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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)59
The number (and %) of the onco-proteins19 (32.20 %)
The number (and %) of the tumor suppressors9 (15.25 %)
Total number of binary PPIs (saturation %)208 (12.16 %)
The number (and %) of affected PPIs59 (28.37 %)
The number of possible different fusions15
PPI diameter4
PPI radius2
The average degree of PPI6.339
Assortativity coefficient-0.2624
The network average Clustering coefficient0.445
The number (and %) of a zero Clustering coefficients11 (18.64 %)
The number (and %) of a zero Betweenness Centrality12 (20.34 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SCARB2,LAMP2 All fusions
: BE890392;
Proteins found in more fusions TUBG1 (see 1 fusions); LGALS3 (see 2 fusions); APEH (see 1 fusions); EWSR1 (see 2 fusions); EIF2AK2 (see 1 fusions); PRPF8 (see 3 fusions); MCM7 (see 2 fusions); PCNA (see 1 fusions); TNF (see 1 fusions); LYN (see 1 fusions); PRPF19 (see 2 fusions); LAMP2 (see 1 fusions); HSPA8/HSPD1 (see 1 fusions); NPM1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SCARB2parental protein180.052706.832CD36 (PF01130, IPR002159): CD36 family
2 LAMP2parental protein410.0971283.548Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
3 APEHoncoprotein4034.143Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
4 ATP4Ainteractor200Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
H-K_ATPase_N (PF09040, IPR015127): Gastric H+/K+-ATPase, N terminal domain
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5 ATP6V1B1interactor50.40099.688ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
6 BCAS2interactor70.52410.615BCAS2 (PF05700, IPR008409): Breast carcinoma amplified sequence 2 (BCAS2)
ZapB (PF06005, IPR009252): Cell division protein ZapB
7 DDX1oncoprotein40.6679.374DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8 DDX21interactor50.7001.754CRT10 (PF08728, IPR014839): CRT10
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
GUCT (PF08152, IPR012562): GUCT (NUC152) domain
Sulfatase (PF00884, IPR000917): Sulfatase
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
9 EIF2AK2oncoprotein50.50017.449dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Pkinase (PF00069, IPR000719): Protein kinase domain
10 ELAVL1oncoprotein170.200218.104RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 EPRSinteractor30.6670.421GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
12 EWSR1oncoprotein90.53613.535RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
13 GEMinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
AAA_22 (PF13401, IPR003593): AAA domain
14 HIF1Asuppressor40.6671.333Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
15 HNRNPUinteractor150.25798.804CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
16 HP1BP3interactor40.8330.421RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal
SDA1 (PF05285, IPR007949): SDA1
YL1 (PF05764, IPR008895): YL1 nuclear protein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
17 HSPA8oncoprotein110.36450.370HSP70 (PF00012, IPR013126): Hsp70 protein
18 HSPD1suppressor50.50038.722Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19 IMPDH1interactor200.421IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
20 LGALS3oncoprotein50.33350.690Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
21 LGALS8interactor40.16730.946Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
22 LYNoncoprotein60.6007.337Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23 MCM7protein found in more fusions70.40012.809MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
24 MDM2oncoprotein100.36116.700Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
25 METTL21Binteractor40.5008.239Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
26 MYOFinteractor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
FerA (PF08165, IPR012560): FerA (NUC095) domain
FerB (PF08150, IPR012561): FerB (NUC096) domain
FerI (PF08151, IPR012968): FerI (NUC094) domain
Pex24p (PF06398, IPR010482): Integral peroxisomal membrane peroxin
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
27 NAALADL2interactor100Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
DUF4731 (PF15875, IPR031744): Domain of unknown function (DUF4731)
28 NCSTNinteractor100.35693.698Nicastrin (PF05450, IPR008710): Nicastrin
Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
29 NONOoncoprotein60.50021.480GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PAS_7 (PF12860): PAS fold
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
30 NPM1suppressor110.37836.361Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
31 NTRK1oncoprotein310.117763.229I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32 PCNAoncoprotein80.4298.617PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
33 PDS5Bsuppressor30.6670.421AT_hook (PF02178, IPR017956, SM00384): AT hook motif
HEAT (PF02985, IPR000357): HEAT repeat
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain
DUF3665 (PF12427, IPR024614): Branched-chain amino acid aminotransferase
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
34 PIAS4interactor21.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
35 PNKDinteractor203.619Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
36 PRPF19protein found in more fusions110.42247.455Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
37 PRPF8oncoprotein90.50077.570PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain
PROCN (PF08083, IPR012592): PROCN (NUC071) domain
PROCT (PF08084, IPR012984): PROCT (NUC072) domain
RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8
U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8
U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
38 PTPRKsuppressor30.33316.508fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
39 PXKinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PX (PF00787, IPR001683, SM00312): PX domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
MNR (PF15718, IPR031447): Protein moonraker
40 RBBP4oncoprotein50.6002.904eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
41 RFC1interactor40.6670.921AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
Nexin_C (PF08628, IPR013937): Sorting nexin C terminal
RFC1 (PF08519, IPR013725): Replication factor RFC1 C terminal domain
DUF2316 (PF10078, IPR018757): Uncharacterized protein conserved in bacteria (DUF2316)
42 RNF13interactor2023.155DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
43 SAFBsuppressor80.46471.302RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
44 SF3B3interactor90.52818.028CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
45 SF3B6interactor80.53616.878RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
46 SMC6interactor31.0000SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
47 SNCAinteractor70.6004.722Synuclein (PF01387, IPR001058): Synuclein
48 SNRPA1interactor80.50015.987LRR_9 (PF14580): Leucine-rich repeat
49 SRP14interactor31.0000SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
50 SUB1interactor31.0000Dehydrin (PF00257, IPR000167): Dehydrin
PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4)
51 TAF15oncoprotein206.300API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
GRP (PF07172, IPR010800): Glycine rich protein family
Presenilin (PF01080, IPR001108): Presenilin
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
52 THBS1suppressor2010.786EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EndIII_4Fe-2S (PF10576, IPR003651): Iron-sulfur binding domain of endonuclease III
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
53 THOC6interactor30.6671.532WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
54 TNFoncoprotein41.0000TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
55 TUBA1Binteractor31.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
56 TUBBinteractor100.42239.196Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
57 TUBG1protein found in more fusions80.57115.461Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
58 UCHL1suppressor40.6671.617Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
59 WISP3suppressor100Cys_knot (PF00007, IPR006208): Cystine-knot domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein

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