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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SEC23B (from a repository: Sat Nov 12 16:37:27 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)51
The number (and %) of the onco-proteins12 (23.53 %)
The number (and %) of the tumor suppressors5 (9.80 %)
Total number of binary PPIs (saturation %)201 (15.76 %)
The number (and %) of affected PPIs51 (25.37 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI7.373
Assortativity coefficient-0.3766
The network average Clustering coefficient0.688
The number (and %) of a zero Clustering coefficients4 (7.84 %)
The number (and %) of a zero Betweenness Centrality21 (41.18 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SEC23B All fusions
: BG222141; AW361690;
Proteins found in more fusions NF2 (see 1 fusions); SYK (see 1 fusions); CUL3 (see 1 fusions); SRPK2 (see 1 fusions); SEC23B (see 2 fusions); KDELR1 (see 2 fusions); MCM2 (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SEC23Bparental protein510.1131732.116Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
2 CAND1interactor150.49523.740Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
3 CENPJinteractor50.7002.333DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein
Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
AAA_23 (PF13476): AAA domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
4 CPNE2interactor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
5 CPSF7interactor80.5006.786CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 CSNK1A1suppressor50.9000.222Pkinase (PF00069, IPR000719): Protein kinase domain
7 CUL3protein found in more fusions160.49527.932Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
8 DAB2suppressor50.7001.233PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
9 DCUN1D1interactor41.0000Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
10 DTX2oncoprotein31.0000WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
11 FATE1interactor21.0000Miff (PF05644, IPR008518): Mitochondrial and peroxisomal fission factor Mff
12 FN1oncoprotein110.49116.124fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
13 FYCO1interactor31.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
RUN (PF02759, IPR004012, SM00593): RUN domain
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
14 GALNT1interactor100Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
Ricin_B_lectin (PF00652, IPR000772, SM00458): Ricin-type beta-trefoil lectin domain
15 HOXA3oncoprotein100DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF4074 (PF13293, IPR025281): Domain of unknown function (DUF4074)
16 KCNJ10interactor31.0000IRK (PF01007, IPR016449): Inward rectifier potassium channel
17 KDELR1protein found in more fusions31.0000ER_lumen_recept (PF00810, IPR000133): ER lumen protein retaining receptor
18 MAN2A1interactor21.0000Alpha-mann_mid (PF09261, IPR015341, SM00872): Alpha mannosidase middle domain
Glyco_hydro_38 (PF01074, IPR000602): Glycosyl hydrolases family 38 N-terminal domain
Glyco_hydro_38C (PF07748, IPR011682): Glycosyl hydrolases family 38 C-terminal domain
19 MCM2oncoprotein160.36254.496AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
20 NF2suppressor31.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
21 NTRK1oncoprotein180.47837.717I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
22 PRRC1interactor21.0000NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
23 PXNoncoprotein70.47610.000LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
24 SEC13interactor110.6895.227WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
25 SEC16Ainteractor150.55221.073APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
26 SEC23Ainteractor190.41567.759Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
27 SEC24Ainteractor110.65510.675Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
28 SEC24Binteractor160.42548.866Gelsolin (PF00626, IPR007123): Gelsolin repeat
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
29 SEC24Cinteractor130.55120.510Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
30 SEC24Dinteractor70.8102.400Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
Transp_Tc5_C (PF04236, IPR007350): Tc5 transposase C-terminal domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
31 SEC31Ainteractor80.7862.144P3A (PF08727, IPR014838): Poliovirus 3A protein like
SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
32 SIRT7interactor100.5119.886DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
33 SLC25A35interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
34 SNW1protein found in more fusions80.6192.657SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
35 SRPK1interactor70.7621.738FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
36 SRPK2oncoprotein80.7622.038DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
37 SRSF3oncoprotein90.6115.569DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38 STILoncoprotein30.6670.500STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
39 SUMO2interactor31.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
40 SUMO3interactor21.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
41 SYKsuppressor31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
42 SYNE4interactor21.0000KASH (PF10541, IPR012315): Nuclear envelope localisation domain
43 TMED1interactor31.0000EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
44 TMED10interactor40.8330.667EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
45 TMED2interactor31.0000EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
46 TMED9interactor50.6003.667EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
47 TMEM17interactor50.9000.286Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
48 TMEM216interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
49 UGT1A1interactor100UDPGT (PF00201, IPR002213): UDP-glucoronosyl and UDP-glucosyl transferase
50 XPO1interactor180.42554.322CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
51 ZYXsuppressor60.8001.317DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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