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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins2 (5.26 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)63 (8.96 %)
The number (and %) of affected PPIs38 (60.32 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.684
Assortativity coefficient-0.6665
The network average Clustering coefficient0.219
The number (and %) of a zero Clustering coefficients25 (65.79 %)
The number (and %) of a zero Betweenness Centrality28 (73.68 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions PRPF40A (see 2 fusions); SDCBP2 (see 1 fusions); CTH (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SDCBP2parental protein380.0211276.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
2 ADAP1interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
3 ARF4interactor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
4 BEND7interactor70.3339.333BEN (PF10523, IPR018379, SM01025): BEN domain
5 C11orf57interactor21.0000Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
RAMP4 (PF06624, IPR010580): Ribosome associated membrane protein RAMP4
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
FAM60A (PF15396, IPR026065): Protein Family FAM60A
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
NKAP (PF15692): NF-kappa-B-activating protein
6 C1orf35interactor100Protamine_P1 (PF00260, IPR000221): Protamine P1
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
MMtag (PF10159, IPR019315): Kinase phosphorylation protein
7 CT45A3interactor100INT_SG_DDX_CT_C (PF15300, IPR029307): INTS6/SAGE1/DDX26B/CT45 C-terminus
8 CT45A5interactor100INT_SG_DDX_CT_C (PF15300, IPR029307): INTS6/SAGE1/DDX26B/CT45 C-terminus
9 CTHprotein found in more fusions200Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
10 DPPA2interactor40.6670.667SAP (PF02037, IPR003034, SM00513): SAP domain
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
11 EIF1ADinteractor30.6670.667eIF-1a (PF01176, IPR006196): Translation initiation factor 1A / IF-1
12 FAM133Ainteractor30.6670.667DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
DUF2346 (PF09803, IPR018625): Uncharacterized conserved protein (DUF2346)
NPAT_C (PF15712, IPR031442): NPAT C terminus
NuDC (PF16273, IPR032572): Nuclear distribution C domain
MFMR_assoc (PF16596): Disordered region downstream of MFMR
13 FAM13Cinteractor200Mnd1 (PF03962, IPR005647): Mnd1 family
SlyX (PF04102, IPR007236): SlyX
MRI (PF15325, IPR028278): Modulator of retrovirus infection
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
14 FAM9Binteractor31.0000Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
15 FBXO28interactor100Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
F-box (PF00646, IPR001810, SM00256): F-box domain
FAM76 (PF16046, IPR032017): FAM76 protein
16 GABRA3interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
17 LGALS14interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
18 LGALS2interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
19 LYARinteractor21.0000DEK_C (PF08766, IPR014876): DEK C terminal domain
zf-LYAR (PF08790, IPR014898): LYAR-type C2HC zinc finger
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
20 NPM2interactor100Nucleoplasmin (PF03066): Nucleoplasmin
YL1 (PF05764, IPR008895): YL1 nuclear protein
21 NUF2interactor100Nuf2 (PF03800, IPR005549): Nuf2 family
DUF2209 (PF09974, IPR014514): Uncharacterized protein conserved in archaea (DUF2209)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
22 PAFAH1B3interactor200Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
23 PRPF38Ainteractor40.6670.667PRP38 (PF03371, IPR005037): PRP38 family
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
24 PRPF40Aprotein found in more fusions40.6670.667FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
25 PRR13interactor40.6670.667DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
26 PTMSinteractor100Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
27 RNPS1interactor30.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
28 SEC23Ainteractor100Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
29 SREK1IP1interactor100zf-CCHC_3 (PF13917): Zinc knuckle
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
30 TDO2interactor200Trp_dioxygenase (PF03301, IPR004981): Tryptophan 2,3-dioxygenase
31 THAP6interactor100THAP (PF05485, IPR006612, SM00980): THAP domain
DUF4686 (PF15742, IPR031476): Domain of unknown function (DUF4686)
32 TIFAinteractor200FHA (PF00498, IPR000253, SM00240): FHA domain
33 TNP1interactor100TP1 (PF02079, IPR001319): Nuclear transition protein 1
34 YTHDC1interactor100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
YTH (PF04146, IPR007275): YT521-B-like domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
TFB6 (PF17110, IPR031349): Subunit 11 of the general transcription factor TFIIH
35 ZCCHC10interactor70.28614.000Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-CCHC_3 (PF13917): Zinc knuckle
36 ZCCHC17interactor100S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
37 ZNF581interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
38 ZRSR2interactor100Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26

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