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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RYR2 (from a repository: Sun Nov 13 08:37:43 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins3 (12.00 %)
The number (and %) of the tumor suppressors2 (8.00 %)
Total number of binary PPIs (saturation %)54 (18.00 %)
The number (and %) of affected PPIs25 (46.30 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI3.760
Assortativity coefficient-0.2512
The network average Clustering coefficient0.663
The number (and %) of a zero Clustering coefficients4 (16.00 %)
The number (and %) of a zero Betweenness Centrality15 (60.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RYR2 All fusions
Proteins found in more fusions RYR2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RYR2parental protein250.083480.667Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RYDR_ITPR (PF01365, IPR000699): RIH domain
RyR (PF02026, IPR003032): RyR domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
YjfB_motility (PF14070, IPR025906): Putative motility protein
2 AKAP6interactor40.5002.667IPK (PF03770, IPR005522): Inositol polyphosphate kinase
Spectrin (PF00435, IPR002017): Spectrin repeat
3 ALBinteractor100Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 CACNA1Cinteractor30.6671.000Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
Ion_trans (PF00520, IPR005821): Ion transport protein
Rer1 (PF03248, IPR004932): Rer1 family
ODV-E18 (PF10717, IPR019655): Occlusion-derived virus envelope protein ODV-E18
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
CAC1F_C (PF16885, IPR031688): Voltage-gated calcium channel subunit alpha, C-term
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
5 CALM1interactor40.5003.000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
6 CFTRsuppressor60.4005.667ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
7 FKBP1Binteractor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
8 HOMER1interactor21.0000WH1 (PF00568, IPR000697, SM00461): WH1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
9 HSPB2interactor31.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
10 MDM2oncoprotein31.0000Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
11 PPP1CAsuppressor40.6672.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
12 PPP1CBinteractor40.6672.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
13 PPP1CConcoprotein31.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
14 PRKACAinteractor60.6005.000Pkinase (PF00069, IPR000719): Protein kinase domain
15 PRKACBinteractor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
16 PRKACGinteractor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
17 PRKAR2Ainteractor50.7002.667RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
18 PRKAR2Binteractor50.8001.333RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
19 RYR1interactor21.0000CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
Mak16 (PF04874, IPR006958): Mak16 protein C-terminal region
MIR (PF02815, IPR016093, SM00472): MIR domain
Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RYDR_ITPR (PF01365, IPR000699): RIH domain
RyR (PF02026, IPR003032): RyR domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
Urb2 (PF10441, IPR018849): Urb2/Npa2 family
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
20 RYR3interactor21.0000Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RYDR_ITPR (PF01365, IPR000699): RIH domain
RyR (PF02026, IPR003032): RyR domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
21 SMAD5interactor100MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
22 SNTA1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
23 SRIoncoprotein31.0000EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
24 TERF1interactor31.0000TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
25 TERF2interactor31.0000Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif

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