobe-specific silk protein SSP160
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
AL702234
26 SUCLG1interactorCoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
CoA_binding_2 (PF13380, IPR003781): CoA binding domain
AL702234
27 TCOF1interactorCENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Gal-3-0_sulfotr (PF06990, IPR009729): Galactose-3-O-sulfotransferase
Treacle (PF03546, IPR003993): Treacher Collins syndrome protein Treacle
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
AP3D1 (PF06375): AP-3 complex subunit delta-1
AL702234
28 TMEM177interactorNAAL702234
29 TMEM189interactorMARVEL (PF01284, IPR008253): Membrane-associating domain
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
AL702234
30 TMEM9interactorTmemb_9 (PF05434, IPR008853): TMEM9AL702234
31 TOMM40interactorPorin_3 (PF01459, IPR027246): Eukaryotic porinAL702234
32 TSTinteractorRhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domainAL702234
33 VCAM1interactorC2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
AL702234
34 VDAC2interactorPorin_3 (PF01459, IPR027246): Eukaryotic porinAL702234
35 XRCC1interactorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
SPX (PF03105, IPR004331): SPX domain
XRCC1_N (PF01834, IPR002706): XRCC1 N terminal domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
AL702234

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