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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SACM1L (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins4 (28.57 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)35 (38.46 %)
The number (and %) of affected PPIs14 (40.00 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.857
Assortativity coefficient-0.4801
The network average Clustering coefficient0.465
The number (and %) of a zero Clustering coefficients6 (42.86 %)
The number (and %) of a zero Betweenness Centrality9 (64.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SACM1L All fusions
Proteins found in more fusions COPB1 (see 2 fusions); SACM1L (see 1 fusions); COPA (see 2 fusions); COPG1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SACM1Lparental protein140.179121.000DSS1_SEM1 (PF05160, IPR007834): DSS1/SEM1 family
Syja_N (PF02383, IPR002013): SacI homology domain
2 COPAprotein found in more fusions70.8671.000Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
3 COPB1protein found in more fusions70.8671.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform
4 COPEinteractor61.0000Coatomer_E (PF04733, IPR006822): Coatomer epsilon subunit
TPR_19 (PF14559): Tetratricopeptide repeat
5 COPG1protein found in more fusions70.8671.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain
Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
6 CREB3interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
7 EVA1Cinteractor100Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
FAM176 (PF14851): FAM176 family
8 FOXB1interactor41.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
9 LPAR1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
10 NTRK1oncoprotein70.7334.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
11 P2RY12interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
12 PRKCAinteractor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
13 SPINT2interactor100Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
14 TM9SF4interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)

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