Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins RXRA (from a repository: Fri Nov 11 23:10:20 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 109 The number (and %) of the onco-proteins 39 (35.78 %) The number (and %) of the tumor suppressors 34 (31.19 %) Total number of binary PPIs (saturation %) 698 (11.86 %) The number (and %) of affected PPIs 109 (15.62 %) The number of possible different fusions 27 PPI diameter 2 PPI radius 1 The average degree of PPI 11.908 Assortativity coefficient -0.2573 The network average Clustering coefficient 0.538 The number (and %) of a zero Clustering coefficients 3 (2.75 %) The number (and %) of a zero Betweenness Centrality 19 (17.43 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: RXRA	All fusions : AW881282; AW881216;
Proteins found in more fusions	PPARD (see 1 fusions); RARA/PML (see 20 fusions); VDR (see 2 fusions); POU2F1 (see 1 fusions); CASP2 (see 3 fusions); MAPK1 (see 1 fusions); GSK3B (see 1 fusions); HDAC4 (see 1 fusions); NFKB1 (see 2 fusions); NCOA1 (see 2 fusions); NCOA6 (see 1 fusions); SP1 (see 1 fusions); RARA (see 4 fusions); MYOD1 (see 1 fusions); PIK3R1 (see 1 fusions); POU2F2 (see 5 fusions); POLR2A (see 2 fusions); RXRA (see 2 fusions); EP300 (see 1 fusions); PML (see 4 fusions); ZBTB16 (see 3 fusions); PSMC5 (see 2 fusions); THRA (see 3 fusions); STAT1 (see 1 fusions); GRIP1 (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	RXRA	parental protein	109	0.094	6829.110	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
2	ACVR1B	oncoprotein	2	1.000	0	Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain Pkinase (PF00069, IPR000719): Protein kinase domain TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3	ALOX15B	suppressor	2	1.000	0	Lipoxygenase (PF00305, IPR013819): Lipoxygenase PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
4	ARID5A	oncoprotein	3	0.667	0.118	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
5	ARNTL	suppressor	6	0.867	0.800	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_11 (PF14598): PAS domain
6	BCL3	oncoprotein	9	0.583	4.838	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
7	BHLHE40	interactor	5	0.667	1.067	Hairy_orange (PF07527, IPR003650): Hairy Orange HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
8	BHLHE41	suppressor	7	0.533	5.667	Adeno_PIX (PF03955, IPR005641): Adenovirus hexon-associated protein (IX) Hairy_orange (PF07527, IPR003650): Hairy Orange HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
9	BRD8	interactor	2	1.000	0	Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
10	CASP2	suppressor	3	1.000	0	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
11	CHD9	oncoprotein	3	0.667	0.286	BUD22 (PF09073, IPR015158): BUD22 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain Chorion_2 (PF03964, IPR005649): Chorion family 2 Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain cIII (PF08134, IPR012995): cIII protein family Peptidase_M10 (PF00413, IPR001818): Matrixin SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Vpu (PF00558, IPR008187): Vpu protein Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain BRK (PF07533, IPR006576, SM00592): BRK domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Sox_N (PF12444, IPR022151): Sox developmental protein N terminal FNIP_N (PF14636, IPR028084): Folliculin-interacting protein N-terminus
12	CLOCK	interactor	7	0.714	3.800	DivIC (PF04977, IPR007060): Septum formation initiator HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) PAS (PF00989, IPR013767, SM00091): PAS fold RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4 PAS_11 (PF14598): PAS domain FlgT_N (PF16548, IPR032370): Flagellar assembly protein T, N-terminal domain
13	CNOT1	interactor	2	1.000	0	Not1 (PF04054, IPR007196): CCR4-Not complex component, Not1 DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439) DUF3819 (PF12842, IPR024557): Domain of unknown function (DUF3819) EF-hand_8 (PF13833, IPR002048): EF-hand domain pair CNOT1_CAF1_bind (PF16415, IPR032191): CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind (PF16417, IPR032193): CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT (PF16418, IPR032194): CCR4-NOT transcription complex subunit 1 HEAT repeat
14	CSNK2B	interactor	9	0.464	10.019	CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
15	CTCF	suppressor	2	1.000	0	cwf18 (PF08315, IPR013169): cwf18 pre-mRNA splicing factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
16	CTNNB1	oncoprotein	18	0.359	55.637	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
17	CTSL	oncoprotein	1	0	0	Inhibitor_I29 (PF08246, IPR013201, SM00848): Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
18	DNMT3L	interactor	7	0.429	4.302	CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
19	DNTTIP2	interactor	2	1.000	0	BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II) E7 (PF00527, IPR000148): E7 protein, Early protein Fcf2 (PF08698, IPR014810): Fcf2 pre-rRNA processing FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
20	EDF1	interactor	5	0.600	1.450	MBF1 (PF08523, IPR013729): Multiprotein bridging factor 1 HTH_3 (PF01381, IPR001387, SM00530): Helix-turn-helix
21	EP300	oncoprotein	44	0.256	382.478	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
22	FUS	suppressor	8	0.393	5.089	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
23	GADD45A	suppressor	5	0.833	0.500	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
24	GADD45G	suppressor	6	0.400	3.588	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
25	GK	interactor	2	1.000	0	FGGY_C (PF02782, IPR018485): FGGY family of carbohydrate kinases, C-terminal domain FGGY_N (PF00370, IPR018484): FGGY family of carbohydrate kinases, N-terminal domain
26	GRIP1	protein found in more fusions	10	0.583	9.148	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
27	GSK3B	suppressor	16	0.295	44.948	Pkinase (PF00069, IPR000719): Protein kinase domain
28	HDAC3	suppressor	24	0.439	55.789	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
29	HDAC4	oncoprotein	19	0.471	27.696	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
30	IGFBP3	suppressor	2	1.000	0	IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
31	ITGB3BP	interactor	5	0.667	0.444	CENP-R (PF06729, IPR009601): Kinetochore component, CENP-R
32	JAZF1	oncoprotein	2	1.000	0	ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2 zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger
33	KIF1A	interactor	4	0.833	0.500	FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain KIF1B (PF12423, IPR022140): Kinesin protein 1B Sox_N (PF12444, IPR022151): Sox developmental protein N terminal DUF3694 (PF12473, IPR022164): Kinesin protein Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
34	KLF5	suppressor	12	0.576	7.720	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
35	MAPK1	oncoprotein	13	0.530	13.242	Pkinase (PF00069, IPR000719): Protein kinase domain
36	MAPK3	oncoprotein	8	0.571	4.611	Pkinase (PF00069, IPR000719): Protein kinase domain
37	MED1	interactor	15	0.418	25.096	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
38	MED24	interactor	12	0.333	23.846	Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
39	MED25	interactor	7	0.800	0.903	Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2 Med25_SD1 (PF11235, IPR021397): Mediator complex subunit 25 synapsin 1 Med25_NR-box (PF11244, IPR021406): Mediator complex subunit 25 C-terminal NR box-containing Med25_VWA (PF11265, IPR021419): Mediator complex subunit 25 von Willebrand factor type A
40	MYOD1	oncoprotein	11	0.422	16.675	Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Mfp-3 (PF04202, IPR007328): Foot protein 3 Myf5 (PF12232, IPR022032): Myogenic determination factor 5
41	NCOA1	oncoprotein	33	0.282	167.291	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
42	NCOA2	oncoprotein	16	0.483	14.351	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
43	NCOA3	oncoprotein	27	0.365	92.102	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
44	NCOA4	suppressor	3	1.000	0	ARA70 (PF12489, IPR022174): Nuclear coactivator
45	NCOA6	oncoprotein	25	0.359	69.873	DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator
46	NCOR1	oncoprotein	28	0.397	78.089	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
47	NCOR2	oncoprotein	33	0.335	148.683	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
48	NFKB1	suppressor	26	0.417	71.177	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
49	NFKBIB	interactor	6	0.800	0.622	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
50	NPAS2	suppressor	7	0.762	2.467	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold DehI (PF10778, IPR019714): Halocarboxylic acid dehydrogenase DehI PAS_11 (PF14598): PAS domain
51	NR0B2	suppressor	13	0.385	14.469	Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
52	NR1H2	oncoprotein	15	0.457	20.166	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
53	NR1H3	interactor	10	0.422	9.981	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
54	NR1H4	interactor	8	0.643	2.799	LRV_FeS (PF05484, IPR008665): LRV protein FeS4 cluster zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
55	NR1I2	suppressor	12	0.409	14.350	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
56	NR1I3	interactor	11	0.345	17.517	PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
57	NR2E3	interactor	4	0.667	0.182	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
58	NR2F6	oncoprotein	5	0.700	1.619	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
59	NR3C2	oncoprotein	7	0.429	3.823	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
60	NR4A1	suppressor	11	0.564	16.634	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
61	NR4A2	oncoprotein	4	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
62	NRBF2	interactor	4	0.500	0.543	NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
63	NRIP1	oncoprotein	13	0.295	19.647	ALMT (PF11744, IPR020966): Aluminium activated malate transporter NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1 NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2 NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3 NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
64	NSD1	oncoprotein	8	0.429	6.252	PHD (PF00628, IPR019787, SM00249): PHD-finger PWWP (PF00855, IPR000313, SM00293): PWWP domain SET (PF00856, IPR001214, SM00317): SET domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
65	PIK3R1	oncoprotein	6	0.700	1.450	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
66	PLK1	suppressor	4	0.500	1.022	Pkinase (PF00069, IPR000719): Protein kinase domain POLO_box (PF00659, IPR000959): POLO box duplicated region
67	PML	suppressor	26	0.347	88.790	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
68	POLR2A	protein found in more fusions	15	0.308	37.520	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
69	POU2F1	protein found in more fusions	9	0.571	2.665	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
70	POU2F2	oncoprotein	3	1.000	0	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Totivirus_coat (PF05518, IPR008871): Totivirus coat protein Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
71	PPARA	suppressor	17	0.338	44.454	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
72	PPARD	oncoprotein	16	0.438	17.970	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
73	PPARG	suppressor	47	0.193	561.746	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
74	PPARGC1A	interactor	19	0.380	42.201	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
75	PRKD2	interactor	3	0.667	1.000	ABC1 (PF03109, IPR004147): ABC1 family Pkinase (PF00069, IPR000719): Protein kinase domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
76	PSMC5	protein found in more fusions	15	0.264	25.384	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Laminin_II (PF06009, IPR010307): Laminin Domain II RILP (PF11461, IPR021563): Rab interacting lysosomal protein AAA_16 (PF13191): AAA ATPase domain
77	RAD54L2	interactor	3	1.000	0	SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
78	RARA	oncoprotein	41	0.177	410.692	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
79	RARB	suppressor	7	0.286	7.830	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
80	RARG	oncoprotein	9	0.444	8.079	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
81	RELA	oncoprotein	27	0.329	114.203	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
82	RNF8	suppressor	2	0	0	FHA (PF00498, IPR000253, SM00240): FHA domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
83	ROBO4	interactor	3	0.667	0.143	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
84	RPS6KA6	suppressor	5	0.400	3.233	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
85	SMAD2	suppressor	15	0.385	28.595	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
86	SMARCA4	suppressor	17	0.419	33.365	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
87	SMARCD3	interactor	8	0.321	7.344	SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
88	SMN1	interactor	5	0.500	1.186	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
89	SNW1	protein found in more fusions	17	0.325	50.617	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
90	SP1	protein found in more fusions	23	0.437	61.249	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
91	SRC	oncoprotein	10	0.472	7.290	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
92	SRF	interactor	15	0.615	7.608	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
93	STAT1	suppressor	15	0.484	15.268	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
94	TADA3	interactor	5	0.600	1.708	GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
95	TAF1B	interactor	3	1.000	0	Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
96	TBP	interactor	16	0.314	42.546	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
97	TDG	interactor	7	0.619	1.283	Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
98	THRA	suppressor	23	0.255	85.683	C1_2 (PF03107, IPR004146): C1 domain zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
99	THRB	suppressor	20	0.251	68.237	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
100	TK1	oncoprotein	3	1.000	0	TK (PF00265, IPR001267, SM00203): Thymidine kinase
101	TMPRSS3	oncoprotein	1	0	0	Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A Trypsin (PF00089, IPR001254, SM00020): Trypsin SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
102	TRAF2	interactor	7	0.400	6.133	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
103	TRIM24	suppressor	8	0.571	2.413	PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Siva (PF05458, IPR022773): Cd27 binding protein (Siva) zf-MYND (PF01753, IPR002893): MYND finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 Imm68 (PF15583, IPR028276): Immunity protein 68 SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
104	TRIM32	suppressor	4	0.667	1.000	NHL (PF01436, IPR001258): NHL repeat zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
105	TRIP4	interactor	14	0.451	21.473	ASCH (PF04266, IPR007374, SM01022): ASCH domain UxaC (PF02614, IPR003766): Glucuronate isomerase zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
106	UBE2I	interactor	29	0.235	185.447	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
107	UBQLN4	interactor	4	0.667	1.000	CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Arm_2 (PF04826, IPR006911): Armadillo-like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
108	VDR	suppressor	29	0.257	138.353	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
109	ZBTB16	suppressor	14	0.500	25.814	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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