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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)92
The number (and %) of the onco-proteins18 (19.57 %)
The number (and %) of the tumor suppressors5 (5.43 %)
Total number of binary PPIs (saturation %)262 (6.26 %)
The number (and %) of affected PPIs92 (35.11 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI5.130
Assortativity coefficient-0.2671
The network average Clustering coefficient0.573
The number (and %) of a zero Clustering coefficients18 (19.57 %)
The number (and %) of a zero Betweenness Centrality45 (48.91 %)


List of the fusions

PPI for parental proteins: RTN4 All fusions
: AA180924; AA180908; BE694253; AA180827; CN418139; BP251731; W27023; BE007854;
Proteins found in more fusions BCL2L1 (see 1 fusions); SNX1 (see 1 fusions); HUWE1 (see 2 fusions); DDB1 (see 2 fusions); RPA1 (see 1 fusions); EEF1D (see 3 fusions); WWP1 (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RTN4parental protein920.0357224.808CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
2 ACAA2interactor70.5248.667Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 ARL6IP1interactor110.20033.833Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
4 ARL6IP5suppressor60.4008.667PRA1 (PF03208, IPR004895): PRA1 family protein
RBD-FIP (PF09457, IPR019018): FIP domain
5 ATF2oncoprotein70.6004.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
6 ATIConcoprotein21.0000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
7 ATL3interactor30.6670.400GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
8 ATP1B1interactor41.0000Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
9 ATP1B3interactor70.33313.667Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
10 ATP5Ointeractor50.6003.067OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
11 BAIAP2interactor31.0000IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
12 BCL2oncoprotein40.6671.000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
13 BCL2L1oncoprotein40.6671.000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
14 C4orf32interactor30.6671.000DUF4605 (PF15378, IPR027953): Domain of unknown function (DUF4605)
15 CFL1interactor60.4676.567Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
16 CIRBPinteractor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
17 CLN8interactor30.6670.667TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
18 CNTNAP1interactor31.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
19 COL4A3BPinteractor40.6670.400Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
PH (PF00169, IPR001849, SM00233): PH domain
START (PF01852, IPR002913, SM00234): START domain
20 CRMP1interactor50.6670.722Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
21 CYB5R3interactor100FAD_binding_6 (PF00970, IPR008333): Oxidoreductase FAD-binding domain
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
22 DDB1protein found in more fusions90.5009.675CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
23 DDX46interactor80.5717.075CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
CdAMP_rec (PF06153, IPR010375): Cyclic-di-AMP receptor
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FAM176 (PF14851): FAM176 family
24 DERL1interactor41.0000DER1 (PF04511, IPR007599): Der1-like family
25 DERL2interactor31.0000DER1 (PF04511, IPR007599): Der1-like family
26 EEF1Dprotein found in more fusions90.46411.833EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
27 EPPK1interactor100DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HupF_HypC (PF01455, IPR001109): HupF/HypC family
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
RPA_interact_N (PF14766, IPR028158): Replication protein A interacting N-terminal
28 FAM210Binteractor100DUF1279 (PF06916, IPR009688): Protein of unknown function (DUF1279)
RepB (PF07506, IPR011111): RepB plasmid partitioning protein
29 FXR2interactor50.5001.467Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
30 GOLT1Binteractor80.5009.500Got1 (PF04178, IPR007305): Got1/Sft2-like family
31 GRHPRinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
32 HLA-DPB1interactor100MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
33 HNRNPMinteractor60.6672.841RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M
Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
34 HSD17B10interactor70.5716.067adh_short (PF00106, IPR002198): short chain dehydrogenase
35 HSDL1interactor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
36 HUWE1oncoprotein110.42216.222BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
37 IGFBP7interactor100IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
Ig_3 (PF13927): Immunoglobulin domain
38 ILF3oncoprotein70.6194.341dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
39 KCNA1interactor31.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
40 KCNA2interactor41.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
41 KIAA1033interactor50.8000.508WASH-7_mid (PF14744, IPR028282): WASH complex subunit 7
WASH-7_N (PF14745, IPR028191): WASH complex subunit 7, N-terminal
WASH-7_C (PF14746, IPR028283): WASH complex subunit 7, C-terminal
42 KTN1oncoprotein50.6003.000ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
43 LAMA4interactor100DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
44 LRCH4interactor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
LRR_8 (PF13855, IPR001611): Leucine rich repeat
45 LRPAP1interactor100Alpha-2-MRAP_C (PF06401, IPR010483): Alpha-2-macroglobulin RAP, C-terminal domain
Alpha-2-MRAP_N (PF06400, IPR009066): Alpha-2-macroglobulin RAP, N-terminal domain
46 METTL7Binteractor100Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
47 NAPAoncoprotein41.0000SNAP (PF14938): Soluble NSF attachment protein, SNAP
48 NR4A1suppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
49 NTRK1oncoprotein310.133344.867I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
50 PLEKHF2interactor30.6671.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
51 POT1interactor50.8330.500POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
52 PRAF2interactor100PRA1 (PF03208, IPR004895): PRA1 family protein
53 PRR13interactor31.0000DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
54 RAB33Aoncoprotein30.6670.400Ras (PF00071, IPR001806, SM00173): Ras family
55 RPA1suppressor110.6007.808Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
56 RPA2oncoprotein110.47315.467RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
57 RPA3interactor110.48912.967Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
58 RPS27interactor100Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
59 RTN1interactor30.6671.000Reticulon (PF02453, IPR003388): Reticulon
60 RTN2interactor21.0000Reticulon (PF02453, IPR003388): Reticulon
61 RTN3interactor120.18240.833Reticulon (PF02453, IPR003388): Reticulon
62 RTN4IP1interactor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
63 S100A16interactor100S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
64 SBNO1oncoprotein21.0000Helicase_C_4 (PF13871, IPR026937): C-terminal domain on Strawberry notch homologue
AAA_34 (PF13872): P-loop containing NTP hydrolase pore-1
65 SCAMP1interactor40.6671.000SCAMP (PF04144, IPR007273): SCAMP family
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
66 SCAMP2interactor21.0000SCAMP (PF04144, IPR007273): SCAMP family
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
67 SGCZinteractor21.0000Sarcoglycan_1 (PF04790, IPR006875): Sarcoglycan complex subunit protein
68 SH3PXD2Ainteractor21.0000DUF1604 (PF07713, IPR011666): Protein of unknown function (DUF1604)
PX (PF00787, IPR001683, SM00312): PX domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
69 SIRT2suppressor21.0000SIR2 (PF02146, IPR003000): Sir2 family
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
70 SLC25A10interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
71 SLC9A3R2interactor100EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
72 SNX1protein found in more fusions60.5003.467PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
73 SNX12interactor21.0000PX (PF00787, IPR001683, SM00312): PX domain
74 SNX15interactor21.0000MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
PX (PF00787, IPR001683, SM00312): PX domain
75 SNX2interactor40.8330.667PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
76 SPG21interactor21.0000Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
77 SPOPoncoprotein40.6671.000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
MATH (PF00917, IPR002083, SM00061): MATH domain
78 SSR3interactor21.0000TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
79 SYT16interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
DUF3684 (PF12449, IPR022155): Protein of unknown function (DUF3684)
80 TBL2suppressor21.0000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
FdsD (PF11390, IPR021074): NADH-dependant formate dehydrogenase delta subunit FdsD
81 TERF1interactor70.4676.667TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
82 TJP1interactor40.6672.000DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
83 TMEM216interactor60.4677.167Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
84 TMEM43interactor40.8330.333TMEM43 (PF07787, IPR012430): Transmembrane protein 43
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
85 TMEM65interactor21.0000TMEM65 (PF10507, IPR019537): Transmembrane protein 65
86 TMEM70interactor100TMEM70 (PF06979, IPR009724): Assembly, mitochondrial proton-transport ATP synth complex
87 UNKinteractor50.4005.000MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
88 UQCRC1interactor70.6674.300Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
89 UQCRC2oncoprotein100.44419.533Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
90 VAPAinteractor130.32143.033DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
91 WWP1oncoprotein200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
92 ZFYVE21interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
ZFYVE21_C (PF16696, IPR032031): Zinc finger FYVE domain-containing protein 21 C-terminus

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